Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 362, Issue 23, Pages 5506-5512Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202000875
Keywords
Asymmetric Catalysis; Heterogeneous Catalysis; Porous Organic Polymer; Michael Addition; Continuous Flow
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Funding
- Independent Research Fund Denmark [6111-00237]
- Villum Foundation [13158]
- Haldor TopsOe A/S
- Lundbeck Foundation [R250-2017-1292]
- Villum Fonden [00013158] Funding Source: researchfish
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We report a polystyrene-incorporated chiral nickel(II)-bisdiamine complex, which is accessible on gram-scale. This metal complex functions as a heterogeneous catalyst for the enantioselective Michael addition between malonates and aliphatic nitroalkenes, and it provides yields and enantioselectivities on par with homogeneous catalysts. Good functional group tolerance is reported for this reaction. Upon recycling, the catalyst achieves significantly higher TONs than previously reported. We demonstrate scalability to multigram-scale, compatibility with continuous flow production (4.43 gram), and application to the synthesis of the blockbuster drug Pregabalin. Finally, a new tandem reaction is disclosed.
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