Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Chemistry, Multidisciplinary
Bolong Tao, Ruoxin Du, Xiangmei Zhang, Bo Jia, Yuan Gao, Yipu Zhao, Yunjiang Liu
Summary: A novel biomimetic nanoplatform was developed to target HER2-positive breast cancer brain metastasis. This nanoplatform, consisting of chimeric antigen receptor-natural killer (CAR-NK) cell-derived exosomes and a nanobomb, successfully crossed the blood-brain barrier and selectively targeted HER2+ breast cancer cells. By disrupting ferroptosis defense mechanisms, it enhanced the effectiveness of antitumor treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
Soon A. Park, Hye Rim Han, Stephen Ahn, Chung Heon Ryu, Sin-Soo Jeun
Summary: This study examined the synergistic effect of valproic acid (VPA) in enhancing MSC-delivered TRAIL efficacy, as well as the induced tumor tropism of MSCs. Combination treatment with VPA and MSCs-TRAIL increased therapeutic effect against glioma by enhancing death receptor 5 and caspase activation. Migration assays showed increased MSC migration in glioma cells and tumor site in glioma-bearing mice when treated with VPA and MSCs-TRAIL. In vivo experiments demonstrated greater therapeutic efficacy when MSC-based TRAIL gene delivery was used in VPA-treated tumors compared to each agent alone.
Review
Oncology
Siyi Xiong, Xuanni Tan, Xiujuan Wu, Andi Wan, Guozhi Zhang, Cheng Wang, Yan Liang, Yi Zhang
Summary: Breast cancer is the most commonly diagnosed cancer worldwide, and brain metastasis of breast cancer is a major cause of mortality with no effective treatment. Understanding the cellular and molecular mechanisms of brain metastasis is crucial for developing new therapeutic strategies. This review focuses on the molecular subtype of breast cancer, brain microenvironment, exosomes, miRNAs/lncRNAs, and genetic background in brain metastasis. It also discusses novel approaches to bypass the blood-brain barrier and blood-tumor barrier, as well as the potential application of immunotherapies and genetic editing techniques in treating brain metastasis.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Review
Genetics & Heredity
Tejveer Singh, Mahesh Kaushik, Lokesh Chandra Mishra, Chesta Behl, Vijay Singh, Hardeep Singh Tuli
Summary: Breast cancer is a heterogeneous disease with a high degree of diversity between and within tumors. Various factors influence its prevalence, and early diagnosis and optimal management are crucial for reducing mortality. Nanotechnology, specifically the use of nanomaterial properties for drug delivery mechanisms, is showing promise in breast cancer treatment. Exosomes, a type of nanovesicles, are emerging as novel tools for diagnosing and treating breast cancer.
FRONTIERS IN GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Shaojuan Huang, Ming Dong, Qiang Chen
Summary: Breast cancer metastasis, which is the leading cause of death in breast cancer patients, is a complex process involving multiple physiological changes. Recent studies have shown that exosomes, membrane-bound extracellular vesicles, play a crucial role in cancer metastasis. In this review, the role of breast cancer-derived exosomes in metastasis organotropism is summarized, and the potential clinical applications of targeting exosomes for breast cancer diagnosis and therapy are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Abraham Akonnor, Masaki Makise, Akihiko Kuniyasu
Summary: A CXCR4-targeted antitumor peptidomimetic (CTCE-KLAK) was developed and showed cell-selective cytotoxicity against breast cancer cells and induced rapid necrotic cell death. In a mouse model, CTCE-KLAK significantly inhibited tumor growth and lung metastasis, highlighting its potential as a promising agent for treating triple-negative breast cancer.
Review
Biochemistry & Molecular Biology
John W. W. Weaver, Jinyu Zhang, Juan Rojas, Phillip R. R. Musich, Zhiqiang Yao, Yong Jiang
Summary: Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks well-defined molecular targets. Exosomes play an important role in the tumorigenesis and treatment of TNBC, serving as biomarkers for diagnosis, monitoring, and treatment, as well as a nanosized drug-delivery system.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Pathology
Alireza Soleimani Mamalo, Vahid Alivirdiloo, Azadeh Sadeghnejad, Mobasher Hajiabbasi, Morad Kohandel Gargari, Mohammad Valilo
Summary: Exosomes are extracellular vesicles that contain various substances, including miRNA, which are related to cancer. The role of circulating exosomal miRNA in breast cancer diagnosis and monitoring is still not well understood.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Instruments & Instrumentation
Fahima Danesh Pouya, Yousef Rasmi, Maria Gazouli, Eleni Zografos, Mohadeseh Nemati
Summary: MicroRNAs play a crucial role in the development and progression of breast cancer, with their expression patterns serving as indicators of metastatic potential. The identification of key microRNAs could lead to the development of novel therapeutic molecules, while an efficient delivery system is essential for microRNA-based therapies.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Mohd Mughees, Krishna Kumar, Saima Wajid
Summary: Exosomes play a potential role in breast cancer therapy and serve as important drug carriers. In BC cells, exosomes can assist in the efficient targeted delivery of therapeutic substances, including proteins, nucleic acid, and anti-cancer drugs. The properties of exosomes as an efficient delivery system show promise for future exploration and potential use in other forms of cancer as well.
