Article
Biochemistry & Molecular Biology
Heng Zhou, Yin Zhou, Feng Zhang, Wenxue Guan, Ye Su, Xingxing Yuan, Yanjie Xie
Summary: The OsLCD1 gene enhances H2S production in rice and confers drought tolerance. Additionally, endogenous H2S production regulates nitrate reductase activity and influences rice drought tolerance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Horticulture
Zhiqiang Liu, Juanjuan Qu, Liping Zhang, Xin Liu, Guangdong Yang, Yanxi Pei
Summary: The study identified CsaLCD and CsaDES2 as the main enzymes responsible for endogenous H2S production in cucumber, playing a crucial role in H2S generation during stress responses.
SCIENTIA HORTICULTURAE
(2021)
Article
Biochemistry & Molecular Biology
Maria A. Munoz-Vargas, Salvador Gonzalez-Gordo, Jose M. Palma, Francisco J. Corpas
Summary: The study revealed variations in endogenous hydrogen sulfide (H2S) content and emission among different plants, with the highest levels found in Allium species. The activity of L-cysteine desulfhydrase (LCD) correlated positively with H2S content in plants, particularly in Allium species, suggesting potential health benefits associated with consuming these plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria A. Munoz-Vargas, Javier Lopez-Jaramillo, Salvador Gonzalez-Gordo, Alberto Paradela, Jose M. Palma, Francisco J. Corpas
Summary: This study aims to analyze the interrelationship between nitric oxide (NO) and hydrogen sulfide (H2S) during pepper fruit ripening. The results show that the activity of H2S-generating enzymes LCD and DCD is downregulated during ripening, but it can be reversed by NO treatment. These findings enhance our understanding of the relationship between NO and H2S during pepper fruit ripening.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Kangdi Hu, Xiangjun Peng, Gaifang Yao, Zhilin Zhou, Feng Yang, Wanjie Li, Yuqi Zhao, Yanhong Li, Zhuo Han, Xiaoyan Chen, Hua Zhang
Summary: The study revealed the important role of H2S-generating enzyme LCD1 in regulating leaf senescence in tomato. Overexpression of LCD1 delayed leaf senescence, while its deletion accelerated the process. The expression of LCD1 was correlated with chlorophyll degradation, ROS accumulation, and the expression of senescence-related genes, providing insight into the physiological functions of LCD1 in tomato leaf senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lixia Hou, Zhaoxia Wang, Guangxia Gong, Ying Zhu, Qing Ye, Songchong Lu, Xin Liu
Summary: This study reveals that hydrogen sulfide (H2S) plays an important role in alleviating manganese (Mn) stress in Arabidopsis. H2S reduces Mn content, decreases reactive oxygen species accumulation, and enhances antioxidant enzyme activity, thereby mitigating the inhibitory effect of Mn stress on Arabidopsis seedling growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Daniel Vojtovic, Lenka Luhova, Marek Petrivalsky
Summary: Studies have revealed the importance of DES in modulating H2S production, particularly in response to biotic and abiotic stress stimuli. Mutants of the model plant Arabidopsis thaliana have uncovered the molecular mechanisms of H2S as a signaling and defense molecule in plant-pathogen interactions. H2S signaling pathways, including S-persulfidation of protein cysteines, play a crucial role in activating downstream components of the H2S signaling pathway.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Plant Sciences
Huihui Fang, Zhenyuan Yu, Kehong Xing, Lingyi Zhou, Yuke Shao, Xiaofang Zhang, Yanxi Pei, Lu Zhang
Summary: Numerous studies have shown that hydrogen sulfide (H2S) functions as a gasotransmitter in various biological processes. However, its involvement in sulfur metabolism and/or Cys synthesis makes its role as a signaling molecule unclear. In this study, we found that exogenous H2S fumigation and Cys treatment affected the production rate and content of endogenous H2S and Cys. Transcriptomic analysis revealed that H2S regulates gene expression independently of Cys, mainly involved in plant hormone signal transduction and plant-pathogen interaction.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ana Jurado-Flores, Luis C. Romero, Cecilia Gotor
Summary: Hydrogen sulfide-mediated signaling pathways play crucial roles in regulating physiological and pathophysiological processes in mammals and plants. Through quantitative proteomic analysis, this study identified a substantial number of persulfidated proteins in Arabidopsis roots, revealing alterations in persulfidation levels under nitrogen deprivation. These persulfidated proteins are involved in a wide range of biological functions, including primary metabolism, stress responses, growth and development, RNA translation, and protein degradation.
