Article
Infectious Diseases
Tommaso Bardi, Vicente Pintado, Maria Gomez-Rojo, Rosa Escudero-Sanchez, Amal Azzam Lopez, Yolanda Diez-Remesal, Nilda Martinez Castro, Patricia Ruiz-Garbajosa, David Pestana
Summary: Co-infection of bacteria and fungi is common in ICU-admitted COVID-19 patients and usually presents as a severe form of infection, associated with a high mortality rate and longer ICU stay.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Immunology
Nobuaki Matsunaga, Kayoko Hayakawa, Mari Terada, Hiroshi Ohtsu, Yusuke Asai, Shinya Tsuzuki, Setsuko Suzuki, Ako Toyoda, Kumiko Suzuki, Mio Endo, Naoki Fujii, Michiyo Suzuki, Sho Saito, Yukari Uemura, Taro Shibata, Masashi Kondo, Kazuo Izumi, Junko Terada-Hirashima, Ayako Mikami, Wataru Sugiura, Norio Ohmagari
Summary: This study in Japan examined hospitalized patients with COVID-19, finding that they are typically middle-aged males with close contact to confirmed or suspected cases. The most common comorbidities were hypertension and diabetes. Most patients admitted were nonsevere cases, with a majority not requiring oxygen support during hospitalization.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Kevin Roedl, Dominik Jarczak, Olaf Boenisch, Geraldine de Heer, Christoph Burdelski, Daniel Frings, Barbara Sensen, Axel Nierhaus, Stefan Kluge, Dominic Wichmann
Summary: More than half of critically ill patients with COVID-19 suffer from chronic critical illness (CCI). Patients with CCI have higher short and long-term survival rates compared to patients without CCI, and prolonged therapy should be provided when resources permit.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Eva Tabernero, Luis A. Ruiz, Pedro P. Espana, Raul Mendez, Leyre Serrano, Borja Santos, Ane Uranga, Paula Gonzalez, Patricia Garcia, Antoni Torres, Rosario Menendez, Rafael Zalacain
Summary: In younger COVID-19 patients, heart disease, low oxygen saturation, high LDH and lymphocyte count < 800/mL are independent factors associated with poor outcome. CURB and PSI scores are not suitable criteria for deciding admission in this population.
Article
Oncology
Astha Thakkar, Jesus D. Gonzalez-Lugo, Niyati Goradia, Radhika Gali, Lauren C. Shapiro, Kith Pradhan, Shafia Rahman, So Yeon Kim, Brian Ko, R. Alejandro Sica, Noah Kornblum, Lizamarie Bachier-Rodriguez, Margaret McCort, Sanjay Goel, Roman Perez-Soler, Stuart Packer, Joseph Sparano, Benjamin Gartrell, Della Makower, Yitz D. Goldstein, Lucia Wolgast, Amit Verma, Balazs Halmos
Summary: Most cancer patients show high seroconversion rates after receiving COVID-19 vaccines, but those with hematologic malignancies, especially after highly immunosuppressive therapies, exhibit lower conversion rates. Patients on immune checkpoint inhibitor therapy or hormonal therapy display high conversion rates.
Article
Biochemistry & Molecular Biology
Alessandro Russo, Chiara Davoli, Cristian Borrazzo, Vincenzo Olivadese, Giancarlo Ceccarelli, Paolo Fusco, Alessandro Lazzaro, Rosaria Lionello, Marco Ricchio, Francesca Serapide, Bruno Tassone, Elio Gentilini Cacciola, Claudio Maria Mastroianni, Carlo Torti, Gabriella D'Ettorre, Enrico Maria Trecarichi
Summary: This study found that high-dose methylprednisolone treatment may be associated with a significant reduction in mortality in hospitalized COVID-19 patients compared to dexamethasone 6 mg once daily.
