Article
Medicine, General & Internal
B. Neal, Y. Wu, X. Feng, R. Zhang, Y. Zhang, J. Shi, J. Zhang, M. Tian, L. Huang, Z. Li, Y. Yu, Y. Zhao, B. Zhou, J. Sun, Y. Liu, X. Yin, Z. Hao, J. Yu, K. -C. Li, X. Zhang, P. Duan, F. Wang, B. Ma, W. Shi, G. L. Di Tanna, S. Stepien, S. Shan, S. -A. Pearson, N. Li, L. L. Yan, D. Labarthe, P. Elliott
Summary: The study found that among individuals with a history of stroke or aged 60 or older with high blood pressure, using a salt substitute can reduce the rates of stroke, major cardiovascular events, and death.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Yishu Liu, Hongling Chu, Ke Peng, Xuejun Yin, Liping Huang, Yangfeng Wu, Sallie-Anne Pearson, Nicole Li, Paul Elliott, Lijing L. Yan, Darwin R. Labarthe, Zhixin Hao, Xiangxian Feng, Jianxin Zhang, Yuhong Zhang, Ruijuan Zhang, Bo Zhou, Zhifang Li, Jixin Sun, Yi Zhao, Yan Yu, Maoyi Tian, Bruce Neal, Hueiming Liu
Summary: Lowering sodium intake is essential for reducing blood pressure and cardiovascular disease risk. The use of salt substitutes in rural China faces challenges due to a lack of understanding of sodium reduction and salt substitutes, as well as habitual consumption of high-sodium foods.
Article
Peripheral Vascular Disease
Hiroyuki Takase, Naomi Kawakatsu, Kazusa Hayashi, Fumihiko Kin, Takeru Isogaki, Yasuaki Dohi
Summary: The study found a significant association between urinary Na/K ratio and the development of chronic kidney disease in the general Japanese population, especially after adjusting for important factors.
HYPERTENSION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Xuejun Yin, Ellie Paige, Maoyi Tian, Qiang Li, Liping Huang, Jie Yu, Anthony Rodgers, Paul Elliott, Yangfeng Wu, Bruce Neal
Summary: The SSaSS study found that potassium-enriched salt can have definitive effects on cardiovascular outcomes and death. By quantifying the amount of potassium-enriched salt used, researchers were able to estimate the impact on risk reduction and the potential for population-wide scale-up. The results showed that even a partial replacement of regular salt with potassium-enriched salt can deliver significant health gains.
Article
Nutrition & Dietetics
Sharon Turban, Stephen P. Juraschek, Edgar R. Miller, Cheryl A. M. Anderson, Karen White, Jeanne Charleston, Lawrence J. Appel
Summary: In individuals with chronic kidney disease, increasing dietary potassium intake did not significantly lower blood pressure. However, there was a potential risk of hyperkalemia associated with a higher potassium diet, indicating the need for caution when adjusting dietary potassium intake in this population.
Editorial Material
Medicine, General & Internal
Julie R. Ingelfinger
Summary: Opinions about the effects of sodium intake on blood pressure and stroke risk have been varied over the years, but data shows that high sodium intake is associated with increased risks of cardiovascular disease, stroke, and death. Reducing sodium intake while increasing potassium intake can lower blood pressure levels and decrease morbidity.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Peripheral Vascular Disease
Matti Marklund, Fikru Tullu, Sudhir Raj Thout, Jie Yu, Tammy M. Brady, Lawrence J. Appel, Bruce Neal, Jason H. Y. Wu, Rachita Gupta
Summary: Modeling nationwide salt substitution in India consistently estimated substantial net benefits, preventing around 8% to 14% of annual cardiovascular deaths. Even allowing for potential hyperkalemia risks there were net benefits estimated for individuals with chronic kidney disease.
Review
Peripheral Vascular Disease
Sheon Mary, Philipp Boder, Sandosh Padmanabhan, Martin W. McBride, Delyth Graham, Christian Delles, Anna F. Dominiczak
Summary: The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in kidney and cardiovascular research. Variants of uromodulin are associated with chronic kidney diseases and hypertension. Urinary and circulating uromodulin levels reflect kidney and cardiovascular health and overall mortality. Genetically driven levels of uromodulin have been shown to have a causal and adverse effect on kidney function. Uromodulin is involved in salt reabsorption and plays a significant role in the pathophysiology of hypertension. This review provides an overview of the multifaceted physiology and pathophysiology of uromodulin, including recent advances in its genetics, cellular trafficking, and mechanistic and clinical studies.