JOURNAL OF DRUG TARGETING
(2021)
Article
Oncology
Sumin Geng, Shaohua Tu, Zhenwei Bai, Yixiong Geng
Summary: Brain metastasis of lung cancer is a severe complication that affects patient survival. This study found that high-metastatic lung cancer cells have a higher capacity to pass through the blood-brain barrier (BBB) compared to low-metastatic cells. Brain microvascular endothelial cells can internalize exosomes derived from metastatic cells, promoting the passage of non-metastatic cells across the BBB. The upregulated exosomal long noncoding RNA (lncRNA) LINC01356 derived from metastatic cells plays a key role in remodeling the BBB system and participating in brain metastasis in lung cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Yi Wang, Yuqiu Li, Junpei Zhong, Miao Li, Youjia Zhou, Qing Lin, Siwen Zong, Wenting Luo, Jiayang Wang, Keqin Wang, Jie Wang, Lixia Xiong
Summary: Cav-1 in exosomes derived from breast cancer cells promotes lung metastasis by regulating intercellular communication and PMN formation.
Article
Oncology
Jie Hao, Heng Lu, Debarati Mukherjee, Lin Yu, Jihe Zhao
Summary: Metastasis and drug resistance in breast cancer are closely linked processes that significantly impact patient prognosis. The KLF8-CXCR4 signaling axis plays a crucial role in chemotherapy resistance and multi-organ metastasis, with aberrant high levels of KLF8 and CXCR4 inducing enhanced tumor angiogenesis and cellular activities related to metastasis. Targeting the KLF8-CXCR4 signaling axis may offer a new therapeutic approach for drug-resistant breast cancer metastasis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Li Xing, Xiaolong Tang, Kaikai Wu, Xiong Huang, Yi Yi, Jinliang Huan
Summary: The study revealed that miR-106a-5p promoted TNBC progression through mesenchymal stem cell-derived exosomes, while HAND2-AS1 inhibited TNBC growth by suppressing miR-106a-5p levels.
Article
Chemistry, Applied
Qiang Li, Yulan Hu, Bingjian Zhang
Summary: This study successfully synthesized two tetraalkylphosphonium polyoxometalate ionic liquids with excellent antibacterial activity and prepared hydrogels containing these ILs, showing that hydrogels with higher chitosan content exhibit better antibacterial efficacy. This may provide a new strategy for combating bacterial communities colonizing ancient artworks.
CARBOHYDRATE POLYMERS
(2021)
Article
Archaeology
Xinxin Wang, Cuisong Zhang, Bingjian Zhang, Yulan Hu, Juan Wan, JianXiong Zhang
Summary: The Humen Forts in Guangdong were built during the Jiaqing dynasty, featuring bases made with tabia. Modern inspection revealed some forts had high elastic modulus exceeding ordinary cement. Experimental tests showed that organic additives like sticky rice and protein influenced the material strength of tabia in the forts.
JOURNAL OF CULTURAL HERITAGE
(2021)
Article
Architecture
Lina Xie, Bingjian Zhang, Yulan Hu
Summary: This paper presents a novel method for preparing weathered sandstone specimens, which can achieve controlled microstructural, physical, and mechanical alterations by controlling the variables in the preparation process. The obtained specimens exhibit good precision in compressive strength values and similar physical properties to the naturally weathered sample.
INTERNATIONAL JOURNAL OF ARCHITECTURAL HERITAGE
(2023)
Article
Archaeology
Xinxin Wang, Bingjian Zhang, Yulan Hu
Summary: Underwater cultural relics, especially organic ones, are more fragile than terrestrial relics due to complex preservation conditions. Using veratraldehyde for in-situ reinforcement and extraction experiments can nearly preserve the original state of fragile bamboo slips underwater. This is a safe and reliable underwater technology for solidifying extraction of cultural relics.
