Article
Oncology
Yue Chen, Chenyu Sun, Yile Wu, Xin Chen, Sujatha Kailas, Zeid Karadsheh, Guangyuan Li, Zhichun Guo, Hongru Yang, Lei Hu, Qin Zhou
Summary: The use of PPI is negatively associated with the risk of progression to HGD/EAC in BE patients, and the risk of HGD/EAC can be reduced with the prolonged use of PPI. Sensitivity analysis showed the stable results of this meta-analysis, and no publication bias was detected.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ksenia Maslenkina, Liudmila Mikhaleva, Maxim Naumenko, Rositsa Vandysheva, Michail Gushchin, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann
Summary: Barrett's esophagus (BE) is a premalignant lesion that can develop into esophageal adenocarcinoma (EAC). The development of BE is caused by biliary reflux and involves various stem cell origins. The concept of healing has been replaced by the cytokine storm and inflammatory microenvironment, leading to intestinal metaplasia. This review discusses the roles of molecular pathways in the pathogenesis of BE and EAC, including NOTCH, hedgehog, NF-?B, and IL6/STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Pelin Ergun, Sezgi Kipcak, Serhat Bor
Summary: Barrett's esophagus (BE) is a condition resulting from chronic gastroesophageal reflux disease, which may progress to esophageal adenocarcinoma (EAC). The histological dysplasia grade is commonly used as a biomarker, but its effectiveness is limited due to cost and lack of progression in many BE patients. Clinicians require multiple or more quantitative biomarkers for early diagnosis of EAC, which has high mortality. Epigenetic factors in the early stages of neoplastic transformation show promise as predictive biomarkers. This review summarizes current research on DNA methylations, histone modifications, and noncoding RNAs (miRNAs) during the progression from BE dysplasia to EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Tarek Sawas, Saam Dilmaghani, Lovekirat Dhaliwal, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka
Summary: The study found that compared to BE patients, EAC patients had significantly lower rates of heartburn, diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome. Therefore, optimal strategies for screening for prevalent EAC may need to be adjusted.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Nan Yi, Hailiang Zhao, Juan He, Xike Xie, Liexin Liang, Guowen Zuo, Mingyue Xiong, Yunxiao Liang, Tingzhuang Yi
Summary: Almost 50% of esophageal adenocarcinoma (EAC) patients are progressed from Barrett's esophagus (BE). However, effective stratification and therapy methods for BE and EAC are still lacking. Differentially expressed genes (DEGs) between BE and EAC were identified through the analysis of two public datasets (GSE26886 and GSE37200), followed by bioinformatics analyses to explore potential biomarkers associated with BE-EAC. The results revealed a number of up- and down-regulated genes, which were highly involved in tumorigenesis according to the GO and KEGG enrichment analysis. In addition, the study identified several potential diagnostic and prognostic biomarkers in BE-EAC.
SCIENTIFIC REPORTS
(2023)
Article
Surgery
Jenifer Barrie, Fady Yanni, Mohamed Sherif, Asha K. Dube, Anand P. Tamhankar
Summary: The study found that nearly 20% of dysplasia in BE occurs in BE < 1 cm, and over 40% occurs in BE < 3 cm. Similarly, approximately 20% of EAC occurs within 1 cm of GEJ and 40% within 3 cm. The majority of dysplasia diagnosed within 3 cm of the GEJ is found on index endoscopy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Multidisciplinary Sciences
Chengjiao Yao, Yilin Li, Lihong Luo, Qin Xiong, Xiaowu Zhong, Fengjiao Xie, Peimin Feng
Summary: The study identified differentially expressed miRNAs (DEMs) and genes (DEGs) between EAC and BE tissue samples, performed pathway and functional enrichment analysis, and identified enriched functions and pathways. Some hub genes, such as GART and TNFSF11, as well as highly connected miRNAs like hsa-miR-143 and hsa-miR-133b were determined. This research provides insights into the development mechanism of BE and EAC.
Article
Multidisciplinary Sciences
Mamoru Tokunaga, Kenichiro Okimoto, Naoki Akizue, Kentaro Ishikawa, Yosuke Hirotsu, Kenji Amemiya, Masayuki Ota, Keisuke Matsusaka, Motoi Nishimura, Kazuyuki Matsushita, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Tatsuya Kaneko, Hirotaka Oura, Kengo Kanayama, Yuki Ohta, Takashi Taida, Keiko Saito, Tomoaki Matsumura, Tetsuhiro Chiba, Hitoshi Mochizuki, Makoto Arai, Jun Kato, Jun-ichiro Ikeda, Masao Omata, Naoya Kato
Summary: This study investigated the genetic characteristics of nondysplastic Barrett's esophagus (NDBE) to early esophageal adenocarcinoma (EAC) in the Japanese population. The results showed that the genetic variants of TP53 in Japanese early EAC were similar to those in western countries, and TP53 putative drivers were even detected in Japanese patients with nondysplastic short-segment Barrett's esophagus, indicating a potential higher risk of progression. Proper follow-ups may be necessary for patients with short-segment Barrett's esophagus to monitor the risk of progression to high-grade dysplasia or EAC.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Franz Ludwig Dumoulin, Fabian Dario Rodriguez-Monaco, Alanna Ebigbo, Ingo Steinbruck
Summary: Esophageal adenocarcinoma is the most common subtype of esophageal cancer in Western societies and its incidence is increasing. The development and validation of artificial intelligence systems in the field of gastroenterology may help address unresolved issues in the prevention and surveillance of this cancer.
