Review
Multidisciplinary Sciences
Amanda J. Krause, Erin H. Walsh, Philip A. Weissbrod, Tiffany H. Taft, Rena Yadlapati
Summary: Laryngopharyngeal reflux (LPR) is a syndrome caused by the reflux of gastric contents into the pharynx or larynx, leading to a variety of symptoms. Treatment options for LPR include medical therapies such as proton pump inhibitors and noninvasive treatment options like lifestyle therapy. Due to the complexity of patients with LPR, a treatment algorithm is proposed to assist clinicians in diagnosing and treating patients effectively.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Medicine, General & Internal
Gaia Pellegatta, Benedetto Mangiavillano, Rossella Semeraro, Francesco Auriemma, Elisa Carlani, Alessandro Fugazza, Edoardo Vespa, Alessandro Repici
Summary: Extraesophageal reflux symptoms are common in the Western population and their clinical management is controversial. This study evaluated a new treatment method for patients with GERD experiencing extraesophageal symptoms. The results showed that the treatment method reduced symptom frequency and severity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Misbah Baqir, Amit Vasirreddy, Ann N. Vu, Teng Moua, Alanna M. Chamberlain, Ryan D. Frank, Jay H. Ryu
Summary: The study found that patients with IPF were more likely to have GERD compared to controls with non-IPF ILD or no diagnosed lung disease. This suggests that GERD may be an important factor contributing to the development of lung fibrosis.
RESPIRATORY MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Joan W. Chen, Marcelo F. Vela, Kathryn A. Peterson, Dustin A. Carlson
Summary: This article provides practical advice for the clinical management of patients with suspected extraesophageal gastroesophageal reflux disease. The advice is based on available evidence from published studies, clinical trials, and clinical guidelines. It emphasizes the importance of considering extraesophageal manifestations of gastroesophageal reflux disease and the need for a multidisciplinary approach in diagnosis and treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Vikram Rangan, Lawrence F. Borges, Wai-Kit Lo, Sravanya Gavini, Mariel Bailey, Kelly E. Hathorn, Hilary J. Goldberg, Walter W. Chan
Summary: This study evaluated the relationship between novel metrics (MNBI and PSPW index) and lung function decline in patients with IPF. The results showed that lower MNBI and PSPW index were associated with more severe lung function decline. These metrics may have prognostic value for IPF and support the role of reflux in its pathogenesis.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Respiratory System
Aparna C. Swaminathan, Anne S. Hellkamp, Megan L. Neely, Shaun Bender, Luca Paoletti, Eric S. White, Scott M. Palmer, Timothy P. M. Whelan, Daniel F. Dilling
Summary: This study identifies the factors associated with lung transplant or death in patients with idiopathic pulmonary fibrosis (IPF). Age, income, and access to lung transplant centers are found to influence the likelihood of receiving a lung transplant or dying. Interventions are needed to address the socioeconomic disparities in lung transplantation.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Gastroenterology & Hepatology
Ramsah Cheah, Supphamat Chirnaksorn, Ahmed H. Abdelrahim, Laura Horgan, Toby Capstick, John Casey, Daniel Peckham, Alison Boland, Timothy J. T. Sutherland, Paul Beirne, Augustine S. Lee, Kenneth R. DeVault, Lesley A. Houghton
Summary: The study showed that patients with idiopathic pulmonary fibrosis (IPF) who had esophageal motility disorders, especially ineffective esophageal motility (IEM), had more severe pulmonary disease and more proximal reflux events. In patients with IEM, intrathoracic pressure was negatively correlated with the number of proximal events, while inspiratory lower esophageal sphincter pressure was positively correlated with the percentage of reflux events reaching the proximal esophagus.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Pharmacology & Pharmacy
Yiliang Su, Li Shen, Fen Zhang, Xing Jiang, Xiaofeng Jin, Yuan Zhang, Yang Hu, Ying Zhou, Qiuhong Li, Huiping Li
Summary: The study included 44 patients with idiopathic pulmonary fibrosis and 30 healthy individuals for laryngopharyngeal pH monitoring, suggesting the presence of laryngopharyngeal reflux in patients and showing different manifestations in the upright and supine positions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jesse M. P. Rappaport, Siva Raja, Scott Gabbard, Lucy Thuita, Madhusudhan R. Sanaka, Eugene H. Blackstone, Usman Ahmad
Summary: This study evaluated the safety and clinical effectiveness of per-oral endoscopic pyloromyotomy in relieving gastroparesis after lung transplant. The results showed that this procedure can effectively alleviate the symptoms of gastroparesis and also improve gastroesophageal reflux and allograft function.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Review
Biochemistry & Molecular Biology
Roxana-Elena Cirjaliu, Mariana Deacu, Ioana Gherghisan, Angela Stefania Marghescu, Manuela Enciu, Gabriela Izabela Baltatescu, Antonela Anca Nicolau, Doina-Ecaterina Tofolean, Oana Cristina Arghir, Ariadna-Petronela Fildan
Summary: This review provides a comprehensive analysis of the risk factors, clinical, radiologic, and histological features of both post-COVID-19 pulmonary fibrosis (PCPF) and idiopathic pulmonary fibrosis (IPF). It highlights the similarities and differences between these two diseases by gathering relevant articles published in English up until October 2022 using multiple databases. This review aims to assist clinicians, pathologists, and researchers in making accurate diagnoses and selecting patients for anti-fibrotic therapies and future therapeutic perspectives.
