Journal
PATHOGENS
Volume 9, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/pathogens9080639
Keywords
Aspergillus fumigatus; Pseudomonas aeruginosa; cystic fibrosis; combined infection
Categories
Funding
- NIHR Manchester Biomedical Research Centre
- NC3Rs Training Fellowship [NC/P002390/1]
- MRC Career Development Award [MR/N008707/1]
- MRC [MR/N008707/1] Funding Source: UKRI
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Pseudomonas aeruginosahas long been established as the most prevalent respiratory pathogen in Cystic Fibrosis (CF) patients, with opportunistic infection causing profound morbidity and mortality. Recently,Aspergillus fumigatushas also been recognised as a key contributor to CF lung deterioration, being consistently associated with decreased lung function and worsened prognosis in these patients. As clinical evidence for the common occurrence of combined infection with these two pathogens increases, research into the mechanism and consequences of their interaction is becoming more relevant. Clinical evidence suggests a synergistic effect of combined infection, which translates into a poorer prognosis for the patients. In vitro results from the laboratory have identified a variety of possible synergistic and antagonistic interactions betweenA. fumigatusandP. aeruginosa. Here, we present a comprehensive overview of the complex environment of the CF lung and discuss how it needs to be considered to determine the exact molecular interactions thatA. fumigatusandP. aeruginosaundergo during combined infection and their effects on the host.
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