Article
Chemistry, Multidisciplinary
Xiaojun He, Ji-Ting Hou, Xiaoshuai Sun, Paramesh Jangili, Jusung An, Yuna Qian, Jong Seung Kim, Jianliang Shen
Summary: Ultrasound-mediated sonodynamic therapy using sodium molybdenum bronze nanoparticles has shown effective antimicrobial activity against bacterial infections and biofilms, offering a promising approach for biomedical applications.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Jingyi Liang, Yaning Sun, Kaili Wang, Yawen Zhang, Linqing Guo, Zhihong Bao, Dun Wang, Haiyan Xu, Jiani Zheng, Yue Yuan
Summary: A nanoplatform was designed in this study, consisting of Cu-doped mesoporous Prussian blue (CMPB) encapsulating glucose oxidase (GOx) and coated with hyaluronic acid (HA) modified with a nitric oxide donor (HN). The nanoplatform combines multiple therapeutic approaches, including chemodynamic therapy (CDT), photothermal therapy (PTT), and starvation therapy, resulting in significant inhibition of tumor growth.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Na Tao, Huihuang Li, Liu Deng, Senfeng Zhao, Jiang Ouyang, Mei Wen, Wansong Chen, Ke Zeng, Chuanwan Wei, You-Nian Liu
Summary: The study presents a multifunctional platform based on Au nanoparticles and carbon dots modified hollow black TiO2 nanosphere for reversing immunosuppression and alleviating hypoxia in the tumor microenvironment. This platform effectively kills tumor cells by eliciting immune infiltration, alleviating hypoxia, and improving sonodynamic therapy efficiency.
Article
Medicine, Research & Experimental
Chenyang Yin, ZeKun Wang, Chunxue Dai, Bangjia Yang, Weiyun Wang, Endong Yang, Feng Guo, Cundong Fan, Pu Zhang, Jikui Sun, Dongdong Sun
Summary: This study proposes a new strategy to enhance the effectiveness of photodynamic therapy (PDT) and photothermal therapy (PTT) for tumor treatment by utilizing a hybrid of photosynthetic bacteria/photosensitizer/photothermal agent to generate oxygen through photosynthesis. The combination of photosensitizer and photothermal agent with photosynthetic bacteria effectively enhances their accumulation in tumor tissues, and the oxygen produced through photosynthesis is converted to reactive oxygen species (ROS) to further enhance the therapeutic effect.
Article
Chemistry, Applied
Peixia Zhang, Lu Zhang, Jun Wang, Lisheng Zhu, Ziying Li, Haijun Chen, Yu Gao
Summary: CEPH nanoplatform has the potential to enhance the efficacy of oxygen dependent SDT and overcome hypoxia-induced TMT resistance for improved synergistic TMT/SDT, by alleviating hypoxia, suppressing NSCLC cell growth, and enhancing the production of reactive oxygen species through ultrasound activation.
CARBOHYDRATE POLYMERS
(2021)
Article
Engineering, Environmental
Ningxi Li, Xiaodan Wei, Honglin Huang, Junhan Guo, Qingzhi Li, Hong Yang, Lulu Cai, Yiyao Liu, Chunhui Wu
Summary: This study developed a smart biomimetic nanoplatform for photothermal cascade immunotherapy, which can stimulate immune response and modulate tumor-associated macrophages. The platform effectively induced immunogenic tumor cell death and reprogrammed macrophages, resulting in inhibition of tumor growth and prevention of metastasis.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Chemistry, Multidisciplinary
Zhengyu Cao, Guotao Yuan, Lingli Zeng, Lu Bai, Xiao Liu, Maoxiong Wu, Runlu Sun, Zhiteng Chen, Yuan Jiang, Qingyuan Gao, Yangxin Chen, Yuling Zhang, Yue Pan, Jingfeng Wang
Summary: Sonodynamic therapy (SDT) and photothermal therapy (PTT) are combined using hyaluronic acid and PEG-modified copper sulfide/titanium oxide heterostructure nanosheets to target and treat early atherosclerotic plaques. The synergistic therapy induces apoptosis of proinflammatory macrophages, reduces heat shock protein 90 expression, and mitigates inflammation, preventing plaque progression.
Article
Engineering, Biomedical
Ju Huang, Xiaojing Leng, Tao Jiang, Lihong Xu, Jun Zheng, Mingxiao Fang, Jingxue Wang, Zhigang Wang, Liang Zhang
Summary: Immunotherapy has great potential for treating tumors, but antigen exposure and immuno-suppressive tumor microenvironment (TME) caused by hypoxia limit its effectiveness. This study developed an oxygen-carrying nanoplatform to reprogram the immunosuppressive TME and enhance photothermal-immunotherapy. The nanoplatform showed efficient oxygen release behavior and excellent hyperthermia performance, attenuating tumor hypoxia and exposing tumor-associated antigens. The combination of photothermal therapy with anti-PD-1 immunotherapy induced a strong antitumor immune response and suppressed tumor growth.