Article
Gastroenterology & Hepatology
Annelies Geeraerts, Livia Guadagnoli, Ans Pauwels, Hannelore Geysen, Thomas Neyens, Lukas Van Oudenhove, Tim Vanuytsel, Jan Tack
Summary: This study aimed to investigate the association between psychological symptoms and reflux phenotype along the GERD spectrum in refractory reflux patients. The findings suggest that psychological symptoms do not differ across reflux phenotypes and do not predict reflux phenotype membership in refractory reflux patients.
Article
Pediatrics
Rachel Rosen, Reza Rahbar, Karen Watters, Anne Hseu, Carlos J. Munoz, Lynne Ferrari, Robert Holzman, Shoaib Mohammad, Alexandra Cohen, Maritha Du, Anna Akkara, Andrea Catacora, Tregony Simoneau, Sarah Connearney, Paul Mitchell, Samuel Nurko
Summary: The objective of this study was to validate a novel biomarker, airway impedance, for extraesophageal disease. The study recruited patients with respiratory symptoms and performed endoscopy and direct laryngoscopy. The results showed no significant correlation between airway impedance and reflux scores, but patients with aspiration had lower airway impedance. Therefore, airway impedance may be an important tool for diagnosing gastroesophageal reflux or aspiration.
JOURNAL OF PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Megane Lebel, Dominic O. Cliche, Martine Charbonneau, Damien Adam, Emmanuelle Brochiero, Claire M. Dubois, Andre M. Cantin
Summary: Idiopathic pulmonary fibrosis (IPF) is characterized by abnormal fibroblast accumulation in the lung leading to compromised lung function. This study investigated the mechanisms of interstitial invasion and remodeling by lung fibroblasts in IPF and found increased invadosome formation. Additionally, two drugs approved for treating IPF, nintedanib and pirfenidone, were found to suppress invadosome formation in IPF lung fibroblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Respiratory System
Yet H. Khor, Brittany Bissell, Marya Ghazipura, Derrick Herman, Stephanie M. Hon, Tanzib Hossain, Fayez Kheir, Shandra L. Knight, Michael Kreuter, Madalina Macrea, Manoj J. Mammen, Maria Molina-Molina, Moises Selman, Marlies Wijsenbeek, Ganesh Raghu, Kevin C. Wilson
Summary: There is currently insufficient evidence to support the use of antacid medication or antireflux surgery for improving respiratory outcomes in patients with IPF. Well-designed prospective studies with objective evaluation of GER are needed to determine the role of these interventions.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Respiratory System
Xiaoping Wu, Yunju Jeong, Sergio Poli de Frias, Imaani Easthausen, Katherine Hoffman, Clara Oromendia, Shahrad Taheri, Anthony J. Esposito, Luisa Quesada Arias, Ehab A. Ayaub, Rie Maurer, Ritu R. Gill, Hiroto Hatabu, Mizuki Nishino, Michelle L. Frits, Christine K. Iannaccone, Michael E. Weinblatt, Nancy A. Shadick, Paul F. Dellaripa, Augustine M. K. Choi, Edy Y. Kim, Ivan O. Rosas, Fernando J. Martinez, Tracy J. Doyle
Summary: The study identified molecular signatures associated with interstitial lung disease in rheumatoid arthritis, providing potential non-invasive diagnostic tools and future therapeutic targets.