JOURNAL OF CULTURAL HERITAGE
(2021)
Article
Archaeology
Lina Xie, Xue-Qiang Chen, Bingjian Zhang, Yulan Hu
Summary: This study examines the effectiveness of a novel nano-MgO-based consolidant in restoring the structure and mechanical strength of weathered sandstone. The consolidant shows promising results in improving the cohesion between sand grains and enhancing mechanical properties. The salt crystallization test further confirms its durability. This research highlights the importance of the new consolidant in cultural heritage conservation.
Article
Archaeology
Xinxin Wang, Bingjian Zhang, Yulan Hu, Longguan Zhu
Summary: In this study, the effects of seawater salinity, water temperature, and hydrostatic pressure on the solidification rate of veratraldehyde were systematically discussed, along with the development of related techniques and methods for in-situ artifact extraction using veratraldehyde in marine archaeology.
JOURNAL OF CULTURAL HERITAGE
(2022)
Article
Archaeology
Xin Wang, Yulan Hu, Zhao Zhang, Bingjian Zhang
Summary: Thymol-loaded chitosan nanoparticles were successfully prepared and verified to control the release of natural biocides. These nanoparticles showed better performance against Aspergillus niger compared to free thymol, offering a novel approach to reduce the amount and frequency of biocides application for the preservation of outdoor stone-built cultural heritage sites.
JOURNAL OF CULTURAL HERITAGE
(2022)
Article
Environmental Sciences
Jintao He, Nan Zhang, Abrar Muhammad, Xiaoqiang Shen, Chao Sun, Qiang Li, Yulan Hu, Yongqi Shao
Summary: The study revealed niche differentiation among microbial communities on deteriorating limestone, with certain microbial groups potentially contributing to stone biodeterioration, while microbial coexistence maintained network robustness within stone microbiotas.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Multidisciplinary
Qiang Li, Yulan Hu, Bingjian Zhang
Summary: In order to prevent fungal deterioration of historical stone artworks, phosphonium-based ionic liquids (ILs) were used as potent antifungal agents against dematiaceous fungi commonly found on heritage stones. The study found that the alkyl chain length of the tetraalkylphosponium cation had a significant influence on the thermal stability and antifungal activity of the ILs. Additionally, the ILs showed significant inhibition of fungal growth on sandstone surfaces, indicating their potential applications in heritage sandstone conservation.
Article
Nanoscience & Nanotechnology
Qiang Li, Yulan Hu, Bingjian Zhang
Summary: Researchers have developed a composite material containing ZnO nanoparticles, calcium phosphate oligomers, and oxidized sodium alginate, which exhibits good antimicrobial properties. The composite material shows potential cultural heritage conservation value when used as a protective coating on sandstone.
ACS APPLIED NANO MATERIALS
(2021)
Article
Archaeology
Chengshuai Zhu, Qiang Li, Xin Wang, Yulan Hu, Bingjian Zhang
Summary: This research tested and evaluated a large number of biocides for their efficacy in addressing the degradation of stone cultural relics by mosses. Traditional herbicides and metal oxide nanoparticles were found to be ineffective, while certain plant hormones and essential oils showed good effects at all stages of moss growth. It was also observed that biocides containing copper ions can cause chromaticity changes on rock surfaces. In the end, six efficient and safe biocides were obtained, which have significant implications for biological control in cultural heritage protection.
STUDIES IN CONSERVATION
(2023)
Article
Computer Science, Information Systems
Liang Xie, Tom H. Luan, Zhou Su, Qichao Xu, Nan Chen
Summary: This study proposes a secure fog server platform based on a reputation incentive mechanism to address security issues in crowdsourcing-based indoor navigation systems. By utilizing an offensive and defensive game model and maximizing social welfare, the study achieves game equilibriums and system welfare optimization.
IEEE INTERNET OF THINGS JOURNAL
(2022)
Article
Environmental Sciences
Chengshuai Zhu, Biao Wang, Mengxia Tang, Xin Wang, Qiang Li, Yulan Hu, Bingjian Zhang
Summary: The statues and monuments in the Leshan Giant Buddha and West Lake areas have been affected by colonizing organisms. Next-generation sequencing technology was used to analyze the biofilm in these areas, revealing differences in microbial composition, diversity, and potential functions. Petrographic properties and environmental conditions were found to be the main factors influencing microbiome colonization in these regions.
GEOMICROBIOLOGY JOURNAL
(2023)
Article
Archaeology
Fanglu Wang, Xueqiang Chen, Xinxin Wang, Bingjian Zhang, Yulan Hu, Longguan Zhu
Summary: This study successfully simulated and extracted lacquerware using specific materials and techniques, achieving safe extraction and preservation of fragile underwater artifacts.
JOURNAL OF MARITIME ARCHAEOLOGY
(2021)
