Article
Geriatrics & Gerontology
Qi Feng, Luoyu Wang, Xue Tang, Xiuhong Ge, Hanjun Hu, Zhengluan Liao, Zhongxiang Ding
Summary: Hippocampal subfield volume can serve as a predictive marker for aMCI, and the findings underscore the sensitivity of hippocampal subfield volume to overall cognitive performance.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Yanlu Huang, Lin Huang, Yifan Wang, Yuchen Liu, Chun-Yi Zac Lo, Qihao Guo
Summary: This study aimed to examine the relationship between hippocampal subfield volumes and visual memory in SCD and aMCI patients. The results indicate different associations between visual memory and hippocampal subfield volumes in SCD and aMCI patients.
Article
Neurosciences
Qingze Zeng, Kaicheng Li, Xiao Luo, Shuyue Wang, Xiaopei Xu, Zheyu Li, Tianyi Zhang, Xiaocao Liu, Yanv Fu, Xiaojun Xu, Chao Wang, Tao Wang, Jiong Zhou, Zhirong Liu, Yanxing Chen, Peiyu Huang, Minming Zhang
Summary: Longitudinal assessment of hippocampal sub-regional differences showed faster volume loss in subiculum and molecular layer among pMCI patients, suggesting a higher risk of disease progression. However, hippocampal volumes may not perform better than the whole hippocampus in predicting MCI prognosis.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Engineering, Biomedical
Rodrigo San-Martin, Erin Johns, Godofredo Quispe Mamani, Guilherme Tavares, Natalie A. Phillips, Francisco J. Fraga
Summary: Group differences in current source density (CSD) patterns from EEG signals before and after working memory (WM) tasks were investigated between mild cognitive impaired (MCI) subjects and healthy elderly (HE). MCI patients showed increased spectral CSD in low-frequency delta and theta bands, as well as decreased spectral CSD in high-frequency alpha and beta bands compared to HE. Notably, abnormalities in the gamma band were observed in MCI patients. Support Vector Machine (SVM) classifier achieved high accuracy in predicting group membership when combining spectral CSD features from both pre- and post-stimulus periods.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Neurosciences
Kichang Kwak, Marc Niethammer, Kelly S. Giovanello, Martin Styner, Eran Dayan
Summary: Using deep learning, the researchers delineated the contribution of hippocampal subfields to the progression of MCI and proposed a high-accuracy neural network architecture. They also identified specific regions within the hippocampal subfields that play a crucial role in the model's performance.
Article
Psychiatry
Stephanie Langella, Muhammad Usman Sadiq, Peter J. Mucha, Kelly S. Giovanello, Eran Dayan
Summary: Studies have shown that functional redundancy in the hippocampus plays a protective role against cognitive decline in aging, impacting memory performance, without sacrificing network efficiency.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Engineering, Biomedical
Shanghu Song, Jianfeng Qiu, Weizhao Lu
Summary: This study investigated volumetric changes in the amygdaloid and hippocampal subfields as predictors of disease severity in children with ADHD-C. The SBE-SVR model accurately predicted ADHD severity and identified specific brain regions associated with ADHD severity. The findings suggest that amygdaloid and hippocampal structures can serve as potential biomarkers for the progression and evaluation of ADHD.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Clinical Neurology
Sara Becker, Oliver Granert, Maarten Timmers, Andrea Pilotto, Luc van Nueten, Benjamin Roeben, Giacomo Salvadore, Wendy R. Galpern, Johannes Streffer, Klaus Scheffler, Walter Maetzler, Daniela Berg, Inga Liepelt-Scarfone
Summary: The study found that hippocampal volume loss is associated with cognitive status rather than CSF Aβ42 levels. Smaller hippocampal volumes were correlated with poorer performance in memory, language, spatial working memory, and executive functioning tests.