Article
Nutrition & Dietetics
Jie Yu, Sudhir Raj Thout, Qiang Li, Maoyi Tian, Matti Marklund, Clare Arnott, Mark D. Huffman, Devarsetty Praveen, Claire Johnson, Liping Huang, Simone Pettigrew, Bruce Neal, Jason H. Y. Wu
Summary: The study showed that using reduced-sodium added-potassium salt substitute can effectively lower blood pressure in hypertensive patients in rural India. Participants reported high satisfaction with the study salt and rated its taste positively.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Urology & Nephrology
Robert W. Hunter, Neeraj Dhaun, Matthew A. Bailey
Summary: Salt intake is a biological necessity that is deeply rooted in physiological systems, human societies, and global culture. However, excessive salt intake is associated with high blood pressure and is estimated to cause around 5 million deaths worldwide each year. Animal research has identified various mechanisms by which high salt intake contributes to diseases in different organ systems, but many of these pathways have not been tested for potential therapeutic interventions. Salt-reduction interventions can lower blood pressure, but the presence of "hidden" salt in processed foods makes it difficult for individuals to control their intake. In addition, growing inequalities in the food systems pose challenges to maintaining individual dietary control of salt intake. The most effective salt-reduction interventions have been implemented at the population level and involve multiple components, including government, education, and the food industry.
NATURE REVIEWS NEPHROLOGY
(2022)
Review
Peripheral Vascular Disease
Xiaohan Lu, Steven D. Crowley
Summary: Dr Lewis Dahl's observations on renal mechanisms of hypertension are still relevant, as recent experiments show that immune system dysfunction contributes to hypertension. Inflammatory cytokines and reactive oxygen species can alter kidney functions and lead to sustained hypertension. Targeting immune-mediated mechanisms while considering the kidney's importance in blood pressure regulation poses a challenge.
Article
Multidisciplinary Sciences
Saoraya Chanmuang, Bo-Min Kim, Su-Yeon Gu, Ye-Jin Son, Huong-Giang Le, Young-Do Nam, Eun-Ji Song, Kyung-Sik Ham, Hyun-Jin Kim
Summary: High salt intake is positively associated with health problems, but the effect of mineral-rich sea salt (SS) is rarely studied. This study found that high SS intake may be linked to kidney dysfunction and gut health problems, and salt-related physiological changes may be sex-specific.
Article
Multidisciplinary Sciences
Zhifang Li, Xiangxian Feng, Tao Wu, Lijing Yan, Paul Elliott, Yangfeng Wu
Summary: By involving media reporters in a salt reduction trial, there was a significant increase in media reports on salt and health. The impact of this intervention was sustained over a prolonged period, and local citizens showed improved awareness of knowledge on salt and health after the intervention.
Article
Nutrition & Dietetics
Sang Heon Suh, Su Hyun Song, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Kook-Hwan Oh, Joongyub Lee, Seung Hyeok Han, Yeong Hoon Kim, Dong-Wan Chae, Seong Kwon Ma, Soo Wan Kim
Summary: In patients with pre-dialysis CKD, low urine potassium excretion is associated with high blood pressure variability and an increased risk of cardiovascular events. Individualized dietary potassium intake restriction is recommended for these patients.
Article
Urology & Nephrology
Soshiro Ogata, Yuumi Akashi, Takaya Sakusabe, Shigehito Yoshizaki, Yuko Maeda, Kunihiro Nishimura, Kenji Maeda, Shigeru Nakai
Summary: This study found that there is an association between kidney function decline in patients with chronic kidney disease and sodium and potassium intake. Higher sodium intake was positively correlated, while higher potassium intake was negatively correlated with kidney function decline. Higher sodium intake but lower potassium intake was associated with more severe decline in kidney function.
