CTLA-4 Blockade, during HIV Virus-Like Particles Immunization, Alters HIV-Specific B-Cell Responses

Immune checkpoint modulation enhances HIV-1 antibody induction

(2020) Todd Bradley et al.   Nature Communications

CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

(2020) Justin Harper et al.   NATURE MEDICINE

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

(2019) Kimberly M. Cirelli et al.   CELL

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

(2018) Robert K. Abbott et al.   IMMUNITY

HIV Vaccination: A Roadmap among Advancements and Concerns

(2018) Maria Trovato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses

(2018) Jonathan Richard et al.   mBio

Factors influencing the induction of high affinity antibodies to Plasmodium falciparum merozoite antigens and how affinity changes over time

(2018) Muyideen K. Tijani et al.   Scientific Reports

Functional Antibody Response Against V1V2 and V3 of HIV gp120 in the VAX003 and VAX004 Vaccine Trials

(2018) Preetha Balasubramanian et al.   Scientific Reports

CD8 + effector memory T cells induce acute rejection of allogeneic heart retransplants in mice possibly through activating expression of inflammatory cytokines

(2017) Gang Du et al.   EXPERIMENTAL CELL RESEARCH

Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem

(2017) Colin Havenar-Daughton et al.   IMMUNOLOGICAL REVIEWS

Foxp1 Negatively Regulates T Follicular Helper Cell Differentiation and Germinal Center Responses by Controlling Cell Migration and CTLA-4

(2017) Bi Shi et al.   JOURNAL OF IMMUNOLOGY

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

(2017) Ling Xu et al.   SCIENCE

Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial

(2017) David Easterhoff et al.   PLoS Pathogens

How to assess the binding strength of antibodies elicited by vaccination against HIV and other viruses

(2016) P. J. Klasse   Expert Review of Vaccines

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth

(2016) Jinghe Huang et al.   IMMUNITY

T follicular regulatory cells

(2016) Peter T. Sage et al.   IMMUNOLOGICAL REVIEWS

A proliferation inducing ligand (APRIL) promotes IL-10 production and regulatory functions of human B cells

(2016) Charlotte Hua et al.   JOURNAL OF AUTOIMMUNITY

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function

(2016) Peter T Sage et al.   NATURE IMMUNOLOGY

Broadly Neutralizing Antibodies for HIV-1 Prevention or Immunotherapy

(2016) Marina Caskey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toll-like receptor 3 adjuvant in combination with virus-like particles elicit a humoral response against HIV

(2016) Ethan Poteet et al.   VACCINE

Broadly Neutralizing Antibodies for HIV Eradication

(2016) Kathryn E. Stephenson et al.   Current HIV/AIDS Reports

Animal Models for HIV Cure Research

(2016) Benjamin B. Policicchio et al.   Frontiers in Immunology

Development of an avidity assay for detection of recent HIV infections

(2015) Samantha J. Shepherd et al.   JOURNAL OF VIROLOGICAL METHODS

A Novel Prime and Boost Regimen of HIV Virus-Like Particles with TLR4 Adjuvant MPLA Induces Th1 Oriented Immune Responses against HIV

(2015) Ethan Poteet et al.   PLoS One

Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

(2015) J. G. Jardine et al.   SCIENCE

HIV Vaccine Efficacy and Immune Correlates of Risk

(2014) Robert O'Connell et al.   CURRENT HIV RESEARCH

Treg Cells and CTLA-4: The Ball and Chain of the Germinal Center Response

(2014) Michelle A. Linterman et al.   IMMUNITY

Regulatory T Cells Control Antigen-Specific Expansion of Tfh Cell Number and Humoral Immune Responses via the Coreceptor CTLA-4

(2014) James Badger Wing et al.   IMMUNITY

The Coinhibitory Receptor CTLA-4 Controls B Cell Responses by Modulating T Follicular Helper, T Follicular Regulatory, and T Regulatory Cells

(2014) Peter T. Sage et al.   IMMUNITY

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Immune Activation Driven by CTLA-4 Blockade Augments Viral Replication at Mucosal Sites in Simian Immunodeficiency Virus Infection

(2014) V. Cecchinato et al.   JOURNAL OF IMMUNOLOGY

Characterization and Immunogenicity of a Novel Mosaic M HIV-1 gp140 Trimer

(2014) J. P. Nkolola et al.   JOURNAL OF VIROLOGY

HIV-1 Vaccine-Induced C1 and V2 Env-Specific Antibodies Synergize for Increased Antiviral Activities