MATERIALS TODAY BIO
(2023)
Article
Engineering, Biomedical
Shuting Lu, Wei Feng, Caihong Dong, Xinran Song, Xiang Gao, Jinhe Guo, Yu Chen, Zhongqian Hu
Summary: A hybrid sonosensitizer, M@C, integrating cyanobacteria and ultrasmall oxygen-deficient bimetallic oxide nanosonosensitizers, is designed to overcome hypoxia-induced tumor resistance and enhance sonodynamic therapy (SDT) efficiency. The sustained oxygen production by cyanobacteria under light illumination promotes nanosonosensitizers to generate more ROS against cancer cells, ultimately improving SDT effectiveness. This work demonstrates the potential of rationally engineered biohybrid microorganism-based sonosensitizers for enhancing SDT in the treatment of hypoxic tumors.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Environmental
Heng Dong, Weijun Xiu, Ling Wan, Qiang Li, Yu Zhang, Meng Ding, Jingyang Shan, Kaili Yang, Zhaogang Teng, Lihui Yuwen, Yongbin Mou
Summary: This study proposes a nanoplatform that improves the efficacy of bacterial biofilm treatment. The platform releases degrading enzymes and antimicrobial agents to promote biofilm degradation and enhance antimicrobial agent penetration in the biofilm microenvironment. Additionally, it relieves the hypoxic microenvironment, further enhancing the effects of sonodynamic therapy.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Biomaterials
Likai Wang, Ya Tian, Kexin Lai, Yeping Liu, Juan Mou, Shiping Yang, Huixia Wu
Summary: Ultrasound-triggered sonodynamic therapy (SDT) has gained significant attention as a non-invasive and deep tissue penetration alternative for cancer treatment. However, the efficacy of SDT alone is limited by the hypoxic nature of solid tumors. Therefore, this study develops an intelligent theranostic nanoplatform that combines SDT and nitric oxide (NO) therapy to enhance cancer treatment.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Wen Yang, Ning Wang, Jin Yang, Chao Liu, Shuang Ma, Xiye Wang, Wenzhen Li, Meiling Shen, Qinjie Wu, Changyang Gong
Summary: By constructing a multifunctional Golden Cicada nanoplatform (MGCN) with efficient gene delivery ability and excellent photothermal effects, the cellular thermoresistance of tumor cells and the insufficient accumulation of indocyanine green (ICG) in the tumor region are overcome, resulting in a better therapeutic effect.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ye Tian, Wei Sang, Hao Tian, Lisi Xie, Guohao Wang, Zhan Zhang, Wenxi Li, Yunlu Dai
Summary: This study proposes a two-step strategy to alleviate tumor hypoxia and enhance tumor radiotherapy using physical stimulation and nanoparticles. The results show that this strategy effectively inhibits tumor growth and activates immune response.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Physical
Sihan Jia, Sunkui Ke, Li Tu, Shengqiang Chen, Bingkun Luo, Yeqi Xiong, Yang Li, Peiyuan Wang, Shefang Ye
Summary: In this study, a tumor microenvironment (TME)-responsive Cu-based metal-mesoporous organosilica nanoplatform incorporating vitamin k3 (VK3) was developed for enhanced chemodynamic therapy (CDT) of cancer. The nanoplatform could deplete glutathione (GSH) and specifically regenerate hydrogen peroxide (H2O2), resulting in synergistic CDT against tumors. Both in vitro and in vivo studies demonstrated the excellent biosafety and highly efficient tumor therapy potential of the CuO@MON-PEG/VK3 nanoplatform with multiple oxidative stress amplification.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Materials Science, Biomaterials
Ruixuan He, Peida Yang, Aoxue Liu, Yueli Zhang, Yuqi Chen, Cong Chang, Bo Lu
Summary: Nanomaterial-based cancer therapy has limitations due to the complexity of the tumor microenvironment (TME), but starvation therapy using glucose oxidase (GOx) shows potential for providing a foundation for other therapeutic methods by manipulating TME properties. This review comprehensively elucidates innovative cascade strategies for GOx-based synergetic therapy and discusses remaining challenges and the future of GOx-facilitated cancer treatment.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Zibo Li, Qing Xu, Xuefeng Lin, Kunyi Yu, Ling Lin, Yangjia Liu, Zhiqiang Yu, Tiancai Liu, Dixian Luo
Summary: A promising liposomal drug CholesPt(IV)-Liposomes was synthesized to overcome the limitations of platinum-based anticancer agents, such as poor water-solubility and chemoresistance. The liposomes showed small particle size, rapid release of platinum ions, and significant apoptosis of cancer cells. In animal experiments, CholesPt(IV)-Liposomes demonstrated better therapeutic effect and reduced drug toxicity compared to traditional platinum drugs.