Article
Gastroenterology & Hepatology
Nayna A. Lodhia, Laura Horton, Thapa Namisha, Alison H. Goldin, Walter W. Chan
Summary: This retrospective cohort study analyzed the relationship between recent opioid use in constipated patients and anorectal sensation, defecatory function, and balloon expulsion. Results showed that recent opioid use was associated with anorectal dysfunction and difficulty in passing stools.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Rena Yadlapati, Alexander M. Kaizer, Daniel R. Sikavi, Madeline Greytak, Jennifer X. Cai, Thomas L. Carroll, Samir Gupta, Sachin Wani, Paul Menard-Katcher, Tsung-Chin Wu, Philip Weissbrod, Andrew M. Vahabzadeh-Hagh, John E. Pandolfino, Walter W. Chan
Summary: The study identified different clinicophysiologic phenotypes of patients with laryngeal symptoms referred for reflux evaluation, including LPR and GERD with hiatal hernia, mild LPR/GERD, no LPR/No GERD, reflex cough, and mixed/possible obstructive esophagogastric junction, which may inform targeted clinical trial design and improve outcomes.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Engineering, Biomedical
Kewang Nan, Sahab Babaee, Walter W. Chan, Johannes L. P. Kuosmanen, Vivian R. Feig, Yiyue Luo, Shriya S. Srinivasan, Christina M. Patterson, Ahmad Mujtaba Jebran, Giovanni Traverso
Summary: An inexpensive catheter-like device made of a piezoresistive elastic silicone-liquid-metal composite has been developed for measuring the tone and contractile patterns of the gastrointestinal tract. The device performs comparably to commercial devices and can be used in low-resource settings.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Gastroenterology & Hepatology
Sanjay Salgado, Lawrence F. Borges, Jennifer X. Cai, Wai-Kit Lo, Thomas L. Carroll, Walter W. Chan
Summary: Diagnosis of laryngopharyngeal reflux (LPR) is challenging due to variable symptomatology and response to therapy. This study found that clinical symptoms, such as VHI and RSI, were not correlated with LPR, and laryngeal and esophageal symptoms were not predictive of pharyngeal reflux events. Objective reflux monitoring should be considered for patients with suspected LPR symptoms.
DISEASES OF THE ESOPHAGUS
(2023)
Editorial Material
Gastroenterology & Hepatology
Alicia Muratore, Eric D. Shah, Walter W. Chan
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Afrin N. Kamal, Shumon Dhar, Jonathan M. Bock, John O. Clarke, Jerome R. Lechien, Jacqueline Allen, Peter C. Belafsky, Joel H. Blumin, Walter W. Chan, Ronnie Fass, P. Marco Fisichella, Michael Marohn, Ashli K. O'Rourke, Gregory Postma, Edoardo Savarino, Michael F. Vaezi, Thomas L. Carroll, Lee M. Akst
Summary: Best practice statements for the treatment of LPR were identified using a well-tested methodology. These statements serve as a guide for physicians in making treatment decisions for LPR.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Wai-Kit Lo, Hilary J. Goldberg, Nirmal Sharma, Jon O. Wee, Walter W. Chan
Summary: This study aimed to evaluate the effect of timely antireflux treatment guided by routine reflux testing on postlung transplant rejection outcomes. The results showed that timely antireflux treatment was associated with reduced rejection risks and demonstrated noninferiority to patients without reflux. Therefore, a standardized peri-transplant test-and-treat algorithm may be used to guide timely reflux management and improve lung transplant outcomes.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Emily Wechsler, Nitin K. Ahuja, Darren Brenner, Walter Chan, Lin Chang, William D. Chey, Anthony J. Lembo, Baha Moshiree, Judy Nee, Shailja C. Shah, Kyle Staller, Eric D. Shah
Summary: This study assessed the discrepancy between clinical guidelines and actual practice in investigating dyspepsia without alarm features in young patients. The results showed that noninvasive management strategies had inferior cost-effectiveness and patient satisfaction outcomes compared to strategies promoting up-front endoscopy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Christopher Velez, Christopher Kirwan, Walter W. Chan
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Ryan Flanagan, Mayssan Muftah, Molly Perencevich, Walter Chan, Daniel J. Stein
Summary: The prevalence and motivations for implementing the gastroenterology hospitalist model, as well as its effects on fellowship training, were investigated. The majority of respondents believed that hiring a gastroenterology hospitalist would reduce burnout and workload for outpatient faculty, and improve fellowship education and inpatient care.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Alison H. Goldin, Mayssan Muftah, Shikha Mangla, Jason L. Hornick, Karen Hsu Blatman, Matthew J. Hamilton, Wai-Kit Lo, Walter W. Chan
Summary: This study compared the clinical and allergy profiles of patients with eosinophilic esophagitis (EoE) who responded to proton-pump inhibitor (PPI) therapy (PPI-r-EoE) with those who did not respond (PPI-nr-EoE) and patients with erosive esophagitis (EE). Allergic conditions and esophageal rings were found to be independent predictors for distinguishing between the different groups. The study concluded that PPI-r-EoE is clinically similar to PPI-nr-EoE but significantly different from EE.
