Article
Cardiac & Cardiovascular Systems
Moyang Wang, Guangyuan Song, Mao Chen, Yuan Feng, Jian'an Wang, Xianbao Liu, Shenghua Zhou, Zhenfei Fang, Yaling Han, Kai Xu, Bo Yu, Bo Xu, Yuejin Yang, Nicolo Piazza, Yongjian Wu, Run-Lin Gao
Summary: The study confirmed the safety and efficacy of the TaurusOne transcatheter aortic valve system in treating Chinese patients with symptomatic severe aortic stenosis. The one-year mortality rate of 6.7% in 120 patients was lower than the expected performance goal, with other adverse events occurring at varying rates.
Article
Cardiac & Cardiovascular Systems
Piotr P. Buszman, Mateusz Kachel, Carlos Fernandez Ceballos, Karolina Lukasik, Wojciech Domaradzki, Maciej Pruski, Armando Tellez, Serge Rousselle, Marta Konopko, Michal Glanc, Pawel Kazmierczak, Krzysztof P. Milewski, Pawel E. Buszman
Summary: The study evaluated a balloon expandable transcatheter heart valve system in an ovine banding model. The results showed that the valve system had good functionality and biocompatibility.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Review
Medicine, General & Internal
Michele Pighi, Davide Giovannini, Roberto Scarsini, Nicolo Piazza
Summary: Aortic stenosis is the most common valvular heart disease, and TAVI has become the standard of care for high surgical risk patients, as well as low and intermediate surgical risk individuals. Preprocedural work-up is crucial, including surgical risk evaluation, clinical assessment, multimodality imaging of the valve, and management of coronary artery disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Francesco Saverio Mennini, Francesco Meucci, Gabriele Pesarini, Pietro Vandoni, Maddalena Lettino, Archita Sarmah, Judith Shore, Michelle Green, Stefano Giardina
Summary: This cost-utility analysis showed that TAVI with SAPIEN 3 is likely to be cost effective compared with SAVR for the treatment of low-risk sSAS patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Costanza Pellegrini, Tobias Rheude, Matthias Renker, Alexander Wolf, Jan Martin Wambach, Hector A. Alvarez-Covarrubias, Oliver Doerr, Parminder Singh, Efstratios Charitos, Erion Xhepa, Michael Joner, Won-Keun Kim
Summary: This study compared the outcomes of transcatheter aortic valve implantation (TAVI) using the ACURATE neo2 and SAPIEN 3 Ultra valves. The Neo2 had a higher rate of device success and lower transvalvular gradients, while the Ultra had lower rates of mild paravalvular leakage. Clinical events at 30 days were comparable.
Review
Cardiac & Cardiovascular Systems
Muzamil Khawaja, Hafeez Ul Hassan Virk, Dhrubajyoti Bandyopadhyay, Mario Rodriguez, Johao Escobar, Mahboob Alam, Hani Jneid, Chayakrit Krittanawong
Summary: For patients with a clinical indication for aortic valve replacement, they can choose surgical aortic valve replacement or Transcatheter Aortic Valve Implantation. The choice depends on factors such as age, life expectancy, comorbidities, frailty, and patient preference. However, there are controversies regarding the outcomes of TAVI, including death, stroke, and major cardiovascular events. We propose that a precision medicine approach should be emphasized in the selection and management of TAVI patients.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Health Care Sciences & Services
Igor Volodarsky, Vladimir Perhulov, Galyna Gochman, Valeriu Cuciuc, Michael Welt, Gera Gandelman, Jacob George
Summary: Transcatheter aortic valve implantation (TAVI) is commonly used for patients with aortic valve stenosis. CT is crucial in planning TAVI to measure the aortic annulus and choose the appropriate prosthesis. This study explores extracardiac measurements to improve annulus sizing for TAVI.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Rueck, Won-Keun Kim, Mohamed Abdel-Wahab, Holger Thiele, Tanja K. Rudolph, Alexander Wolf, Jan Martin Wambach, Ole De Backer, Lars Sondergaard, Christian Hengstenberg, Mika Laine, Hirokazu Miyashita, Henrik Bjursten, Matthias Goetberg, Costanza Pellegrini, Stefan Toggweiler, Joanna J. Wykrzykowska, Osama Soliman, Nawzad Saleh, Christopher U. Meduri
Summary: This study aimed to evaluate the safety and efficacy of ACURATE neo2 in transcatheter aortic valve implantation in Europe. The results showed favorable postoperative hemodynamics and clinical outcomes, as well as a low rate of postoperative pacemaker implantation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Marco Angelillis, Giulia Costa, Chiara Primerano, Cristina Giannini, Marianna Adamo, Giuliano Chizzola, Alessandro Iadanza, Massimo Fineschi, Marta Barletta, Francesco Bedogni, Erica Ferrara, Arnaldo Poli, Francesco De Felice, Giuseppe Bruschi, Marco De Carlo, Anna S. Petronio