CHINESE CHEMICAL LETTERS
(2022)
Article
Biochemical Research Methods
Lun Bian, Yufeng Xiong, Hui Zhao, Huiling Guo, Zhaoyue Li, Ke Ye, Zhigao Zhang, Tiancai Liu, Yingsong Wu, Guanfeng Lin
Summary: In this study, a Eu (III) chelate nanoparticles based lateral flow immunoassay was developed to achieve real-time monitoring of Cys C concentration in serum within 15 min. This method showed a wide detection range and a low limit of detection, and exhibited satisfactory correlation with chemiluminescence immunoassay.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Lun Bian, Junyu Liang, Hui Zhao, Ke Ye, Zhaoyue Li, Tiancai Liu, Jie Peng, Yingsong Wu, Guanfeng Lin
Summary: Establishing personalized medication plans for patients to maximize therapeutic efficacy and minimize the toxicity of vancomycin (VAN) requires rapid, simple, and accurate monitoring of VAN concentration in body fluid. In this study, a simple and rapid analytical method using CN-EUs and LFIA was developed for the real-time monitoring of VAN concentration in serum within 15 minutes. The method demonstrated a wide linear range of detection and a low limit of detection, with satisfactory correlation to results measured by LC-MS/MS.
FRONTIERS IN CHEMISTRY
(2021)
Article
Oncology
Li Lin, Geng-Xi Cai, Xiang-Ming Zhai, Xue-Xi Yang, Min Li, Kun Li, Chun-Lian Zhou, Tian-Cai Liu, Bo-Wei Han, Zi-Jia Liu, Mei-Qi Chen, Guo-Lin Ye, Ying-Song Wu, Zhi-Wei Guo
Summary: The study reveals the potential application of circRNAs in plasma EVs as non-invasive liquid biopsies for diagnosis and management of breast cancer, by developing classifiers based on circRNA expression profiles to distinguish between breast cancer patients and controls.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Analytical
Yue Cao, Zhenhua Chen, Xijiu Li, Zhaoyue Li, Guanfeng Lin, Tiancai Liu, Yingsong Wu
Summary: The dual-color quantum dots-loaded nanoparticles based lateral flow biosensor offers high accuracy by eliminating heterogeneity caused by different membrane locations, showing success in detecting pepsinogen with ultra-low limits of detection. The capability and reliability of the multiplex biosensor are validated, demonstrating negligible crosstalk and cross-reaction during simultaneous detection.
ANALYTICA CHIMICA ACTA
(2022)
Article
Engineering, Environmental
Xiao-Shuai Zhang, Kai Cheng, Jian-Shuang Wei, Zhuo-Yao Huang, Xiao-Lin Hou, Yong-Guo Hu, Xiao-Quan Yang, Fang Zhang, Xing Sun, Wei Chen, Bo Liu, Yuan-Di Zhao
Summary: This paper presents the development of a stable and dispersed nanocomposite probe by wrapping hydrophobic silver sulfide and ultra-small gold nanoparticles. The probe combines the functions of silver sulfide and gold nanoparticles, offering excellent optical imaging and therapeutic capabilities.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Xiao-Shuai Zhang, Jian-Shuang Wei, Jian-Wei Chen, Kai Cheng, Fang Zhang, Ghazal Ashraf, Yan Li, Xiao-Lin Hou, Ruo-Yun Zhang, Yong-Guo Hu, Xiao-Quan Yang, Wei Chen, Bo Liu, Yuan-Di Zhao
Summary: A multifunctional HASAIC nanoprobe with a hollow Ag2S/Ag nanocomposite shell has been successfully synthesized, showing improved tumor killing capability in real-time CT and PAI imaging. The probe utilizes its various functionalities to enhance efficiency and demonstrate high effectiveness in diagnosis and treatment.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Immunology
Lixia Gao, Jie Yang, Jutao Feng, Ziying Liu, Ying Dong, Jiangyan Luo, Liangzhentian Yu, Jiamei Wang, Hongying Fan, Weifeng Ma, Tiancai Liu
Summary: This study developed a novel strategy to suppress HBV DNA replication and eliminate cccDNA by preparing biomimetic nanoparticles with high targeting ability. The nanoparticles showed excellent stability and safety property, and exhibited significant inhibitory effects on various CHB-related markers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiaoyan Zhang, Jingxin Li, Tiancai Liu, Min Zhao, Baozhu Liang, Hong Chen, Zhen Zhang
Summary: This study analyzed the differential gene expression profiles of liver tissue after bariatric surgery, revealing the impact of surgery on gene expression. Functional enrichment analysis indicated the involvement of differentially expressed genes in immune response. Through the identification of hub genes and the analysis of immune cell infiltration, the study found that one gene, LCP1, was correlated with specific immune cells. These findings are of great significance in further understanding the therapeutic mechanisms of bariatric surgery in NAFLD and NASH and identifying new biomarkers and therapeutic targets.
