Article
Radiology, Nuclear Medicine & Medical Imaging
Umi Nabilah Ismail, Che Ahmad Azlan, Shasha Khairullah, Raja Rizal Azman, Nur Farhayu Omar, Mohammad Nazri Md Shah, Chai Hong Yeong, Nicholas Jackson, Kwan Hoong Ng
Summary: The study found that in patients with beta-thalassemia, marrow fat content significantly decreased with disease severity, while fat unsaturation level increased. The use of K-means clustering analysis can clearly differentiate the morphological changes in marrow fat content in different regions.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhenghua Liu, Dageng Huang, Yonghong Jiang, Xiaowen Ma, Yuting Zhang, Rong Chang
Summary: This study investigated the correlation between R2* and vertebral fat fraction (FF) and bone mineral density (BMD), and explored its role in the quantitative assessment of osteoporosis (OP). The results showed that R2* was significantly correlated with FF and BMD. In addition, the area under the curve (AUC) for FF in diagnosing OP was higher than that for R2*. Therefore, R2* can be used as a complement to FF and BMD for the quantitative assessment of OP.
EUROPEAN RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Julien Paccou, Sammy Badr, Daniela Lombardo, Huda Khizindar, Valerie Deken, Stefan Ruschke, Dimitrios C. Karampinos, Anne Cotten, Bernard Cortet
Summary: This study aimed to determine the association between proton density fat fraction (PDFF) and fractures. A case-control study was conducted on postmenopausal women, and it was found that MRI-based measurement of proximal femur PDFF can discriminate between postmenopausal women with and without clinical vertebral fractures, independent of age, CCI, and BMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Miriam A. Bredella, Colleen Buckless, Pouneh K. Fazeli, Clifford J. Rosen, Martin Torriani, Anne Klibanski, Karen K. Miller
Summary: The composition of BMAT shows different responses to short-term high-caloric feeding and fasting, with an increase in SI of rBMAT during high-caloric feeding and differential response to fasting with an increase in SI of rBMAT, a decrease in SI and UI of femoral cBMAT, and a decrease in UI of tibial cBMAT.
Article
Endocrinology & Metabolism
Nina N. Sorensen, Christina M. Andreasen, Pia R. Jensen, Ellen M. Hauge, Jens Bollerslev, Jean-Marie Delaisse, Moustapha Kassem, Abbas Jafari, Marta Diaz-delCastillo, Thomas L. Andersen
Summary: This study found that increased cortisol production in patients with CS leads to increased bone marrow adiposity, primarily mediated by adipocyte hypertrophy. The differential pattern of adiposity in patients with CS and GC-O highlights that bone marrow adipocytes and their progenitors may respond differently in these two GC-mediated bone diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jessica L. Pierce, Anuj K. Sharma, Rachel L. Roberts, Kanglun Yu, Debra L. Irsik, Vivek Choudhary, Jennifer S. Dorn, Husam Bensreti, Reginald D. Benson, Helen Kaiser, Andrew Khayrullin, Colleen Davis, Chase J. Wehrle, Maribeth H. Johnson, Wendy B. Bollag, Mark W. Hamrick, Xingming Shi, Carlos M. Isales, Meghan E. McGee-Lawrence
Summary: Deficiency in glucocorticoid receptor (GR) in aging-associated osteoporosis leads to low bone mass and bone marrow adipose tissue accumulation, as well as alterations in muscle mass, metabolic rate, and blood pressure. The study suggests a role for GR in facilitating healthy bone maintenance with aging in females and highlights the importance of bone as an endocrine organ.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhenghua Liu, Dageng Huang, Yuting Zhang, Rong Chang, Xiaoyue Zhang, Yonghong Jiang, Xiaowen Ma
Summary: This study evaluated the accuracy of dual-energy computed tomography (DECT) in quantifying bone marrow adipose tissue (BMAT) and its applicability in the study of osteoporosis (OP), comparing it with magnetic resonance imaging (MRI). The results showed that DECT can accurately quantify BMAT and has the same applicability as MRI.
