Article
Oncology
Lifei Zhu, Yi Huang, Dao Lam, H. Michael Gach, Imran Zoberi, Dennis E. Hallahan, Perry W. Grigsby, Hong Chen, Michael B. Altman
Summary: The majority of late-stage cervical cancer primaries can be targeted by MRgHIFU HT with minimal or no intervention. A rotation of 0 degrees or 25 degrees-30 degrees relative to the transducer may improve anterior and posterior targetability, respectively. Certain demographic and anatomical parameters could be useful in screening patients for treatability.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Engineering, Biomedical
Harshini Ashar, Akansha Singh, Deepan Kishore, Tina Neel, Sunil More, Chenang Liu, Danielle Dugat, Ashish Ranjan
Summary: High intensity focused ultrasound (HIFU) is a non-invasive technique for solid tumor treatment. This study compared HIFU thermal ablation and histotripsy ablation in dogs with spontaneous tumors, and evaluated the effects of HIFU hyperthermia on Doxorubicin delivery and immunomodulation. The results showed that HIFU thermal ablation achieved tumor remission in most patients, while histotripsy achieved partial response. HIFU hyperthermia also improved drug delivery and immune responses. These findings highlight the potential of HIFU as a promising cancer treatment approach.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Oncology
Orane Lorton, Pauline Coralie Guillemin, Andrea Peloso, Yacine M'Rad, Lindsey Alexandra Crowe, Thibaud Koessler, Pierre-Alexandre Poletti, Sana Boudabbous, Alexis Ricoeur, Rares Salomir
Summary: This study aimed to demonstrate the feasibility and accuracy of a new MRgHIFU transducer for the treatment of deep intrahepatic tumors. The experiments conducted on six pigs confirmed the effectiveness of the transducer and its ability to induce thermal lesions without significant side effects on surrounding tissues.
Article
Oncology
S. Ambrogio, R. M. Baesso, F. Bosio, F. Fedele, K. Ramnarine, B. Zeqiri, P. Miloro
Summary: This study presents a new HIFU test object that provides temperature measurement in a reference material compatible with MR and ultrasound. The test object demonstrated stability and validity during a 12-month testing period, making it a useful tool for evaluating device performance. The study also highlighted potential limitations of existing QA and monitoring methods, emphasizing the importance of temperature monitoring along the entire acoustic path.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Oncology
Sanne Nieuwenhuizen, Madelon Dijkstra, Robbert S. Puijk, Florentine E. F. Timmer, Irene M. Nota, Jip Opperman, Bente van den Bemd, Bart Geboers, Alette H. Ruarus, Evelien A. C. Schouten, Jan J. J. de Vries, Hester J. Scheffer, Anne M. van Geel, Jan Hein T. M. van Waesberghe, Rutger-Jan Swijnenburg, Kathelijn S. Versteeg, Birgit Lissenberg-Witte, M. Petrousjka van den Tol, Cornelis J. A. Haasbeek, Martijn R. Meijerink
Summary: Vaginal epithelial shedding is a common gynecological issue that may result from the loss of vaginal epithelial cells. Treatment can involve medication or surgery, depending on the severity of the condition.
Article
Oncology
Orane Lorton, Pauline C. Guillemin, Yacine M'Rad, Andrea Peloso, Sana Boudabbous, Caecilia Charbonnier, Ryan Holman, Lindsey A. Crowe, Laura Gui, Pierre-Alexandre Poletti, Alexis Ricoeur, Sylvain Terraz, Rares Salomir
Summary: A novel design of a HIFU phased-array transducer dedicated to transcostal hepatic thermo-ablation has been developed and demonstrated to be capable of creating thermal lesions in deep tissues without the need for rib protection measures.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Biomedical
Ounay Ishak, Elodie Breton, Karine Choquet, Anne Josset, Paolo Cabras, Jonathan Vappou
Summary: The paper proposes an all-in-one method for monitoring high intensity focused ultrasound (HIFU) thermal ablations using magnetic resonance-supersonic shear wave imaging (MR-SSI) and proton resonance frequency shift (PRFS). The method allows simultaneous monitoring of temperature and elasticity changes, ensuring the efficacy and accuracy of HIFU therapies.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Anton A. Popov, Zaneta Swiatkowska-Warkocka, Marta Marszalek, Gleb Tselikov, Ivan Zelepukin, Ahmed Al-Kattan, Sergey M. Deyev, Sergey M. Klimentov, Tatiana E. Itina, Andrei Kabashin
Summary: This research describes a method to synthesize nanocomposites by laser ablation and gold nanoparticles, which combines magnetic and plasmonic properties and has potential applications in the treatment of cancer and other diseases.
