Review
Nutrition & Dietetics
Helena Lahoda Brodska, Jiri Klempir, Jan Zavora, Pavel Kohout
Summary: Micronutrients are essential for basic metabolic reactions in the human body, and their abnormal levels have been linked to the etiopathogenesis and complications of neurological diseases.
Review
Neurosciences
Jiuhan Zhao, Zhenwei He, Jialu Wang
Summary: Neurological disorders are characterized by progressive neuron loss and neurological deterioration, with neuroinflammatory response playing a key role. miR-124 plays an important role in regulating microglia function in the central nervous system, with potential therapeutic implications for various CNS diseases.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Neurosciences
Judyta Juranek, Konark Mukherjee, Bernard Kordas, Michal Zalecki, Agnieszka Korytko, Kamila Zglejc-Waszak, Jaroslaw Szuszkiewicz, Marta Banach
Summary: This review discusses the role of RAGE in the nervous system and highlights the incomplete understanding of this signaling pathway. While some clinical trials have not shown the expected therapeutic efficacy, there is still hope for treating nervous system diseases through the use of different blocking agents.
NEUROSCIENCE BULLETIN
(2022)
Review
Biochemistry & Molecular Biology
Siyu Zhou, Jianfei Nao
Summary: Nesfatin-1 is closely associated with neurological disorders and its level changes can indicate disease progression and prognosis, guiding treatment options. Regulation of Nesfatin-1 expression or level improves neuroinflammation and other indicators, showing neuroprotective effects.
NEUROCHEMICAL RESEARCH
(2023)
Review
Clinical Neurology
Samir Abu-Rumeileh, Ahmed Abdelhak, Matteo Foschi, Lucio D'Anna, Michele Russo, Petra Steinacker, Jens Kuhle, Hayrettin Tumani, Kaj Blennow, Markus Otto
Summary: Abu-Rumeileh et al. provide an overview of the role of neurofilament light chain protein as a biomarker in various medical fields. Its validation and application have greatly impacted the diagnosis and prognosis of neurological diseases. Recent studies have also explored its potential applications in non-primary neurological conditions.
Article
Chemistry, Analytical
Saralammma Madanan Anju, Asokan Omana Aswathy, Susan Varghese, Merin Kodinattumkunnel Abraham, Ragini Sanjeevan Lekshmi, Ali Ibrahim Shkhair, Girija Muraleedharan Lekha, Sasidharanpillai S. Syamchand, Sony George
Summary: This study presents the development of a cost-effective fluorescence assay for detecting homocysteine (Hcy) by utilizing carbon quantum dots as the probe and combining them with folic acid. The probe showed a fluorescence turn-on response with increasing Hcy concentration, allowing for accurate detection up to 50 mu M.
Article
Chemistry, Analytical
Xinchi Zhou, Lin Li, Yuhui Wang, Tong Kong, Zhanglei Cao, Huiyuan Xie, Wei Liang, Yiting Wang, Sihua Qian, Jie Chao, Jianping Zheng
Summary: Developing highly active and sensitive nanozymes for biothiol analysis is of vital significance due to their essential roles in disease diagnosis. In this study, metal ion-doped carbon dots with high peroxidase-like activity were designed and prepared for biothiol detection and identification through a colorimetric sensor array technique. The developed sensor array showed accurate discrimination of the three most important biothiols, with a detection limit of 5 nM, and could also recognize a single biothiol with various concentrations and biothiol mixtures. Furthermore, actual samples such as cells and sera could be well distinguished, demonstrating its potential in disease diagnosis.
ANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Manish Kumar, Guohong Li
Summary: MicroRNAs (miRNAs or miRs) are small non-coding RNAs that negatively regulate gene expression by interacting with target mRNAs. The miR-30 family, including miR-30c, plays a role in tissue development and is implicated in neurological disorders. miR-30c may act as a multi-functional regulator in autophagy, apoptosis, stress response, inflammation, thrombosis, and neurovascular function, contributing to different disease states.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Jessica Maiuolo, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Federica Scarano, Saverio Nucera, Miriam Scicchitano, Francesca Bosco, Stefano Ruga, Maria Caterina Zito, Roberta Macri, Rosamaria Bulotta, Carolina Muscoli, Vincenzo Mollace
Summary: Metabolic syndrome is a collection of cardiovascular disease risk factors, including obesity, hypertension, insulin resistance, and dyslipidemia. Insufficient autophagy may lead to metabolic imbalance and contribute to the onset of metabolic syndrome. Understanding the underlying mechanisms of this disease is crucial for developing effective treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Vivek Kumar Sharma, Thakur Gurjeet Singh, Vineet Mehta, Ashi Mannan
Summary: Neurological disorders are a significant threat to social health and are responsible for high mortality and morbidity. Although drug development and therapy have improved, inadequate diagnosis and understanding of these disorders have hindered the effectiveness of treatment options. Biomarkers have been seen as a potential solution to the complexities of neurological disorders, providing insight into pathophysiology and guiding therapeutic interventions. However, challenges such as brain complexity, conflicting data, poor diagnostics, and high costs limit biomarker development. Research in this area is crucial for advancing our understanding and treatment of neurological disorders.
