The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer

Pan-cancer analysis of RNA methyltransferases identifies FTSJ3 as a potential regulator of breast cancer progression

(2020) Morenci Manning et al.   RNA Biology

‘High vault-age’: non-coding RNA control of autophagy

(2020) Magdalena Büscher et al.   Open Biology

Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease

(2020) Min Han et al.   Frontiers in Neuroscience

Multiple links between 5-methylcytosine content of mRNA and translation

(2020) Ulrike Schumann et al.   BMC BIOLOGY

Wilms' tumour 1‐associating protein inhibits endothelial cell angiogenesis by m6A‐dependent epigenetic silencing of desmoplakin in brain arteriovenous malformation

(2020) Lin‐jian Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner

(2020) Lin Mei et al.   Cell Death & Disease

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis

(2020) Eleftheria Saplaoura et al.   Jove-Journal of Visualized Experiments

Sphingosine Kinase 1 in Breast Cancer—A New Molecular Marker and a Therapy Target

(2020) Heba Alshaker et al.   Frontiers in Oncology

Human vtRNA1-1 Levels Modulate Signaling Pathways and Regulate Apoptosis in Human Cancer Cells

(2020) Lisamaria Bracher et al.   Biomolecules

Overview of distinct 5-methylcytosine profiles of messenger RNA in human hepatocellular carcinoma and paired adjacent non-tumor tissues

(2020) Qiyao Zhang et al.   Journal of Translational Medicine

YBX1 mediates autophagy by targeting p110β and decreasing the sensitivity to cisplatin in NSCLC

(2020) Yanwei Cui et al.   Cell Death & Disease

Eukaryotic 5-methylcytosine (m5C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease

(2019) Katherine Bohnsack et al.   Genes

Transcriptome-Wide Effects of Sphingosine Kinases Knockdown in Metastatic Prostate and Breast Cancer Cells: Implications for Therapeutic Targeting

(2019) Heba Alshaker et al.   Frontiers in Pharmacology

The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction

(2019) Xiang Li et al.   NATURE NEUROSCIENCE

Expression profiles of long noncoding RNAs associated with the NSUN2 gene in HepG2 cells

(2019) Zhen Sun et al.   Molecular Medicine Reports

The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy

(2019) Rastislav Horos et al.   CELL

Oncogenic Y‐box binding protein‐1 ( YBX 1) as an effective therapeutic target in drug‐resistant cancer

(2019) Michihiko Kuwano et al.   CANCER SCIENCE

RNA modifications regulating cell fate in cancer

(2019) Sylvain Delaunay et al.   NATURE CELL BIOLOGY

Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell lung cancer

(2019) Jiahui Xu et al.   Frontiers of Medicine

m6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2

(2019) Junchen Chen et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs

(2019) Xin Chen et al.   NATURE CELL BIOLOGY

Recessive gene disruptions in autism spectrum disorder

(2019) Ryan N. Doan et al.   NATURE GENETICS

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs

(2019) Lindsey Van Haute et al.   NUCLEIC ACIDS RESEARCH

Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs

(2019) Saori Shinoda et al.   NUCLEIC ACIDS RESEARCH

Mitochondria at the interface between neurodegeneration and neuroinflammation

(2019) Verian Bader et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Epitranscriptomic mechanisms of N6-methyladenosine methylation regulating mammalian hypertension development by determined spontaneously hypertensive rats pericytes

(2019) Qingbin Wu et al.   Epigenomics

Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation

(2019) Abdulrahim A. Sajini et al.   Nature Communications

Latest Advances in the Development of Eukaryotic Vaults as Targeted Drug Delivery Systems

(2019) Amanda Muñoz-Juan et al.   Pharmaceutics

Depletion of TRDMT1 affects 5-methylcytosine modification of mRNA and inhibits HEK293 cell proliferation and migration

(2019) Songlei Xue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NOP 2/Sun RNA methyltransferase 2 promotes tumor progression via its interacting partner RPL 6 in gallbladder carcinoma

(2019) Yuan Gao et al.   CANCER SCIENCE

Dynamic effects of Fto in regulating the proliferation and differentiation of adult neural stem cells of mice

(2019) Yuhang Cao et al.   HUMAN MOLECULAR GENETICS

Chemical inhibitors make their RNA epigenetic mark

(2019) Megan Cully   NATURE REVIEWS DRUG DISCOVERY

N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

(2019) Ri-Xin Chen et al.   Nature Communications

METTL14-dependent m6A regulates vascular calcification induced by indoxyl sulfate

(2019) Jing Chen et al.   LIFE SCIENCES

Targeting Phosphorylation of Y-Box–Binding Protein YBX1 by TAS0612 and Everolimus in Overcoming Antiestrogen Resistance