INSIGHTS INTO IMAGING
(2022)
Review
Endocrinology & Metabolism
Ziru Li, Clifford J. Rosen
Summary: Bone marrow adipose tissue (BMAT) is a significant component of the bone marrow space in healthy adults, but its expansion is associated with aging, obesity, anorexia nervosa, and irradiation. While traditionally viewed as a negative component, recent studies have revealed that BMAT can serve as an energy reservoir and also plays a role in regulating bone formation and hematopoiesis. This review summarizes the unique characteristics of BMAT and provides an updated understanding of its physiological roles based on a newly established mouse model.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Yu-Hee Kim, Hyun-Ji Lee, Kyung-Ah Cho, So-Youn Woo, Kyung-Ha Ryu
Summary: This study found that conditioned medium obtained from human tonsil-derived MSCs (T-MSC CM) can inhibit adipocyte differentiation by regulating glucocorticoid signal transduction, thereby reducing obesity. The experiments showed that T-MSC CM can attenuate early-stage adipocyte differentiation and protect mice from the negative effects induced by glucocorticoid treatment. Additionally, T-MSC CM enhances megakaryocyte differentiation and protects blood platelet counts.
Article
Radiology, Nuclear Medicine & Medical Imaging
Cristina Borelli, Doriana Vergara, Riccardo Guglielmi, Filippo Aucella, Valentina Testini, Giuseppe Guglielmi
Summary: This study found that the proton density fat fraction (PDFF) assessed by magnetic resonance spectroscopy (MRS) at the lumbar spine is higher in patients with chronic kidney disease (CKD) compared to healthy individuals, and it correlates with bone loss measured by quantitative computed tomography (QCT) and increases with worsening renal function. The study suggests that MRS is a reliable tool for quantifying PDFF in CKD patients.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Endocrinology & Metabolism
Noa Ofir, Yuval Mizrakli, Yariv Greenshpan, Yftach Gepner, Omri Sharabi, Gal Tsaban, Hila Zelicha, Anat Yaskolka Meir, Uta Ceglarek, Michael Stumvoll, Matthias Blueher, Yoash Chassidim, Assaf Rudich, Anat Reiner-Benaim, Iris Shai, Ilan Shelef, Roi Gazit
Summary: In this study, the researchers found that long-term weight loss can temporarily reduce bone marrow adipose tissue (BMAT) in adults, with more prominent effects in younger adults. The storage and dynamics of BMAT are largely independent of other fat depots or cardio-metabolic risk markers, highlighting its unique functions.
Article
Endocrinology & Metabolism
Kerensa M. Beekman, Martine Regenboog, Aart J. Nederveen, Nathalie Bravenboer, Martin den Heijer, Peter H. Bisschop, Carla E. Hollak, Erik M. Akkerman, Mario Maas
Summary: This study aimed to determine region-specific variations and age- and gender-specific differences in bone marrow adipose tissue (BMAT) in healthy subjects. The results showed distinct distribution of BMAT throughout the human skeleton, which was associated with age and gender. Furthermore, the study found that BMAT unsaturation was highest within the axial skeleton compared to the appendicular skeleton.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Florian Tilman Gassert, Leander Glanz, Christof Boehm, Jonathan Stelter, Felix Gerhard Gassert, Yannik Leonhardt, Georg C. Feuerriegel, Markus Graf, Markus Wurm, Thomas Baum, Rickmer F. Braren, Benedikt J. Schwaiger, Marcus R. Makowski, Dimitrios Karampinos, Alexandra S. Gersing
Summary: This study longitudinally assessed changes in proton-density fat fraction (PDFF), T2* and cross-sectional area (CSA) of the paraspinal musculature (PSM) over 6 months in patients with and without osteoporosis. The results showed that the PSM CSA decreased significantly longitudinally in patients with osteoporosis/osteopenia, compared to those without. Higher vertebral and PSM PDFF at baseline were associated with stronger changes in vertebral bone marrow T2*.
Article
Oncology
Giorgio Raia, Maria Del Grande, Ilaria Colombo, Marta Nerone, Lucia Manganaro, Maria Luisa Gasparri, Andrea Papadia, Filippo Del Grande, Stefania Rizzo
Summary: This study aimed to assess the associations between computed tomography (CT)-based whole-body composition values and overall survival (OS) and progression free survival (PFS) in patients with epithelial ovarian cancer (EOC). The study also investigated the association between body composition and chemotherapy-related toxicity. The findings revealed significant associations between various body composition parameters and OS and PFS, suggesting the potential use of body composition profiling in EOC patients.
