Review
Emergency Medicine
Shahin Homaeigohar, Meng Li, Aldo R. Boccaccini
Summary: The research on silicate bioactive glass has expanded beyond bone regeneration to soft tissue repair and wound healing, with tailored compositions of BGs influencing cellular activities through the release of biologically active ions. By mimicking the physical structure of skin's extracellular matrix, BG fibrous materials have shown success in wound healing applications by inducing new vessels formation and maintaining an anti-infection environment.
Article
Cell & Tissue Engineering
Tayyba Sher Waris, Syed Tahir Abbas Shah, Azra Mehmood, Zohaib Iqbal, Mubashra Zehra, Aqif Anwar Chaudhry, Ihtesham Ur Rehman, Muhammad Yar
Summary: This research investigates the angiogenic and wound healing abilities of thyroxine/heparin-based cotton wound dressing. The results suggest that thyroxine possesses greater potential for angiogenesis and wound healing than heparin.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Vojtech Pavlik, Lubos Sobotka, Jaroslav Pejchal, Martin Cepa, Kristina Nesporova, Monika Arenbergerova, Adela Mrozkova, Vladimir Velebny
Summary: The study compared the healing of chronic wounds treated with a standard silver dressing and a dressing containing octenidine antiseptic, finding that the octenidine dressing promoted wound healing, reduced wound slough, and observed direct effects of silver on wound cells during treatment.
Review
Health Care Sciences & Services
Andreea Barbu, Bogdan Neamtu, Marius Zahan, Gabriela Mariana Iancu, Ciprian Bacila, Vioara Miresan
Summary: Chronic wounds pose a major public health issue with high costs globally. An ideal wound dressing should possess various characteristics such as adhesion, non-antigenicity, biocompatibility, semi-permeability, and biodegradability. This paper explores the use of biopolymer materials, specifically alginate forms, in advanced wound healing applications, focusing on hydrogels, nanofibers networks, and 3D-scaffolds.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Engineering, Biomedical
Francois Berthiaume, Henry C. Hsia
Summary: This article describes new experimental approaches, including biophysical techniques and biochemical methods, to improve the regenerative response of skin. Various treatment approaches exist to help heal chronic skin wounds, but the healed tissue often lacks mechanical properties and appendages. Therefore, harnessing the potential of stem cells to regenerate the skin appears to be a promising option. These approaches primarily focus on the local wound environment and should be combined with other interventions addressing regional and systemic diseases and social determinants of health.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING
(2022)
Review
Medicine, Research & Experimental
Shahriar Sharifi, Mohammad Javad Hajipour, Lisa Gould, Morteza Mahmoudi
Summary: Chronic wounds pose challenges due to poor healing, bacterial infection, and inflammation imbalance. Current therapies have limitations, but nanomedicine offers promise by stimulating cellular and molecular mechanisms in the wound microenvironment. Incorporating nanomedicine into chronic wound management may provide opportunities for improved outcomes.
MOLECULAR PHARMACEUTICS
(2021)
Article
Engineering, Environmental
Laura Miranda-Calderon, Cristina Yus, Cristina Remirez de Ganuza, Monica Paesa, Guillermo Landa, Elena Tapia, Estela Perez, Marta Perez, Victor Sebastian, Silvia Irusta, Gracia Mendoza, Manuel Arruebo
Summary: Advanced medicated wound dressings fabricated by electrospinning and electrospraying provide dually controlled antibiotic release kinetics, effectively eradicating bacterial infections and preventing biofilm formation. They also exhibit no cytotoxicity to eukaryotic cells and have been proven effective in a chronic wound murine model.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Abdur R. Aleem, Lubna Shahzadi, Muhammad Nasir, Pegah Hajivand, Farah Alvi, Amna Akhtar, Mubashra Zehra, Azra Mehmood, Muhammad Yar
Summary: This study developed a novel biomaterial by cross-linking chitosan and cellulose, loading sulfur-doped titanium oxide nanoparticles, and demonstrated its potential for promoting angiogenesis. The membranes loaded with titanium oxide nanoparticles showed superior angiogenic effects and promising abilities in enhancing cellular metabolism and wound healing, as confirmed by various tests conducted.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Wentao Shu, Yinan Wang, Xi Zhang, Chaoyang Li, Hanxiang Le, Fei Chang
Summary: Burn treatment is a challenging clinical issue with the future lying in the development of active dressings such as hydrogel dressings that can accelerate wound healing. Various treatment strategies for burns are reviewed, emphasizing the clinical value of hydrogel dressings.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yonghong Luo, Edymarie Vivaldi Marrero, Vivek Choudhary, Wendy B. Bollag
Summary: This review suggests the use of DOPG as a potential treatment to improve healing of diabetic wounds. Diabetic wounds are characterized by enhanced inflammation and oxidative stress, which impair the ability of keratinocytes to restore epidermal integrity. DOPG, by promoting keratinocyte proliferation and inhibiting inflammation, shows promise in counteracting these detrimental effects and promoting wound healing.