(2019) Tomohiro Shibata et al.   MOLECULAR CANCER THERAPEUTICS

Methyltransferase Inhibitors: Competing with, or Exploiting the Bound Cofactor

(2019) Renato Ferreira de Freitas et al.   MOLECULES

Transfer RNA methyltransferase gene NSUN2 mRNA expression modifies the effect of T cell activation score on patient survival in head and neck squamous carcinoma

(2019) Lingeng Lu et al.   ORAL ONCOLOGY

The Biogenesis and Precise Control of RNA m6A Methylation

(2019) Huilin Huang et al.   TRENDS IN GENETICS

Increased m6A methylation level is associated with the progression of human abdominal aortic aneurysm

(2019) Yuchen He et al.   Annals of Translational Medicine

The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia

(2018) Eytan M. Stein et al.   BLOOD

High tRNA Transferase NSUN2 Gene Expression is Associated with Poor Prognosis in Head and Neck Squamous Carcinoma

(2018) Lingeng Lu et al.   CANCER INVESTIGATION

Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma

(2018) Yuan Li et al.   CANCER LETTERS

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms

(2018) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications

(2018) Yang Wang et al.   NATURE NEUROSCIENCE

Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning

(2018) Jessica L. Koranda et al.   NEURON

Vault RNAs partially induces drug resistance of human tumor cells MCF-7 by binding to the RNA/DNA-binding protein PSF and inducing oncogene GAGE6

(2018) Jianjun Chen et al.   PLoS One

Author Correction: RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

(2018) Jason X. Cheng et al.   Nature Communications

The Role of m6A/m-RNA Methylation in Stress Response Regulation

(2018) Mareen Engel et al.   NEURON

Mechanistic insights into m6A RNA enzymes

(2018) Tina Lence et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation

(2018) Zeyu Zhang et al.   CELL RESEARCH

BisAMP: A web-based pipeline for targeted RNA cytosine-5 methylation analysis

(2018) Felix Bormann et al.   METHODS

m6A facilitates hippocampus-dependent learning and memory through YTHDF1

(2018) Hailing Shi et al.   NATURE

LCE: an open web portal to explore gene expression and clinical associations in lung cancer

(2018) Ling Cai et al.   ONCOGENE

The sphingosine kinase-1/sphingosine-1-phosphate axis in cancer: Potential target for anticancer therapy

(2018) Xiangjin Zheng et al.   PHARMACOLOGY & THERAPEUTICS

Effects of NSUN2 deficiency on the mRNA 5-methylcytosine modification and gene expression profile in HEK293 cells

(2018) Zhen Sun et al.   Epigenomics

The dynamic RNA modification 5‐methylcytosine and its emerging role as an epitranscriptomic mark

(2018) Lukas Trixl et al.   Wiley Interdisciplinary Reviews-RNA

Association of tRNA methyltransferase NSUN2/IGF-II molecular signature with ovarian cancer survival

(2017) Jia-cheng Yang et al.   Future Oncology

Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs

(2017) Carine Legrand et al.   GENOME RESEARCH

NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation

(2017) Qiu Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

RMBase v2.0: deciphering the map of RNA modifications from epitranscriptome sequencing data

(2017) Jia-Jia Xuan et al.   NUCLEIC ACIDS RESEARCH

MODOMICS: a database of RNA modification pathways. 2017 update

(2017) Pietro Boccaletto et al.   NUCLEIC ACIDS RESEARCH

Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility

(2017) Joana V. Flores et al.   Stem Cell Reports

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

(2017) Darshan S. Chandrashekar et al.   NEOPLASIA

NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1Novelty and Significance

(2016) Yuhong Luo et al.   CIRCULATION RESEARCH

Experience-Dependent Accumulation of N 6 -Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice

(2016) Jocelyn Widagdo et al.   JOURNAL OF NEUROSCIENCE

Stem cell function and stress response are controlled by protein synthesis

(2016) Sandra Blanco et al.   NATURE

N6-methyladenosine–encoded epitranscriptomics

(2016) Nian Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N6-methyladenosine–encoded epitranscriptomics

(2016) Nian Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence

(2016) Xiaoyu Cai et al.   Oncotarget

Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer

(2016) Jie Yi et al.   Oncotarget

mRNA methylation by NSUN2 in cell proliferation

(2016) Wengong Wang   Wiley Interdisciplinary Reviews-RNA

NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation

(2015) Hao Tang et al.   Aging-US

Proteinase-activated Receptor 2 Promotes Cancer Cell Migration through RNA Methylation-mediated Repression of miR-125b

(2015) Lan Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Single-Nucleotide Deletion (c.1020delA) in NSUN2 Causes Intellectual Disability in an Emirati Child

(2015) Makanko Komara et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation

(2015) Junyue Xing et al.   MOLECULAR AND CELLULAR BIOLOGY

Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells

(2015) Anna Lewinska et al.   TOXICOLOGY LETTERS

Expression of the vault RNA protects cells from undergoing apoptosis

(2015) Melanie Amort et al.   Nature Communications

BPTF promotes tumor growth and predicts poor prognosis in lung adenocarcinomas

(2015) Meng Dai et al.   Oncotarget

HMGA2 induces transcription factor Slug expression to promote epithelial-to-mesenchymal transition and contributes to colon cancer progression

(2014) Yang Li et al.   CANCER LETTERS

Role of RNA methyltransferases in tissue renewal and pathology

(2014) Sandra Blanco et al.   CURRENT OPINION IN CELL BIOLOGY

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

(2014) S. Blanco et al.   EMBO JOURNAL

Methylation by NSun2 Represses the Levels and Function of MicroRNA 125b

(2014) S. Yuan et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcriptome-wide target profiling of RNA cytosine methyltransferases using the mechanism-based enrichment procedure Aza-IP

(2014) Vahid Khoddami et al.   Nature Protocols

tRNA Modifying Enzymes, NSUN2 and METTL1, Determine Sensitivity to 5-Fluorouracil in HeLa Cells

(2014) Mayumi Okamoto et al.   PLoS Genetics

ChromoHub V2: cancer genomics

(2013) Muhammad A. Shah et al.   BIOINFORMATICS

Genomic pathway analysis reveals that EZH2 and HDAC4 represent mutually exclusive epigenetic pathways across human cancers

(2013) Adam L Cohen et al.   BMC Medical Genomics

Whole exome sequencing unravels disease-causing genes in consanguineous families in Qatar

(2013) S. Fahiminiya et al.   CLINICAL GENETICS

Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase family genes in early mouse embryogenesis

(2013) Lijun Chi et al.   GENE EXPRESSION PATTERNS

The Mouse Cytosine-5 RNA Methyltransferase NSun2 Is a Component of the Chromatoid Body and Required for Testis Differentiation

(2013) S. Hussain et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of direct targets and modified bases of RNA cytosine methyltransferases

(2013) Vahid Khoddami et al.   NATURE BIOTECHNOLOGY

Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer

(2013) Balázs Győrffy et al.   PLoS One

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Epigenetic Approaches for Chemosensitization of Refractory Diffuse Large B-Cell Lymphomas

(2013) J. J. Steinhardt et al.   Cancer Discovery

NSun2-Mediated Cytosine-5 Methylation of Vault Noncoding RNA Determines Its Processing into Regulatory Small RNAs

(2013) Shobbir Hussain et al.   Cell Reports

Transcriptome-Wide Mapping of 5-methylcytidine RNA Modifications in Bacteria, Archaea, and Yeast Reveals m5C within Archaeal mRNAs

(2013) Sarit Edelheit et al.   PLoS Genetics

Mutation in NSUN2, which Encodes an RNA Methyltransferase, Causes Autosomal-Recessive Intellectual Disability

(2012) Muzammil Ahmad Khan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in NSUN2 Cause Autosomal- Recessive Intellectual Disability

(2012) Lia Abbasi-Moheb et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Transient Low Doses of DNA-Demethylating Agents Exert Durable Antitumor Effects on Hematological and Epithelial Tumor Cells

(2012) Hsing-Chen Tsai et al.   CANCER CELL

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Going beyond five bases in DNA sequencing

(2012) Jonas Korlach et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Whole exome sequencing identifies a splicing mutation inNSUN2as a cause of a Dubowitz-like syndrome

(2012) Fernando Jose Martinez et al.   JOURNAL OF MEDICAL GENETICS

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

(2012) Francesca Tuorto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA

(2012) Jeffrey E. Squires et al.   NUCLEIC ACIDS RESEARCH

The tRNA methyltransferase NSun2 stabilizes p16INK4 mRNA by methylating the 3′-untranslated region of p16

(2012) Xiaotian Zhang et al.   Nature Communications

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Overexpression of HMGA2 Promotes Metastasis and Impacts Survival of Colorectal Cancers

(2011) X. Wang et al.   CLINICAL CANCER RESEARCH

Frequent Increased Gene Copy Number and High Protein Expression of tRNA (Cytosine-5-)-Methyltransferase (NSUN2) in Human Cancers

(2011) Mayumi Okamoto et al.   DNA AND CELL BIOLOGY

The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate

(2011) Sandra Blanco et al.   PLoS Genetics

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

(2010) M. Schaefer et al.   GENES & DEVELOPMENT

Expression of Noncoding Vault RNA in Human Malignant Cells and Its Importance in Mitoxantrone Resistance

(2010) S. C. B. Gopinath et al.   MOLECULAR CANCER RESEARCH

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution

(2010) Julian König et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genomic Aberrations in Lung Adenocarcinoma in Never Smokers

(2010) Bastien Job et al.   PLoS One

Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer

(2009) Michaela Frye et al.   CANCER LETTERS

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability

(2009) Shobbir Hussain et al.   JOURNAL OF CELL BIOLOGY