Inhibition of ABCC6 Transporter Modifies Cytoskeleton and Reduces Motility of HepG2 Cells via Purinergic Pathway

Inhibition of the adenosinergic pathway: the indispensable part of oncological therapy in the future

(2019) Yi Huang et al.   Purinergic Signalling

Adenosine Metabolism: Emerging Concepts for Cancer Therapy

(2019) Detlev Boison et al.   CANCER CELL

Prognostic significance and molecular mechanisms of adenosine triphosphate-binding cassette subfamily C members in gastric cancer

(2019) Xianshuang Mao et al.   MEDICINE

Plasma inorganic pyrophosphate and alkaline phosphatase in patients with pseudoxanthoma elasticum

(2019) Ana María Sánchez-Tévar et al.   Annals of Translational Medicine

ATP Release Channels

(2018) Akiyuki Taruno   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of ATP Release by Inflammatory Cells

(2018) Michel Dosch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ABCC6 plays a significant role in the transport of nilotinib and dasatinib, and contributes to TKI resistance in vitro, in both cell lines and primary patient mononuclear cells

(2018) Laura N. Eadie et al.   PLoS One

Comparison of clinicopathologic characteristics, epigenetic biomarkers and prognosis between renal pelvic and ureteral tumors in upper tract urothelial carcinoma

(2018) Dong Fang et al.   BMC Urology

CD73 inhibition by purine cytotoxic nucleoside analogue-based diphosphonates

(2018) Charles Dumontet et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural analysis reveals pathomechanisms associated with pseudoxanthoma elasticum–causing mutations in the ABCC6 transporter

(2018) Yanchao Ran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular nucleotides and nucleosides as signalling molecules

(2018) Anna Lisa Giuliani et al.   IMMUNOLOGY LETTERS

Ecto-5′-nucleotidase (CD73) is a potential target of hepatocellular carcinoma

(2018) Shalaimaiti Shali et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PXE, a Mysterious Inborn Error Clarified

(2018) Piet Borst et al.   TRENDS IN BIOCHEMICAL SCIENCES

The P-glycoprotein inhibitor diltiazem-like 8-(4-chlorophenyl)-5-methyl-8-[(2Z)-pent-2-en-1-yloxy]-8H-[1,2,4]oxadiazolo[3,4-c][1,4]thiazin-3-one inhibits esterase activity and H3 histone acetylation

(2018) Flavia Cuviello et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural characterization of the L0 cytoplasmic loop of human multidrug resistance protein 6 (MRP6)

(2018) Angela Ostuni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The ABCC6 Transporter: A New Player in Biomineralization

(2017) Guillaume Favre et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Selective activation of anti-CD73 mechanisms in control of primary tumors and metastases

(2017) Dipti Vijayan et al.   OncoImmunology

STAT3 but Not HIF-1α Is Important in Mediating Hypoxia-Induced Chemoresistance in MDA-MB-231, a Triple Negative Breast Cancer Cell Line

(2017) Hoda Soleymani Abyaneh et al.   Cancers

Identification of genetic variants in pharmacokinetic genes associated with Ewing Sarcoma treatment outcome

(2016) S. Ruiz-Pinto et al.   ANNALS OF ONCOLOGY

New insights into the roles of the N-terminal region of the ABCC6 transporter

(2016) Rocchina Miglionico et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Stabilization of Nucleotide Binding Domain Dimers Rescues ABCC6 Mutants Associated with Pseudoxanthoma Elasticum

(2016) Yanchao Ran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Pyrazolo[3,4-d]pyrimidine Compound Reduces Cell Viability and Induces Apoptosis in Different Hematological Malignancies

(2016) Ilaria Laurenzana et al.   Frontiers in Pharmacology

Membrane insertion and topology of the amino-terminal domain TMD0 of multidrug-resistance associated protein 6 (MRP6)

(2015) Flavia Cuviello et al.   FEBS LETTERS

ABCC6–Mediated ATP Secretion by the Liver Is the Main Source of the Mineralization Inhibitor Inorganic Pyrophosphate in the Systemic Circulation—Brief Report

(2014) Robert S. Jansen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dysregulation of gene expression in ABCC6 knockdown HepG2 cells

(2014) Rocchina Miglionico et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

The Roles of CD73 in Cancer

(2014) Zhao-wei Gao et al.   Biomed Research International

ABCC6 Is a Basolateral Plasma Membrane Protein

(2013) Viola Pomozi et al.   CIRCULATION RESEARCH

ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release

(2013) R. S. Jansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Study of the Nucleotide-Binding Domain 1 of the Human Transporter Protein MRP6

(2012) Angela Ostuni et al.   PROTEIN AND PEPTIDE LETTERS

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*-Mediated Suppression of SOX2

(2011) H.-M. Jeon et al.   CANCER RESEARCH

The nucleotide-binding domain 2 of the human transporter protein MRP6

(2011) Angela Ostuni et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc

(2010) Haitao Luo et al.   Cancer Cell International

A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform

(2009) J F Deeken et al.   PHARMACOGENOMICS JOURNAL

Probenecid, a gout remedy, inhibits pannexin 1 channels

(2008) William Silverman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of Actin Assembly Associated With Protrusion and Adhesion in Cell Migration

(2008) Christophe Le Clainche et al.   PHYSIOLOGICAL REVIEWS