Article
Oncology
Wei Peng, Jin Chen, Yanping Xiao, Guangjian Su, Yan Chen, Zhaolei Cui
Summary: The upregulation of LDHC/LDH-C4 expression in LUAD is associated with clinical characteristics and prognosis. LDHC has potential clinical applications in the diagnosis of LUAD, serving as a biomarker for diagnosis, efficacy evaluation, and recurrence monitoring.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medical Laboratory Technology
Ting Wang, Hengkai Zhu, Min Xiao, Shao Zhou
Summary: The study found that serum exosomal lncRNA CRNDE is significantly increased in HCC patients, and is associated with tumor size, differentiation, and prognosis. High expression is linked to poorer prognosis, while patients with low expression have longer survival. Therefore, serum lncRNA CRNDE may serve as a potential biomarker for diagnosis and prognosis of HCC.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Oncology
Chunxia Zhang, Zhouwei Zhan, Yunxiang Fang, Yuanyuan Ruan, Mingan Lin, Zhisen Dai, Yanping Zhang, Shanshan Yang, Shuxiang Xiao, Bijuan Chen
Summary: This study suggests that PNI and LDH could be valuable predictors of prognosis for non-metastatic NPC patients, and the combination of PNI and LDH can enhance prognostic accuracy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Shuying Chen, Yinqi Mao, Wei Chen, Chenbin Liu, Han Wu, Jingjun Zhang, Shenghao Wang, Chengpan Wang, Yong Lin, Yuan Lv
Summary: This study found that serum exosomal miR-34a is significantly down-regulated in patients with hepatocellular carcinoma (HCC), and it may serve as a novel non-invasive biomarker for the diagnosis and prognosis of HCC.
Article
Surgery
Yuantao Gan, Fengwei Gao, Bo Du, Yu Liu, Qian Xue, Jinqiang Fu
Summary: Hepatic arterial chemoembolization is effective for treating HCC and improving survival rates, but long-term prognosis remains unfavorable for patients. Serum LDH has potential as an indicator for predicting tumor proliferation and progression, but its relationship with HCC prognosis is still unclear.
FRONTIERS IN SURGERY
(2022)
Review
Oncology
Ying Zhao, Jinmei Yao
Summary: Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related deaths worldwide. It is often diagnosed at advanced stages with poor prognosis due to lack of early symptoms. Exosomal circRNAs have been shown to play promoter or suppressor roles in the carcinogenesis, progression, and metastasis of HCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Jinxia Lin, Shicong Wang, Wenliang Lan, Ming Ji, Mei Li
Summary: This study compared the effects of the Chinese medicine formula Pien Tze Huang (PZH) and the anti-tumor drug sorafenib on hepatocellular carcinoma (HCC). It found that PZH and sorafenib both have anti-tumor effects through metabolic regulation, but differ in the regulation of some metabolic nodes.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Mengqin Shen, Ruixue Zhang, Wenzhi Jia, Zongping Zhu, Xiaoping Zhao, Li Zhao, Gang Huang, Jianjun Liu
Summary: The multifunction scaffold protein p54(nrb)/NONO has been found to play a crucial role in regulating hypoxia transcription signals, enhancing liver cancer progression. Clinical data has shown that NONO is significantly upregulated and associated with poor prognosis in HCC patients. NONO interacts with HIF-1/2 complexes and their downstream transcripts to facilitate the expression of hypoxia-induced genes, suggesting its potential as a therapeutic target for HCC.
Article
Oncology
Haocheng Wang, Dongfeng Shan, Ya Dong, Xue Yang, Linwei Zhang, Zhuang Yu
Summary: The study investigated the impact of serum Cys C, UA, and LDH concentrations on the prognosis of patients with small-cell lung cancer (SCLC) before initial treatment. Elevated levels of Cys C, UA, and LDH prior to chemotherapy were associated with shorter progression-free survival and overall survival times in SCLC patients. LDH concentration may serve as an independent prognostic factor for both progression-free and overall survival in SCLC patients.
Article
Clinical Neurology
Xiao-Yong Chen, Jin-Yuan Chen, Yue Chen, Jia-Fang Chen, Ni Lin, Chen-Yu Ding, De-Zhi Kang, Deng-Liang Wang, Wen-Hua Fang
Summary: This study demonstrated that preoperative serum LDH level is closely related to the prognosis of glioma patients, serving as a reliable predictive indicator when combined with WHO grade and other factors for survival analysis. Further multicenter studies are needed to confirm these findings.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Cell Biology
Kai Zhu, Qiqi Tao, Jiatao Yan, Zhichao Lang, Xinmiao Li, Yifei Li, Congcong Fan, Zhengping Yu
Summary: The study found that exosome-related gene signatures can accurately predict the prognosis of hepatocellular carcinoma patients and have potential clinical value.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Yue Li, Huanye Mo, Shengli Wu, Xin Liu, Kangsheng Tu
Summary: The study revealed that lactate metabolism-related genes have significant clinical importance in HCC and reflect the characteristics of the tumor microenvironment. LMRGS has the ability to independently predict the prognosis of HCC patients, with patients in the high LMRGS group having significantly shorter survival than those in the low LMRGS group, and differences in tumor mutation burden between the two LMRGS subgroups.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Psychiatry
Qian Yao, Hang Liu, Yan Li
Summary: This study investigated the difference in serum LDH levels between patients with major depressive disorder and the normal population, revealing that a decrease in LDH levels may be an independent risk factor for suicide attempt in MDD patients.
GENERAL HOSPITAL PSYCHIATRY
(2022)
Article
Biochemical Research Methods
Haixi Yan, Xiao Liang, Juping Du, Zebao He, Yu Wang, Mengge Lyu, Liang Yue, Fangfei Zhang, Zhangzhi Xue, Luang Xu, Guan Ruan, Jun Li, Hongguo Zhu, Jiaqin Xu, Shiyong Chen, Chao Zhang, Dongqing Lv, Zongmei Lin, Bo Shen, Yi Zhu, Biyun Qian, Haixiao Chen, Tiannan Guo
Summary: Serum LDH levels are associated with the severity of COVID-19, and elevated serum LDH may be consequences of hypoxia and tissue injuries induced by inflammation.
Article
Oncology
Genghui Zhuang, Yuping Xie, Junfeng Hong, Shan Lin, Tingting Chen, Wenzheng Fang
Summary: The study found that an increase in lactate dehydrogenase (LDH) index is closely associated with worse overall survival (OS) in hepatocellular carcinoma (HCC) patients.
INFECTIOUS AGENTS AND CANCER
(2022)
