Article
Engineering, Biomedical
Ju Huang, Xiaojing Leng, Tao Jiang, Lihong Xu, Jun Zheng, Mingxiao Fang, Jingxue Wang, Zhigang Wang, Liang Zhang
Summary: Immunotherapy has great potential for treating tumors, but antigen exposure and immuno-suppressive tumor microenvironment (TME) caused by hypoxia limit its effectiveness. This study developed an oxygen-carrying nanoplatform to reprogram the immunosuppressive TME and enhance photothermal-immunotherapy. The nanoplatform showed efficient oxygen release behavior and excellent hyperthermia performance, attenuating tumor hypoxia and exposing tumor-associated antigens. The combination of photothermal therapy with anti-PD-1 immunotherapy induced a strong antitumor immune response and suppressed tumor growth.
MATERIALS TODAY BIO
(2023)
Review
Pharmacology & Pharmacy
Bhagavathi Sundaram Sivamaruthi, Subramanian Thangaleela, Periyanaina Kesika, Natarajan Suganthy, Chaiyavat Chaiyasut
Summary: Complete recovery from infection, sepsis, injury, or trauma requires a vigorous inflammatory response. Nanoparticles have become an efficient medical tool for diagnosing, preventing, and treating diseases due to their unique interactions with biological molecules. Mesoporous silica nanoparticles (MSNs) play a significant role in nano therapy and have several advantages such as easy synthesis, loading, and biocompatibility. MSNs can be used as theranostics in immune-modulatory nano systems to diagnose and treat inflammatory diseases.
Article
Chemistry, Physical
Yangyi Sheng, Qian Ren, Cheng Tao, Mei Wen, Pu Qu, Nuo Yu, Maoquan Li, Zhigang Chen, Xiaoyun Xie
Summary: The synthesis of efficient nanoagents for cancer treatment is challenging. In this study, Ce6@CuS-Pt/PEG nanoplatforms were synthesized and used for nanozyme-enhanced PDT-PTT combined therapy, resulting in successful tumor suppression.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Ruizhi Hu, Chen Dai, Chunmei Wang, Jie Lin, Hui Hu, Zhifang Li, Han Lin, Li Ding, Yu Chen, Bo Zhang
Summary: By developing 2D arsenic-phosphorus (AsP) nanosheets, toxic arsenic is confined into AsP crystals, improving the biosafety and biocompatibility of arsenic-based chemotherapeutic drugs. AsP nanosheets exhibit high light absorption and strong photothermal-conversion efficiency in the second near infrared biowindow (NIR-II), enabling contrast-enhanced photoacoustic imaging and local tumor hyperthermia, leading to a synergistic arsenic-mediated antineoplastic effect.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yue Huang, Saifun Nahar, M. D. Masud Alam, Shuo Hu, Daniel W. McVicar, De Yang
Summary: This study developed a reactive oxygen species-responsive mesoporous silica nanoparticle (MSN@TheraVac) loaded with a therapeutic vaccine for the curative treatment of colon cancer. The vaccine triggered the maturation of tumor-infiltrating dendritic cells and elicited robust anti-tumor immune responses. In animal experiments, the vaccine led to complete tumor cure and the generation of protective memory.
Article
Chemistry, Multidisciplinary
Yinying Pu, Wencheng Wu, Bangguo Zhou, Huijing Xiang, Jifeng Yu, Haohao Yin, Yan Zhang, Dou Du, Yu Chen, Huixiong Xu
Summary: In this study, a cascade nanoreactor named LGT was engineered using liposomal nanoparticles to achieve in-situ photothermal immunotherapy for inhibiting primary and metastasized tumors. The nanoreactor encapsulates a pro-photothermal agent and a tumor starvation mediator, which are converted into an NIR-II absorbing charge transfer complex in the tumor microenvironment. The combination of starvation therapy with anti-CTLA-4 checkpoint blockade therapy effectively inhibits tumor metastasis.
Article
Chemistry, Multidisciplinary
Chenlu Huang, Li Zhang, Qing Guo, Yueyue Zuo, Nannan Wang, Hai Wang, Deling Kong, Dunwan Zhu, Linhua Zhang
Summary: The nanoparticle-based combination therapy of photothermal therapy (PTT) and immunotherapy shows promising potential for cancer treatment by ablating tumors and eliciting host immune responses.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Xiang Ling, Zhaokui Jin, Qi Jiang, Xiaotao Wang, Bin Wei, Zhongchang Wang, Yangsen Xu, Tianye Cao, Jonathan W. Engle, Weibo Cai, Chenliang Su, Qianjun He
Summary: This study successfully tunes the cytotoxicity of tellurium nanomaterials by incorporating biocompatible selenium into their lattice, forming TeSex nano-alloys as a new theranostic nanoplatform. These nano-alloys exhibit high NIR-II photothermal conversion efficiency and therapeutic functions guided by multimodal imaging, providing a new approach for the development of biomedical nanoplatforms.
