Article
Cell Biology
Gina M. Gallucci, Bader Alsuwayt, Adam M. Auclair, James L. Boyer, David N. Assis, Nisanne S. Ghonem
Summary: Fenofibrate has anti-inflammatory effects in chronic liver diseases by inhibiting NF-kappa B signaling and reducing the secretion of pro-inflammatory cytokines.
Article
Multidisciplinary Sciences
Jue Zhang, Jackie Chang, Mirza Ahmar Beg, Wenxin Huang, Yiqiong Zhao, Wen Dai, Xiaopeng Wu, Weiguo Cui, Sneha S. Pillai, Hari Vishal Lakhani, Komal Sodhi, Joseph I. Shapiro, Daisy Sahoo, Ze Zheng, Roy L. Silverstein, Yiliang Chen
Summary: This study found that NKA alpha 1 plays a role in suppressing LPS-induced pro-inflammatory signaling through the inhibition of Lyn.
Article
Cell Biology
Zhongqian Lu, Xing Li, Peng Yang, Genhua Mu, Lei He, Chunmei Song, Feng Xu
Summary: Heparin-binding protein (HBP) modulates the inflammatory response in sepsis by regulating lactate-dependent glycolysis in macrophages, increasing NF-κB pathway activation and TNF-α expression. This mechanism plays a crucial role in the initial inflammatory reaction, highlighting the importance of lactate in regulating proinflammatory factor release.
Review
Food Science & Technology
Katarzyna Chojnacka, Urszula Lewandowska
Summary: This article reviews the anti-inflammatory role of phenol-rich natural extracts, particularly in modulating the NF-kappa B signaling pathway and inhibiting proinflammatory cytokines. Plant extracts have anti-inflammatory activity and can be used as therapeutic agents in various diseases. Additionally, consuming food rich in polyphenols may have a protective effect on human health.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Yan Wang, Mengling Liao, Yu Zhang, Fei Deng, Jing Luo, Nuoyan Wang, Min Liu, Lin Ao, Qimei Fang, Qingchun Wang, Hong Zhou
Summary: The study demonstrated that artesunate has immunomodulatory effects on hydrocortisone-induced immunosuppression, enhancing bacterial clearance ability and increasing inflammatory response. Artesunate's effect is related to the improvement of the TLR4/NF-kappa B signal transduction pathway by inhibiting the upregulation of GILZ mRNA. Further investigation into the immunomodulatory effects of artesunate is warranted.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Xinyi Lou, Shixin Duan, Mengkai Li, Yao Yuan, Shiyi Chen, Zhiming Wang, Zishu Wang, Lei Sun, Feng Qian
Summary: IL-36 alpha activates NF-kappa B and MAPK signaling pathways in macrophages, leading to the expression of inflammatory factors. Additionally, IL-36 alpha has significant anti-tumor effects by altering the tumor microenvironment and promoting the infiltration of immune cells while decreasing suppressor cells and regulatory T cells.IL-36 alpha also synergizes with PD-L1 antibody to enhance its anti-tumor effect on melanoma. This study reveals a new role for IL-36 alpha in promoting anti-tumor immune responses and suggests its potential for cancer immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Paola Galozzi, Ola Negm, Sara Bindoli, Patrick Tighe, Paolo Sfriso, Leonardo Punzi
Summary: This study aimed to increase understanding of the inflammatory pathways in the development of monogenic autoinflammatory diseases (mAIDs). The researchers evaluated signaling pathways and inflammatory mediators in mAIDs patients and observed upregulation of multiple intermediates in the signaling pathways, as well as differences in cytokine and chemokine levels between patients with different diseases. These findings suggest ongoing subclinical inflammation and define an elevated inflammatory cytokine signature. The activation of Th17-related cytokines also highlights the important role of Th17 and/or Th17-like cells in mAIDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Zahirrah BM. Rasheed, Yun S. S. Lee, Sung H. H. Kim, Tg Teoh, David A. A. MacIntyre, Phillip R. R. Bennett, Lynne Sykes
Summary: The study found that 15dPGJ2 has differential effects on inflammatory modulation depending on cell type, and is therefore unlikely to be a useful therapeutic agent for the prevention of preterm birth.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Lara K. Abramowitz, John A. Hanover
Summary: Inflammation is an immune response to harmful stimuli, but excessive inflammation can lead to chronic inflammatory diseases. Macrophages play a crucial role in this process, responding to the local microenvironment by polarizing into M1 or M2 phenotypes. Elevated O-GlcNAc levels in M1 polarized macrophages are associated with increased expression of pro-inflammatory cytokines. O-GlcNAc interacts with iNOS and affects its activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Shuguang Yan, Ping Wang, Hailiang Wei, Rui Jia, Meijia Zhen, Qian Li, Chang Xue, Jingtao Li
Summary: This study showed that Wu-Mei-Wan can inhibit intestinal inflammation and promote the repair of damaged intestinal mucosa, thus treating ulcerative colitis.
