Article
Immunology
Lili Cheng, Qi Song, Mengke Liu, Yan Wang, Hongmei Yi, Ying Qian, Pengpeng Xu, Shu Cheng, Chaofu Wang, Li Wang, Weili Zhao
Summary: PBL is a rare and aggressive hematological malignancy that commonly occurs in immune incompetent patients, with no specific standard treatment currently available. In some cases, immune therapy may be a potential treatment option for PBL, providing new insights into its management.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Virology
Yuting Sun, Jing Xue
Summary: During HIV/SIV infection, upregulated immune checkpoint markers can lead to chronic T cell exhaustion and regulate disease progression by mediating T cell responses and enriching viral reservoirs. Overexpression of these markers inhibits cell proliferation and cytokine production, affecting viral persistence. Targeting immune checkpoints has shown potential therapeutic efficacy in HIV treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Guillaume Manson, Amaeshi Chukwunonye Lemchukwu, Fatima-Zohra Mokrane, Egesta Lopci, Nicolas Aide, Laetitia Vercellino, Roch Houot, Laurent Dercle
Summary: The development of immunotherapy, particularly immune checkpoint inhibitors (ICIs), has greatly improved cancer treatment. This article reviews the use of FDG-PET/CT in patients with Hodgkin lymphoma treated with ICIs, focusing on image interpretation for response monitoring and detecting adverse events.
EUROPEAN RADIOLOGY
(2022)
Review
Oncology
Michael P. Randall, Michael A. Spinner
Summary: The treatment landscape of relapsed/refractory classic Hodgkin lymphoma (cHL) has significantly evolved over the past decade and has led to improved cure rates and overall survival. This review discusses the management of first relapse, maintenance therapy after transplant, relapse after transplant, and treatment of older adults and frail patients. Additionally, emerging immunotherapies in clinical trials are highlighted.
Review
Oncology
Alessandro Cellini, Federico Scarmozzino, Francesco Angotzi, Edoardo Ruggeri, Angelo Paolo Dei Tos, Livio Trentin, Marco Pizzi, Andrea Visentin
Summary: Immune evasion through overexpression of PD-L1 and PD-L2 proteins and the role of the microenvironment are key factors in classical Hodgkin Lymphoma. This review discusses the strategies used by cHL to create an immunosuppressive microenvironment and achieve optimal immune evasion, as well as the success and resistance mechanisms of checkpoint inhibitors in cHL immunotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xi Chen, Wanchun Wu, Wenwen Wei, Liqun Zou
Summary: Peripheral T-cell lymphomas (PTCLs) are highly heterogeneous and immune checkpoint therapies, particularly PD-1/PD-L1 blockers, show promise as a treatment option for this disease. The clinical trials of these blockers have demonstrated good efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vibor Milunovic, Ida Hude, Goran Rincic, Davor Galusic, Aron Grubesic, Marko Martinovic, Nika Popovic, Suncana Divosevic, Klara Brcic, Marin Medugorac, Luka Kuzat, Dejan Strahija, Stefan Mrdenovic, Inga Mandac Smoljanovic, Delfa Radic-Kristo, Slavko Gasparov, Igor Aurer, Slobodanka Ostojic Kolonic
Summary: Elderly patients with newly diagnosed Hodgkin lymphoma represent a significant portion of cases, but their outcomes are often poor compared to younger patients. Tailored and personalized treatment approaches are needed due to the unique challenges faced by this population.
Article
Virology
Ke Zhuang, Yongxi Zhang, Pingzheng Mo, Liping Deng, Yong Jiang, Lei Yu, Fanghua Mei, Shaoxin Huang, Xi Chen, Yajun Yan, Hongbin Tang, Xiangdong Li, Yong Xiong, Shuwen Wu, Hengning Ke, Xien Gui, Ke Lan
Summary: The identification of differentially expressed proteins in the plasma of patients with AIDS-NHL may lead to the development of biomarkers for screening, diagnosis, treatment, and prognosis. Immunoglobulin and complement components were found to be common proteins in this study. These proteins play a role in the pathogenesis of AIDS-NHL.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Oncology
Arina Martynchyk, Rakin Chowdhury, Eliza A. Hawkes, Colm Keane
Summary: Approximately 15% of classical Hodgkin lymphoma (cHL) patients experience relapsed or refractory (RR) disease despite standard treatment. Targeted agents such as anti-PD-1 agents and brentuximab vedotin have improved therapy beyond chemotherapy and radiotherapy. The tumour microenvironment (TME) of cHL, characterized by immune-rich composition, plays a crucial role in disease progression and treatment response. Advances in high-throughput technologies and single-cell sequencing have allowed deeper analysis of the TME and understanding of the interactions between immune cells and malignant Hodgkin Reed-Sternberg cells. This review provides insights into the evolving understanding of the prognostic role of immune cells within the TME and presents emerging prognostic data on cHL.
