Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease

The current state and future directions of RNAi-based therapeutics

(2019) Ryan L. Setten et al.   NATURE REVIEWS DRUG DISCOVERY

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

(2019) Florian R. Greten et al.   IMMUNITY

Hepatic-targeted RNA interference provides robust and persistent knockdown of alpha-1 antitrypsin levels in ZZ patients

(2018) Alice M. Turner et al.   JOURNAL OF HEPATOLOGY

Alpha-1-Antitrypsin Deficiency Liver Disease

(2018) Dhiren Patel et al.   Clinics in Liver Disease

Clinical and histologic features of adults with alpha-1 antitrypsin deficiency in a non-cirrhotic cohort

(2018) Virginia C. Clark et al.   JOURNAL OF HEPATOLOGY

Is severe progressive liver disease caused by alpha-1-antitrypsin deficiency more common in children or adults?

(2016) Andrew S. Chu et al.   LIVER TRANSPLANTATION

α1-Antitrypsin deficiency

(2016) Catherine M. Greene et al.   Nature Reviews Disease Primers

Alpha-1-antitrypsin deficiency: from genoma to liver disease. PiZ mouse as model for the development of liver pathology in human

(2014) Isabella Giovannoni et al.   LIVER INTERNATIONAL

Alpha-1 antitrypsin and liver disease: mechanisms of injury and novel interventions

(2014) Jeffrey H Teckman et al.   Expert Review of Gastroenterology & Hepatology

Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection

(2013) Christine I Wooddell et al.   MOLECULAR THERAPY

Prevalence and Risk Factors for Liver Involvement in Individuals with PiZZ-related Lung Disease

(2012) Muhammad F. Dawwas et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Oxidative stress contributes to liver damage in a murine model of alpha-1-antitrypsin deficiency

(2012) Nancy Y Marcus et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation

(2011) Natasha T. Snider et al.   JOURNAL OF CELL BIOLOGY

Characteristics of hepatocellular carcinoma in a murine model of alpha-1-antitrypsin deficiency

(2010) Nancy Y. Marcus et al.   HEPATOLOGY RESEARCH

Hepatic Progenitor Cell Proliferation and Liver Injury in α-1-Antitrypsin Deficiency

(2010) Elizabeth M Brunt et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Mechanisms of emphysema in  1-antitrypsin deficiency: molecular and cellular insights

(2009) B. Gooptu et al.   EUROPEAN RESPIRATORY JOURNAL

Autophagic disposal of the aggregation-prone protein that causes liver inflammation and carcinogenesis in α-1-antitrypsin deficiency

(2008) D H Perlmutter   CELL DEATH AND DIFFERENTIATION