NEUROCHEMICAL RESEARCH
(2023)
Review
Nutrition & Dietetics
Diana Pietrzak, Kamila Kasperek, Pawel Rekawek, Iwona Piatkowska-Chmiel
Summary: The ketogenic diet may be a therapeutic option for neurological diseases by effectively controlling oxidative processes, neurotransmitter balance, inflammation, and gut microbiome composition.
Review
Behavioral Sciences
Francesca Longhena, Gaia Faustini, Viviana Brembati, Marina Pizzi, Fabio Benfenati, Arianna Bellucci
Summary: Synapsins are phosphoproteins involved in neuronal development and neurotransmitter release, with multiple functions in synaptic formation, vesicle mobilization, and recycling. Dysregulation in their expression, modifications, or encoding genes can lead to brain network dysfunction and psychiatric or neurological disorders. This review provides the latest information on Syns structure, function, physiology, and their role in central nervous system disorders.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Neurosciences
Chuncao Ao, Chenchen Li, Jinlun Chen, Jieqiong Tan, Liuwang Zeng
Summary: Neurological disorders are a group of disorders caused by the malfunction of the central or peripheral nervous system, resulting in motor, sensory or cognitive impairments. Cyclin-dependent kinase 5 (Cdk5) plays a vital role in the development of the nervous system, but its aberrant activation can lead to pathological changes. It is associated with various neurological disorders, and inhibiting Cdk5 may have neuroprotective effects.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Marika Cordaro, Rosalba Siracusa, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola, Daniela Impellizzeri
Summary: An increase in HCY levels may contribute to arterial damage and cardiovascular disease, while its relationship with brain disorders remains poorly understood. Recent studies suggest that alterations in HCY metabolism can lead to changes in calcium influx and protein accumulation in cells, ultimately resulting in neuronal death.
Article
Biochemistry & Molecular Biology
Lucia Coppo, Simona Scheggi, Graziella DeMontis, Raffaella Priora, Simona Frosali, Antonio Margaritis, Domenico Summa, Danila Di Giuseppe, Monica Ulivelli, Paolo Di Simplicio
Summary: This article discusses the relationship between increased plasma concentrations of total homocysteine (tHcy) and the onset/progression of diseases, but it is not yet clear how the increase in tHcy leads to pathological conditions. It is suggested that albumin may play a role in homocysteine toxicity, and further research on the redox role of albumin and thiol-disulfide exchange reactions could offer new therapeutic insights for reducing homocysteine toxicity.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Food Science & Technology
Umm-e-Tazeem Arshad, Ali Hassan, Talha Ahmad, Maha Naeem, Maryam T. Chaudhary, Syed Qamar Abbas, Muhammad Atif Randhawa, Tatiana C. Pimentel, Adriano Gomes da Cruz, Rana Muhammad Aadil
Summary: This review article discusses the recent advancements in converting cheese whey into high-value-added products, including biofuels, bioelectricity and whey-based food items. It also proposes new strategies for utilizing cheese whey to develop innovative products with various applications, mainly focusing on sustainable alternatives at the industrial level. Biotechnological approaches for whey utilization are highlighted as the most recent and promising alternatives.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Cheng Zhang, Xiaomei Lyu, Rana Muhammad Aadil, Yanjun Tong, Wei Zhao, Ruijin Yang
Summary: This study aimed to investigate the effects of microwave pretreatment instead of blanching on the quality of French fries. The results showed that microwave pretreatment could inhibit enzymatic browning and improve the appearance and texture of the fries. Additionally, microwave pretreatment significantly reduced the oil content and altered the microstructure of the fries.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2023)
Review
Biochemistry & Molecular Biology
Yan-Yan Huang, Yan-Tong Liang, Jia-Min Wu, Wei-Tong Wu, Xin-Tong Liu, Ting-Ting Ye, Xiao-Rong Chen, Xin-An Zeng, Muhammad Faisal Manzoor, Lang-Hong Wang
Summary: Food allergies are a serious concern for food safety and public health, with common allergens including soybean, dairy, aquatic, poultry, and nut products. Probiotics play a crucial role in maintaining intestinal microorganisms and have therapeutic effects in preventing allergies and improving gastrointestinal health. This review explores the impact of probiotics on food allergy progression and mechanisms, and highlights their potential in relieving symptoms and preventing food allergies.
Review
Microbiology
Bakhtawar Shafique, Muhammad Modassar Ali Nawaz Ranjha, Mian Anjum Murtaza, Noman Walayat, Asad Nawaz, Waseem Khalid, Shahid Mahmood, Muhammad Nadeem, Muhammad Faisal Manzoor, Kashif Ameer, Rana Muhammad Aadil, Salam A. Ibrahim
Summary: This article discusses the application of bacteriocins, peptides or proteins produced by bacteria, in food. However, the activity of bacteriocins in food matrices is influenced by various factors. Fortunately, nanotechnology-based encapsulation has emerged as a promising solution.