DISEASES OF THE ESOPHAGUS
(2023)
Review
Gastroenterology & Hepatology
Joyce C. Zhou, Sravanya Gavini, Walter W. Chan, Wai-Kit Lo
Summary: Esophageal disorders, including GERD, are common among patients with IPF, and the relationship between GERD and IPF is likely bidirectional. Objective diagnostic tools are often needed to identify esophageal dysfunction or pathologic reflux in patients with IPF. Impedance-based testing may provide additional diagnostic value. The main treatment options include acid suppressants and anti-reflux surgery, but further validations are needed for their potential benefits in pulmonary outcomes of IPF. Future research should focus on identifying IPF patients who may benefit from esophageal testing and treatment, determining the optimal testing strategy, and assessing different esophageal therapies.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Mariel E. Bailey, Lawrence F. Borges, Hilary J. Goldberg, Kelly E. Hathorn, Sravanya Gavini, Wai-Kit Lo, Walter W. Chan
Summary: This study evaluated the association between multichannel intraluminal impedance and pH testing (MII-pH) and 3-year pulmonary outcomes in IPF patients. Increased bolus exposure time (BET) on MII-pH was found to be an independent predictor of poor pulmonary outcomes and mortality over 3 years in IPF patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Jerome R. Lechien, Michael F. Vaezi, Walter W. Chan, Jacqueline E. Allen, Petros D. Karkos, Sven Saussez, Kenneth W. Altman, Milan R. Amin, Tareck Ayad, Maria R. Barillari, Peter C. Belafsky, Joel H. Blumin, Nikki Johnston, Francois Bobin, Matthew Broadhurst, Fabio P. Ceccon, Christian Calvo-Henriquez, Young-Gyu Eun, Carlos M. Chiesa-Estomba, Lise Crevier-Buchman, John O. Clarke, Giovanni Dapri, Claudia A. Eckley, Camille Finck, P. Marco Fisichella, Abdul-Latif Hamdan, Stephane Hans, Kathy Huet, Rui Imamura, Blair A. Jobe, Toshitaka Hoppo, Lance P. Maron, Vinciane Muls, Ashli K. O'Rourke, Paulo S. Perazzo, Gregory Postma, Vyas M. N. Prasad, Marc Remacle, Geraldo D. Sant'Anna, Robert T. Sataloff, Edoardo V. Savarino, Antonio Schindler, Nora Siupsinskiene, Ping-Huei Tseng, Craig H. Zalvan, Karol Zelenik, Bernard Fraysse, Jonathan M. Bock, Lee M. Akst, Thomas L. Carroll
Summary: The objective of this work was to propose a global definition and diagnostic approach of laryngopharyngeal reflux (LPR) through an international consensus group, in order to guide primary care and specialist physicians in the management of LPR.
Article
Gastroenterology & Hepatology
Brent Hiramoto, Walker D. Redd, Mayssan Muftah, Saikiran Jonnadula, Noreen C. Okwara, Andrew Jenkins, Eliza Cricco-Lizza, Darren J. H. Lee, Jennifer X. Cai, Walter W. Chan
Summary: Obesity is associated with increased esophageal symptom burden and worse physical health-related quality of life, which correlate with higher acid/bolus reflux burden but not altered esophageal motility/transit/contractile reserve. Among patients with esophageal symptoms, higher obesity classes were associated with increased symptom burden, worse health-related quality of life, and more significant reflux burden, but not esophageal motility, transit, and contractile reserve.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
