Article
Biology
Cristina Almeida-Santiago, Juan Carlos Quevedo-Abeledo, Maria Vanesa Hernandez-Hernandez, Antonia de Vera-Gonzalez, Alejandra Gonzalez-Delgado, Miguel Angel Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to analyze the linear correlation between IL-1ra and IL-6 in patients with rheumatoid arthritis (RA) and their relationship with disease's inflammatory activity. IL-6 and IL-1ra levels were measured in 407 RA patients. No correlation was found between serum levels of IL-6 and IL-1ra. However, both cytokines were positively associated with disease activity and acute phase reactants. After controlling for covariates, disease activity scores were more strongly associated with IL-1ra compared to IL-6.
Article
Immunology
Hana Starobova, Mercedes Monteleone, Christelle Adolphe, Lena Batoon, Cheyenne J. Sandrock, Bryan Tay, Jennifer R. Deuis, Alexandra V. Smith, Alexander Mueller, Evelyn Israel Nadar, Grace Pamo Lawrence, Amanda Mayor, Elissa Tolson, Jean-Pierre Levesque, Allison R. Pettit, Brandon J. Wainwright, Kate Schroder, Irina Vetter
Summary: The study found that vincristine-induced peripheral neuropathy is driven by activation of the NLRP3 inflammasome and release of interleukin-1 beta. Treatment with NLRP3 inhibitor or IL-1 receptor antagonist could effectively reduce mechanical allodynia and gait disturbances. Repurposing anakinra may be an effective co-treatment strategy to prevent vincristine-induced peripheral neuropathy.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yukitoshi Izumi, Chika Fujii, Kazuko A. O'Dell, Charles F. Zorumski
Summary: Research has shown that acrylamide impairs cognitive function in rats through the activation of pro-inflammatory cytokines. Acrylamide inhibits the induction of long-term potentiation (LTP), and this effect can be overcome by inhibiting toll-like receptor 4 (TLR4) or microglial activation.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Meng-Bing Chen, Meng-Hua Li, Li-Yuan Wu, Rong Wang, Xi Long, Liang Zhang, Wei Sun, Wei-Wei Guo, Yong Pan, Yun-Shi Zhang, Chang Lin, Xi Shi, Shi-Ming Yang
Summary: Using RNA sequencing analysis, this study found that the traditional medicine oridonin (Ori) may protect against noise-induced hearing loss (NIHL) by regulating the expression of interleukin 1 receptor type 2 (IL1R2). Overexpression of IL1R2 in the inner ears of mice significantly reduced noise-induced ribbon synapse lesions and hearing loss by blocking the cytokine storm. This study provides a novel theoretical foundation for guiding the clinical treatment of NIHL.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Immunology
Tomohiro Koga, Atsushi Kawakami
Summary: IL-6 plays an important role in autoinflammatory diseases and is considered a promising therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Mariasilvia Colantuoni, Raisa Jofra Hernandez, Emanuela Pettinato, Luca Basso-Ricci, Laura Magnani, Grazia Andolfi, Chiara Rigamonti, Annamaria Finardi, Valentina Romeo, Monica Soldi, Lucia Sergi Sergi, Martina Rocchi, Serena Scala, Hal M. Hoffman, Silvia Gregori, Anna Kajaste-Rudnitski, Francesca Sanvito, Luca Muzio, Luigi Naldini, Alessandro Aiuti, Alessandra Mortellaro
Summary: This study developed a lentivirus-mediated gene transfer strategy using transplanted autologous hematopoietic stem/progenitor cells (HSPCs) as a source of IL-1 receptor antagonist (IL-1RA) for systemic delivery to tissues and organs. The HSPC-mediated IL-1RA delivery showed therapeutic efficacy in various IL-1-driven inflammation models.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Mariasilvia Colantuoni, Raisa Jofra Hernandez, Emanuela Pettinato, Luca Basso-Ricci, Laura Magnani, Grazia Andolfi, Chiara Rigamonti, Annamaria Finardi, Valentina Romeo, Monica Soldi, Lucia Sergi Sergi, Martina Rocchi, Serena Scala, Hal M. Hoffman, Silvia Gregori, Anna Kajaste-Rudnitski, Francesca Sanvito, Luca Muzio, Luigi Naldini, Alessandro Aiuti, Alessandra Mortellaro
Summary: We developed a gene transfer strategy using transplanted autologous hematopoietic stem/progenitor cells (HSPCs) as a source of IL-1 receptor antagonist (IL-1RA) for systemic delivery to tissues and organs. Our findings demonstrate the potential of HSPC-mediated IL-1RA delivery as a therapeutic modality for suppressing tissue and organ inflammation in diverse immune-related diseases involving IL-1-driven inflammation.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Jiarui Mi, Zhengye Liu, Shengduo Pei, Xia Wu, Nan Zhao, Lingjuan Jiang, Zhenjie Zhang, Xiaoyin Bai