Article
Nanoscience & Nanotechnology
Maximilian Regenold, Pauric Bannigan, James C. Evans, Adam Waspe, Michael J. Temple, Christine Allen
Summary: A single disappointing study does not mean the end for ThermoDox, which still has potential to be an effective cancer treatment. Despite challenges faced, heat-triggered drug delivery platforms still hold tremendous potential for development.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Brett Z. Fite, James Wang, Aris J. Kare, Asaf Ilovitsh, Michael Chavez, Tali Ilovitsh, Nisi Zhang, Weiyu Chen, Elise Robinson, Hua Zhang, Azadeh Kheirolomoom, Matthew T. Silvestrini, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah M. Tam, Ryan R. Davis, Clifford G. Tepper, Alexander D. Borowsky, Katherine W. Ferrara
Summary: High intensity focused ultrasound (HIFU) can rapidly and non-invasively destroy tumor tissue. A combination of HIFU with innate immune agonist CpG and checkpoint inhibitor anti-PD-1 can modulate the immune response, leading to enhanced anti-tumor effects. Both mechanical disruption HIFU and thermal ablation induce potent inflammatory responses, while priming with CpG can further enhance immune response, alter macrophage polarization, and increase T-cell activation.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Leonardo Bianchi, Martina Bontempi, Sabrina De Simone, Martina Franceschet, Paola Saccomandi
Summary: This study characterizes the temperature dependence of thermal properties of heart and lung tissues, focusing on ex vivo porcine hearts and deflated lungs. The thermal diffusivity, thermal conductivity, and volumetric heat capacity of these tissues were measured and analyzed. The results showed that the thermal properties of heart tissue remained nearly constant until around 80 degrees C, while a more significant variation was observed above that temperature. For lung tissue, there was an exponential increase in the thermal diffusivity and thermal conductivity with temperature, especially at supraphysiological and ablative temperatures. Regression analysis was used to develop temperature-dependent models for these properties, which can be useful for simulation-based preplanning of thermal procedures and tissue-mimicking materials.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinrui Zhang, Lisa Landgraf, Nikolaos Bailis, Michael Unger, Thies H. Jochimsen, Andreas Melzer
Summary: Image-guided high-intensity focused ultrasound (HIFU) has gained increasing popularity in medicine for tumor ablation, neurological disease treatment, and bone metastases management. The mechanical and thermal effects of focused ultrasound enable tissue histotripsy, supportive radiation therapy, and targeted drug delivery. Integration of imaging modalities into HIFU systems enhances treatment precision and safety, showing potential to reduce adverse effects and improve postoperative quality of life.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Oncology
Rachel Rinat Bitton, Evgeni Sheingaouz, Benny Assif, Nathaniel Kelm, Mor Dayan, Kim Butts Pauly, Pejman Ghanouni
Summary: The study evaluated the performance of a dual-channel radiofrequency receive-only head coil for tcMRgFUS, showing improved SNR, visualization, and precision in imaging and thermometry compared to the volume body coil. The findings suggest that the dual-channel head coil provides better access to treatment day visualization for treatment planning and higher precision intra-operative thermometry.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Multidisciplinary Sciences
Evan McNabb, Deepa Sharma, Lakshmanan Sannachi, Anoja Giles, Wenyi Yang, Gregory J. Czarnota
Summary: High intensity focused ultrasound (HIFU) systems are used to cause tissue ablation or induced hyperthermia, and can be enhanced by the use of microbubble agents. This study investigated the effectiveness of reduced acoustic power and pressure on a commercial MR-integrated HIFU system in combination with radiation therapy for tumor treatment. The results showed that the combined therapy group exhibited statistically significant tumor cell death compared to the control group.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Peter Vaupel, Helmut Piazena, Markus Notter, Andreas R. Thomsen, Anca-L. Grosu, Felix Scholkmann, Alan Graham Pockley, Gabriele Multhoff
Summary: Mild hyperthermia (mHT) has significant effects on tumor oxygenation, which enhances the efficacy of radiotherapy, chemotherapy, and immunotherapy. The underlying mechanisms and the extent of these effects are not fully understood. This review discusses the biological mechanisms induced by mHT that are relevant to radio-oncology and immunotherapy.