Article
Immunology
Lindsay Kim, Shikha Garg, Alissa O'Halloran, Michael Whitaker, Huong Pham, Evan J. Anderson, Isaac Armistead, Nancy M. Bennett, Laurie Billing, Kathryn Como-Sabetti, Mary Hill, Sue Kim, Maya L. Monroe, Alison Muse, Arthur L. Reingold, William Schaffner, Melissa Sutton, H. Keipp Talbot, Salina M. Torres, Kimberly Yousey-Hindes, Rachel Holstein, Charisse Cummings, Lynnette Brammer, Aron J. Hall, Alicia M. Fry, Gayle E. Langley
Summary: This study identified factors associated with severe outcomes among adults hospitalized with COVID-19, including age, sex, comorbidities like obesity, immunosuppression, and diabetes. Older age, male gender, and certain underlying conditions were independently linked to increased risk of ICU admission and in-hospital mortality.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Maria Damps, Elzbieta Byrska-Maciejasz, Malgorzata Kowalska, Jowita Rosada-Kurasinska, Beata Rybojad, Joanna Sordyl, Marzena Zielinska, Alicja Bartkowska-Sniatkowska
Summary: This study analyzed children admitted to PICUs due to severe SARS-CoV-2 infection and found that children with comorbidities are more likely to develop severe symptoms and respiratory failure, while high values of aspartate aminotransferase (AST) are associated with poor prognosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Sung Eun Choi, Corneliu Sima, Laura Pesquera Colom, Giang T. Nguyen, William Giannobile
Summary: This study aimed to evaluate the effectiveness of a surveillance COVID-19 testing program in an academic dental institution. The results showed that implementing an adaptive testing cadence based on individual risk status can reduce the risk of SARS-CoV-2 infection within the institution. Participation in clinical activities did not pose additional risk compared to other in-person activities.
Editorial Material
Pediatrics
Walter S. Gilliam, Amyn A. Malik, Mehr Shafiq, Madeline Klotz, Chin Reyes, John Eric Humphries, Thomas Murray, Jad A. Elharake, David Wilkinson, Saad B. Omer
Summary: The study found that exposure to child care in the US during the early months of the pandemic did not increase the risk of COVID-19 transmission to providers. The findings emphasize the importance of infection mitigation efforts in child care programs.
Article
Virology
Yasmine Boukhalfa, Nejla Stambouli, Adel Driss, Maissa Daiki, Amal Abouda, Rabie Razgallah, Hedi Gharsallah, Walid Sellami, Rym Abid, Souha Hannachi, Riadh Battikh, Mohamed Benmoussa, Chakib Mazigh, Mustapha Ferjani, Amel B. B. Elgaaied, Iheb Labbene
Summary: This study investigated whether sCXCL16 concentration on the first day of hospitalization could predict death in COVID-19 patients. The results showed significantly higher levels of sCXCL16 in the nonsurvivors' group compared to the survivors' group, and sCXCL16 concentration above 2095 pg/mL was associated with a higher risk of death.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Camille Chenevier-Gobeaux, Morgane Ducastel, Jean-Francois Meritet, Yassine Ballaa, Nicolas Chapuis, Frederic Pene, Nicolas Carlier, Nicolas Roche, Tali-Anne Szwebel, Benjamin Terrier, Didier Borderie
Summary: This study found that endocan is associated with thrombotic events in COVID-19 patients and may serve as a useful biomarker. Endocan concentrations increased with the severity of the disease, and patients experiencing thrombotic events had significantly higher levels of endocan. Combining endocan measurement with D-dimers improved the identification of thrombotic events. The combination of endocan and D-dimers better discriminated patients with thrombotic events. The combination of D-dimers and endocan was independently associated with thrombotic events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Virology
Sijin Wen, Apoorv Prasad, Kerri Freeland, Sanjiti Podury, Jenil Patel, Roshan Subedi, Erum Khan, Medha Tandon, Saurabh Kataria, Wesley Kimble, Shitiz Sriwastava
Summary: This study found that older patients with underlying comorbidities had poor outcomes among SARS-CoV-2 infected patients in West Virginia, and the in-hospital mortality rate was similar to the national average. Shortness of breath was the most common baseline symptom, and hypertension was the most common comorbidity.
Article
Biology
William L. Hamilton, Gerry Tonkin-Hill, Emily R. Smith, Dinesh Aggarwal, Charlotte J. Houldcroft, Ben Warne, Luke W. Meredith, Myra Hosmillo, Aminu S. Jahun, Martin D. Curran, Surendra Parmar, Laura G. Caller, Sarah L. Caddy, Fahad A. Khokhar, Anna Yakovleva, Grant Hall, Theresa Feltwell, Malte L. Pinckert, Iliana Georgana, Yasmin Chaudhry, Colin S. Brown, Sonia Goncalves, Roberto Amato, Ewan M. Harrison, Nicholas M. Brown, Mathew A. Beale, Michael Spencer Chapman, David K. Jackson, Ian Johnston, Alex Alderton, John Sillitoe, Cordelia Langford, Gordon Dougan, Sharon J. Peacock, Dominic P. Kwiatowski, Ian G. Goodfellow, M. Estee Torok
Summary: COVID-19 poses significant challenges in care homes due to high mortality rates and varied patterns of viral transmission. Limiting viral spread within care homes is crucial to reducing COVID-19 mortality in this population.
