Article
Biochemistry & Molecular Biology
Wojciech Gierlikowski, Katarzyna Broniarek, Lukasz Cheda, Zbigniew Rogulski, Marta Kotlarek-Lysakowska
Summary: In the context of papillary thyroid carcinoma, miR-181a-5p has been found to directly regulate the expression of SLC5A5, potentially reducing the efficacy of radioiodine treatment. This suggests that miR-181a-5p could serve as a promising target to enhance the efficacy of radioactive iodine therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Leticia Ferreira Alves, Murilo Vieira Geraldo
Summary: In this study, it was found that overexpression of miR-495-3p can inhibit the migration and invasion of PTC cells and affect the expression of genes related to PTC development, indicating the important role of miR-495-3p in the progression of PTC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Yulu Gu, Xin Zhang, Yong Li, Jikang Shi, Heran Cui, Yaxuan Ren, Sainan Liu, Yichun Qiao, Yi Cheng, Yawen Liu
Summary: In this study, we found that miR-204-5p is down-regulated in papillary thyroid carcinoma (PTC) tissues. The levels of miR-204-5p in the serum of PTC patients were associated with PTC risk, and the expression was lower in patients with both PTC and benign lesions compared to those with only PTC. Furthermore, miR-204-5p inhibited proliferation, migration, invasion, and cell cycle progression, and induced apoptosis in PTC cells. We identified AP1S2 as a target of miR-204-5p. Overall, miR-204-5p functions as a suppressor for PTC pathogenesis via the miR-204-5p/AP1S2 axis.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Zongyu Li, Xin Huang, Aru Liu, Jinkai Xu, Jingyue Lai, Hao Guan, Jiancang Ma
Summary: In this study, circ_PSD3 was found to be upregulated in papillary thyroid carcinoma (PTC), promoting cell proliferation, metastasis, and inhibiting apoptosis by regulating the miR-637/HEMGN axis and activating the PI3K/Akt signaling pathway. The circ_PSD3/miR-637/HEMGN signaling axis may serve as a potential therapeutic target for PTC.
Article
Oncology
Yu Ding, Luyao Wu, Xi Zhuang, Jingsheng Cai, Houchao Tong, Yan Si, Hao Zhang, Xiaoting Wang, Meiping Shen
Summary: With the advancement in diagnostic technology, the importance of exploring molecular targets for improving the treatment and prognosis of papillary thyroid carcinoma (PTC) is evident. Studies have shown the involvement of FAM84A in the development of various tumors, making it a potential diagnostic and therapeutic target for PTC.
MOLECULAR ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Lei Dai, Weidong Zhang, Yinchun Wang, Kejie Yu, Qi Le, Xianjiang Wu
Summary: This study analyzed the dysregulated profile of circular RNAs (circRNAs) in papillary thyroid cancer (PTC) tissues and found that circAGTPBP1 was upregulated and correlated with tumor characteristics. The downstream targets of circAGTPBP1 were identified as miR-34a-5p and NOTCH1. Functional experiments showed that circAGTPBP1 knockdown inhibited PTC cell migration, invasion, and metastasis, and miR-34a-5p inhibitor reversed these effects. CircAGTPBP1 knockdown also inhibited tumor growth in vivo, suggesting its potential as a therapeutic target for PTC.
Article
Cell Biology
Deguang Zhang, Li Tao, Nizheng Xu, Xiaoxiao Lu, Jianle Wang, Gaofei He, Qinghu Tang, Kangmao Huang, Shuying Shen, Junjie Chu
Summary: In this study, circRNA high-throughput sequencing was used to identify alterations in circRNA expression levels in PTC tissues. circTIAM1 was found to be upregulated in PTC and associated with apoptosis, proliferation, and migration of PTC cells. Mechanistically, circTIAM1 acted as a sponge of microRNA-646 and functioned in PTC by targeting miR-646 and heterogeneous ribonucleoprotein A1. These findings highlight the oncogenic role of circTIAM1 in PTC and suggest its potential as a therapeutic target for PTC progression.
CELL DEATH DISCOVERY
(2022)
Article
Endocrinology & Metabolism
Daqi Zhang, Mingyu Yang, Xin Zhang, Cheng Wang, Kunlin Li, Hongbo Wang, Hao Chi, Chengqiu Sui, Gianlorenzo Dionigi, Hui Sun
Summary: This study presents a rare case series of synchronous occurrence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) in the same thyroid gland. The synchronous MTC/PTC were classified into 4 subtypes and the clinical and pathological aspects as well as the results were presented.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Zhaohui Zeng, Qiangfeng Teng, Jinhong Xiao
Summary: ILF3-AS1 is upregulated in PTC and its knockdown inhibits proliferation, migration, and invasion of PTC cells. Mechanistic studies reveal that ILF3-AS1 exerts its tumor-promoting role in PTC through targeting the miR-4306/PLAGL2 axis.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Zeyu Zhang, Fada Xia, Lei Yao, Bo Jiang, Xinying Li
Summary: PTC is the most common endocrine malignancy, causing a relatively heavy burden on financial costs, human health, and quality of life. Emerging research has shown that circRNAs play a significant regulatory role in PTC, although the functions and mechanisms of circRNAs derived from SSU72 remain unknown.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Congjun Wang, Ye Wang, Zhao Fu, Weijia Huang, Zhu Yu, Jiancheng Wang, Kaitian Zheng, Siwen Zhang, Shen Li, Junqiang Chen
Summary: The study revealed that miR-29b-3p was significantly downregulated in PTC tissues, and its decreased expression was strongly associated with the TNM stage of PTC patients. Overexpression of miR-29b-3p inhibited migration, invasion, proliferation, and EMT of PTC cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yujuan Wang, Huafeng Zong, Haicheng Zhou
Summary: This study confirmed the up-regulation of circ_0062389 in PTC, which was associated with tumor size and positive lymphatic metastasis. Knocking down circ_0062389 could inhibit the proliferation, migration, and EMT process of PTC cells, with miR-1179 identified as a downstream molecule of circ_0062389.
Article
Endocrinology & Metabolism
Jiahao Wang, Jun Wang, Jinxing Quan, Juxiang Liu, Limin Tian, Changhong Dong
Summary: The expression level of NDRG3 can be used for the differential diagnosis between papillary thyroid carcinoma and benign thyroid nodules, and also serves as a molecular marker for the diagnosis of papillary thyroid carcinoma.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Francesca Galuppini, Simona Censi, Isabella Merante Boschin, Matteo Fassan, Marta Sbaraglia, Nicola Valeri, Jens Claus Hahne, Loris Bertazza, Giada Munari, Marco Galasso, Luciano Cascione, Susi Barollo, Massimo Rugge, Federica Vianello, Angelo Paolo Dei Tos, Caterina Mian, Gianmaria Pennelli
Summary: This study analyzed the miRNA expression profiles of different histological variants and mutations in papillary thyroid carcinoma (PTC) samples and found that miRNA signatures were associated with specific histotypes and BRAF mutations.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Chong Zhang, Huxia Gu, Dingrong Liu, Fuyun Tong, Huijie Wei, Dan Zhou, Jing Fang, Xiaolu Dai, Haibo Tian
Summary: Circ_FAM53B affects the biological behaviors of papillary thyroid carcinoma (PTC) cells through the miR-183-5p-CCDC6 axis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