Review
Materials Science, Biomaterials
Ana Beatriz Sousa, Artur P. Aguas, Mario A. Barbosa, Judite N. Barbosa
Summary: Successful wound healing involves three phases: inflammatory, proliferative, and remodeling. Chronic wounds are characterized by persistent inflammation that hampers the healing process. Macrophages play a crucial role in wound healing, promoting cleaning and phagocytosis at the early stage and then facilitating the resolution of inflammation, as well as expressing growth factors and cytokines needed for cell proliferation and tissue repair. In chronic wounds, the presence of pro-inflammatory M1 macrophages inhibits tissue repair. Immunomodulatory biomaterials are being explored as potential solutions to overcome the continued inflammatory phase that impairs chronic wound healing.
REGENERATIVE BIOMATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Jiaqi Liu, Minmin Wu, Jie Lu, Qiang He, Jing Zhang
Summary: Long-term recurrent infections hinder the healing of chronic diabetic wounds, posing a significant clinical challenge. In this study, Janus hydrogel dressings were developed with the ability to adjust the wound microenvironment to promote healing. These dressings had an antifouling surface to prevent bacterial adhesion and an adhesive surface for wound fixation. The incorporation of gentamicin sulfate-modified hyaluronic acid allowed intelligent release of antibiotics in response to the infected wound's acidic environment. In vivo results demonstrated that the Janus hydrogel dressings effectively inhibited inflammation, accelerated tissue regeneration, and facilitated wound healing. This multifunctional dressing holds promise for clinical application in chronic wound healing.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Dermatology
Sebastian P. Nischwitz, Daniel Popp, David Shubitidze, Hanna Luze, Robert Zrim, Klaus Klemm, Matthias Rapp, Herbert L. Haller, Manuel Feisst, Lars-Peter Kamolz
Summary: The study investigated the healing potential of Suprathel in chronic wounds and found a significant reduction in wound size after 8 weeks of treatment, with diabetic and old chronic wounds showing the most pronounced effect. Further research is needed to explore the full potential of advanced wound dressing materials.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Priscila Schilrreff, Ulrike Alexiev
Summary: This review discusses the crucial role of chronic inflammation in chronic wounds and its close association with immune regulation. The dysregulation of the immune system leads to persistent inflammation and impaired wound healing, resulting in chronic skin wounds. Furthermore, it explores the potential of natural bioactive compounds in wound treatment, particularly focusing on compounds with antioxidant, anti-inflammatory, and antibacterial activities, as well as recent advancements in wound treatments utilizing nanotechnology or new biomaterial platforms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Le Wang, Wenfu Zheng, Qinghong Hou, Leni Zhong, Qizhen Li, Xingyu Jiang
Summary: In this study, L-thioproline and Boc-capped L-thioproline-decorated gold nanoparticles were used to develop wound dressings with potent antibacterial activity against multidrug-resistant bacteria. The dressings, composed of TBT-GNPs and bacterial cellulose, demonstrated excellent antimicrobial performance both in vitro and in vivo. Additionally, the dressings were breathable and stretchable, facilitating gas exchange and accelerating wound healing.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Dermatology
Barbara Blanco-Fernandez, Oscar Castano, Miguel Angel Mateos-Timoneda, Elisabeth Engel, Soledad Perez-Amodio
Summary: The incidence of chronic wounds is rising with the aging population and diabetes, leading to the development of nanotechnology-based therapeutic agents. Despite the potential biomaterials and nanotechnology-based applications for wound healing, there is a lack of commercially available products containing nanomaterials.