Summary: Symptoms of aortic stenosis (AS) are not proportional to its severity and patients with very severe AS (VSAS) remain asymptomatic for a long time. The appropriate time for intervention in patients with VSAS and the effects of transcatheter aortic valve implantation (TAVI) on left ventricular hypertrophy (LVH) remain debated. This study compares the procedural and 30-day outcomes of TAVI between patients with VSAS and patients with severe AS (SAS) and the changes in LVH.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Markus Mach, Thomas Poschner, Waseem Hasan, Tillmann Kerbel, Philipp Szalkiewicz, Ena Hasimbegovic, Martin Andreas, Christoph Gross, Andreas Strouhal, Georg Delle-Karth, Martin Grabenwoeger, Christopher Adlbrecht, Andreas Schober
Summary: In high-risk patients aged 75 or younger, while TAVR surgery showed a higher short-term survival rate, isolated surgical aortic valve replacement (iSAVR) was associated with a significantly higher long-term survival rate.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Fanny Lassalle, Mickael Rosa, Bart Staels, Eric Van Belle, Sophie Susen, Annabelle Dupont
Summary: Transcatheter aortic valve replacement (TAVR) has revolutionized the treatment of severe aortic valve stenosis (AVS) and is considered an alternative to open heart surgery. TAVR has shown good prognosis for patients, but is still associated with postprocedural complications like bleeding or thrombosis. This study aimed to provide a comprehensive overview of the impact of TAVR on monocyte phenotype and subset distribution and their association with clinical outcomes in patients with severe AVS who underwent TAVR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Darko Boljevic, Milovan Bojic, Mihajlo Farkic, Dragan Sagic, Dragan Topic, Vladimir Kovacevic, Jovana Lakcevic, Stefan Veljkovic, Milan Dobric, Sasa Hinic, Nenad Ilijevski, Marko Nikolic, Aleksandra Kaludjerovic, Matjaz Bunc, Aleksandra Nikolic
Summary: The Dedinje Cardiovascular Institute has successfully established a TAVI program, and the initial results are comparable to previous large randomized trials, setting the foundation for further development.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Pier Pasquale Leone, Andrea Scotti, Edwin C. Ho, Manaf Assafin, James Doolittle, Mei Chau, Leandro Slipczuk, Matthew Levitus, Damiano Regazzoli, Antonio Mangieri, Azeem Latib
Summary: Transcatheter aortic valve implantation (TAVI) has emerged as a safe and effective alternative to surgical aortic valve replacement for severe aortic stenosis. This review focuses on commercially available TAVI devices and provides a guide for selecting the appropriate prosthesis based on patient-related factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Moritz Seiffert, Reinhard Vonthein, Helmut Baumgartner, Michael A. Borger, Yeong-Hoon Choi, Volkmar Falk, Norbert Frey, Andreas Hagendorff, Christian Hagl, Christian Hamm, Inke R. Koenig, Ulf Landmesser, Steffen Massberg, Hermann Reichenspurner, Holger Thiele, Raphael Twerenbold, Maren Vens, Thomas Walther, Andreas Ziegler, Jochen Cremer, Stefan Blankenberg
Summary: TAVI has become the preferred treatment option for severe aortic stenosis, but the optimal treatment strategy for younger, low-risk patients remains controversial. The DEDICATE-DZHK6 Trial aims to investigate the efficacy and safety of TAVI compared to SAVR in low-to intermediate-risk patients aged 65 years or older, and provide important information for clinical practice.
Article
Cardiac & Cardiovascular Systems
Tzlil Grinberg, Yaron Aviv, Mordehay Vaturi, Leor Perl, Maya Wiessman, Hanna Vaknin-Assa, Pablo Codner, Yaron Shapira, Ran Kornowski, Katia Orvin
Summary: Noninvasive hemodynamic evaluation using NICaS revealed unique short-term adaptive changes in patients with severe aortic stenosis soon after TAVI, which contributes to a better understanding of complex hemodynamic changes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Konrad Pieszko, Jaroslaw Hiczkiewicz, Jan Budzianowski, Bogdan Musielak, Dariusz Hiczkiewicz, Wojciech Faron, Janusz Rzezniczak, Pawel Burchardt
Summary: Artificial intelligence (AI) is considered the fourth industrial revolution, with rapid advancements in its applications in medicine promising more precise diagnoses, streamlined workflows, and increased accessibility to healthcare services. Despite the popularity of AI technologies, many healthcare practitioners still lack a comprehensive understanding of AI methods and potential risks.
