Article
Oncology
Adam Kline, Pramod Kamalapathy, Katharine Bruce, Kevin Raskin, Joseph Schwab, Santiago Lozano-Calderon
Summary: This study aimed to identify nutritional indicators and physiological characteristics associated with wound infection in soft tissue sarcoma patients. Results showed that postoperative plasma glucose levels, preoperative albumin levels, and smoking status were useful variables in predicting wound infection in STS excisional procedures.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
V Batumalai, J. Descallar, G. P. Delaney, G. Gabriel, K. Wong, J. Shafiq, S. K. Vinod, M. B. Barton
Summary: The study found that single-fraction radiation therapy (SFRT) is underused for the treatment of bone metastases in New South Wales, Australia, with a higher 30-day mortality rate compared to multi-fraction radiation therapy (MFRT). Older patients, those with lower socioeconomic status, residing in outer regional areas, or with multiple comorbidities were more likely to receive SFRT. This indicates a need to increase the utilization of SFRT for bone metastases treatment.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Orthopedics
David Slawaska-Eng, Aaron M. Gazendam, Joseph Kendal, Patricia Schneider, Ricardo G. Becker, Joao Paulo Freitas, Nicholas Bernthal, Michelle Ghert, PARITY Investigators
Summary: This secondary analysis of the PARITY study data found that the only independent risk factor for surgical site infection (SSI) was hospital length of stay (LOS). It may therefore be reasonable for clinicians to consider streamlined discharge plans for orthopaedic oncology patients to potentially reduce the risk of SSI.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Oncology
W. L. Ong, D. L. Ball, R. L. Milne, F. Foroudi, J. L. Millar
Summary: The study found that SF-CRT for bone metastases in lung cancer patients in Australia is still underutilized, with most courses opting for ART. There is a trend of increasing ART usage over time, while SF-CRT remains fluctuating.
Editorial Material
Cardiac & Cardiovascular Systems
Paola Caruso, Lorenzo Scappaticcio, Maria Ida Maiorino, Katherine Esposito, Dario Giugliano
Summary: Diabetes is strongly associated with lower extremity amputations (LEA), and the relaxation of glycemic targets may lead to an increase in LEA. Studies have shown that glycemic control can reduce the incidence of LEA, and glucagon-like peptide-1 receptor agonists may potentially lower the risk of LEA in diabetic patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Surgery
Alexander F. Mericli, Malke Asaad, Valerae O. Lewis, Patrick P. Lin, Christopher J. Goodenough, David M. Adelman, Scott D. Oates, Matthew M. Hanasono
Summary: This study evaluated outcomes of vascularized bone flap reconstruction for oncologic bony extremity defects and compared union rates based on different insetting methods. A retrospective review of patients who received fibula flap reconstruction after oncologic resection was conducted. The overall union rate was 91.7%, with a mean time to full weightbearing of 16 months for lower extremity reconstructions.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Review
Cell Biology
Jozef Ban, Valerie Fock, Dave N. T. Aryee, Heinrich Kovar
Summary: Bone and bone marrow are common metastatic sites of cancer, often associated with poor disease prognosis. Current therapeutic options for bone metastases are limited and mainly palliative. Further research into the molecular pathways of bone metastasis is needed to develop more successful treatments for improved patient outcomes.
Article
Oncology
Ahmet S. Tunceroglu, Bin Gui, Shou-En Lu, Julian Sison, Rahul Parikh, Sharad Goyal, Bruce G. Haffty, Sung Kim, Salma K. Jabbour
Summary: The study investigated the efficacy of kV image guidance in the treatment of painful bone metastases, finding that its use can improve pain control, particularly for tumors of the lower extremities, extraosseous disease extension, and fewer treatment fractions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Michael Pezold, Sheila Blumberg, Mikel Sadek, Thomas Maldonado, Neal Cayne, Glenn Jacobowitz, Herbert James, Todd Berland
Summary: Antegrade superficial femoral artery (SFA) access for peripheral artery disease is a safe and effective alternative to retrograde common femoral artery (CFA) access, with significantly less utilization of fluoroscopy and contrast. The study found no significant differences in technical success or complications between antegrade SFA and retrograde CFA access in the outpatient setting.