Article
Medicine, General & Internal
Yoann Zerbib, Nelly Guilain, Sebastien Eymieux, Rustem Uzbekov, Sandrine Castelain, Emmanuelle Blanchard, Catherine Francois, Denis Chatelain, Clement Brault, Julien Maizel, Philippe Roingeard, Michel Slama
Summary: This study provides a detailed histopathological description of fatal COVID-19 and compares the lesions in ICU and non-ICU patients. It reveals that lung injury differs between ICU and non-ICU patients, and extrapulmonary damage, such as kidney and myocardial injury, is more frequent in ICU patients. The study also presents the first description of SARS-CoV-2-induced double-membrane vesicles in kidney biopsy samples, indicating intense viral replication in this organ.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Naci Senkal, Istemi Serin, Sacide Pehlivan, Mustafa Pehlivan, Alpay Medetalibeyoglu, Timurhan Cebeci, Hilal Konyaoglu, Yasemin Oyaci, Gozde Yesil Sayin, Ummuhan Isoglu-Alkac, Tufan Tukek, Murat Kose
Summary: Oxidative stress and DNA damage caused by Coronavirus disease 2019 (COVID-19) were evaluated in a Turkish population. DNA repair gene variants (XRCC4 rs28360071, rs6869366, and XRCC1 rs25487) were found to be associated with COVID-19 susceptibility and clinical course. XRCC4 rs6869366 G/G genotype and G allele frequency were increased in patients compared to controls, while XRCC4 rs6869366 G/T and T/T genotypes were more common in controls. The A/A and A/G genotypes of XRCC1 rs25487 were significantly associated with COVID-19 disease. The study highlights the importance of DNA repair gene variants in COVID-19 susceptibility.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2023)
Article
Public, Environmental & Occupational Health
Tufan Tukek, Sacide Pehlivan, Alpay Medetalibeyoglu, Istemi Serin, Yasemin Oyaci, Huzeyfe Arici, Naci Senkal, Mustafa Pehlivan, Ummuhan Isoglu-Alkac, Murat Kose
Summary: This study compares the gene polymorphisms and methylation status of the SOCS1 gene between patients with COVID-19 and healthy controls, and demonstrates the association of the SOCS1 rs33989964 polymorphism with the severity of COVID-19 infection.
PATHOGENS AND GLOBAL HEALTH
(2023)
Article
Rheumatology
Shirkhan Amikishiyev, M. Guven Gunver, Murat Bektas, Sarvan Aghamuradov, Burak Ince, Nevzat Koca, Ege Sinan Torun, Numune Aliyeva, Selma Sari, Cigdem Cetin, Banu C. Yalcin-Dulundu, Rabia Deniz, Fatih Kemik, Besim Fazil Agargun, Ubeyde Ayse Gulseren, Beliz Besisik, Onur Alkan, Ceren Bagriacik, Yavuz B. Tor, Naci Senkal, Yunus Catma, Gorkem Durak, Sevim Mese, Ali Agacfidan, Murat Kose, Mustafa Erelel, A. Atahan Cagatay, Serap Simsek-Yavuz, Sevgi Kalayoglu-Besisik, Figen Esen, Ahmet Guel
Summary: This study aimed to identify criteria for early detection of hyperinflammation (HI) in patients with COVID-19, and found a 12-item criteria that showed high sensitivity and specificity. The use of these criteria can help identify patients in need of treatment earlier and initiate timely interventions.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Naci Senkal, Latif Karahan, Ali Emre Bardak, Hilal Konyaoglu, Ebru Teberik Kama, Ismail Inci, Leman Damla Ercan, Alpay Medetalibeyoglu, Tufan Tukek
Summary: This study aimed to assess whether five admission Ranson parameters could differentiate edematous pancreatitis from necrotizing pancreatitis in the emergency department. The results showed that aRS had little utility in predicting pancreatic necrosis.
JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
(2023)
Article
Medicine, General & Internal
Ali Emre Bardak, Mehmet Oguzcan Alada, Naci Senkal, Alpay Alibeyoglu, Murat Kose
Summary: A 45-year-old male patient with a previous history of acute intermittent porphyria (AIP) presented with an AIP attack complicated by rhabdomyolysis triggered by COVID-19 infection. While there are known triggers for AIP attacks, some studies have also shown an association between COVID-19 and porphyria. These studies suggest that the accumulation of by-products in the heme synthesis pathway during COVID-19 infection may cause attacks resembling acute intermittent porphyria. We believe that patients with porphyria are particularly susceptible to exacerbations during a COVID-19 infection and require careful monitoring.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
D. Baykiz, Z. G. Demirtakan, E. A. Govdeli, M. Kaytaz, M. L. Yavuz, S. Emet, A. Elitok, E. Ademoglu, S. Umman, B. Umman, Z. Bugra
Summary: This study investigated the performance of aortic elasticity and aortic deformation in patients with bicuspid aortic valve and hypertension-associated aortopathy, as well as the possible relationship between biomarkers such as endotrophin and matrix metalloproteinase-2 with ascending aorta dilatation. The results showed that aortic strain and distensibility were significantly decreased, while the aortic stiffness index was significantly increased in patient groups compared to the control group. Endotrophin was found to be a predictive biomarker of ascending aorta dilatation.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Naci Senkal, Yasemin Oyaci, Timurhan Cebeci, Hilal Konyaoglu, Murat Kose, Mustafa Onel, Alpay Medetalibeyoglu, Yesil Gozde Sayin, Mustafa Pehlivan, Sacide Pehlivan, Ummihan Isoglu-Alkac, Tufan Tukek
Summary: This study aims to evaluate the association between eNOS G894T and VNTR functional variants and COVID-19 susceptibility. The results indicate that the T/T genotype and T allele carriers of eNOS G894T are more susceptible to COVID-19, while the G/G genotype is more common in the control group. However, no significant difference was found in eNOS VNTR genotype and allele frequencies between patients and controls. These findings provide evidence for potential new treatment options.
JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
(2023)
Article
Pharmacology & Pharmacy
M. Kose, N. Senkal, H. Konyaoglu, A. Emet, Y. Oyaci, S. Pehlivan, G. Y. Sayin
Summary: This study explores the possible association between the course of COVID-19 and hereditary thrombotic factors and comorbidities. It is found that the FII G20210A and Beta-fibrinogen G-455A genotypes are significantly higher compared to previous data. Further studies with larger samples are needed to verify this finding.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Oncology
Ferhat Ferhatoglu, Tanju Kapagan, Nail Paksoy, Naziye Ak, Alpay Medetalibeyoglu, Naci Senkal, Esra Aydin, Sezai Vatansever
Summary: Cancer patients infected with COVID-19 have poor survival outcomes, with lung cancer diagnosis and elevated NT-proBNP levels identified as the most crucial prognostic risk factors.
TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY
(2023)
Article
Medicine, General & Internal
Merve Guzel Dirim, Lamiya Mammadzada, Naci Senkal, Alpay Medetalibeyoglu, Murat Kose
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Medicine, General & Internal
Alpay Medetalibeyoglu, Elif Ezirmik, Naci Senkal, Sena Bayrakdar, Irem Aktar, Reyhan Akas, Ebru Yilmaz, Huzeyfe Arici, Murat Kose, Timur Selcuk Akpinar, Atahan Cagatay, Tufan Tukek
Summary: This study analyzed the demographic characteristics, symptoms, and comorbidities of 504 patients hospitalized for COVID-19. It found that older age, comorbidities, hypertension, coronary artery disease, congestive heart failure, and dyspnea were factors associated with ICU admission.
JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
(2022)
Article
Pharmacology & Pharmacy
M. Kose, N. Senkal, T. Tukek, T. Cebeci, S. C. Atalar, M. Altinkaynak, H. Arici, S. Genc, Y. Catma, M. Kocaaga, A. Medetalibeyoglu, S. Emet
Summary: This study investigated the association between serum endocan levels, as a biomarker of endothelial inflammation, and vitamin D levels in healthy individuals without subclinical atherosclerosis. The results showed that the group with the lowest serum vitamin D level had the highest serum endocan concentration, while the group with normal serum vitamin D levels had the lowest concentration. The study also found that serum vitamin D concentration could predict endocan levels, which may serve as an indicator for endothelial inflammation. These findings have important implications for the prevention of cardiovascular mortality and morbidity.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Naci Senkal, Esen Kiyan, Ali Aslan Demir, Yasemin Yalcinkaya, Ahmet Gul, Murat Inanc, Mahmude Lale Ocal, Bahar Artim Esen
Summary: This study found a high prevalence of interstitial lung disease (ILD) in patients with systemic lupus erythematosus (SLE). Spirometry, diffusion tests, and chest x-ray were valuable tools for diagnosing ILD in SLE patients. Patients with ILD had longer disease duration, lower lung function, and higher frequency of other symptoms and diseases.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Medical Laboratory Technology
Alpay Medetalibeyoglu, Murat Kaytaz, Naci Senkal, Sema Genc, Irem Aktar, Beyhan Omer, Oral Oncul, Tufan Tukek
Summary: This study evaluated the prognostic roles of hemostatic tests and their relationship with inflammatory markers in COVID-19 patients. Results showed significant differences in coagulation parameters between mild and severe cases, emphasizing the importance of monitoring these parameters for disease prognosis and treatment decisions.
CLINICAL LABORATORY
(2022)