Article
Environmental Sciences
Li-Hong Li, Hui-Lan Yi, Xiu-Ping Liu, Hong-Xue Qi
Summary: The study showed that pre-exposure to an appropriate level of SO2 enhanced drought tolerance of wheat seedlings by inducing H2S signaling pathway. This provides a new strategy for improving plant tolerance to drought stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Jia-Qi Wang, Ru-Hua Xiang, Zhong-Guang Li
Summary: This study investigated the crosstalk between hydrogen sulfide (H2S) and abscisic acid (ABA), as well as their role in inducing thermotolerance in maize seedlings. The results showed that H2S and ABA levels in maize seedlings could be induced by regulating their metabolic enzyme activity and gene expression. Additionally, H2S and ABA improved thermotolerance in maize seedlings by enhancing the ROS-scavenging system and reducing ROS levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Wenqiang Chang, Ming Zhang, Xueyang Jin, Haijuan Zhang, Hongbo Zheng, Sha Zheng, Yanan Qiao, Haina Yu, Bin Sun, Xuben Hou, Hongxiang Lou
Summary: The emergence of antifungal resistance necessitates the search for alternative antifungal agents. This study identified cystathionine beta-synthase (CBS) as a major enzyme involved in hydrogen sulfide synthesis in the pathogenic fungus Candida albicans. The inhibitor of CBS, protolichesterinic acid, neutralized the virulence of C. albicans and showed therapeutic efficacy in a mouse candidiasis model.
Article
Biochemistry & Molecular Biology
Huawei Niu, Yuhan Duan, Yuanyuan Zhang, Xinting Hua, Chuan Xu, Zhaozhou Li, Jinliang Ma, Fangyuan Qin, Yaping Zhai, Yong Ye, Yufen Zhao
Summary: Most existing probes can only identify Cys or H2S and are interfered by other molecules. In this study, a bifunctional fluorescent probe NJB was constructed to respond to Cys and H2S through PET & ICT processes. NJB showed excellent selectivity and low detection limits for Cys and HS-. It has been successfully applied in cellular detection and holds promise for studying the physiological and pathological functions of Cys and H2S.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Emeline Joulia, Christian M. Metallo
Summary: Methionine restriction influences tumour growth and ageing processes by affecting various metabolic processes. Ji et al. demonstrate that methionine restriction decreases the production of hydrogen sulfide (H2S), which impairs H2S-mediated immune signaling and leads to increased cancer progression in immunocompetent mice.
Article
Chemistry, Analytical
Junbin Li, Ying Zhou, Lifei Song, Sheng Yang, Qianqian Wang, Yibo Zhou, Xiao-Bing Zhang, Zhihe Qing, Ronghua Yang
Summary: In this study, a nanobeacon sensitive to hydrogen sulfide (H2S) was developed for monitoring in situ antioxidant fluctuation during epilepsy. The nanobeacon revealed that H2S levels were elevated during mild epilepsy but significantly suppressed during severe epilepsy. This research provides important insights into the pathology of epilepsy.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Barbara Karpinska, Nurhayati Razak, Euan K. James, Jenny A. Morris, Susan R. Verrall, Peter E. Hedley, Robert D. Hancock, Christine H. Foyer
Summary: The WHIRLY DNA/RNA binding proteins play important roles in leaf development, particularly in regulating chloroplast development and transcription. Knockdown of WHY1 in barley lines resulted in slower development and changes in certain transcripts and metabolites compared to the wild type.