CARDIOLOGY JOURNAL
(2021)
Article
Nutrition & Dietetics
Mohamed Abouzid, Marlena Kruszyna, Pawel Burchardt, Lukasz Kruszyna, Franciszek K. Glowka, Marta Karazniewicz-Lada
Summary: This study found that the BsmI AA genotype may have a protective effect against cardiovascular diseases. Specific VDR genotypes are associated with conditions such as obesity, hypertension, and heart failure. There is a correlation between vitamin D levels and VDR genotypes, which warrants further investigation into the underlying mechanisms.
Article
Pharmacology & Pharmacy
Jan Budzianowski, Janusz Rzezniczak, Jaroslaw Hiczkiewicz, Dominika Kasprzak, Anna Winnicka-Zielinska, Bogdan Musielak, Konrad Pieszko, Pawel Burchardt
Summary: In this case report, a 78-year-old male patient with non-ST-segment elevation myocardial infarction had severe normocytic normochromic anemia resolved after the introduction of empagliflozin, suggesting that SGLT2 inhibitors may improve erythropoiesis in diabetic patients.
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Philipp C. Seppelt, Silvia Mas-Peiro, Arnaud Van Linden, Sonja Iken, Kai Zacharowski, Thomas Walther, Stephan Fichtlscherer, Mariuca Vasa-Nicotera
Summary: This study showed that low baseline ScO2 not responding to oxygen supply might indicate impaired cardiopulmonary function and is associated with worse 1 year survival and prolonged in-hospital stay after transfemoral TAVI.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Badder Kattih, Daniel C. Carstens, Felicitas Boeckling, Tina Rasper, Graziella Pergola, Stefanie Dimmeler, Mariuca Vasa-Nicotera, Andreas M. Zeiher, Silvia Mas-Peiro
Summary: This study assessed the prognostic value of circulating musclin as a novel biomarker in identifying high-risk patients undergoing transcatheter aortic valve implantation (TAVI). The results showed that circulating musclin is an independent predictor of 1-year overall survival in TAVI patients, and when combined with EuroSCORE II, it can improve the prediction of mortality in low to intermediate clinical risk TAVI patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Ioannis Drosos, Roberta De Rosa, Sebastian Cremer, Philipp C. Seppelt, Katrin Hemmann, Jana Oppermann, Recha Blessing, Silvia Mas-Peiro, Mariuca Vasa-Nicotera, Andreas M. Zeiher, Zisis Dimitriadis
Summary: The study demonstrates that percutaneous LAAO may be a feasible alternative strategy for stroke prevention, which can be safely performed in high-risk, multimorbid patients with high bleeding risk or contraindications to oral anticoagulation.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Silvia Mas-Peiro, Gloria Faerber, Dimitra Bon, Eva Herrmann, Timm Bauer, Sabine Bleiziffer, Raffi Bekeredjian, Andreas Boening, Christian Frerker, Andreas Beckmann, Helge Moellmann, Stephan Ensminger, Christian W. Hamm, Friedhelm Beyersdorf, Stephan Fichtlscherer, Thomas Walther
Summary: The study compared TAVI and SAVR in patients with moderate-to-severe CKD and found similar 1-year survival rates. TAVI patients had more pacemaker implantations and vascular complications, while SAVR patients had more myocardial infarctions and bleeding. Temporary dialysis was more common in SAVR patients.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Silvia Mas-Peiro, Graziella Pergola, Alexander Berkowitsch, Manja Meggendorfer, Michael A. Rieger, Mariuca Vasa-Nicotera, Stefanie Dimmeler, Andreas M. Zeiher
Summary: Mutations in DNMT3A and TET2 genes are associated with long-term prognosis in patients undergoing TAVR for aortic valve stenosis. These mutations are more common in older women and are linked to increased mortality up to 4 years after the procedure.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Review
Infectious Diseases
Nils Wetzstein, Thomas A. Kohl, Margo Diricks, Silvia Mas-Peiro, Tomas Holubec, Johanna Kessel, Christiana Graf, Benjamin Koch, Eva Herrmann, Maria J. G. T. Vehreschild, Michael Hogardt, Stefan Niemann, Christoph Stephan, Thomas A. Wichelhaus
