Review
Gastroenterology & Hepatology
Yanhong Wu, Zihao Guo, Chuan Zhang, Yutao Zhan
Summary: Gastroesophageal reflux disease (GERD) is a common and increasingly prevalent disease worldwide. The diagnosis of GERD is currently challenging due to the lack of definitive criteria. A novel impedance parameter called mean nocturnal baseline impedance (MNBI) has been proposed, which can reflect the burden of longitudinal reflux and the integrity of the esophageal mucosa. MNBI shows great promise in improving the diagnostic rate of multichannel intraluminal impedance-pH (MII-pH) monitoring and in predicting the response to treatment in patients with reflux symptoms.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Jin-soo Park, Hans Van der Wall, Gregory Leighton Falk
Summary: This study confirmed the effectiveness of a simple method in diagnosing reflux disease by measuring mean nocturnal baseline impedance in patients with laryngopharyngeal reflux and gastroesophageal reflux disease. The results showed a high level of agreement between the two methods in the distal esophagus, and moderate agreement in the proximal esophagus and pharynx.
JOURNAL OF DIGESTIVE DISEASES
(2021)
Article
Gastroenterology & Hepatology
Hua-Nong Luo, Chen -Chi Wang, Ying-Cheng Lin, Chun-Yi Chuang, Yung-An Tsou, Ja-Chih Fu, Sheng-Shun Yang, Chi-Sen Chang, Han -Chung Lien
Summary: This study showed that mean nocturnal baseline impedance (MNBI) in the distal esophagus can predict pathological esophagopharyngeal reflux (pH+) in patients with isolated laryngopharyngeal reflux symptoms (ILPRS). Patients with pH+ had lower distal esophageal MNBI values compared to patients with pH- and healthy controls. Therefore, distal esophageal MNBI can be used as a predictive marker for pathological reflux in ILPRS patients.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Otorhinolaryngology
Jerome R. Lechien, Walter W. Chan, Lee M. Akst, Toshitaka Hoppo, Blair A. Jobe, Carlos M. Chiesa-Estomba, Vinciane Muls, Francois Bobin, Sven Saussez, Thomas L. Carroll, Michael F. Vaezi, Jonathan M. Bock
Summary: The review found substantial heterogeneity in the definitions and criteria for healthy individuals, as well as in the characterization of PRE and HRE events across studies. Future large multicenter studies are needed to establish consensual normative criteria for LPR on ambulatory reflux monitoring.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Medicine, Research & Experimental
Christopher M. Kurylo, Daniel Eastwood, Joel H. Blumin, Nikki Johnston, Jonathan M. Bock
Summary: The study found a significant correlation between distal esophageal MNBI and phenotypic and biological markers of LPR, indicating that MNBI has the potential to be used as a diagnostic tool and treatment response predictor for LPR.
Article
Gastroenterology & Hepatology
Yolainis Rosado-Arias, Erick Manuel Toro-Monjaraz, Roberto Cervantes-Bustamante, Flora Zarate-Mondragon, Jose Cadena-Leon, Karen Ignorosa-Arellano, Alejandro Loredo-Mayer, Jaime Ramirez-Mayans
Summary: This study investigated the association between baseline impedance (BI) and mean nocturnal baseline impedance (MNBI) with pathological acid exposure time (AET) in children. The results showed that children with pathological AET had lower impedance values than those with normal AET. Therefore, BI and MNBI measurements should be part of the routine MII-pH assessment in children.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Yanhong Wu, Zihao Guo, Chuan Zhang, Yutao Zhan
Summary: This study demonstrates that mean nocturnal baseline impedance (MNBI) has a good diagnostic value for evidence against pathological reflux in patients with refractory GERD symptoms. The authors suggest that MNBI should be referred to in impedance-pH tracing reports for its simplicity and reproducibility.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Benjamin Rogers, Sabyasachi Samanta, Kevan Ghobadi, Amit Patel, Edoardo Savarino, Sabine Roman, Daniel Sifrim, C. Prakash Gyawali
