Synthesis, characterization, antifungal and antibacterial activities evaluation of copper (II), zinc (II) and cadmium (II) chloride and bromide complexes with new (E)-1-(3,4-dimethoxybenzylidene)-4-methylthiosemicarbazone ligand

The reactions of Cu (II), Zn (II) and Cd (II) chloride or bromide with (E)-1-(3,4-dimethoxybenzylidene)-4-methylthiosemicarbazone (MTSVT) lead to the formation of new complexes. They were characterized by spectroscopic studies: IR,H-1 and(13)C NMR. The crystal structures of the compounds [MTSVT] (L), [ZnBr2(MTSVT)(2)] (2), [CdCl2(MTSVT)(2)] (3) and [CdBr2(MTSVT)(2)(H2O)-H-.] (4) were determined by X-ray diffraction. For complexes2-4, the ion is coordinated through the sulfur atom. All compounds were tested for their antifungal activity against human pathogenic fungiCandida albicansandAspergillus fumigatus, and for their antibacterial activity against Gram (+)Bacillus subtilisandEnterococcus faecalisas well as against Gram (-) bacteria such asParacoccus yeeiandAcinetobacter baumanii.The results indicated that the metal complexes exhibited a marked enhancement in antibacterial activity compared with the parent Schiff base.