Review
Endocrinology & Metabolism
Nicole Aaron, Samantha Costa, Clifford J. Rosen, Li Qiang
Summary: BMAT is now recognized as a metabolically active organ that plays versatile roles in endocrine function, hematopoiesis, bone homeostasis, and metabolism. Age-related inflammatory changes associated with BMAT accrual and the downstream effect on endocrine function, energy expenditure, and metabolism are discussed, with potential therapeutic strategies addressed to prevent dysfunction during aging. Further research is needed to fully understand the explicit characterization of BMAT in aging.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Luca Maria Sconfienza, Miraude Adriaensen, Domenico Albano, Andrea Alcala-Galiano, Georgina Allen, Maria Pilar Aparisi Gomez, Giacomo Aringhieri, Alberto Bazzocchi, Ian Beggs, Vito Chianca, Angelo Corazza, Danoob Dalili, Miriam De Dea, Jose Luis del Cura, Francesco Di Pietto, Elena Drakonaki, Fernando Facal de Castro, Dimitrios Filippiadis, Salvatore Gitto, Andrew J. Grainger, Simon Greenwood, Harun Gupta, Amanda Isaac, Slavcho Ivanoski, Monica Khanna, Andrea Klauser, Ramy Mansour, Silvia Martin, Vasco Mascarenhas, Giovanni Mauri, Catherine McCarthy, David McKean, Eugene McNally, Kalliopi Melaki, Rebeca Miron Mombiela, Ricardo Moutinho, Marina Obradov, Cyprian Olchowy, Davide Orlandi, Raquel Prada Gonzalez, Mahesh Prakash, Magdalena Posadzy, Saulius Rutkauskas, Ziga Snoj, Alberto Stefano Tagliafico, Alexander Talaska, Xavier Tomas, Violeta Vasilevska-Nikodinovska, Jelena Vucetic, David Wilson, Federico Zaottini, Marcello Zappia, Carmelo Messina
Summary: Interventional procedures around the knee are widely adopted for treating musculoskeletal conditions. The Ultrasound and Interventional Subcommittees of the ESSR reviewed existing literature and highlighted controversies surrounding imaging guidance and medications efficacy. Ultrasonography guidance is recommended for precision in procedures, with further studies needed for better understanding of imaging guidance and medications efficacy.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Luca Maria Sconfienza, Miraude Adriaensen, Domenico Albano, Andrea Alcala-Galiano, Georgina Allen, Maria Pilar Aparisi Gomez, Giacomo Aringhieri, Alberto Bazzocchi, Ian Beggs, Vito Chianca, Angelo Corazza, Danoob Dalili, Miriam De Dea, Jose Luis del Cura, Francesco Di Pietto, Elena Drakonaki, Fernando Facal de Castro, Dimitrios Filippiadis, Salvatore Gitto, Andrew J. Grainger, Simon Greenwood, Harun Gupta, Slavcho Ivanoski, Monica Khanna, Andrea Klauser, Ramy Mansour, Silvia Martin, Vasco Mascarenhas, Giovanni Mauri, Catherine McCarthy, David McKean, Eugene McNally, Kalliopi Melaki, Carmelo Messina, Rebeca Miron Mombiela, Ricardo Moutinho, Cyprian Olchowy, Davide Orlandi, Raquel Prada Gonzalez, Mahesh Prakash, Magdalena Posadzy, Saulius Rutkauskas, Ziga Snoj, Alberto Stefano Tagliafico, Alexander Talaska, Xavier Tomas, Violeta Vasilevska Nikodinovska, Jelena Vucetic, David Wilson, Federico Zaottini, Marcello Zappia, Amanda Isaac
Summary: This study conducted a Delphi-based consensus on image-guided interventional procedures for peripheral nerves of the lower limb, concluding that while some treatments received strong consensus, there is still a lack of evidence on the efficacy of most procedures.
EUROPEAN RADIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Arianna Farina, Chiara Gasperini, Maria Pilar Aparisi Gomez, Alberto Bazzocchi, Stefano Fanti, Cristina Nanni
Summary: Sarcoma is a rare type of cancer that accounts for a small percentage of adult malignancies but a higher percentage in children and young adults. It has various subtypes with different clinical behaviors, with osteosarcoma and Ewing sarcoma being the most common primary bone tumors. MRI and PET/CT imaging play a crucial role in evaluating sarcoma patients, while whole-body MRI provides comprehensive and radiation-free assessment. These technologies are important for staging, treatment evaluation, relapse detection, and prognostic assessment of sarcomas.