ANNALS OF VASCULAR SURGERY
(2021)
Article
Oncology
Angela M. Hong, Cora Waldstein, Brindha Shivalingam, Matteo S. Carlino, Victoria Atkinson, Richard F. Kefford, Grant A. McArthur, Alexander M. Menzies, John F. Thompson, Georgina Long
Summary: The brain is a common site of metastatic disease for patients with advanced melanoma, with treatment approaches including surgery, radiotherapy, and systemic therapy. Management of melanoma brain metastases should involve a multidisciplinary team and consider optimal combinations and sequencing of treatments. It is important to establish appropriate guidelines for the management of melanoma brain metastases and update them regularly as new treatment options become available.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Surgery
Z-Hye Lee, Elie P. Ramly, Allyson R. Alfonso, David A. Daar, Christodoulos Kaoutzanis, Rami S. Kantar, Vishal Thanik, Pierre B. Saadeh, Jamie P. Levine
Summary: A systematic review was conducted to derive evidence-based recommendations for dangling protocols after lower extremity microvascular reconstruction, revealing significant heterogeneity in practice. Patient comorbidities and flap characteristics appear to influence tolerance to dangling, suggesting the need for tailored protocols based on risk factors to ensure clinical vigilance.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Surgery
Sungshin Na, Natale Mazzaferro, Weiyi Xia, Patricia Greenberg, William Beckerman
Summary: This study aimed to determine factors associated with an increased risk of developing postoperative SSI in patients undergoing lower extremity revascularization. Risk factors for SSI included age, body mass index, comorbidities, and procedure time. Patients who developed an SSI were more likely to have adverse outcomes such as myocardial infarction/stroke and major amputation.
ANNALS OF VASCULAR SURGERY
(2023)
Article
Oncology
Saksham Gupta, Hassan Dawood, Alexandra Giantini Larsen, Luis Fandino, Erik H. Knelson, Timothy R. Smith, Eudocia Q. Lee, Ayal Aizer, Ian F. Dunn, Wenya Linda Bi
Summary: Brain metastases are the most common brain tumors in adults, whose management remains nuanced. A nationwide, multicenter analysis was conducted with a retrospective cohort of adult patients who received craniotomy for resection of brain metastasis. Results showed that frailty and infratentorial approach were associated with increased risks of reoperation before discharge, while pre-frailty and frailty were associated with increased odds for post-discharge mortality. An optimization of metrics contributing to patient frailty and heightened surveillance in patients with infratentorial metastases may be considered in the peri-operative period.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Pauline Roussille, Marie Auvray, Damien Vansteene, Thierry Lecomte, Eugenie Rigault, Marianne Maillet, Christophe Locher, Marie Dior, Vincent Hautefeuille, Pascal Artru, May Mabro, Yann Touchefeu, Lysiane Marthey, Valerie Moulin, Samy Louafi, Cedric Lecaille, Romain Chautard, Astrid Lievre, Aziz Zaanan, Jaafar Bennouna, Antoine Berger, Sheik Emambux, Violaine Randrian, David Tougeron
Summary: This study evaluated prognostic factors of brain metastases from colorectal cancer and found that ECOG performance status, number of brain metastases, and number of chemotherapy lines are the most relevant factors in the management of patients with this condition.
RADIOTHERAPY AND ONCOLOGY
(2021)
Review
Oncology
Iromi R. Paranavithana, David Stirling, Montserrat Ros, Matthew Field
Summary: With recent progress in radiation therapy, precise delineation of metastatic lesions is crucial for the curative treatment of bone metastases. However, automatic segmentation algorithms for tumor segmentation still need improvement due to limited contrast and the lack of a widely agreed gold standard. Many proposed methods also lack evidence for their suitability in clinical practice.