Summary: This study aimed to investigate the clinical characteristics and outcome of HCU-associated Mycobacterium chimaera infections. The study found that these infections were characterized by high morbidity and mortality, as well as challenges in diagnosis and treatment. Reoperation was associated with better survival.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Cardiac & Cardiovascular Systems
Silvia Mas-Peiro, Wesley T. Abplanalp, Tina Rasper, Alexander Berkowitsch, David M. Leistner, Stefanie Dimmeler, Andreas M. Zeiher
Summary: This study found that mosaic loss of Y chromosome (LOY) in blood cells is associated with significantly impaired long-term survival even after successful transcatheter aortic valve replacement (TAVR). LOY induces cardiac fibrosis, mimicking the consequences of aortic valve stenosis, and is related to age-related diseases. The study also identified a pro-fibrotic gene signature in LOY monocytes. These findings highlight the importance of LOY in TAVR and provide new insights for targeted therapies based on LOY-induced cardiac fibrosis.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Alexandra Steyer, Silvia Mas-Peiro, David M. Leistner, Valentina O. Puntmann, Eike Nagel, Damini Dey, Markus Goeller, Vitali Koch, Christian Booz, Thomas J. Vogl, Simon S. Martin
Summary: This study aims to assess the attenuation of pericoronary adipose tissue (PCAT) surrounding the proximal right coronary artery (RCA) in patients with aortic stenosis (AS) and undergoing transcatheter aortic valve replacement (TAVR). The results show that RCA PCAT attenuation is a more reliable marker for evaluating coronary inflammation and identifying patients at risk for major adverse cardiovascular events (MACE) than conventional CAD diagnostic tools.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Arturo Giordano, Silvia Mas-Peiro, Stephan Fichtlscherer, Andreas Schaefer, Martin Beyer, Francesco Maisano, Guido Ascione, Nicola Buzzatti, Rui Teles, Joao Brito, Francisco Albuquerque, Lars Sondergaard, Maarten Vanhaverbeke, Angelo Quagliana, Giuliano Costa, Marco Barbanti, Paolo Ferraro, Alberto Morello, Michele Cimmino, Michele Albanese, Martino Pepe, Luca Bardi, Salvatore Giordano, Antonio Cittadini, Nicola Corcione, Giuseppe Biondi-Zoccai
Summary: This study aimed to assess the long-term outcome of patients undergoing TAVI with the Portico valve. The results showed that the use of the Portico valve was associated with favorable long-term clinical outcomes.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ioannis Drosos, Roberta De Rosa, Philipp C. Seppelt, Sebastian Cremer, Silvia Mas-Peiro, Katrin Hemmann, Jana Oppermann, Recha Blessing, Mariuca Vasa-Nicotera, Andreas M. Zeiher, Zisis Dimitriadis
Summary: This study evaluates the hemodynamic effects of iatrogenic atrial septa' defects (iASD) after percutaneous left atrial appendage occlusion (LAAO), as well as the incidence of persistent iASD at three months. The study finds that iASD does not result in significant shunts directly after the procedure, although there is a significant increase in mean right atrial pressure. The occurrence of persistent iASD after percutaneous LAAO seems to be relatively rare at three months.
JOURNAL OF GERIATRIC CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Philipp Christian Seppelt, Roberta De Rosa, Silvia Mas-Peiro, Andreas Michael Zeiher, Mariuca Vasa-Nicotera
Summary: Transcatheter aortic valve implantation (TAVI) with self-expandable prostheses can lead to immediate reduction in left ventricular contractility and impaired diastolic function, but also indicates an improvement in global cardiovascular energy efficiency.
CARDIOVASCULAR INTERVENTION AND THERAPEUTICS
(2022)
Review
Cardiac & Cardiovascular Systems
Dominika Kasprzak, Janusz Rzezniczak, Teresa Ganowicz, Tomasz Luczak, Marek Slomczynski, Jaroslaw Hiczkiewicz, Pawel Burchardt
Summary: According to the World Health Organization, by 2030, the number of people suffering from dementia worldwide is projected to reach 82 million, placing a significant burden on health and social care systems. Epidemiological data suggests a link between coronary heart disease and cognitive impairment, with a potential increase in risk of CI for patients after ACS. Late diagnosis of CI could result in serious clinical implications, such as increased hospitalizations and mortality.