SEMINARS IN NUCLEAR MEDICINE
(2022)
Editorial Material
Orthopedics
Fatima-Ezzahrae Badi, Paolo Simoni
SKELETAL RADIOLOGY
(2023)
Editorial Material
Orthopedics
Fatima-Ezzahrae Badi, Paolo Simoni
SKELETAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Paolo Simoni, Lysandre Kozlowski, Grammatina Boitsios, Riccardo De Angelis, Alessandro De Leucio
Summary: This study evaluates the clinical scenarios addressed by the EURO-2000 guidelines and the ACR appropriateness criteria for referring children to MRI, and assesses the referring physician compliance with both guidelines. The study finds that two-thirds of clinical scenarios in children are not addressed by either the EURO-2000 guidelines or the ACR appropriateness criteria.
ACADEMIC RADIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Lea Tannouri, Paolo Simoni
Summary: MCTO is a rare autosomal-dominant inherited disorder that causes bone destruction and appendicular bone deformity in children, especially affecting the carpal and tarsal bones. Imaging is helpful in distinguishing MCTO from other diseases that cause joint osteolysis in children. The diagnosis of MCTO is confirmed by a mutation in the MAFB gene.
JOURNAL OF THE BELGIAN SOCIETY OF RADIOLOGY
(2023)
Editorial Material
Orthopedics
Thomas Saliba, Paolo Simoni, Valerie Segers, Grammatina Boitsios
SKELETAL RADIOLOGY
(2023)
Letter
Pediatrics
Grammatina Boitsios, Paolo Simoni
PEDIATRIC RADIOLOGY
(2023)
Article
Pediatrics
Grammatina Boitsios, Giovanni Briganti, Ayoub Mokhtari, Federico De Lucia, Maria Pilar Aparisi Gomez, Paolo Simoni
Summary: The aim of this study was to create and evaluate an online software program, Boneureka, based on linear metacarpal length measurements, to assess bone age in healthy children. The results showed that the length of the second metacarpal had a good correlation and agreement with chronological age, and both the GP atlas and the automated software evaluation methods had excellent agreement with chronological age. Based on these findings, an online software program based on the second metacarpal length was developed to obtain bone age estimates. The software is reliable and user-friendly, but further studies on a larger population are needed to validate the reference values.
PEDIATRIC RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Iwona Sudol-Szopinska, Nele Herregods, Anna Zejden, Lennart Jans, Chiara Giraudo, Mikael Boesen, Fabio Becce, Alberto Bazzocchi, Paolo Simoni, Pilar Aparisi, Jacob Jaremko, Mario Maas, James Teh, Kay-Geert Hermann, Flavia Menegotto, Amanda Isaac, Monique Reijnierse, Amit Shah, Winston Rennie, Anne Grethe Jurik
Summary: This opinion article discusses the current use of conventional radiography (CR) in the diagnosis of sacroiliac joint arthritis in adults and juveniles with suspected axial spondyloarthritis (axSpA). Comparisons with magnetic resonance imaging (MRI) and computed tomography (CT) are made, and the advantages and limitations of CR are presented. The article concludes that MRI is more sensitive in detecting early sacroiliitis, while CR remains the method of choice for detecting structural changes in late-stage axSpA or established disease.
SEMINARS IN MUSCULOSKELETAL RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Thomas Saliba, Paolo Simoni, Alessandro De Leucio
Summary: This study presents a case of siblings with lateral discoid menisci, confirmed by knee magnetic resonance imaging (MRI), reinforcing the existence of familial discoid menisci. The father of the children also had a discoid meniscus, although proof was unavailable. This case is discussed in the context of other rare similar cases.
JOURNAL OF THE BELGIAN SOCIETY OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maria Pilar Aparisi Gomez, Alberto Bazzocchi, Paolo Simoni, Emilio J. Inarejos J. Clemente
Summary: This article reviews the surgical treatment required for different types of foot and ankle pathology in children, emphasizing the role of imaging in surgical planning and postsurgical assessment. The article discusses common issues in postsurgical imaging of the ankle and foot in children and highlights the need for imaging follow-up only in cases of suspected complications or recurrent symptoms. It also emphasizes the importance for radiologists to understand the indications for surgery and the imaging characteristics of common interventions.
SEMINARS IN MUSCULOSKELETAL RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maria Pilar Aparisi Gomez, Carmen Ayuso Benavent, Paolo Simoni, Paula Musa Aguiar, Alberto Bazzocchi, Francisco Aparisi
Summary: The study of bone marrow presents important challenges, and magnetic resonance (MR) techniques have been widely used for direct imaging. The use of advanced MR techniques not only has clinical applications, but also provides a foundation for further research on the implications of bone marrow in physiological and pathological conditions.
SEMINARS IN MUSCULOSKELETAL RADIOLOGY
(2022)