Article
Multidisciplinary Sciences
Kai Cheng, Bo Liu, Xiao-Shuai Zhang, Ruo-Yun Zhang, Fang Zhang, Ghazal Ashraf, Guo-Qing Fan, Ming-Yu Tian, Xing Sun, Jing Yuan, Yuan-Di Zhao
Summary: Using a biomimetic multifunctional nanoplatform, this study develops an approach to treat tumors and inhibit metastasis. The platform, coated with a metal organic framework and a macrophage membrane, demonstrates good biocompatibility. By releasing Co2+ and H2S, it enhances the photothermal therapy effect and achieves high-concentration gas therapy. Additionally, it alters the balance of NADH/FAD, limiting ATP synthesis and triggering tumor growth inhibition and starvation therapy.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Environmental
Ruo-Yun Zhang, Kai Cheng, Xing Sun, Xiao-Quan Yang, Yong Li, Yong-Guo Hu, Xiao-Shuai Zhang, Bo Liu, Wei Chen, Yuan-Di Zhao, Dong-Sheng Huang
Summary: This study designed a novel biomimetic nanoprobe to comprehensively block immune escape in colorectal cancer. The probe effectively targeted tumors and improved the hypoxic environment, enhancing the therapeutic effect of sonodynamics therapy (SDT). The survival rate of mice was significantly increased.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Medicine, Research & Experimental
Zhi-Wei Guo, Qing Liu, Xu Yang, Geng-Xi Cai, Bo-Wei Han, Li-Min Huang, Chun-Xi Li, Zhi-Kun Liang, Xiang-Ming Zhai, Li Lin, Kun Li, Min Zhang, Tian-Cai Liu, Rui-lin Pan, Ying-Song Wu, Xue-Xi Yang
Summary: The study found that promoter profiling based on nucleosome footprints of cell-free DNA (cfDNA) can be used to evaluate the axillary lymph node status in breast cancer patients. By developing a classifier with multiple machine learning models, it is possible to accurately distinguish between lymph node-positive and lymph node-negative patients and guide the choice of cancer treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zichang Dai, Qiyuan Huang, Xueran Huang, Chuiyu Zhu, Kashif Rafiq Zahid, Tiancai Liu, Qiuyan Li, Chunmei Wu, Minghui Peng, Xiangyan Xiao, Umar Raza, Nan Yu, Tao Zeng
Summary: The expression of KIN17 is significantly increased in HCC and is associated with tumor progression and metastasis. KIN17 promotes migration and invasion of HCC cells by stimulating the TGF-beta/Smad2 pathway. It could serve as a potential therapeutic target and prognostic biomarker in HCC.
MOLECULAR CARCINOGENESIS
(2023)
Article
Chemistry, Multidisciplinary
Chao-Qing Li, Xiao-Lin Hou, Dong-Xue Jiang, Bin Zhang, Meng-Wen Ma, Xiao-Ting Xie, Yuan-Di Zhao, Tian-Cai Liu, Bo Liu
Summary: PT has excellent photothermal conversion capacity, good biocompatibility, and efficient targeting ability after cell membrane coating, can effectively inhibit breast tumors and relieve inflammation.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Biao Li, Wan Li, Tiancai Liu, Longying Zha
Summary: Noncommunicable diseases (NCDs), such as diabetes, can be transmitted in vivo through extracellular vesicles (EVs), despite not being directly transmissible. Insulin resistance, a common issue caused by a long-term high-fat diet, can lead to various health problems like hyperlipidemia, type 2 diabetes mellitus (T2DM), and diabetic peripheral neuropathy (DPN). Current treatments focus on improving insulin sensitivity, but exploring the role of EVs in insulin resistance may provide new preventive and therapeutic strategies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)