BIOCHEMICAL JOURNAL
(2022)
Review
Agronomy
Rachel E. Taylor, Christopher E. West, Christine H. Foyer
Summary: Environmental stresses threaten food security, and understanding the function of proteins that regulate plant responses to stress is crucial for crop improvement strategies. The WHY family of proteins play important roles in organelles and nuclei, regulating synthesis of phytohormones and growth and stress responses. They also contribute to DNA and RNA metabolism and genome stability. WHY proteins have flexible localization and overlapping functions, and are potential targets for breeding stress-tolerant and sustainable crops.
FOOD AND ENERGY SECURITY
(2023)
Article
Plant Sciences
Jiao Wang, Anran Wang, Qian Luo, Zhangjian Hu, Qiaomei Ma, Yimei Li, Teng Lin, Xiao Liang, Jingquan Yu, Christine H. Foyer, Kai Shi
Summary: This study reveals that low light intensity affects plant disease outbreak by altering the levels of apoplastic glucose. Glucose can bind to the tomato regulator of G protein signaling 1 (RGS1) and trigger its endocytosis, influencing the uncoupling of proteins involved in the defense response. RGS1 negatively regulates disease resistance under low light and is required for glucose-enhanced defense. These findings provide important insights into how plants sense extracellular sugars and adjust defense mechanisms in different environments.
Review
Plant Sciences
Christine H. Foyer, Guy Hanke
Summary: ROS like singlet oxygen, superoxide, and hydrogen peroxide serve as markers of living cells and are produced abundantly during oxygenic photosynthesis. These ROS act as signals within chloroplasts, influencing cellular processes and redox signaling pathways. The challenge lies in understanding the organized delivery of regulated ROS from the photosynthetic electron transport chain to transmit redox signals from the environment to the nucleus, with stromal carbohydrate metabolism also playing a key role in chloroplast signaling pathways.
Article
Biochemistry & Molecular Biology
Hendrik Willem Swiegers, Barbara Karpinska, Yan Hu, Ian C. Dodd, Anna-Maria Botha, Christine H. Foyer
Summary: Elevated CO2 concentrations affect plant architecture and susceptibility to insects. The study found that strigolactone is not crucial for plant acclimation to high CO2 levels, while salicylic acid and jasmonic acid play important regulatory roles. Pea aphid infestation affects the accumulation of these hormones, with gibberellic acid levels increased less in strigolactone signaling mutants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Daniel Cantabella, Barbara Karpinska, Neus Teixido, Ramon Dolcet-Sanjuan, Christine H. Foyer
Summary: This study explores the effects of rhizobacterium Pseudomonas oryzihabitans on the root system architecture in Arabidopsis thaliana seedlings. The results show that the presence of P. oryzihabitans significantly increases lateral root density and alters the abundance of transcripts associated with nutrient transport and phytohormone responses. However, no bacterial colonization in the roots is detected. Bacteria-induced changes in root architecture depend on factors such as ethylene response, glutathione synthesis, and strigolactone synthesis.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Plant Sciences
Chaoyi Hu, Shaofang Wu, Jiajia Li, Han Dong, Changan Zhu, Ting Sun, Zhangjian Hu, Christine H. Foyer, Jingquan Yu
Summary: Herbivory has a severe impact on plant growth and crop production. This study reveals the molecular mechanism behind the calcium ion signal initiation of systemic jasmonate burst in response to herbivore attack in tomato plants. The interaction between calcium calmodulin-dependent protein kinase 2 (CaM2) and ethylene response factor 16 (ERF16) enhances ERF16 transcriptional activity, leading to increased jasmonate biosynthesis and defense against Helicoverpa armigera.
Article
Biochemistry & Molecular Biology
Shuting Ding, Jianrong Lv, Zhangjian Hu, Jiao Wang, Ping Wang, Jingquan Yu, Christine H. Foyer, Kai Shi
Summary: Phytosulfokine (PSK) interacts with CPK28 and phosphorylates GS2 at two sites (S334 and S360), regulating plant defense and growth separately. These findings are important for breeding strategies to optimize the balance between growth and defense.