ADVANCES IN WOUND CARE
(2021)
Article
Neuroimaging
Jiahui Li, Oscar Castano, Alejandro Tomasello, Marta de Dios Lascuevas, Pere Canals, Elisabeth Engel, Marc Ribo
Summary: The study characterized the aspiration performance of different catheters on stiff clots in an in vitro vascular model, finding that ADAPT performance is highly influenced by catheter tip shape-adaptability to the clot and that the effective inner diameter (eff-ID) may differ from the labeled-ID specified by manufacturers. Based on experimental findings, considering the eff-ID rather than the labeled-ID is crucial for estimating device efficiency accurately.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Engineering, Biomedical
Adrian Lopez-Canosa, Soledad Perez-Amodio, Eduardo Yanac-Huertas, Jesus Ordono, Romen Rodriguez-Trujillo, Josep Samitier, Oscar Castano, Elisabeth Engel
Summary: The creation of cardiac tissue models for preclinical testing remains a challenge due to the limitations in replicating the complexity of cardiac tissue in vitro. In this study, a microfluidic platform was developed to provide signaling cues to immature cardiac cells, guiding them towards an adult phenotype. The platform demonstrated control over the anisotropy of cardiac tissue and induced the upregulation of key genes through electrical stimulation, validating its potential as a powerful tool for tissue engineering.
Article
Biotechnology & Applied Microbiology
Oscar Castano, Ana Lopez-Mengual, Diego Reginensi, Andreu Matamoros-Angles, Elisabeth Engel, Jose Antonio del Rio
Summary: After spinal cord injury, transplantation of olfactory ensheathing cells (OECs) has shown potential in promoting functional improvement. Studies have found that the migratory properties of OECs are influenced by inhibitory molecules and chemical concentration differences. Research comparing the behavior of TEG3 cells seeded on functionalized nanoscale meshes of Poly(l/dl-lactic acid; PLA) nanofibers showed that 950 nm diameter PLA nanofibers had the best results in terms of cell adhesion and migration. Additionally, functionalized nanofibers with a chemical concentration increment of SDF-1 alpha/CXCL12 greatly enhanced the migratory characteristics of TEG3 cells over inhibitory substrates.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biology
Manuel Jurado, Oscar Castano, Antonio Zorzano
Summary: PRMT5 modulates the MAPK pathway by methylating Raf kinase, reducing the activation of ERK in time and amplitude, thereby avoiding aberrant behavior.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Letter
Neuroimaging
Jiahui Li, Oscar Castano, Marc Ribo
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Neuroimaging
Jiahui Li, Alejandro Tomasello, Manuel Requena, Pere Canals, Riccardo Tiberi, Inaki Galve, Elisabeth Engel, David F. Kallmes, Oscar Castano, Marc Ribo
Summary: This study aims to provide insight into navigating devices through the vascular anatomy with minimal track forces. The use of microcatheter and stent retriever was found to significantly reduce track forces and improve tracking reliability.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Engineering, Biomedical
Adrian Lopez-Canosa, Soledad Perez-Amodio, Elisabeth Engel, Oscar Castano
Summary: Traditional in vitro models for testing biomaterial-driven vascularization lack complexity, while cell culture models based on microfluidic technology offer better tissue biomimicry.
ACTA BIOMATERIALIA
(2022)
Review
Neuroimaging
Cem Bilgin, Jared Hutar, Jiahui Li, Oscar Castano, Marc Ribo, David F. Kallmes
Summary: Neurovascular catheter technology has advanced rapidly in the past decade. However, the relationship between catheter design and performance metrics remains a mystery to most clinicians due to limited resources. To assist neurointerventionalists, this article summarizes the basic concepts of catheter design and construction.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Neuroimaging
Jiahui Li, Riccardo Tiberi, Pere Canals, Daniel Vargas, Oscar Castano, Marc Molina, Alejandro Tomasello, Marc Ribo
Summary: This in vitro evaluation compared the efficacy of single and double Sensormedics balloon catheters in mechanical thrombectomy. The results showed that the double-SR technique was more effective in achieving first-pass recanalization and reducing distal emboli especially in MCA bifurcation occlusions.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Biotechnology & Applied Microbiology
Sujey Palma-Florez, Adrian Lopez-Canosa, Francisco Moralez-Zavala, Oscar Castano, Marcelo J. Kogan, Josep Samitier, Anna Lagunas, Monica Mir
Summary: A BBB-oC platform was developed to evaluate the permeability performance of targeted gold nanorods for theranostics of Alzheimer's disease. The results showed that the chip could mimic physiological conditions in human cells, cross the blood-brain barrier, and potentially replace animal experiments.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biology
Manuel Jurado, Antonio Zorzano, Oscar Castan
Summary: This study presents a minimum computational model to analyze the growth and decay dynamics of K-Ras nanoclusters (NCs) and emphasizes the role of their size in regulating cell signaling. This opens up new possibilities for developing strategies for chronic diseases and cancer treatment.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Meeting Abstract
Cell & Tissue Engineering
Marina Martinez-Hernandez, Jesus Ordono, Laura Tuduri, Oscar Castano, Soledad Perez-Amodio, Elena Martinez, Elisabeth Engel
TISSUE ENGINEERING PART A
(2022)