Summary: This study using Mendelian randomization found that IL-18 is causally associated with an increased risk of IBD, while IL-1Ra is inversely associated with the risk of IBD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Zhen-Yi Long, Yi-Feng Zhou, Hao Yuan, Ya-Meng Peng, Si-Xian Wu, Fang Peng
Summary: The study revealed that the levels of IgG4 and IL-21 in the serum increased with disease progression in collagen-induced arthritis (CIA) rats, and the expression of IgG4 and IL-21 receptors in the ankle joint was significantly higher in the CIA model group. These proteins were closely related to the pathological score, indicating that IL-21 may promote rheumatoid arthritis development by regulating IgG4 content.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Immunology
Fang Liang, Weixiao Qin, Yilan Zeng, Dan Wang
Summary: Autoimmune diseases and autoinflammatory diseases are two types of immune system disorders, and pyroptosis plays a crucial role in these diseases. Gasdermins, a pore-forming protein mainly expressed in immune cells, gastrointestinal tract, and skin, are considered as the executors of pyroptosis and have various functions and pathological effects such as pro-inflammatory responses, immune activation, and tumor mediation. Recent studies have demonstrated the significant role of gasdermins in autoimmune diseases, autoinflammatory diseases, and immune-related neoplastic diseases, making them potential therapeutic targets for immune disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Wei-Sheng Lin, Ting-Rong Hsu
Summary: FIRES is a protracted neuroinflammatory condition of unknown cause that mainly affects school-age children and often leads to permanent neurological sequelae. Limited efficacy of current treatments and the rarity and complexity of the syndrome hamper research. Microglia and the NLRP3 inflammasome are suggested to play pivotal roles in the pathogenesis of FIRES.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Review
Immunology
Hanae Miyazawa, Taizo Wada
Summary: This review discusses recent findings in inflammatory diseases associated with chronic excess of serum IL-18 and describes the clinical and therapeutic relevance of understanding the pathology of this group of diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Dimitri Bulte, Chiara Rigamonti, Alessandro Romano, Alessandra Mortellaro
Summary: Inflammasome complexes and their receptor proteins play crucial roles in regulating innate immune response and inflammation. However, their abnormal activation and gene mutations contribute to the development of human autoimmune and autoinflammatory diseases. In the past decade, significant progress has been made in understanding inflammasome biology and activation mechanisms. This overview provides up-to-date information on various inflammasomes, their mechanisms, and their involvement in common diseases.
Article
Endocrinology & Metabolism
Fangkun Yang, Ning Huangfu, Jiaxi Shen, Pengpeng Su, Lujie Zhu, Hanbin Cui, Shuai Yuan
Summary: Genetically determined IL-1Ra levels are associated with increased risk of CHD and MI. Adjusting for apolipoprotein B reverses the observed association with CHD and slightly attenuates it when accounting for other cardiometabolic risk factors. Lifestyle intervention can lower IL-1Ra concentration and mitigate the heightened risk of CHD it poses.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Annemarie Steiner, Thomas Reygaerts, Alessandra Pontillo, Isabella Ceccherini, Jonas Moecking, Fiona Moghaddas, Sophia Davidson, Francesco Caroli, Alice Grossi, Fabio Fernandes Morato Castro, Jorge Kalil, Florian N. Gohr, Florian Schmidt, Eva Bartok, Thomas Zillinger, Gunther Hartmann, Matthias Geyer, Marco Gattorno, Leonardo Oliveira Mendonca, Seth L. Masters
Summary: NLRC4 (A160T) can lead to recessively inherited autoinflammation and immune dysregulation, or function as a heterozygous risk factor for the development of ulcerative colitis.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Letter
Rheumatology
Sindhu R. Johnson, Martin Aringer
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Alexandru Garaiman, Klaus Steigmiller, Catherine Gebhard, Carina Mihai, Rucsandra Dobrota, Cosimo Bruni, Marco Matucci-Cerinic, Joerg Henes, Jeska De Vries-Bouwstra, Vanessa Smith, Andrea Doria, Yannick Allanore, Lorenzo Dagna, Branimir Anic, Carlomaurizio Montecucco, Otylia Kowal-Bielecka, Mickael Martin, Yoshiya Tanaka, Anna-Maria Hoffmann-Vold, Ulrike Held, Oliver Distler, Mike Oliver Becker
Summary: The DU-VASC model was developed and validated to assist in decision-making for the management of digital ulcers in patients with systemic sclerosis. The model showed that PI treatment was the most important predictor associated with reduced occurrence of digital ulcers.