Summary: The study showed the feasibility of automated AI extraction of baseline impedance and the potential of novel AI metrics in predicting treatment outcomes for GERD patients.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Yan Wang, Bixing Ye, Meifeng Wang, Lin Lin, Liuqin Jiang
Summary: The study compared esophageal mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index in patients without evidence of erosive reflux disease. MNBI and PSPW index were found to differentiate between non-erosive reflux disease (NERD) and functional heartburn (FH) patients and were related to proton pump inhibitor (PPI) treatment efficacy in NERD patients.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Gastroenterology & Hepatology
Yinglian Xiao, Justin C. Y. Wu, Ching-Liang Lu, Ping-Huei Tseng, Lin Lin, Xiaohua Hou, Yanqing Li, Duowu Zou, Bin Lv, Xuelian Xiang, Ning Dai, Xiucai Fang, Minhu Chen
Summary: This article introduces the clinical guidelines for ambulatory esophageal reflux monitoring, which were developed based on thorough literature search and working group conference by experts in gastrointestinal motility. The aim of these guidelines is to facilitate standardized procedures and improve diagnostic accuracy.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Rena Yadlapati, Melina Masihi, C. Prakash Gyawali, Dustin A. Carlson, Peter J. Kahrilas, Billy Darren Nix, Anand Jain, Joseph R. Triggs, Michael F. Vaezi, Leila Kia, Alexander Kaizer, John E. Pandolfino
Summary: This study showed that in patients with typical reflux symptoms, inadequate PPI response, and absence of severe esophagitis, acid exposure on reflux monitoring could predict the ability to discontinue PPIs without symptom escalation. Symptom burden reduction was greater among those who discontinued PPI compared to those who resumed. It is suggested that upfront reflux monitoring off acid suppression can help limit unnecessary PPI use and guide personalized management.
Article
Gastroenterology & Hepatology
Ming-Wun Wong, Tso-Tsai Liu, Chih-Hsun Yi, Wei-Yi Lei, Jui-Sheng Hung, Taher Omari, Charles Cock, Shu-Wei Liang, Chandra Prakash Gyawali, Chien-Lin Chen
Summary: This study aimed to evaluate the feasibility and usefulness of CSI with SLR in complementing the diagnosis of GERD. Results showed that impedance-based metrics were lower in GERD patients compared to non-GERD patients. Particularly, the SLR maneuver increased diagnostic accuracy of CSI for GERD identification, especially in IEM patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Dongke Wang, Chaofan Duan, Xiaohao Zhang, Junying Xu, Xiaohua Hou, Xuelian Xiang
Summary: This study retrospectively investigated the clinical characteristics and correlation of pH-impedance parameters with proton pump inhibitor (PPI) response in Chinese patients with different acid exposure time (AET) levels. The study found that 4% can be used as a threshold to define pathological AET in Chinese patients, and mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave index (PSPWi) can identify GERD patients but may not correlate with PPI response in Chinese GERD patients.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
C. Prakash Gyawali, Radu Tutuian, Frank Zerbib, Benjamin D. Rogers, Marzio Frazzoni, Sabine Roman, Edoardo Savarino, Nicola De Bortoli, Marcelo F. Vela, Daniel Sifrim
Summary: Abnormal metrics identified in pH impedance studies performed while on PPI therapy are associated with nonresponse in patients with proven GERD, providing guidance for treatment escalation, including surgical intervention, especially in regurgitation-predominant GERD cases.
