Elucidation of Inverse Agonist Activity of Bilastine

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The long duration of action of the second generation antihistamine bilastine coincides with its long residence time at the histamine H1 receptor

(2018) Reggie Bosma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The clinical pharmacology of non-sedating antihistamines

(2017) Kazuhiko Yanai et al.   PHARMACOLOGY & THERAPEUTICS

Japanese guidelines for allergic rhinitis 2017

(2017) Kimihiro Okubo et al.   ALLERGOLOGY INTERNATIONAL

Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) Interaction by (−)-Maackiain Suppresses Histamine H1Receptor Gene Transcription in HeLa Cells

(2015) Yuki Nariai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of antihistamine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis induced by controlled cedar pollen challenge in an environmental exposure unit

(2015) Yoshiaki Kitamura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Usefulness of HeLa cells to evaluate inverse agonistic activity of antihistamines

(2013) Hiroyuki Mizuguchi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Involvement of Protein Kinase Cδ/Extracellular Signal-regulated Kinase/Poly(ADP-ribose) Polymerase-1 (PARP-1) Signaling Pathway in Histamine-induced Up-regulation of Histamine H1Receptor Gene Expression in HeLa Cells

(2011) Hiroyuki Mizuguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inverse Agonistic Activity of Antihistamines and Suppression of Histamine H1 Receptor Gene Expression

(2011) Hiroyuki Mizuguchi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Preseasonal prophylactic treatment with antihistamines suppresses nasal symptoms and expression of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis

(2011) H. Mizuguchi et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Structure of the human histamine H1 receptor complex with doxepin

(2011) Tatsuro Shimamura et al.   NATURE

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

(2008) J. Bousquet et al.   ALLERGY

Repeated Pre-treatment With Antihistamines Causes Transcriptional Up-regulations of Histamine H1 Receptor and Interleukin-4 Genes in Toluene-2,4-diisocyanate–Sensitized Rats

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