Journal
APPLIED RADIATION AND ISOTOPES
Volume 164, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2020.109234
Keywords
Boron neutron capture therapy; Glioma; Stem cell; Boronophenylalanine
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Funding
- Japan Society for the Promotion of Science (JSPS) KAKENHI [18K07705, 19K08194, 18H02909]
- Grants-in-Aid for Scientific Research [19K08194, 18K07705, 18H02909] Funding Source: KAKEN
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Tumor sphere-forming (TS) glioma stem cells and cancerous TS cells were analyzed in vivo and in vitro. The boron concentration in murine TS tumors was higher than normal tissue. The boron concentration at 24 h was 0.80 +/- 0.09 mu g/10(7) in the TS cells, and 1.08 +/- 0.08 mu g/10(7) in the cancerous cells. The LAT-1 amino-acid transporter positive rate was 35.4% in the TS cells and 100% in the cancerous cells. These results suggested the relation between LAT-1 expression and boronophenylalanine concentration in vitro.
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