Review
Oncology
Parmida Sadat Pezeshki, Mahsa Eskian, Michael R. Hamblin, Nima Rezaei
Summary: Checkpoint inhibitors like nivolumab and pembrolizumab show promising results in the treatment of relapsed or refractory Hodgkin lymphoma, with relatively high response rates and acceptable safety profiles. Combining checkpoint inhibition with other conventional cancer treatments and researching resistance mechanisms may enhance the efficacy and safety of this immunotherapy, improving patient quality of life.
EXPERT REVIEW OF ANTICANCER THERAPY
(2021)
Article
Medicine, Research & Experimental
Rosaria De Filippi, Fortunato Morabito, Armando Santoro, Giovanni Tripepi, Francesco D'Alo, Luigi Rigacci, Francesca Ricci, Emanuela Morelli, Pier Luigi Zinzani, Antonio Pinto
Summary: In patients with relapsed/refractory classical Hodgkin lymphoma receiving nivolumab, BMI was not associated with treatment efficacy and immune-related toxicity.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Raissa Bila Cabral Fagundes, Leno Goes Delgado de Mederios, Amaxsell Thiago Barros de Souza, Maria Isabel Oliveira da Silva, Matheus Jose Barbosa Moreira, Carolina Colaco Villarrim, Irami Araujo-Filho, Kleyton Santos Medeiros
Summary: This systematic review aims to investigate the impact of HIV infection on individuals with HL by searching multiple databases for relevant studies and conducting meta-analysis, evaluating the quality of outcomes using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, and publishing the study findings in a peer-reviewed journal.
Review
Oncology
Zeinab Davoodi-Moghaddam, Farideh Jafari-Raddani, Maryam Noori, Davood Bashash
Summary: In recent decades, the development of immune checkpoint inhibitors (ICIs) in oncology has brought about a revolution. While tremendous successes have been seen in solid tumors, the application of ICIs in hematologic malignancies, especially non-Hodgkin's lymphoma (NHL), varies considerably. Meta-analysis of the included studies suggests that PD-1 may be a more attractive target in NHL patients compared to PD-L1 and CTLA-4. Additionally, the response to ICI therapy may be correlated with NHL subtypes, with different subtypes showing varying levels of response. Combination strategies, such as the use of ICIs with other treatment approaches, may be necessary to improve efficacy in NHL patients, especially for FL and DLBCL. Furthermore, larger trials with long-term follow-up are needed to confirm the safety and efficacy of ICI therapy in NHL patients.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Hematology
Johanna Veldman, Zainab N. D. Alsada, Anke van den Berg, Wouter J. Plattel, Arjan Diepstra, Lydia Visser
Summary: In this study, it was found that plasma levels of PD-L1 in classical Hodgkin lymphoma patients were correlated with clinical parameters and strongly associated with PD-L1 expression in the tumor microenvironment. Additionally, a positive correlation between VEGF and PD-1 levels in tissue and plasma was observed.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Aneesha Haryal, Matthew J. Townsend, Vinitha Baskaran, Padmavathi Srivoleti, Anita Giobbie-Hurder, Jordan S. Sack, Raymond A. Isidro, Nicole R. LeBoeuf, Elizabeth Buchbinder, F. Stephen Hodi, Shilpa Grover
Summary: Gastrointestinal immune-related adverse events caused by immune checkpoint inhibitors (ICIs) often require interruption of cancer treatment. This study examined the clinical features and treatment outcomes of ICI gastritis. It was found that ICI gastritis can occur alone or more commonly with concurrent enteritis/colitis, with different clinical courses. Gastric biopsies are necessary to diagnose clinically significant cases with normal endoscopic appearance. Most patients with isolated gastritis can continue ICI therapy uninterrupted, but some may require glucocorticoids.