Article
Psychology, Clinical
Deirdre M. O'Shea, Liselotte de Wit, Jared Tanner, Andrea Mejia Kurasz, Priscilla Amofa, Ambar Perez Lao, Shellie-Anne Levy, Melanie Chandler, Glenn Smith
Summary: This study found that there is a relationship between memory difficulties in individuals with MCI and the volume of hippocampal subfields. Specifically, larger volumes of the presubiculum, subiculum, and CA4/dentate gyrus were associated with higher delayed recall scores and fewer informant-reports of memory difficulties.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2022)
Article
Neurosciences
Amir Reza Jahanshahi, Reza Naghdi Sadeh, Davood Khezerloo
Summary: Volumetric analysis of hippocampal subfields and their asymmetry assessment is a useful biomarker in neuroscience research. This study evaluated hippocampal subfields atrophy and their asymmetry patterns in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). MRI images of AD patients, MCI patients, and healthy controls were analyzed, and the volumes of hippocampal subfields were automatically extracted. The results showed that the hippocampal subfields volume in AD patients was significantly smaller than in HC and MCI groups, and the asymmetry index of some subfields differed significantly between AD and MCI as well as between AD and HC.
EXPERIMENTAL BRAIN RESEARCH
(2023)
Review
Clinical Neurology
Shellie-Anne Levy, Glenn Smith, Liselotte De Wit, Brittany DeFeis, Gelan Ying, Priscilla Amofa, Dona Locke, Anne Shandera-Ochsner, Courtney McAlister, Vaishali Phatak, Melanie Chandler
Summary: The comparative effectiveness of behavioral interventions for mitigating cognitive decline is not well understood. This study summarizes the findings from the HABIT (R) program, which includes various interventions for individuals with mild cognitive impairment (pwMCI) and their partners. The results suggest that knowledge-based interventions like wellness education benefit patient well-being, while skill-based interventions like yoga and memory compensation training aid in maintaining functional status. Future personalized interventions may involve different combinations of behavioral strategies to optimize patient outcomes prioritized by their values and preferences.
Article
Engineering, Mechanical
Yu-Tsung Hsiao, Chia-Fen Tsai, Chien-Te Wu, Thanh-Tung Trinh, Chun-Ying Lee, Yi-Hung Liu
Summary: A novel EEG feature, the KERP feature, was proposed for high classification accuracy of MCI versus HC. By introducing relative powers across 21 different subbands and using Fisher's class separability criterion and kernel PCA algorithm, successful classification of MCI and HC was achieved.
Article
Engineering, Biomedical
Chutian Zhang, Hongjun Yang, Chen-Chen Fan, Sheng Chen, Chenyu Fan, Zeng-Guang Hou, Jingyao Chen, Liang Peng, Kexin Xiang, Yi Wu, Hongyu Xie
Summary: This study proposed a streamlined fNIRS preprocessing method and compared multi-dimensional fNIRS features with neural networks for the classification of MCI. The study found that the 3D time-point oxyhemoglobin feature had the highest accuracy in detecting MCI. This study presented a potential approach for fNIRS data processing and promoted the utilization of fNIRS modality with neural network-based classification to detect MCI.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Yuhan Jiang, Bingbing Gao, Mingshuai Li, Yangyingqiu Liu, Yuan Li, Na Liu, Yukun Zhang, Qingwei Song, Xinyu Wen, Jian Jiang, Weiwei Wang, Nan Wang, Yanwei Miao
Summary: End-stage renal disease (ESRD) leads to a decrease in hippocampal volume, particularly in the left CA1 body, left fimbria, right molecular layer head, right molecular layer body, and right HATA. Atrophy of the left fimbria is associated with impaired memory function. Anemia and Urea levels may be related to the atrophy of the left fimbria and CA1 body, respectively.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Giulia Marselli, Francesca Favieri, Maria Casagrande
Summary: Mild cognitive impairment (MCI) is a syndrome characterized by a decline in cognitive performance that exceeds what is expected for an individual based on their age and education level, but does not significantly interfere with daily activities. Previous studies have mainly focused on memory in the analysis of MCI and more severe cases of dementia. Autobiographical memory (AM), a specific memory system, has been extensively studied in Alzheimer's disease, but its impairment in MCI is still controversial.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemical Research Methods
Ben-Heng Xiao, Hua Huang, Li-Fei Wang, Shi-Wen Qiu, Sheng-Wen Guo, Yi Xiang J. Wang
Letter
Biophysics
Ben-Heng Xiao, Yi Xiang J. Wang
NMR IN BIOMEDICINE
(2021)
Editorial Material
Oncology
Yi Xiang J. Wang, Ben-Heng Xiao, Cun-Jing Zheng, Ting Li, Nazmi Che-Nordin, Wei Wang
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gen-Wen Hu, Cun-Jing Zheng, Wei-Xiang Zhong, Dan-Ping Zhuang, Ben-Heng Xiao, Yi Xiang J. Wang
Summary: Liver vessel density can be evaluated using DDVD formula, and in this study, a simplified IVIM imaging protocol with different b-values was used to assess liver DDVD. The combination of various diffusion parameters can effectively distinguish between healthy livers and fibrotic livers.