Article
Gastroenterology & Hepatology
Renske A. B. Oude Nijhuis, Rami Sweis, Humayra Abdul-Razakq, Jeroen M. Schuitenmaker, Terry Wong, Radu-Ionut Rusu, Jac. Oors, Andreas J. P. M. Smout, Albert J. Bredenoord
Summary: This study found that not all patients with nighttime reflux symptoms have pathological acid exposure on every night. Nighttime acid exposure variability is greater than upright acid exposure, and the diagnostic accuracy of pH monitoring within 24 hours is low, improving with longer testing duration.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Zachary Spiritos, Anthony Horton, Alice Parish, Donna Niedzwiecki, Geargin Wilson, Charles Y. Kim, Daniel Wild
Summary: Acute gastrointestinal bleeding is a common reason for emergency department visits and hospital admissions. CT angiography (CTA) has become an important tool in evaluating acute GI bleeding. This study aimed to identify patient and clinical characteristics that predict CTA results. The results showed that a drop in hemoglobin from baseline was significantly associated with a positive CTA.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Peter P. Stanich, Dareen Elgindi, Elena Stoffel, Erika Koeppe, Ajay Bansal, Rachel Stetson, Debra L. Collins, Dana Farengo Clark, Eve Karloski, Beth Dudley, Randall E. Brand, Michael J. Hall, Yana Chertock, Brian A. Sullivan, Charles Muller, Alice Hinton, Bryson W. Katona, Sonia S. Kupfer
Summary: The discovery rate of colorectal neoplasia in CDH1 variant carriers is similar to that of the general population, indicating the importance of colorectal cancer screening in this population.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Letter
Gastroenterology & Hepatology
Brian A. Sullivan, David A. Lieberman
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Health Care Sciences & Services
Brendon O'Connell, Amanda Boyd, Darshan Kothari, Neena Miller, Jennifer Cornejo, Brian Sullivan
Summary: Clear documentation of instructions for resuming anticoagulant and antiplatelet medications is crucial for high-quality postprocedure care. However, these recommendations are often missing, potentially impacting patient safety. Through targeted interventions during outpatient endoscopy, we significantly improved the documentation of postprocedural anticoagulant and antiplatelet instructions.
Article
Gastroenterology & Hepatology
Lin Chang, William D. Chey, Aamer Imdad, Christopher V. Almario, Adil E. Bharucha, Susan Diem, Katarina B. Greer, Brian Hanson, Lucinda A. Harris, Cynthia Ko, M. Hassan Murad, Amit Patel, Eric D. Shah, Anthony J. Lembo, Shahnaz Sultan
Summary: This article is a clinical practice guideline for the pharmacological treatment of chronic idiopathic constipation (CIC) in adults. It provides evidence-based practice recommendations, including the use of polyethylene glycol, sodium picosulfate, linaclotide, plecanatide, and prucalopride. The article also highlights limitations and gaps in the evidence to guide future research opportunities and improve patient care.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Sabrina J. Layne, Zachary S. Lorsch, Amit Patel
Summary: In the current clinical practice, patient symptoms and traditional findings from endoscopy, manometry, and reflux monitoring guide the care of patients with suspected GERD. However, novel metrics and techniques acquired from or performed at these procedures are of great interest as they have the potential to enhance the evaluation and management of these patients.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Amit Patel, C. Prakash Gyawali
Summary: Magnetic sphincter augmentation (MSA) is a surgical procedure that uses a bracelet of magnetized titanium beads to strengthen the barrier function of the esophagogastric junction in gastroesophageal reflux disease (GERD) patients. MSA is an attractive alternative for GERD patients who want to avoid long-term medication or have not found relief through lifestyle changes and medication. Ideal candidates for MSA have prominent regurgitation, no swallowing difficulties or esophageal motor dysfunction, and objective evidence of GERD. Research shows that MSA is associated with better long-term outcomes and lower healthcare costs compared to other established therapies in appropriate clinical scenarios.
DISEASES OF THE ESOPHAGUS
(2023)
Editorial Material
Gastroenterology & Hepatology
Amit Patel, Brian C. Jacobson, Lisa Mathew, Kathleen Teixeira, Sarah Ankney, Rotonya Carr
Article
Gastroenterology & Hepatology
D. Malhotra, S. H. Boyle, E. J. Gifford, B. A. Sullivan, T. H. Nguyen Wenker, Nono-Djotsa Abs, S. T. Ahmed, J. Upchurch, J. Vahey, C. Stafford, J. T. Efird, S. C. Hunt, A. Bradford, K. J. Sims, E. R. Hauser, D. A. Helmer, C. D. Williams
Summary: This study explores the relationship between post-traumatic stress disorder (PTSD), Gulf War Illness (GWI), and self-reported gastrointestinal (GI) disorders, and finds that Gulf War veterans with GWI and PTSD have higher odds of specific GI disorders.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mikhail C. S. S. Higgins, Alex Seren, Marva V. Foster, Daniel J. Sturgeon, Nina Bart, Kierstin Hederstedt, Alex Friefeld, Rebecca P. Lamkin, Brian A. Sullivan, Westyn Branch-Elliman, Hillary J. Mull
Summary: This study aims to evaluate the racial disparities in premature vascular access failure after percutaneous access maintenance procedures following AVG placement. The results showed that African American race was associated with higher rates of premature arteriovenous graft failure.