Article
Food Science & Technology
Ishtiaq Ahmad, Zhouyi Xiong, Hanguo Xiong, Rana Muhammad Aadil, Nauman Khalid, Allah Bakash Jvaid Lakhoo, Asad Nawaz, Noman Walayat, Rao Sanaullah Khan, Rao Sanaullah Khan
Summary: Evidence shows that the storage period has a significant impact on the quality of yogurt. This study prepared three types of yogurt and evaluated their quality characteristics during different storage periods. The findings indicate that enzymatically hydrolyzed potato powder yogurt exhibits desirable water holding capacity, sensory properties, and improved antioxidant activities during storage.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Review
Food Science & Technology
Muhammad Asim Shabbir, Fakiha Mehak, Moazzam Rafiq Khan, Waqar Ahmed, Muhammad Furqan Nawaz, Abdo Hassoun, Zuhaib F. Bhat, Rana Muhammad Aadil
Summary: Osteoarthritis (OA) is a common joint disease that lacks effective treatment options and poses a great challenge for healthcare professionals. The pathophysiology of OA is still poorly understood due to complex mechanistic changes. Experimental research is exploring various therapeutic agents to repair joint degeneration caused by OA and prevent disease progression.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Food Science & Technology
Muhammad Modassar Ali Nawaz Ranjha, Bakhtawar Shafique, Rana Muhammad Aadil, Muhammad Faisal Manzoor, Jun-Hu Cheng
Summary: This review discusses the prospective applications of cold plasma in food packaging, highlighting its effectiveness in surface modification of cellulose, enhancing water and oxygen barrier properties, and its action mechanism in food decontamination and preservation. The integration of cold plasma with cellulose and other polymers like PET and PLA shows significant potential for innovative packaging solutions with antimicrobial properties.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Acoustics
Muhammad Faisal Manzoor, Murtaza Ali, Rana Muhammad Aadil, Anwar Ali, Gulden Goksen, Jian Li, Xin-An Zeng, Charalampos Proestos
Summary: Sonication is an emerging sustainable and eco-friendly technology that has been widely explored in food processing and preservation. It has the advantages of low energy consumption and high efficiency compared to conventional decontamination methods, and it does not generate secondary pollutants. In this study, the impact of sonication on anilazine fungicide reduction, bioactive compounds, antioxidant activity, colloidal stability, and microbial load of tomato juice was analyzed. The results showed that sonication treatment at 40 minutes achieved the highest reduction of anilazine in tomato juice, reaching 80.52%.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Acoustics
Murtaza Ali, Muhammad Faisal Manzoor, Gulden Goksen, Rana Muhammad Aadil, Xin-An Zeng, Muhammad Waheed Iqbal, Jose Manuel Lorenzo
Summary: Sonochemistry is a sustainable technology for food processing, preservation, and pesticide removal. This study investigated the impact of high-intensity ultrasonication on chlorothalonil fungicide degradation and the bioactive availability of spinach juice. The results showed that high-intensity sonication significantly reduced the chlorothalonil residues and increased the bioavailability of bioactive compounds in spinach juice.
ULTRASONICS SONOCHEMISTRY
(2023)
Review
Food Science & Technology
Ume Roobab, Ghulam Muhammad Madni, Muhammad Modassar Ali Nawaz Ranjha, Abdul Waheed Khan, Samy Selim, Mohammed S. Almuhayawi, Mennatalla Samy, Xin-An Zeng, Rana Muhammad Aadil
Summary: This review focuses on novel means of electrochemically activating water for sanitizing carcasses and processing areas during meat production. Recent studies have shown that activated liquids, such as plasma-activated water, electrolyzed water, and ozonated water, are effective in reducing microbial activity in raw and processed meat, enhancing microbiological safety and avoiding negative effects on food organoleptic aspects.
FRONTIERS IN SUSTAINABLE FOOD SYSTEMS
(2023)
Review
Acoustics
Muhammad Hussain, Munkh-Amgalan Gantumur, Muhammad Faisal Manzoor, Kifayat Hussain, Jie Xu, Rana Muhammad Aadil, Abdul Qayum, Ishtiaq Ahmad, Hao Zhong, Rongfa Guan
Summary: High-intensity ultrasound (HIU) is a promising non-chemical technique used in food processing, which can enhance food quality, extract bioactive compounds, and formulate emulsions. HIU has a significant impact on the bioavailability, bioactive properties, and allergenicity of proteins. It can also increase functional properties, release short-chain peptides, and decrease protein allergenicity. However, the application of HIU in industries is still at the research and small scale stage.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Nutrition & Dietetics
Nida Iqbal, Muhammad Asim Shabbir, Moazzam Rafiq Khan, Muhammad Naeem Faisal
Summary: The food industry can repurpose waste byproducts from fruit processing to create functional foods and valuable commodities. In this study, pomegranate seed oil (PSO) was obtained from leftover agro-waste, while sunflower meal protein concentrate (SMPC) was produced from sunflower oilseed cake. These two components were combined to produce High Nutria Omega 5 (HNO5) cookies.
FRONTIERS IN NUTRITION
(2023)