MAGNETIC RESONANCE IMAGING
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yi Xiang J. Wang, Ben-Heng Xiao, Yi Su, Jason C. S. Leung, Patti M. S. Lam, Timothy C. Y. Kwok
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Biochemical Research Methods
Cun-Jing Zheng, Hua Huang, Ben-Heng Xiao, Ting Li, Wei Wang, Yi Xiang J. Wang
Summary: This study investigated whether spleen DDVD is altered in patients with viral hepatitis-b (VHB) liver fibrosis, and found that diffusion MRI shows decreased spleen DDVD in VHB liver fibrosis patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Cun-Jing Zheng, Ben-Heng Xiao, Hua Huang, Nan Zhou, Tai-Yu Yan, Yi Xiang J. Wang
Summary: The study confirmed that fitting IVIM data without utilizing b=0 images can improve the stability of liver IVIM measurement, particularly for the perfusion fraction parameter.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ben-Heng Xiao, Michael S. Y. Zhu, Er-Zhu Du, Wei-Hong Liu, Jian-Bing Ma, Hua Huang, Jing-Shan Gong, Davide Diacinti, Kun Zhang, Bo Gao, Heng Liu, Ri-Feng Jiang, Zhong-You Ji, Xiao-Bao Xiong, Lai-Chang He, Lei Wu, Chuan-Jun Xu, Mei-Mei Du, Xiao-Rong Wang, Li-Mei Chen, Kong-Yang Wu, Liu Yang, Mao-Sheng Xu, Daniele Diacinti, Qi Dou, Timothy Y. C. Kwok, Yi Xiang J. Wang
Summary: This study developed a user-friendly software program for detecting fractures in elderly women's chest radiographs. The program has a low false positivity rate and an acceptably low false negativity rate, and is expected to improve osteoporosis management for elderly women.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yi Xiang J. Wang, Ben-Heng Xiao
Summary: This study estimated the prevalence of osteoporosis in Chinese men and women over the age of 50, and proposed revised T-score cutpoints for defining osteopenia and osteoporosis. The results suggest that the prevalence of osteoporosis in China is lower compared to the US, but the risk of fractures is relatively higher.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Letter
Biophysics
Wei-Ling Yu, Ben-Heng Xiao, Fu-Zhao Ma, Cun-Jing Zheng, Sheng-Nan Tang, Yi Xiang J. Wang
NMR IN BIOMEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Yi Xiang J. Wang, Hua Huang, Cun-Jing Zheng, Ben-Heng Xiao, Olivier Chevallier, Wei Wang
Summary: DWI is sensitive to water molecule mobility and increasingly used in routine body MRI protocols. Challenges in liver imaging include physiological motions and artifacts, requiring high-quality data acquisition and standardized processing for reliable biomarker measures.
AMERICAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Hua Huang, Nazmi Che-Nordin, Li-Fei Wang, Ben-Heng Xiao, Olivier Chevallier, Yong-Xing Yun, Sheng-Wen Guo, Yi Xiang J. Wang
ANNALS OF TRANSLATIONAL MEDICINE
(2019)