Article
Immunology
Peigen Chen, Yu Zhang, Changyan Liang, Yuebo Yang, Yunhui Li, Jing Wan
Summary: Classification of SOC samples into high immune and low immune groups based on immunogenomic profiling showed that high immune group had lower tumor purity, higher anti-tumor immune activity, and longer overall survival time. This novel immunotyping method has potential for prognostic and immunotherapeutic stratification in SOC patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qiqi Lu, Rongfang Nie, Jiangti Luo, Xiaosheng Wang, Linjun You
Summary: The tumor immune microenvironment (TIME) of adrenocortical carcinoma (ACC) can be divided into two immune-specific subtypes: Immunity-H and Immunity-L. Immunity-L subtype has lower immune cell infiltration, worse prognosis, and different molecular characteristics compared to Immunity-H subtype. This classification has clinical implications for prognosis and immunotherapeutic stratification of ACC.
Article
Medicine, Research & Experimental
Qingyu Liang, Jianqi Wu, Xin Zhao, Shuai Shen, Chen Zhu, Tianqi Liu, Xiao Cui, Ling Chen, Chunmi Wei, Peng Cheng, Wen Cheng, Anhua Wu
Summary: This study systematically investigated inflammasome signaling in different types of tumors and found that tumors with activated inflammasome signaling exhibited immunosuppression and resistance to ICB treatment. Evaluation of inflammasome signaling was proposed to be important for tumor classification and relevant therapeutic regimens could be improved based on this evaluation.
Article
Pharmacology & Pharmacy
Yingxue Guo, Weiye Mao, Lu Jin, Linying Xia, Jie Huang, Xia Liu, Ping Ni, Qiyang Shou, Huiying Fu
Summary: The study found that SGR ethyl acetate (SGR-EA) can inhibit tumor growth and metastasis by resetting tumor-associated macrophages to an anti-tumor phenotype.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Lingli Huang, Xin Liu, Li Li, Lei Wang, Nan Wu, Zhixian Liu
Summary: This study classified HER2-positive breast cancer into three subtypes based on immune-related signatures and identified that the Immune-High subtype had higher immune cell infiltration and better clinical outcomes. In contrast, the Immune-Low subtype exhibited depressed immune-related signatures and enhanced activation of specific pathways. These findings suggest potential clinical implications for optimal stratification of HER2-positive breast cancer responsive to immunotherapy.
Article
Plant Sciences
Yu Zhang, Yong Wei, Shun Jiang, Yanmei Dang, Yu Yang, Wenren Zuo, Qingyi Zhu, Ping Liu, Yanhong Gao, Shan Lu
Summary: The study aimed to investigate the regulatory mechanism of CFF-1 on PD-L1/PD-1-mediated tumor immune escape. The results showed that CFF-1 can inhibit tumor growth and lung metastasis by suppressing the PD-1/PD-L1 pathway and improving T lymphocyte immune response.
Article
Medicine, Research & Experimental
Jingyao Yang, Long Li, Xiaoxiao Zheng, Zhaoyang Lu, Hua Zhou
Summary: As a sodium-glucose transporter 2 inhibitor (SGLT2i), Dapagliflozin (DAPA) has been widely recognized for its cardioprotective benefits. This study explored the underlying mechanisms of DAPA on angiotensin II (Ang II)-induced myocardial hypertrophy and found that DAPA treatment can alleviate Ang II-induced cardiac injury, hypertrophy, and fibrosis. It also reversed the changes in HIF-1a and SIRT1 levels induced by Ang II. Overall, activating the SIRT1/HIF-1a signaling pathway may be an effective therapeutic target for pathological cardiac hypertrophy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Liwei Zhang, Mingxing Li, Zhiwei Wang, Peng Sun, Shunbo Wei, Cong Zhang, Haoliang Wu, Hualong Bai
Summary: This study elucidated the mechanisms underlying the cardiovascular risk associated with COVID-19 through multiple omics data analysis. The IL18/IL18R1/HIF1A axis was identified as a potential therapeutic target for cardiovascular protection after SARS-CoV-2 infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Hang Xu, Jiapeng Zhang, Xiaonan Zheng, Ping Tan, Xingyu Xiong, Xianyanling Yi, Yang Yang, Yan Wang, Dazhou Liao, Hong Li, Qiang Wei, Jianzhong Ai, Lu Yang
Summary: Perturbations of the circadian clock, specifically activation of the REV-ERB nuclear receptors, have been found to have antitumor effects on multiple cancers. In this study, the researchers investigated the impact of SR9009, a pharmacological activator of REV-ERB receptors, on prostate cancer (PCa). They discovered that SR9009 specifically killed PCa cells but had no cytotoxic effect on normal prostate cells. SR9009 inhibited colony formation, cell cycle progression, and cell migration, and promoted apoptosis in PCa cells. The researchers also found that SR9009 significantly inhibited the most aggressive and lethal PCa subtype (PCS1) through the FOXM1 pathway blockade. Further analysis identified seven genes involved in the FOXM1 pathway and PCS1, which were all upregulated in PCa tissues and downregulated after SR9009 treatment. Interestingly, knockdown or knockout of REV-ERB receptors did not rescue the anticancer effect of SR9009, indicating that another pathway was involved. The researchers confirmed that SR9009 activated the LXR alpha pathway, and knockdown of LXR alpha resulted in changes in gene expression similar to SR9009 treatment. In vivo studies further validated the effectiveness of SR9009 in inhibiting tumor growth and downregulating FOXM1 expression. Overall, this study suggests that SR9009 can be a potential treatment option for highly aggressive and lethal PCS1 tumors through the mediation of the LXR alpha/FOXM1 pathway independently of REV-ERB receptors.