KIDNEY INTERNATIONAL
(2022)
Review
Cardiac & Cardiovascular Systems
Frank Lezoualc'h, Lina Badimon, Hana Baker, Monique Bernard, Gabor Czibik, Rudolf A. de Boer, Thomas D'Humieres, Micheline Kergoat, Mark Kowala, Jennifer Rieusset, Gemma Vilahur, Maximin Detrait, Chris Watson, Genevieve A. Derumeaux
Summary: Diabetic cardiomyopathy is a distinct, multifactorial disease that leads to ventricular hypertrophy and abnormal myocardial contractility. Animal models provide opportunities to study its mechanisms, but there are limitations when extrapolating findings to humans.
CARDIOVASCULAR RESEARCH
(2023)
Editorial Material
Transplantation
Ron T. Gansevoort, Hans-Joachim Anders, Mario Cozzolino, Danilo Fliser, Denis Fouque, Alberto Ortiz, Maria Jose Soler, Christoph Wanner
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Clinical Neurology
Maerit Jensen, Susanne Sehner, Bastian Cheng, Eckhard Schlemm, Fanny Quandt, Ewgenia Barow, Karl Wegscheider, Florent Boutitie, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Vincent Thijs, Robin Lemmens, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Goetz Thomalla, Christian Gerloff
Summary: The study found that intravenous alteplase may have a potential benefit for health-related quality of life (HRQoL) beyond its effect on functional outcome.
Review
Cell Biology
Julien Pestel, Ferdinand Blangero, Assia Eljaafari
Summary: Adipose tissue-derived mesenchymal stem cells (ASCs) exhibit both pro-inflammatory and anti-inflammatory properties depending on the microenvironmental stimuli. In pathological contexts like obesity, ASCs can contribute to the development of obesity-related inflammatory diseases. This review aims to highlight the pathogenic role of ASCs in obesity and describe the mechanisms leading to their dysfunctions, involving factors such as adhesion molecules, TLRs, Th17 cells, Th22 cells, gamma delta T cells, and immune checkpoint overexpression.
Letter
Endocrinology & Metabolism
Charles Thivolet, Etienne Larger, Bertrand Cariou, Eric Renard, Helene Hanaire, Pierre -Yves Benhamou, Bruno Guerci, Emilie Mathiotte, Karim Chikh
DIABETES & METABOLISM
(2023)
Review
Geriatrics & Gerontology
Gabriel Antherieu, Mael Heiblig, Gilles Freyer, Herve Ghesquieres, Claire Falandry
Summary: This study found a high incidence of lymphopenia in adult patients treated with PARPi, especially in older patients, through a retrospective cohort study and scoping review analysis. Future work is needed to improve patient follow-up and discuss prophylactic strategies.
Review
Nutrition & Dietetics
Kamyar Kalantar-Zadeh, Vincenzo Bellizzi, Giorgina B. Piccoli, Yunying Shi, Soo Kun Lim, Sumira Riaz, Rocio Urbina Arronte, Wai Pooi Lau, Denis Fouque
Summary: An expert advisory board discussed the prevention and treatment of CKD, with a focus on dietary options. The timing of dialysis start is influenced by patients' clinical status and patient-clinician interactions. Therapies that preserve kidney function, such as adjusting lifestyle and diet, can prolong the dialysis-free period and improve CKD management.
JOURNAL OF RENAL NUTRITION
(2023)
Article
Clinical Neurology
Alexandre Bani-Sadr, Laura Mechtouff, Charles De Bourguignon, Aela Mauffrey, Timothe Boutelier, Tae-Hee Cho, Matteo Cappucci, Roxana Ameli, Marc Hermier, Laurent Derex, Norbert Nighoghossian, Yves Berthezene
Summary: This study aimed to investigate the relationship between baseline blood-brain barrier (BBB) permeability and the kinetics of circulating inflammatory markers in acute ischemic stroke (AIS) patients treated with mechanical thrombectomy. It was found that increased BBB permeability was associated with a larger ischemic core and higher levels of inflammatory markers. In patients with symptom onset <6 hours, increased BBB permeability was also associated with higher MMP-9 levels.