Review
Biotechnology & Applied Microbiology
Jitender Singh, Shubhashis Das, Kapuganti Jagadis Gupta, Aashish Ranjan, Christine H. Foyer, Jitendra Kumar Thakur
Summary: The SWEET family of transporters in plants is a novel class of sugar carriers that can transport sugars, sugar alcohols, and hormones. They play important roles in intercellular sugar transport and influence various physiological processes. SWEETs regulate the development of sink organs, respond to abiotic stresses, and affect host-pathogen interactions.
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Rachel E. Taylor, Wanda Waterworth, Christopher E. West, Christine H. Foyer
Summary: The WHY family of DNA/RNA binding proteins in plants have various functions that are not well understood. By analyzing mutants and wild type controls, it was found that loss of WHY1 and WHY3 functions in Arabidopsis seeds resulted in a delay in flowering, decreased seed production, and reduced vigor and viability in aged seeds. The expression of genes related to oxygen sensing and hypoxia decreased in the mutant seeds, especially in aged seeds. These findings indicate that WHY1 and WHY3 proteins play a role in the response to oxygen availability and hypoxia during seed imbibition, and loss of these proteins impairs seed aging resistance.
BIOCHEMICAL JOURNAL
(2023)
Review
Plant Sciences
Barkha Ravi, Christine H. Foyer, Girdhar K. Pandey
Summary: Reactive oxygen species (ROS) and calcium (Ca2+) signalling play important roles in plant growth, development, and defense. They function together with electric signals in directional cell-to-cell systemic signalling and even plant-to-plant communication. However, there is still limited understanding of the molecular mechanisms underlying the management of ROS and Ca2+ signals, as well as the synchronous and independent signaling in different cellular compartments. This review focuses on the proteins that may connect different pathways during abiotic stress responses, and highlights the crosstalk between ROS and Ca2+ pathways in cell signaling.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Plant Sciences
Michael J. Considine, Christine H. Foyer
Summary: Quiescence is an important survival mechanism in cells, where cell division is temporarily repressed. Recent studies have shown that quiescence is an actively monitored process influenced by environmental stimuli, contrary to its previous perception as an inactive state. This article provides a perspective on the quiescent state and discusses the regulation of this process by energy, nutrient and oxygen status, as well as the pathways involved in sensing and transmitting these signals. It highlights the role of canonical regulators, signaling mechanisms, mitochondrial functions, and reactive oxygen species in the orchestration of quiescence.
Article
Cell Biology
Katie Schulz, Gabriela Machaj, Paul Knox, Robert D. Hancock, Susan R. Verrall, Risto Korpinen, Pekka Saranpaa, Anna Karkonen, Barbara Karpinska, Christine H. Foyer
Summary: The blackening of cut carrots during processing is caused by substantial changes in molecular and metabolic processes, particularly in the composition of the cell wall. The processing triggers a shift from primary to secondary metabolism, leading to a decrease in sugars and amino acids, and an increase in phenolic compounds. This process alters the composition of the pectin in the cell wall, making carrots more susceptible to blackening.
Article
Biochemistry & Molecular Biology
Yazhini Velappan, Ambra de Simone, Santiago Signorelli, John A. Considine, Christine H. Foyer, Michael J. Considine
Summary: Hydrogen cyanamide (HC) is commonly used in horticulture to promote bud burst after dormancy, however, its use is banned in some countries due to health concerns. The mechanism of HC action is not well understood, hindering the search for safe alternatives. This study investigated the effects of HC on reactive oxygen species (ROS), redox homeostasis, and cell division in Arabidopsis thaliana seedlings. HC treatment resulted in reversible inhibition of root growth and an accumulation of cells in the G2/M phase accompanied by increased cellular oxidation.
Editorial Material
Food Science & Technology
Davide Cammarano, Jorgen Eivind Olesen, Katharina Helming, Christine Helen Foyer, Martin Schoenhart, Gianluca Brunori, Keerthi Kiran Bandru, Marco Bindi, Gloria Padovan, Bo Jellesmark Thorsen, Florian Freund, Diego Abalos
Summary: The lack of strong interconnection between research, policy, and societal action inhibits climate change mitigation in agri-food systems. Modelling tools, international superordinate bodies, and stakeholder-inclusive assessment frameworks can facilitate better alignment between these three pillars of human progress.