Glasdegib as maintenance therapy for patients with AML and MDS patients at high risk for postallogeneic stem cell transplant relapse

Azacitidine maintenance after intensive chemotherapy improves DFS in older AML patients

(2019) Gerwin Huls et al.   BLOOD

Hedgehog signaling inhibitors in solid and hematological cancers

(2019) Jorge E. Cortes et al.   CANCER TREATMENT REVIEWS

Glasdegib plus intensive/nonintensive chemotherapy in untreated acute myeloid leukemia: BRIGHT AML 1019 Phase III trials

(2019) Jorge E Cortes et al.   Future Oncology

CC-486 Maintenance after Stem Cell Transplantation in Patients with Acute Myeloid Leukemia or Myelodysplastic Syndromes

(2018) Marcos de Lima et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Maintenance azacitidine after myeloablative allogeneic hematopoietic cell transplantation for myeloid malignancies

(2018) Kathryn T. Maples et al.   LEUKEMIA & LYMPHOMA

Glasdegib in combination with cytarabine and daunorubicin in patients with AML or high-risk MDS: Phase 2 study results

(2018) Jorge E. Cortes et al.   AMERICAN JOURNAL OF HEMATOLOGY

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

(2017) Richard M. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

GLI2 inhibition abrogates human leukemia stem cell dormancy

(2015) Anil Sadarangani et al.   Journal of Translational Medicine

Treatment with PF-04449913, an oral smoothened antagonist, in patients with myeloid malignancies: a phase 1 safety and pharmacokinetics study

(2015) Giovanni Martinelli et al.   Lancet Haematology

Targeting acute myeloid leukemia stem cells: a review and principles for the development of clinical trials

(2014) D. A. Pollyea et al.   HAEMATOLOGICA

Revised International Prognostic Scoring System for Myelodysplastic Syndromes

(2012) P. L. Greenberg et al.   BLOOD

Risk and prognostic factors for acute GVHD based on NIH consensus criteria

(2012) S-E Lee et al.   BONE MARROW TRANSPLANTATION

Allogeneic hematopoietic cell transplantation for acute lymphoblastic leukemia in adults

(2012) Samer K. Khaled et al.   CURRENT OPINION IN ONCOLOGY

Comparative Analysis of the Value of Allogeneic Hematopoietic Stem-Cell Transplantation in Acute Myeloid Leukemia With Monosomal Karyotype Versus Other Cytogenetic Risk Categories

(2012) Jan J. Cornelissen et al.   JOURNAL OF CLINICAL ONCOLOGY

Aberrant Activation of the Hedgehog Signaling Pathway in Malignant Hematological Neoplasms

(2011) Chi Young Ok et al.   AMERICAN JOURNAL OF PATHOLOGY

Monitoring MRD with flow cytometry: an effective method to predict relapse for ALL patients after allogeneic hematopoietic stem cell transplantation

(2011) Xiao-Su Zhao et al.   ANNALS OF HEMATOLOGY

Risk factors for acute GVHD and survival after hematopoietic cell transplantation

(2011) M. Jagasia et al.   BLOOD

Allogeneic transplantation as post-remission therapy for cytogenetically high-risk acute myeloid leukemia: landmark analysis from a single prospective multicenter trial

(2011) M. Stelljes et al.   HAEMATOLOGICA

Persistence of Cytogenetic Abnormalities at Complete Remission After Induction in Patients With Acute Myeloid Leukemia: Prognostic Significance and the Potential Role of Allogeneic Stem-Cell Transplantation

(2011) Yiming Chen et al.   JOURNAL OF CLINICAL ONCOLOGY

Impact of Pretransplantation Minimal Residual Disease, As Detected by Multiparametric Flow Cytometry, on Outcome of Myeloablative Hematopoietic Cell Transplantation for Acute Myeloid Leukemia

(2011) Roland B. Walter et al.   JOURNAL OF CLINICAL ONCOLOGY

Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened

(2011) Michael J. Munchhof et al.   ACS Medicinal Chemistry Letters

Acute myeloblastic leukaemias and myelodysplastic syndromes in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2010) M. F. Fey et al.   ANNALS OF ONCOLOGY

Hedgehog signaling maintains chemoresistance in myeloid leukemic cells

(2010) K C S Queiroz et al.   ONCOGENE

Relapse after Allogeneic Hematopoietic Cell Therapy

(2009) Marcel R.M. van den Brink et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells

(2009) Masayoshi Kobune et al.   CANCER SCIENCE

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

(2009) Chen Zhao et al.   NATURE

Minimal residual disease diagnostics in myeloid malignancies in the post transplant period

(2008) U Bacher et al.   BONE MARROW TRANSPLANTATION

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

Toward Optimization of Postremission Therapy for Residual Disease–Positive Patients With Acute Myeloid Leukemia

(2008) Luca Maurillo et al.   JOURNAL OF CLINICAL ONCOLOGY