Article
Multidisciplinary Sciences
Yanli Zhao, Qi Zheng, Hanchao Gao, Mengtao Cao, Huiyun Wang, Rong Chang, Changchun Zeng
Summary: CELECOXIB treatment attenuates cardiac hypertrophy and fibrosis after injury in P8 ICR mice, promotes the recruitment of M1-like macrophages during early wound healing, and improves cardiac function.
Article
Pharmacology & Pharmacy
Yuantong Tian, Jun Luo, Qian Xu, Yueyang Liu, Ruiping Cai, Ming-Sheng Zhou
Summary: The study found that the use of LEC significantly reduced Ang II-induced cardiac hypertrophy and fibrosis, as well as cardiac macrophage infiltration, improved endothelium-dependent relaxation, and slightly reduced systolic blood pressure. In addition, LEC also decreased the expression of inflammatory and fibrotic factors in the heart, preventing the phosphorylation of ERK1/2 and c-Jun-N-terminal kinase induced by Ang II.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Cell Biology
Fangyu Liu, Yulin Wang, Xitong Huang, Dingqian Liu, Wenjun Ding, Hao Lai, Chunsheng Wang, Qiang Ji
Summary: Long intergenic nonprotein coding RNA 2015 (LINC02015) is upregulated in aortic dissection and AT-II-treated HAVSMCs, and its knockdown promotes cell proliferation and inhibits apoptosis in HAVSMCs through an RXRA-related transcriptional regulation network, suggesting it as a potential therapeutic target for aortic diseases.
CELL DEATH DISCOVERY
(2023)
Article
Pharmacology & Pharmacy
Chang-Bo Zheng, Wen-Cong Gao, Mingxu Xie, Zhichao Li, Xin Ma, Wencong Song, Dan Luo, Yongxiang Huang, Jichen Yang, Peng Zhang, Yu Huang, Weimin Yang, Xiaoqiang Yao
Summary: This study demonstrates that Ang II promotes excessive cardiomyocyte autophagy through SOCE/Orai1, which are major contributing factors in cardiac hypertrophy. Inhibition of SOCE or silencing of Orai1 attenuated Ang II-induced cardiomyocyte autophagy and pathological cardiac hypertrophy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Drew Theobald, Anand R. Nair, Srinivas Sriramula, Joseph Francis
Summary: Toll-like receptor 4 (TLR4) plays a crucial role in the innate immune response and cardiovascular diseases. This study found that cardiomyocyte-specific deletion of TLR4 provides protection against hypertension, cardiac hypertrophy, and remodeling. The results showed that in mice with cardiomyocyte-specific TLR4 knockdown, angiotensin II-induced hypertension and cardiac hypertrophy were attenuated, myocardial fibrosis was reduced, and cardiac function was improved.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jingwei Yu, Yuan Tang, Yu Wang, Mi Zhou, Yanwen Li, Jiahuan Hong, Chunmei Li, Bin Xu, Xinmin Guo, Jianwen Mao
Summary: Identifying the key factors mediating the progression from hypertension to cardiac hypertrophy is crucial for preventing heart failure. A study found that serum exosomes from SHR induced hypertrophy in cardiomyocytes and injection of SHR exosomes caused ventricular wall thickening and decreased cardiac function in mice. These exosomes carried RAS proteins into cardiomyocytes, leading to increased secretion of Ang II. This new mechanism helps to better understand the progression from hypertension to cardiac hypertrophy.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yang Liu, Guanlin Yang, Shiqiao Huo, Jiabi Wu, Ping Ren, Yonggang Cao, Jingquan Gao, Liquan Tong, Dongyu Min
Summary: This study found that lutein has a protective effect on cardiac microvascular endothelial cell ferroptosis induced by pressure overload in cardiac hypertrophy. Lutein supplementation increased interferon regulatory factor expression, providing protection and inhibiting ferroptosis by regulating solute carrier family 7 member 11 and glutathione peroxidase 4 expression. Therefore, targeting interferon regulatory factor may be a promising therapeutic strategy for effective cardioprotection in patients with cardiac hypertrophy and heart failure.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tiecheng Zhong, Zonggui Wang, Sayeman Islam Niloy, Yue Shen, Stephen T. O'Rourke, Chengwen Sun
Summary: Cardiac hypertrophy is initially an adaptive response to cardiac overload, but can progress to decompensation, leading to heart failure and sudden cardiac death. This study found that both PI3KC1 and PI3KC3 are involved in Ang II-induced cardiac hypertrophy, with PI3KC1 inhibiting autophagy activity leading to ROS accumulation and hypertrophy, while PI3KC3 activation improving autophagy activity, reducing ROS production, and providing a protective effect against Ang II-induced cardiac hypertrophy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Hung-Jen Lin, Ramasamy Mahendran, Hsiang-Yen Huang, Ping-Ling Chiu, Yung-Ming Chang, Cecilia Hsuan Day, Ray-Jade Chen, V. Vijaya Padma, Yang Liang-Yo, Wei-Wen Kuo, Chih-Yang Huang
Summary: Solanum nigrum, traditionally used in Asian countries for various health conditions, shows anti-tumor activity and can attenuate cardiac hypertrophy by suppressing specific protein kinases and signaling pathways. In vivo experiments on rats demonstrate the potential of S. nigrum in reducing heart size and alleviating heart enlargement caused by hypertension.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Canzhang Liu, Xin Yi, Jie Yan, Qiang Liu, Teng Cao, Shuipeng Liu
Summary: The aim of this study was to investigate the protective effect of paeonol (pae) on an angiotensin II (AngII)-induced cardiac hypertrophy mouse model. The results showed that pae significantly reduced the surface area of myocardial cells and improved myocardial function. Pae protected the hearts of AngII mice by upregulating the expression of xCT and GPX4 and resisting AngII-induced ferroptosis in cardiomyocytes.
Article
Cardiac & Cardiovascular Systems
Meryl Musicante, Hannah H. Kim, Yuanjian Chen, Fang Liao, Syamal K. Bhattacharya, Lu Lu, Yao Sun
Summary: This study revealed that eNOS plays a beneficial role in preventing cardiac myocyte hypertrophy and fibrosis, supporting the idea that eNOS may modify the severity of HCM phenotypes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xiangxiang Wei, Jiayu Jin, Jian Wu, Yunquan He, Jieyu Guo, Zhaohua Yang, Liang Chen, Kui Hu, Liliang Li, Mengping Jia, Qinhan Li, Xiaoyu Lv, Fei Ge, Siyu Ma, Huijie Wu, Xiuling Zhi, Xinhong Wang, Lindi Jiang, Elena Osto, Jianyi Zhang, Dan Meng
Summary: This research investigates the function and mechanisms of BACH1 in the regulation of cardiac hypertrophy. The study found that cardiac-specific knockout of BACH1 protected against cardiac hypertrophy induced by Ang II or TAC, while cardiac-specific overexpression of BACH1 exaggerated cardiac hypertrophy and fibrosis. Mechanistically, BACH1 regulated the AT1R expression and the Ca2+/CaMKII pathway to mediate cardiac hypertrophy.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Pilong Shi, Chao Song, Hanping Qi, Jing Ren, Ping Ren, Jiabi Wu, Yawen Xie, Meitian Zhang, Hongli Sun, Yonggang Cao
Summary: This study identified the IRF3-SLC7A11-arachidonate 12-lipoxygenase axis as a new pathway responsible for pressure overload-mediated microvascular damage via initiating endothelial ferroptosis. DHA supplementation suppressed endothelial ferroptosis by up-regulating IRF3 expression, conferring a protective advantage to the endothelial system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Environmental Sciences
Yen-Lun Kung, Cheng-You Lu, Khan Fareen Badrealam, Wei-Wen Kuo, Marthandam Asokan Shibu, Cecilia Hsuan Day, Ray-Jade Chen, Shang-Yeh Lu, Viswanadha Vijaya Padma, Chih-Yang Huang
Summary: The study demonstrates that AMG can alleviate Ang II-induced cardiomyocyte enlargement, reduce the expression of hypertrophic and inflammatory markers, and increase oxidative stress related proteins. These findings highlight the cardio-protective role of AMG against Ang II-induced cardiomyopathies.
ENVIRONMENTAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Stephanie L. Padula, Nivedhitha Velayutham, Katherine E. Yutzey
Summary: During the postnatal period, mammalian cardiomyocytes undergo significant maturational changes related to increased cardiac function, such as hypertrophic growth, cell cycle exit, sarcomeric protein isoform switching, and mitochondrial maturation. These changes lead to a loss of regenerative capacity in the heart, contributing to heart failure after cardiac injury in adults. Understanding the transcriptional regulators responsible for these maturation processes could have potential therapeutic implications in cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jing Shao, Xinyu Weng, Lili Zhuo, Liming Yu, Zilong Li, Kaiping Shen, Wenping Xu, Mingming Fang, Yong Xu
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2019)
Article
Biochemistry & Molecular Biology
Xinyu Weng, Yuanyuan Zhang, Zilong Li, Liming Yu, Feng Xu, Mingming Fang, Lei Hou, Junbo Ge, Yong Xu
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2019)
Article
Biochemistry & Molecular Biology
Ming Kong, Xuyang Chen, Fangqiao Lv, Haozhen Ren, Zhiwen Fan, Hao Qin, Liming Yu, Xiaolei Shi, Yong Xu
Article
Cell Biology
Zilong Li, Xiaochen Kong, Yuanyuan Zhang, Yangxi Zhang, Liming Yu, Junli Guo, Yong Xu
CELL DEATH & DISEASE
(2020)
Article
Cell Biology
Yuyu Yang, Guang Yang, Liming Yu, Ling Lin, Li Liu, Mingming Fang, Yong Xu
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Cell Biology
Baoyu Chen, Qianwen Zhao, Tongchang Xu, Liming Yu, Lili Zhuo, Yuyu Yang, Yong Xu
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Cell Biology
Nan Li, Shuai Liu, Yuanyuan Zhang, Liming Yu, Yanjiang Hu, Teng Wu, Mingming Fang, Yong Xu
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Review
Peripheral Vascular Disease
Liming Yu, Yao Dai, Chieko Mineo
Summary: SR-BI plays a key role in reverse cholesterol transport as the high-affinity receptor for HDL in the liver, but recent studies have also revealed its novel functions in regulating transcellular transport of LDL and HDL in endothelial cells, which may have both anti-atherogenic and pro-atherogenic effects.
CURRENT ATHEROSCLEROSIS REPORTS
(2021)
Correction
Cell Biology
Zilong Li, Yuanyuan Zhang, Yangxi Zhang, Liming Yu, Bin Xiao, Tianfa Li, Xiaocen Kong, Yong Xu
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Correction
Cell Biology
Yuyu Yang, Guang Yang, Liming Yu, Lin Lin, Li Liu, Mingming Fang, Yong Xu
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Li Liu, Qianwen Zhao, Lin Lin, Guang Yang, Liming Yu, Lili Zhuo, Yuyu Yang, Yong Xu
Summary: Cardiac hypertrophy is an important pathophysiological response of the heart to stress cues, and MKL1 may contribute to pathological hypertrophy by regulating macrophage-derived miR-155 transcription.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Liming Yu, Jun Peng, Chieko Mineo
Summary: Sialylation is a common modification in eukaryotic cells that plays a key role in various biological processes. It regulates protein-protein interactions, intracellular localization, vesicular trafficking, and signal transduction. Sialylation of lipoproteins is closely related to lipoprotein metabolism and atherogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Liming Yu, Lin Xu, Haiyan Chu, Jun Peng, Anastasia Sacharidou, Hsi-hsien Hsieh, Ada Weinstock, Sohaib Khan, Liqian Ma, Jose Gabriel Barcia Duran, Jeffrey McDonald, Erik R. Nelson, Sunghee Park, Donald P. McDonnell, Kathryn J. Moore, Lily Jun-shen Huang, Edward A. Fisher, Chieko Mineo, Linzhang Huang, Philip W. Shaul
Summary: Hypercholesterolemia and vascular inflammation both contribute to the development of atherosclerosis. This study reveals that the cholesterol metabolite 27-hydroxycholesterol plays a key role in the crosstalk between macrophages and endothelial cells, driving vascular inflammation and contributing to atherosclerosis in male mice.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Jun Peng, Liming Yu, Linzhang Huang, Vivian A. Paschoal, Haiyan Chu, Camila O. de Souza, Joseph V. Varre, Da Young Oh, Jennifer J. Kohler, Xue Xiao, Lin Xu, William L. Holland, Philip W. Shaul, Chieko Mineo
Summary: The synthesis and sialylation of sialic acid in the liver play a critical role in regulating hepatic glucose metabolism.
MOLECULAR METABOLISM
(2023)