Review
Gastroenterology & Hepatology
Motasem Alkhayyat, Prabhat Kumar, Krishna O. Sanaka, Prashanthi N. Thota
Summary: The incidence of Barrett's esophagus and esophageal adenocarcinoma has been increasing, leading to a search for chemoprevention strategies. Proton-pump inhibitors and Aspirin have shown effectiveness in reducing cancer incidence in Barrett's patients. Other agents lack sufficient evidence for chemoprevention in these patients.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Review
Pharmacology & Pharmacy
Haijuan Yao, Le Wang, Hongyu Li, Shixue Xu, Zhaohui Bai, Yanyan Wu, Hongxin Chen, Hemant Goyal, Xingshun Qi
Summary: PPIs may have a chemopreventive effect on HGD and/or EAC in BE patients, but high-dose PPIs may not provide further preventive benefit. Significant heterogeneity exists between case-control and cohort studies, possibly due to the sources of information on PPIs.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Chunyang Bao, Richard W. Tourdot, Gregory J. Brunette, Chip Stewart, Lili Sun, Hideo Baba, Masayuki Watanabe, Agoston T. Agoston, Kunal Jajoo, Jon M. Davison, Katie S. Nason, Gad Getz, Kenneth K. Wang, Yu Imamura, Robert Odze, Adam J. Bass, Matthew D. Stachler, Cheng-Zhong Zhang
Summary: By analyzing chromosomal copy-number evolution in early cancers and precancerous lesions of the esophagus, the authors reveal signatures of ongoing chromosomal instability and its role in promoting tumor progression.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Robert Odze, Nicola Frei, Amir M. Khoshiwal, Lucas C. Duits, Jacques Bergman, Matthew D. Stachler
Summary: This study aimed to evaluate whether the degree of crypt atypia in non-dysplastic Barrett's oesophagus patients correlates with progression to high-grade dysplasia/adenocarcinoma. The study showed that non-dysplastic crypts in Barrett's oesophagus are biologically abnormal, suggesting that neoplastic progression begins prior to the onset of dysplasia. The degree of crypt atypia in non-dysplastic Barrett's oesophagus patients correlates with disease progression.
Review
Medicine, General & Internal
Francesco Maione, Alessia Chini, Rosa Maione, Michele Manigrasso, Alessandra Marello, Gianluca Cassese, Nicola Gennarelli, Marco Milone, Giovanni Domenico De Palma
Summary: Barrett's Esophagus is a common condition associated with chronic gastroesophageal reflux disease and has a higher risk of developing esophageal adenocarcinoma. Low and high-grade dysplasia precede neoplastic transformation in this condition. The evaluation of low-grade dysplastic esophageal mucosa is still controversial, but endoscopic surveillance and minimally invasive endoscopic treatments such as endoscopic mucosal resection and radiofrequency ablation are available options. Cryotherapy ablation and argon plasma coagulation are novel endoscopic treatments with high eradication rates and fewer complications and post-procedural pain.
Article
Oncology
Lei Chen, Farah Ballout, Heng Lu, Tianling Hu, Shoumin Zhu, Zheng Chen, Dunfa Peng
Summary: In this study, the gene expression of NEK family members in esophageal adenocarcinoma and its precancerous condition was analyzed. The findings suggest that upregulation of certain NEKs may be important in the development of esophageal adenocarcinoma.
Article
Gastroenterology & Hepatology
Anam Qureshi, Asad Jehangir, Zubair Malik, Henry P. Parkman
Summary: Among patients undergoing HREMI, 9% had RD, with the most common being SSc, RA, and SLE. Patients with RD exhibited upper GI symptoms such as heartburn, regurgitation, nausea, and dysphagia. They also showed higher upper esophageal sphincter pressures, weaker distal contractile integral, lower bolus clearance, and more frequent hiatal hernia in HREMI findings.
DISEASES OF THE ESOPHAGUS
(2021)
Article
Gastroenterology & Hepatology
Dariush Shahsavari, Michael S. Smith, Zubair Malik, Henry P. Parkman
Summary: The study found that larger hiatal hernias are associated with more severe GERD parameters, with HHs greater than 2 cm being specifically linked to higher rates of recurrent acidic reflux and reflux episodes.
DISEASES OF THE ESOPHAGUS
(2022)
Article
Gastroenterology & Hepatology
Samuel E. E. Tanner, Helen B. Burton Murray, Tiffany A. A. Brown, Zubair Malik, Henry P. P. Parkman
Summary: This study aimed to validate a measure of gastrointestinal-specific anxiety in patients with gastroparesis and evaluate the relationship between gastrointestinal-specific anxiety and symptom severity and quality of life. The results showed that higher gastrointestinal-specific anxiety was associated with increased symptom severity and decreased mental health-related quality of life.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Oncology
Raseen Tariq, Sarah Enslin, Maham Hayat, Vivek Kaul