Article
Medicine, Research & Experimental
Oliviero Francesca, Galozzi Paola, Padoan Andrea, Lorenzin Mariagrazia, Scanu Anna, Ramonda Roberta
Summary: This study investigated the frequency and disease distribution of cytophagocytic mononuclear (CPM) cells in synovial fluid of patients with rheumatic diseases over a 12-year period. The results showed a strong association between CPM cells and seronegative spondyloarthritis (SpA), with a seasonal variation in their incidence, peaking in spring and autumn. This suggests that the presence of CPM cells in synovial fluid may offer diagnostic insights into SpA.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Chiara Franco, Anna Ghirardello, Loris Bertazza, Michela Gasparotto, Elisabetta Zanatta, Luca Iaccarino, Hadi Valadi, Andrea Doria, Mariele Gatto
Summary: This study aims to investigate the efficiency of EV isolation and characterization methods using size-exclusion chromatography (SEC) combined with ultrafiltration (UF). The results showed that the combined method is reliable for isolating intact EVs from complex fluids. This could potentially help in early disease characterization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marta Favero, Francesca Ometto, Elisa Belluzzi, Giacomo Cozzi, Laura Scagnellato, Francesca Oliviero, Pietro Ruggieri, Andrea Doria, Mariagrazia Lorenzin, Roberta Ramonda
Summary: This study aimed to evaluate the association between fetuin-A levels and radiographic sacroiliitis and syndesmophytes in early axSpA patients, and to identify potential predictors of radiographic damage. Results showed that fetuin-A levels were negatively associated with sacroiliac joint damage and may serve as a biomarker for predicting early structural damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Beatrice Moccaldi, Laura De Michieli, Marco Binda, Giulia Famoso, Roberto Depascale, Martina Perazzolo Marra, Andrea Doria, Elisabetta Zanatta
Summary: CTD-PAH is a life-threatening complication of connective tissue diseases characterized by increased pulmonary arterial pressure and resistance. Due to non-specific symptoms and lack of consensus on screening strategies, CTD-PAH is often diagnosed at an advanced stage. Non-invasive tools, particularly novel serum biomarkers, may improve early diagnosis and disease monitoring of CTD-PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Rita N. Cunha, Liliana Saraiva, Diogo Jesus, Andrea Doria, Jose P. da Silva, Luis S. Ines
Summary: This study found that anti-U1RNP, SLE-DAS score, and the need for immunosuppressants in patients with LLDAS predict a higher risk of disease flare. Remission without the use of glucocorticoids is associated with a lower risk of flare.
Article
Rheumatology
M. Lorenzin, G. Cozzi, L. Scagnellato, A. Ortolan, S. Vio, G. Striani, V Scapin, G. De Conti, A. Doria, R. Ramonda
Summary: This study aimed to examine the association between sex and clinical features, disease activity indices, and imaging features in early-stage axial spondyloarthritis (axSpA). The results showed that males were more likely to have severe inflammation and spinal progression, while females had more frequent signs of spinal inflammation on MRI. In addition, females were more likely to have involvement in peripheral and entheseal sites. Overall, there were differences in the presentation of axSpA based on sex.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Health Care Sciences & Services
Margherita Zen, Mariele Gatto, Roberto Depascale, Francesca Regola, Micaela Fredi, Laura Andreoli, Franco Franceschini, Maria Letizia Urban, Giacomo Emmi, Fulvia Ceccarelli, Fabrizio Conti, Alessandra Bortoluzzi, Marcello Govoni, Chiara Tani, Marta Mosca, Tania Ubiali, Maria Gerosa, Enrica P. Bozzolo, Valentina Canti, Paolo Cardinaletti, Armando Gabrielli, Giacomo Tanti, Elisa Gremese, Ginevra De Marchi, Salvatore De Vita, Serena Fasano, Francesco Ciccia, Giulia Pazzola, Carlo Salvarani, Simone Negrini, Andrea Di Matteo, Rossella De Angelis, Giovanni Orsolini, Maurizio Rossini, Paola Faggioli, Antonella Laria, Matteo Piga, Alberto Cauli, Salvatore Scarpato, Francesca Wanda Rossi, Amato De Paulis, Enrico Brunetta, Angela Ceribelli, Carlo Selmi, Marcella Prete, Vito Racanelli, Angelo Vacca, Elena Bartoloni, Roberto Gerli, Elisabetta Zanatta, Maddalena Larosa, Francesca Saccon, Andrea Doria, Luca Iaccarino