(2014) Justin Pollara et al.   JOURNAL OF VIROLOGY

CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement

(2014) Chun Jing Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines

(2014) A. W. Chung et al.   Science Translational Medicine

Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination

(2014) N. L. Yates et al.   Science Translational Medicine

Emerging concepts on T follicular helper cell dynamics in HIV infection

(2014) Franco Pissani et al.   TRENDS IN IMMUNOLOGY

In vivo protection by broadly neutralizing HIV antibodies

(2014) Marit J. van Gils et al.   TRENDS IN MICROBIOLOGY

Immunologic Basis for Long HCDR3s in Broadly Neutralizing Antibodies Against HIV-1

(2014) Lei Yu et al.   Frontiers in Immunology

Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection

(2013) Peter Hraber et al.   AIDS

Broadly Neutralizing Antiviral Antibodies

(2013) Davide Corti et al.   Annual Review of Immunology

Differential CTLA-4 expression in human CD4+ versus CD8+ T cells is associated with increased NFAT1 and inhibition of CD4+ proliferation

(2013) D V Chan et al.   GENES AND IMMUNITY

Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype

(2013) Dirk Baumjohann et al.   IMMUNITY

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation

(2013) Radhika Goenka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BAFF- and APRIL-Dependent Maintenance of Antibody Titers after Immunization with T-Dependent Antigen and CD1d-Binding Ligand

(2013) H. B. Shah et al.   JOURNAL OF IMMUNOLOGY

Recent Advances in Humanized Mice: Accelerating the Development of an HIV Vaccine

(2013) A. M. Tager et al.   JOURNAL OF INFECTIOUS DISEASES

The human natural killer cytotoxic cell line NK-92, once armed with a murine CD16 receptor, represents a convenient cellular tool for the screening of mouse mAbs according to their ADCC potential

(2013) Béatrice Clémenceau et al.   mAbs

Harnessing CD4+ T cell responses in HIV vaccine development

(2013) Hendrik Streeck et al.   NATURE MEDICINE

Efficacy Trial of a DNA/rAd5 HIV-1 Preventive Vaccine

(2013) Scott M. Hammer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies from an HIV-1 Vaccine Efficacy Trial Target Multiple Epitopes and Preferentially Use the VH1 Gene Family

(2012) M. Bonsignori et al.   JOURNAL OF VIROLOGY

Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival

(2012) X. Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly neutralizing antibodies against HIV-1: Templates for a vaccine

(2012) Marit J. van Gils et al.   VIROLOGY

Fatal Pancreatitis in Simian Immunodeficiency Virus SIVmac251-Infected Macaques Treated with 2',3'-Dideoxyinosine and Stavudine following Cytotoxic-T-Lymphocyte-Associated Antigen 4 and Indoleamine 2,3-Dioxygenase Blockade

(2011) M. Vaccari et al.   JOURNAL OF VIROLOGY

Safety and efficacy of the HVTN 503/Phambili Study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study

(2011) Glenda E Gray et al.   LANCET INFECTIOUS DISEASES

Broad neutralization coverage of HIV by multiple highly potent antibodies

(2011) Laura M. Walker et al.   NATURE

Immune Modulation through 4-1BB Enhances SIV Vaccine Protection in Non-Human Primates against SIVmac251 Challenge

(2011) Lauren A. Hirao et al.   PLoS One

Correction: Characteristics of the Earliest Cross-Neutralizing Antibody Response to HIV-1

(2011) Iliyana Mikell et al.   PLoS Pathogens

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Incorporation of CD40 ligand into SHIV virus-like particles (VLP) enhances SHIV-VLP-induced dendritic cell activation and boosts immune responses against HIV

(2010) Rongxin Zhang et al.   VACCINE

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

(2009) Karl S. Peggs et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Virus-like Particle (VLP) Lymphatic Trafficking and Immune Response Generation After Immunization by Different Routes

(2009) Rafael Cubas et al.   JOURNAL OF IMMUNOTHERAPY

Virus-like particle vaccine activates conventional B2 cells and promotes B cell differentiation to IgG2a producing plasma cells

(2009) Sheng Zhang et al.   MOLECULAR IMMUNOLOGY

Multiple layers of B cell memory with different effector functions

(2009) Ismail Dogan et al.   NATURE IMMUNOLOGY

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET