Article
Biochemistry & Molecular Biology
Junting Xie, Xiaoning Hou, Wanshi He, Jie Xiao, Yong Cao, Xiaojuan Liu
Summary: Although the specific action site and signal pathway of astaxanthin in weight loss remain unclear, this study used Caenorhabditis elegans to shed light on its efficacy and specific action sites. The supplementation of 60 μM astaxanthin significantly reduced fat deposition and triglyceride levels and prevented obesity caused by excessive energy accumulation. These effects were induced by sbp-1/mdt-15 and insulin/insulin-like growth factor pathways, and co-regulated the down-regulation of specific sites fat-6 and fat-7.
Article
Food Science & Technology
Ya Wu, Hailan Sun, Ruokun Yi, Fang Tan, Xin Zhao
Summary: Liupao tea extract has shown promising effects in reducing body weight, alleviating liver damage, regulating blood lipid profiles and inflammatory cytokines, enhancing antioxidant enzyme levels, and modulating lipid metabolism and oxidative stress to ameliorate obesity-related symptoms.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Plant Sciences
Man Chen, Junping Zheng, Xiaojuan Zou, Cheng Ye, Hui Xia, Ming Yang, Qinghua Gao, Qingxiong Yang, Hongtao Liu
Summary: LRE, mainly composed of ligupurpuroside A and aceteoside, alleviated insulin resistance and improved hepatic metabolism in HFD-fed mice. It also reshaped the gut microbiota structure by increasing the levels of genera Streptococcus, Lactobacillus, and Mucispirillum while decreasing the populations of Alistipes and Lachnospiraceae NK4A136 group in HFD-fed mice. The altered gut microbiota was associated with several metabolic pathways of gut bacteria, indicating the potential of LRE as a gut microbial regulator for preventing metabolic syndrome.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Caibi Zhou, Liuhong Hu, Ren Mu, Xin Mei, Xingli Wu, Chuanming Wang, Xiaolu Zhou
Summary: This study aimed to investigate the effect of compound green tea on liver lipid metabolism in mice using metabolomics analysis. The results showed that compound green tea could regulate lipid metabolism and reduce body weight and blood lipid levels in mice. The metabolomic analysis also identified potential biomarkers and metabolic pathways related to fatty acid metabolism.
Article
Food Science & Technology
Yan Zhu, Xianghui Zhou, Nan Ling, Qiming Yu, Huijuan Wang, Qizhen Du
Summary: This study aimed to investigate the effect of Guisangyou tea (GSY tea) on abnormal lipid metabolism in mice with obesity induced by a high-fat diet (HFD). The results showed that GSY tea decreased serum lipid levels, regulated antioxidant enzyme activities and inflammatory factors, and modulated mRNA and protein expression levels related to lipid synthesis and bile acid production in the liver. These findings indicate that GSY tea can improve abnormal lipid metabolism by enhancing antioxidant capacity, regulating inflammation, and modulating lipid synthesis and bile acid production.
Article
Nutrition & Dietetics
Qianqian Xu, Jiangcheng Ye, Mingxiu Gong, Yifan Zhang, Yiwei Yuan, Jin Zhao
Summary: This study aimed to investigate the effects of theabrownin from Wuniuzao dark tea on hepatic lipid metabolism and gut microbiota in mice fed a high-fat diet. The results showed that theabrownin reduced body weight and epididymis fat weight in obese mice and decreased serum triglycerides, cholesterol, and liver enzyme activities. In addition, theabrownin downregulated gene expression related to fatty acid synthesis and lipid production and improved gut microbiota composition.
Article
Biotechnology & Applied Microbiology
Qionghua Long, Hongyan Chen, Wenhui Yang, Li Yang, Lijuan Zhang
Summary: The study found that Dp3-Sam can reduce body weight gain, visceral fat, and hepatic lipid deposits in rats, as well as improving lipid metabolism dysfunction. This indicates the potential of Dp3-Sam as a therapy for the prevention of obesity and dyslipidemia.
Article
Pharmacology & Pharmacy
Shiyue Luo, Lixiao Zhou, Xuejun Jiang, Yinyin Xia, Lishuang Huang, Run Ling, Shixin Tang, Zhen Zou, Chengzhi Chen, Jingfu Qiu
Summary: Asparagus cochinchinensis, a traditional Chinese medicine, has shown anti-inflammatory properties and the ability to regulate gut microbiota. In a study on obese mice, it was found that the aqueous extract from Asparagus cochinchinensis root (ACE) reduced weight gain and relieved dyslipidemia induced by a high-fat diet. ACE treatment also improved glucose tolerance and insulin resistance, reduced inflammation and lipogenesis in the liver and adipose tissues, and reshaped the gut microbiota of obese mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Zi-Li Ai, Xian Zhang, Wei Ge, You-Bao Zhong, Hai-Yan Wang, Zheng-Yun Zuo, Duan-Yong Liu
Summary: This study aimed to investigate the anti-obesity effects of Sal in rats with HFD-induced obesity by focusing on GM and lipid metabolism. The results showed that Sal treatment significantly reduced weight, body fat index, waistline, and serum lipid levels, while improving lipid factors in the liver and adipose tissues.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Endocrinology & Metabolism
Miaomiao Du, Xueyun Li, Fangyi Xiao, Yinxu Fu, Yu Shi, Sihan Guo, Lifang Chen, Lu Shen, Lan Wang, Huang Cheng, Hao Li, Anran Xie, Yaping Zhou, Kaiqiang Yang, Hezhi Fang, Jianxin Lyu, Qiongya Zhao
Summary: This study demonstrates the importance of SERAC1 protein in lipid metabolism in mice. Serac1 deficiency prevents high-fat diet-induced obesity without affecting energy expenditure. It impairs cholesterol transfer from the liver to the serum and leads to an imbalance in cholesterol distribution. Moreover, Serac1 deficiency may decrease the risk of diet-induced hepatic steatosis.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Biochemistry & Molecular Biology
Wenjing Cao, Keying Wang, Chanhua Liang, Yanming Su, Shuang Liu, Jiali Li, Huishan Qing, Zhen Zeng, Ling Dai, Jia-Le Song
Summary: The combination of tea seed saponins (TSS) and aerobic exercise (AE) can reduce fat accumulation and improve HFD-induced lipid metabolism disorders and oxidative stress.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Wei Guo, Suqin Zhu, Shiyang Li, Yinong Feng, Haohao Wu, Mingyong Zeng
Summary: This study evaluated the anti-obesity effects of two microalgae polysaccharides in obese mice induced by a high-fat diet. The polysaccharides were found to effectively improve obesity-related issues by modulating gut microbiome-mediated host lipid metabolism.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Monica Tognocchi, Maria Conte, Lara Testai, Morena Martucci, Andrea Serra, Stefano Salvioli, Vincenzo Calderone, Marcello Mele, Giuseppe Conte
Summary: Epidemiological studies have shown a positive relationship between dietary fat intake and the onset of metabolic diseases. In this study, the effect of supplementation with cheese enriched with omega-3 fatty acids and CLA on metabolism and lipid profiles of mice was evaluated. The results showed that the enriched cheese reduced saturated fat levels and increased CLA and ALA content in all tissues except the brain. Furthermore, the consumption of enriched cheese resulted in a reduction in the expression of inflammatory genes in all analyzed tissues. These findings indicate the feasibility of using nutritional interventions to modulate inflammation and prevent or delay chronic degenerative diseases.
Article
Food Science & Technology
Yunlong Dong, Hongjie Song, Andrew J. Holmes, Jiabao Yan, Cuiru Ren, Ying Zhang, Wei Zhao, Jianhui Yuan, Yuyang Cheng, David Raubenheimer, Zhenwei Cui
Summary: Growing evidence suggests that ketogenic diets are effective for weight loss, but their unbalanced nutrient composition poses potential health risks. This study aimed to compare the effectiveness of a balanced diet and a ketogenic diet in reversing metabolic syndrome in a mouse model. The results showed that the balanced diet intervention was safer and more effective in ameliorating obesity compared to the ketogenic diet.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2023)
Article
Endocrinology & Metabolism
Zheng-yu Yang, Yi-ying Wu, Yi Zhou, Yun-qi Yang, Jia-hui Zhang, Tao He, Sha Liu
Summary: NITyr reduced lipid accumulation by improving lipid and glucose metabolism involving CB1 and CB2 receptors, without affecting appetite-related indexes and other organ functions.
FRONTIERS IN ENDOCRINOLOGY
(2022)