Article
Clinical Neurology
Zahra Aghelan, Saeed Karima, Seyed Hosein Abtahi, Habibolah Khazaie, Yahya Salimi, Reza Khodarahmi
Summary: A growing body of literature suggests that cytokines can play an important role in chronic insomnia disorder (CID). This study found that levels of proinflammatory mediators, including IL-12, IFN-gamma, and ICAM-1, were elevated in CID patients compared to healthy controls. The duration of REM sleep was also found to decrease with increased concentrations of IL-12 and IFN-gamma. Additionally, a lower serum concentration of IL-1ra was negatively correlated with the severity of insomnia in CID patients. These findings indicate that an imbalance of proinflammatory mediators and anti-inflammatory cytokines is important in the pathogenesis of CID.
Article
Fisheries
Chohelee Choudhury, Ritwik Mazumder, Rajib Biswas, Mahuya Sengupta
Summary: The study investigated the effects of cadmium exposure on the immune response and molecular changes in monocytes/macrophages of Channa punctatus. Results showed alterations in hematological profile, tissue damage, impaired innate immune parameters, ROS generation, and induced inflammation, highlighting the role of NF-kappa B pathway and proinflammatory cytokines such as TNF-alpha, IL-1 beta, IL-6, and IL-12.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Plant Sciences
Monica Zuzarte, Catia Sousa, Carlos Cavaleiro, Maria Teresa Cruz, Ligia Salgueiro
Summary: Portuguese lavenders remain undervalued in global markets due to the lack of high-quality end-products and scarcity of scientific-based studies validating their bioactive potential. This study assessed the anti-inflammatory potential of L. luisieri and L. pedunculata, two prevalent species in Portugal, and correlated it with their chemical variability. The results demonstrated that L. luisieri essential oil with low quantities of necrodane derivatives was the most effective at inhibiting inflammation.
Article
Biochemistry & Molecular Biology
Bulbul Ahmed, Hongwei Si
Summary: The study revealed that aging adipocytes chronologically accumulated lipids and increased pro-inflammatory markers such as interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor-alpha (TNF-alpha); at the same time, NF-kappa B p50 markers were also increased while I kappa B alpha protein was decreased significantly in conditioned medium.
Review
Biochemistry & Molecular Biology
Geovana F. Guedes Silvestre, Renally Pereira de Lucena, Harley da Silva Alves
Summary: Cucurbitacins are natural products with anti-inflammatory, antioxidant, and immunomodulatory potential. Cucurbitacin B and cucurbitacin E are the most investigated compounds, playing important roles in both innate and adaptive immunity. Their mechanisms of action include inhibition of COX-2 and NOS, reduction of oxidative stress, suppression of proinflammatory cytokines, and modulation of acquired immunity proteins.
CURRENT MEDICINAL CHEMISTRY
(2022)