Synchronization of mothers and offspring promotes tolerance and limits allergy

Imprinting of the immune system by the microbiota early in life

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An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint

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Healthy infants harbor intestinal bacteria that protect against food allergy

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Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis

(2019) Mark S. Ladinsky et al.   SCIENCE

A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult

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Goblet cell associated antigen passages support the induction and maintenance of oral tolerance

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Reduced risk of peanut sensitization following exposure through breast-feeding and early peanut introduction

(2018) Tracy J. Pitt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Goblet cell associated antigen passages are inhibited during Salmonella typhimur/cium infection to prevent pathogen dissemination and limit responses to dietary antigens

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Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood

(2018) Edward Mitre et al.   JAMA Pediatrics

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

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c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

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Timing of Allergenic Food Introduction to the Infant Diet and Risk of Allergic or Autoimmune Disease

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Antigen-Specific Development of Mucosal Foxp3+RORγt+T Cells from Regulatory T Cell Precursors

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Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants

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Effect of Avoidance on Peanut Allergy after Early Peanut Consumption

(2016) George Du Toit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine

(2016) K. S. Kim et al.   SCIENCE

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Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Regulatory T Cell Reprogramming toward a Th2-Cell-like Lineage Impairs Oral Tolerance and Promotes Food Allergy

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The allergy epidemics: 1870-2010

(2015) Thomas A.E. Platts-Mills   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy

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The microbiota regulates type 2 immunity through ROR t+ T cells

(2015) C. Ohnmacht et al.   SCIENCE

Individual intestinal symbionts induce a distinct population of ROR + regulatory T cells

(2015) E. Sefik et al.   SCIENCE

Early infancy microbial and metabolic alterations affect risk of childhood asthma

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Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon

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A Systematic Review on the Development of Asthma and Allergic Diseases in Relation to International Immigration: The Leading Role of the Environment Confirmed

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Commensal bacteria protect against food allergen sensitization

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Mother’s and Offspring’s Use of Antibiotics and Infant Allergy to Cow’s Milk

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Frequency and Activation of CD4+CD25highFoxP3+ Regulatory T Cells in Peripheral Blood from Children with Atopic Allergy

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Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Epithelial Expression of the Cytosolic Retinoid Chaperone Cellular Retinol Binding Protein II Is Essential for in Vivo Imprinting of Local Gut Dendritic Cells by Lumenal Retinoids

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Clinical significance of amphiregulin and epidermal growth factor in colostrum

(2012) Takeshi Nojiri et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma

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Plasticity of Foxp3+ T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells

(2012) Takahisa Miyao et al.   IMMUNITY

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Extrathymically generated regulatory T cells control mucosal TH2 inflammation

(2012) Steven Z. Josefowicz et al.   NATURE

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

Commensal bacteria–derived signals regulate basophil hematopoiesis and allergic inflammation

(2012) David A Hill et al.   NATURE MEDICINE

Acute Gastrointestinal Infection Induces Long-Lived Microbiota-Specific T Cell Responses

(2012) T. W. Hand et al.   SCIENCE

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

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Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization

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The genetics of asthma and allergic disease: a 21st century perspective

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GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

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Peripheral education of the immune system by colonic commensal microbiota

(2011) Stephanie K. Lathrop et al.   NATURE

Exposure to Environmental Microorganisms and Childhood Asthma

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The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update

(2010) H. Okada et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy

(2010) Yitzhak Katz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development

(2010) E Mosconi et al.   Mucosal Immunology

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Stability of the Regulatory T Cell Lineage in Vivo

(2010) Y. P. Rubtsov et al.   SCIENCE

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

(2009) Ye Zheng et al.   NATURE

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy

(2008) George Du Toit et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In vivo equilibrium of proinflammatory IL-17+and regulatory IL-10+Foxp3+RORγt+T cells

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TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

High levels of growth factors in human breast milk

(2007) Ritsuyo Kobata et al.   EARLY HUMAN DEVELOPMENT