Summary: This study assessed the efficacy of belimumab in treating joint and skin manifestations in a nationwide cohort of SLE patients. The results showed that belimumab significantly improved joint and skin symptoms and reduced the use of glucocorticoids. A significant proportion of patients who did not achieve complete remission initially achieved remission during follow-up.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Rheumatology
Rossella De Angelis, Clodoveo Ferri, Dilia Giuggioli, Gianluigi Bajocchi, Lorenzo Dagna, Silvia Bellando-Randone, Giovanni Zanframundo, Rosario Foti, Fabio Cacciapaglia, Giovanna Cuomo, Alarico Ariani, Edoardo Rosato, Gemma Lepri, Francesco Girelli, Valeria Riccieri, Elisabetta Zanatta, Silvia Laura Bosello, Ilaria Cavazzana, Francesca Ingegnoli, Maria De Santis, Giuseppe Murdaca, Giuseppina Abignano, Nicoletta Romeo, Alessandra Della Rossa, Maurizio Caminiti, Anna Maria Iuliano, Giovanni Ciano, Lorenzo Beretta, Gianluca Bagnato, Ennio Lubrano, Ilenia De Andres, Alessandro Giollo, Marta Saracco, Cecilia Agnes, Edoardo Cipolletta, Federica Lumetti, Amelia Spinella, Luca Magnani, Corrado Campochiaro, Giacomo De Luca, Veronica Codullo, Elisa Visalli, Claudio Di Vico, Antonietta Gigante, Greta Pellagrino, Erika Pigatto, Maria-Grazia Lazzaroni, Franco Franceschini, Elena Generali, Gianna Mennillo, Simone Barsotti, Giuseppa Pagano Mariano, Federica Furini, Licia Vultaggio, Simone Parisi, Clara Lisa Peroni, Davide Rozza, Anna Zanetti, Greta Carrara, Gianpiero Landolfi, Carlo Alberto Scire, Gerolamo Bianchi, Enrico Fusaro, Gian Domenico Sebastiani, Marcello Govoni, Salvatore D'Angelo, Franco Cozzi, Serena Guiducci, Andrea Doria, Carlo Salvarani, Florenzo Iannone, Marco Matucci-Cerinic
Summary: This study aimed to describe the demographic, clinical, and laboratory features of systemic sclerosis sine scleroderma (ssSSc) within a large SSc cohort. The results showed that ssSSc has longer duration of RP, milder disease course, and higher positivity of anticentromere antibodies compared to lcSSc and dcSSc.
Article
Biochemistry & Molecular Biology
Zahra Rahme, Chiara Franco, Claudio Cruciani, Federico Pettorossi, Alice Zaramella, Stefano Realdon, Luca Iaccarino, Giulia Frontini, Gabriella Moroni, Andrea Doria, Anna Ghirardello, Mariele Gatto
Summary: Cytokines play a role in the pathogenesis of lupus nephritis and can be used as prognostic biomarkers. A study on adult patients with biopsy-proven active LN found correlations between specific cytokines and disease features as well as renal response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Rheumatology
Giacomo Cozzi, Laura Scagnellato, Mariagrazia Lorenzin, Edoardo Savarino, Fabiana Zingone, Francesca Ometto, Marta Favero, Andrea Doria, Stephan R. Vavricka, Roberta Ramonda
Summary: Spondyloarthritis (SpA) is a group of chronic inflammatory diseases affecting the axial and peripheral joints, tendons, and entheses. Inflammatory bowel disease (IBD) is strongly associated with SpA and has significant impacts on patients' quality of life. Effective treatment requires close collaboration between gastroenterologists and rheumatologists to identify and manage joint and intestinal manifestations, and current drug options for both conditions remain limited.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Anna Ghirardello, Mariele Gatto, Chiara Franco, Elisabetta Zanatta, Roberto Padoan, Luana Ienna, Nicoletta Gallo, Margherita Zen, Ingrid E. Lundberg, Michael Mahler, Andrea Doria, Luca Iaccarino
Summary: In this study, the detection of myositis-specific autoantibodies (MSAs) and myositis-associated autoantibodies (MAAs) using multiple analytic methods was found to be useful for the diagnosis and classification of idiopathic inflammatory myopathies (IIMs).
Article
Rheumatology
I. Prevete, A. Iuliano, A. Cauli, M. Piga, F. Iannone, L. Coladonato, A. Bortoluzzi, E. Silvagni, C. Tani, E. Elefante, A. Doria, L. Iaccarino, F. Franceschini, M. Fredi, F. Conti, F. R. Spinelli, B. Frediani, E. Gonzales Garcia, C. A. Scire, A. Zanetti, D. Rozza, G. Carrara, G. D. Sebastiani
Summary: Several studies show that age at onset has an impact on the clinical-serological presentation, comorbidities and disease course of patients with systemic lupus erythematosus (SLE). This study evaluated the correlation between age at onset and clinical-serological manifestations and comorbidities in patients with recent onset SLE. The results showed that early onset SLE had a more active immunological profile, while late onset SLE had a higher incidence of comorbidities.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
