Targeting TLR4 with ApTOLL Improves Heart Function in Response to Coronary Ischemia Reperfusion in Pigs Undergoing Acute Myocardial Infarction

Rosiglitazone alleviates myocardial apoptosis in rats with acute myocardial infarction via inhibiting TLR4/NF‑κB signaling pathway

(2020) Hongzhong Ma et al.   Experimental and Therapeutic Medicine

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

(2019) Emelia J. Benjamin et al.   CIRCULATION

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia–reperfusion injury by inhibiting monocyte-mediated inflammation in mice

(2019) Masaki Fujiwara et al.   CARDIOVASCULAR RESEARCH

Role of TLR4 (Toll-Like Receptor 4) in N1/N2 Neutrophil Programming After Stroke

(2019) Alicia García-Culebras et al.   STROKE

CIBER-CLAP (CIBERCV Cardioprotection Large Animal Platform): A multicenter preclinical network for testing reproducibility in cardiovascular interventions

(2019) Xavier Rossello et al.   Scientific Reports

TLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models

(2018) Gerónimo Fernández et al.   MOLECULAR THERAPY

Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities

(2018) Sang-Bing Ong et al.   PHARMACOLOGY & THERAPEUTICS

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction

(2018) Edward D. Coverstone et al.   BASIC RESEARCH IN CARDIOLOGY

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

(2018) Hans Erik Bøtker et al.   BASIC RESEARCH IN CARDIOLOGY

Inflammatory cells and their non-coding RNAs as targets for treating myocardial infarction

(2018) Mira Jung et al.   BASIC RESEARCH IN CARDIOLOGY

Recombinant human interleukin-1 receptor antagonist treatment protects rats from myocardial ischemia–reperfusion injury

(2018) Jinzhou Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

Interleukin-18: Biological properties and role in disease pathogenesis

(2017) Gilles Kaplanski   IMMUNOLOGICAL REVIEWS

The Biological Basis for Cardiac Repair After Myocardial Infarction

(2016) Sumanth D. Prabhu et al.   CIRCULATION RESEARCH

Silencing cardiomyocyte TLR4 reduces injury following hypoxia

(2016) Orna Avlas et al.   EXPERIMENTAL CELL RESEARCH

Protective effects of ghrelin against oxidative stress, inducible nitric oxide synthase and inflammation in a mouse model of myocardial ischemia/reperfusion injury via the HMGB1 and TLR4/NF-κB pathway

(2016) Ning Sun et al.   Molecular Medicine Reports

Nitric Oxide Induces Cardiac Protection by Preventing Extracellular Matrix Degradation through the Complex Caveolin-3/EMMPRIN in Cardiac Myocytes

(2016) Irene Cuadrado et al.   PLoS One

Cardiac Oxidative Stress and Inflammatory Cytokines Response after Myocardial Infarction

(2015) Margherita Neri et al.   Current Vascular Pharmacology

TLR4 expression on monocyte subsets in myocardial infarction

(2013) L. D. Tapp et al.   JOURNAL OF INTERNAL MEDICINE

Partially Silencing Brain Toll-Like Receptor 4 Prevents in Part Left Ventricular Remodeling with Sympathoinhibition in Rats with Myocardial Infarction-Induced Heart Failure

(2013) Kiyohiro Ogawa et al.   PLoS One

Regulation of the Inflammatory Response in Cardiac Repair

(2012) Nikolaos G. Frangogiannis   CIRCULATION RESEARCH

The Emerging Role of Innate Immunity in the Heart and Vascular System

(2011) Douglas L. Mann   CIRCULATION RESEARCH

CC chemokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in mice

(2011) Fabrizio Montecucco et al.   EUROPEAN HEART JOURNAL

The extracellular matrix metalloproteinase inducer EMMPRIN is a target of nitric oxide in myocardial ischemia/reperfusion

(2011) Carlos Tarin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery and Development of Therapeutic Aptamers

(2010) P.R. Bouchard et al.   Annual Review of Pharmacology and Toxicology

Monocytes: Protagonists of Infarct Inflammation and Repair After Myocardial Infarction

(2010) Matthias Nahrendorf et al.   CIRCULATION

Toll-like receptors 4 induces expression of matrix metalloproteinase-9 in human aortic smooth muscle cells

(2010) Hongli Li et al.   MOLECULAR BIOLOGY REPORTS

Cytokines Link Toll-Like Receptor 4 Signaling to Cardiac Dysfunction After Global Myocardial Ischemia

(2008) John Cha et al.   ANNALS OF THORACIC SURGERY