NATIONAL SCIENCE REVIEW
(2021)
Review
Pharmacology & Pharmacy
Xuerui Wang, Yuhao Liu, Yiqi Wei, Mingfeng Qiu, Jing Su
Summary: This review introduces the advantages of mesoporous silica nanoparticles (MSNs) and their applications in tumor therapy and diagnosis. The focus is on the study of modified MSNs as drug carriers and the application of MSNs in bioimaging. The review also discusses the limitations of MSNs' application and prospects for their future clinical transformation.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Engineering, Biomedical
Xinyao Feng, Fangshen Li, Liangliang Zhang, Wenmo Liu, Xupu Wang, Rui Zhu, Zhen-An Qiao, Bin Yu, Xianghui Yu
Summary: This study successfully achieved enhanced degradation and controllable light irradiation of nanoparticles by introducing calcium oxalate and photon engineering. This method can promote drug release and has potential applications in tumor therapy.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Multidisciplinary
Indika Chandrasiri, Mahesh Loku Yaddehige, Bo Li, Yuzhe Sun, William E. Meador, Austin Dorris, Mohammad Farid Zia, Nathan Hammer, Alex Flynt, Jared H. Delcamp, Edward Davis, Alexander Lippert, Davita L. Watkins
Summary: This study compares the solution behavior and self-assembly pattern of two linear dendritic block copolymers (LDBCs) and finds that the introduction of phenyl substituents improves the stability and loading efficiency of LDBC nanoparticles, which shows great potential for use as nanocarriers in therapeutic nanomedicine.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yuqi Chen, Mengna Jiang, Liwei Xiong, Xianxian Yao, Mingjian Fan, Danyang Chen, Qi Jiang, Zhaokui Jin, Qianjun He
Summary: This study demonstrated a promising multifunctional theranostic nanoplatform for cancer treatment by synthesizing gadolinium boride nanoparticles, showing potential for fluorescence imaging and photothermal therapy in cancer treatment.
CHINESE CHEMICAL LETTERS
(2021)
Review
Engineering, Chemical
Pragya Pallavi, Karthick Harini, Sultan Alshehri, Mohammed M. M. Ghoneim, Areej Alshlowi, Pemula Gowtham, Koyeli Girigoswami, Faiyaz Shakeel, Agnishwar Girigoswami
Summary: The advancements in nanotechnology have led to the development of nanostructured materials with wide applications in medicine and pharmaceuticals. Silica nanoparticles (SNPs) are particularly promising due to their large surface-to-volume ratio, ease of surface modification, and tunable pore size. This review discusses the preparation of SNPs and their various applications in medical fields, including drug delivery, imaging, and phototherapy. The potential harmful effects of SNPs are also reviewed based on in vitro and in vivo experiments. Furthermore, the engineering of SNPs for theranostic applications is highlighted as a way to overcome limitations of traditional therapeutics and diagnostics.
Article
Nanoscience & Nanotechnology
Madhavi Tripathi, Swathi Padmanabhan, Jaya Prakash, Ashok M. Raichur
Summary: This study developed ultrasmall CuS-Au (TSP-CA) nanohybrids using seed-mediated galvanic reduction of gold precursors on the surface of CuS nanoparticles. These nanohybrids showed potential as photothermal therapy and photoacoustic imaging contrast agents for cancer theranostics. In vitro experiments demonstrated the anticancer effects mediated by reactive oxygen species (ROS) on lung cancer cells, while ex vivo studies showed the effectiveness of the nanohybrids in generating photoacoustic signals and performing photothermal therapy at deep tissue depths.
ACS APPLIED NANO MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Khatereh Zarkesh, Reza Heidari, Pooya Iranpour, Negar Azarpira, Fatemeh Ahmadi, Soliman Mohammadi-Samani, Fatemeh Farjadian
Summary: This study successfully synthesized a novel pH-responsive mesoporous silica nanoparticle and achieved targeted drug delivery to cancer cells by coating with hyaluronan. The results showed that the nanoparticles had good biocompatibility and biodegradability, and could improve pharmacokinetic parameters.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)