Article
Health Care Sciences & Services
Nina Bart, Hillary J. Mull, Mikhail Higgins, Daniel Sturgeon, Kierstin Hederstedt, Rebecca Lamkin, Brian Sullivan, Westyn Branch-Elliman, Marva Foster
Summary: Interventional radiology (IR) is a new medical specialty that lacks robust quality assurance metrics, including tools for monitoring adverse events (AEs). Automated electronic triggers offer a potential solution to accurately detect AEs retrospectively in IR outpatient procedures.
JOURNAL OF PATIENT SAFETY
(2023)
Article
Medicine, General & Internal
Douglas J. Robertson, Jason A. Dominitz, Alexander Beed, Kathy D. Boardman, Barbara J. Del Curto, Peter D. Guarino, Thomas F. Imperiale, Andrew LaCasse, Meaghan F. Larson, Samir Gupta, David Lieberman, Beata Planeta, Aasma Shaukat, Shanaz Sultan, Stacy B. Menees, Sameer D. Saini, Philip Schoenfeld, Stephan Goebel, Erik C. von Rosenvinge, Gyorgy Baffy, Ildiko Halasz, Marcos C. Pedrosa, Lyn Sue Kahng, Riaz Cassim, Katarina B. Greer, Margaret F. Kinnard, Divya B. Bhatt, Kerry B. Dunbar, William V. Harford, John A. Mengshol, Jed E. Olson, Swati G. Patel, Fadi Antaki, Deborah A. Fisher, Brian A. Sullivan, Christopher Lenza, Devang N. Prajapati, Helen Wong, Rebecca Beyth, John G. Lieb, Joseph Manlolo, Fernando V. Ona, Rhonda A. Cole, Natalia Khalaf, Charles J. Kahi, Divyanshoo Rai Kohli, Tarun Rai, Prateek Sharma, Jiannis Anastasiou, Curt Hagedorn, Ronald S. Fernando, Christian S. Jackson, M. Mazen Jamal, Robert H. Lee, Farrukh Merchant, Folasade P. May, Joseph R. Pisegna, Endashaw Omer, Dipendra Parajuli, Adnan Said, Toan D. Nguyen, Claudio Ruben Tombazzi, Paul A. Feldman, Leslie Jacob, Rachel N. Koppelman, Kyle P. Lehenbauer, Deepak S. Desai, Mohammad F. Madhoun, William M. Tierney, Minh Q. Ho, Heather J. Hockman, Christopher Lopez, Emily Carter Paulson, Martin Tobi, Hugo L. Pinillos, Michele Young, Nancy C. Ho, Ranjan Mascarenhas, Kirrichai Promrat, Pritesh R. Mutha, William M. Pandak, Tilak Shah, Mitchell Schubert, Frank S. Pancotto, Andrew J. Gawron, Amelia E. Underwood, Samuel B. Ho, Priscilla Magno-Pagatzaurtundua, Doris H. Toro, Charles H. Beymer, Andrew M. Kaz, Jill Elwing, Jeffrey A. Gill, Susan F. Goldsmith, Michael D. Yao, Petr Protiva, Heiko Pohl, Tassos Kyriakides
Summary: The CONFIRM study aimed to compare the mortality outcomes of colorectal cancer among individuals who underwent colonoscopy with those who took annual fecal immunochemical tests (FIT). The study found a growing preference for FIT among individuals declining colonoscopy, particularly in the western US.
Article
Gastroenterology & Hepatology
Brian A. Sullivan, Jackie B. Henson, David A. Leiman, Jill Moore, Ziad F. Gellad
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Kurren Mehta, Anthony Horton, Ami Patel, Monika Fields, Amit Patel
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Aaron Hein, James Helzberg, Kelly Osborne, Darshan Kothari, Amit Patel
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)