Article
Clinical Neurology
Benedikt Frey, Farhad Shenas, Florent Boutitie, Bastian Cheng, Tae-Hee Cho, Martin Ebinger, Matthias B. Endres, Jochen Fiebach, Jens Fiehler, Ivana Galinovic, Ewgenia Barow, Alina Koenigsberg, Eckhard Schlemm, Salvador Pedraza, Robin Lemmens, Vincent W. Thijs, Keith Muir, Norbert Z. Nighoghossian, Claus Simonsen, Christian Gerloff, Goetz Thomalla, WAKE-UP Investigators
Summary: This study aimed to evaluate the impact of white matter hyperintensities burden on the efficacy and safety of thrombolysis in stroke patients with unknown onset. The results showed that WMH burden was associated with worse functional outcome, but did not increase the risk of hemorrhagic transformation. In patients with severe WMH, intravenous thrombolysis was associated with a higher likelihood of excellent outcome without a significant increase in the rate of hemorrhagic transformation.
Correction
Geriatrics & Gerontology
Gaetan Gavazzi, Sabine Drevet, Matthieu Debray, Jean Luc Bosson, Fatah Tidadini, Marc Paccalin, Benoit de Wazieres, Thomas Celarier, Marc Bonnefoy, Virginie Vitrat
Review
Oncology
Zoe Daverio, Aneta Balcerczyk, Gilles J. P. Rautureau, Baptiste Panthu
Summary: Lactic acidosis is a crucial factor in the tumor microenvironment and cancer metabolism. This review aims to explore the mechanisms through which lactic acidosis affects cancer cell metabolism and its contribution to the understanding of tumor metabolism. It also highlights the therapeutic potentials of lactic acidosis.
Article
Cardiac & Cardiovascular Systems
Stefana Enachi, Maxime Schleef, Chahr-Eddine Hadjseyd, Simon Leboube, Charles Fauvel, Lucie Daniel, Antoine Jobbe-Duval, Laurent Sebbag, Sandrine Lemoine, Nathan Mewton
Summary: Chronic kidney disease (CKD) is common in patients with heart failure and reduced ejection fraction (HFrEF), and it is a major factor contributing to adverse outcomes. Despite limited data, studies have shown that HFrEF therapies continue to be effective in improving cardiovascular outcomes in patients with CKD. Most HF drugs cause acute renal hemodynamic changes, but these changes stabilize or even improve after the acute phase, without long-term deterioration of renal function. This paper challenges the misconceptions about the pathophysiology of HF that hinder the implementation of disease-modifying therapy in this context and proposes a strategy for titrating HF drugs in patients with moderate, severe, and end-stage CKD.
CURRENT HEART FAILURE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Pauline Delage, Berenice Segrestin, Kevin Seyssel, Stephanie Chanon, Aurelie Vieille-Marchiset, Annie Durand, Angeline Nemeth, Sylviane Metairon, Aline Charpagne, Patrick Descombes, Jorg Hager, Martine Laville, Hubert Vidal, Emmanuelle Meugnier
Summary: The adaptive response to overfeeding involves significant changes in gene expression in adipose tissue. This study investigated whether supplementation with polyphenols could affect these molecular adaptations in lean men. The results showed that polyphenol supplementation modulated gene expression in adipose tissue and potentially protected against adipose tissue expansion during weight gain.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexandre Bani-Sadr, Dylan Pavie, Laura Mechtouff, Matteo Cappucci, Marc Hermier, Roxana Ameli, Laurent Derex, Charles De Bourguignon, Tae-Hee Cho, Omer Eker, Norbert Nighoghossian, Yves Berthezene
Summary: The presence of brush sign is associated with infarct growth after successful thrombectomy, while cerebral collateral status is not.
EUROPEAN RADIOLOGY
(2023)
Article
Critical Care Medicine
Tarek Sharshar, Raphael Porcher, Pierre Asfar, Lamiae Grimaldi, Julien Jabot, Laurent Argaud, Christine Lebert, Pierre-Edouard Bollaert, Marie Line Harlay, Patrick Chillet, Eric Maury, Francois Santoli, Pascal Blanc, Romain Sonneville, Vu Dinh Chuyen, Benjamin Rohaut, Aurelien Mazeraud, Jean-Claude Alvarez, Vincent Navarro, Bernard Clair, Herve Outin
Summary: This multicentre, double-blind, randomised controlled trial in 244 adults with GCSE found that adding VPA as a complementary treatment to the recommended strategy did not increase the proportion of patients discharged from hospital by day 15.