CELL DEATH & DISEASE
(2022)
Article
Genetics & Heredity
Sarah R. Poll, Renan Martin, Elizabeth Wohler, Elizabeth S. Partan, Elizabeth Walek, Shaima Salman, Daniel Groepper, Lisa Kratz, Mirlene Cernach, Reynaldo Jesus-Garcia, Chad Haldeman-Englert, Yoon Jae Choi, Carol D. Morris, Bernard Cohen, Julie Hoover-Fong, David Valle, Gregg L. Semenza, Nara L. M. Sobreira
Summary: Ollier disease and Maffucci Syndrome are rare disorders characterized by multiple enchondromas and have a high risk of developing malignancies. Variants in HIF1A, VHL, and IDH1 genes have been found to be significantly associated with these disorders. Functional studies are needed to confirm the role of these genetic variants in the development of phenotypic abnormalities in individuals with Ollier disease and Maffucci Syndrome.
Article
Multidisciplinary Sciences
Benedicte Sjo Tislevoll, Monica Hellesoy, Oda Helen Eck Fagerholt, Stein-Erik Gullaksen, Aashish Srivastava, Even Birkeland, Dimitrios Kleftogiannis, Pilar Ayuda-Duran, Laure Piechaczyk, Dagim Shiferaw Tadele, Jorn Skavland, Baliakas Panagiotis, Randi Hovland, Vibeke Andresen, Ole Morten Seternes, Tor Henrik Anderson Tvedt, Nima Aghaeepour, Sonia Gavasso, Kimmo Porkka, Inge Jonassen, Yngvar Floisand, Jorrit Enserink, Nello Blaser, Bjorn Tore Gjertsen
Summary: In this study, the initial signaling response to standard induction chemotherapy in 32 acute myeloid leukemia (AML) patients was investigated using 36-dimensional mass cytometry. The reduction of extracellular-signal-regulated kinase (ERK) 1/2 and p38 mitogen-activated protein kinase (MAPK) phosphorylation in the myeloid cell compartment 24 h post-chemotherapy was found to be a significant predictor of patient 5-year overall survival in this cohort. This study demonstrates the value of mass cytometry in early response evaluation in AML and highlights the potential of functional signaling analyses in precision oncology diagnostics.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Jianyao Gao, Ting Tang, Baohui Zhang, Guang Li
Summary: The study identified two ESCC subtypes and validated the potential benefits of immunotherapy in the Immunity High group.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Environmental
Yuhao Wu, Junke Wang, Tianxin Zhao, Jiadong Chen, Lian Kang, Yuexin Wei, Lindong Han, Lianju Shen, Chunlan Long, Shengde Wu, Guanghui Wei
Summary: Subacute exposure to DEHP leads to ferroptosis in mouse testes via the HIF-1 alpha/HO-1 signaling pathway.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Oncology
Hong Cheng, Yi Wang, Chunhui Liu, Tiange Wu, Shuqiu Chen, Ming Chen
Summary: The study retrieved RNA-seq and clinical data of PCa and normal prostate tissues, identified 193 differentially expressed immune-related genes, established an immune-related PCa prediction model, and found five key prognostic IRGs. Results showed high immune-risk patients were correlated with advanced stage, and S100A2 and AMH expressions were associated with different indicators.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kristina A. Dvornikova, Olga N. Platonova, Elena Y. Bystrova
Summary: The GI tract has a unique oxygenation profile where hypoxia can be characteristic of normal and pathological conditions. Hypoxia-inducible factors play a key role in mediating the response to hypoxia and are regulated by HIF prolyl hydroxylases. This review discusses the involvement of inflammation, hypoxia, and signaling pathways in the pathogenesis of inflammatory bowel disease, emphasizing the role of HIF in immune reactions during intestinal inflammation. The article also provides updates on therapeutic approaches for treating or preventing inflammatory bowel disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)