Review
Biochemistry & Molecular Biology
Eduardo Duran-Jara, Tamara Vera-Tobar, Lorena De Lourdes Lobos-Gonzalez
Summary: Lactadherin is associated with cancer development and progression, and can serve as a biomarker and therapeutic target for cancer. It plays important roles in cell adhesion, angiogenesis, and tissue regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Walther C. Traberg, Johana Uribe, Victor Druet, Adel Hama, Chrysanthi-Maria Moysidou, Miriam Huerta, Reece McCoy, Daniel Hayward, Achilleas Savva, Amaury M. R. Genovese, Suraj Pavagada, Zixuan Lu, Anil Koklu, Anna-Maria Pappa, Rebecca Fitzgerald, Sahika Inal, Susan Daniel, Roisin M. Owens
Summary: A functional phenotypic screening platform based on organic electrochemical transistors (OECTs) is developed for real-time, noninvasive monitoring of tumor-derived extracellular vesicle (TEV)-induced epithelial-to-mesenchymal transition (EMT) and screening of antimetastatic drugs. The TEVs derived from the triple-negative breast cancer cell line MDA-MB-231 induce EMT in nonmalignant breast epithelial cells (MCF10A), and heparin is identified as an effective blocker of TEV-induced EMT.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Oncology
Akira Yokoi, Takahiro Ochiya
Summary: This review summarizes recent studies on EVs from the perspective of EV heterogeneity and highlights their role in various steps from oncogenic to metastatic processes. Recognizing EV subtypes is crucial for identifying pathways affected by EVs and targeting specific subtypes in therapeutic approaches or liquid biopsies.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Oncology
Ramon Handerson Gomes Teles, Rafael Sussumu Yano, Nicolas Jones Villarinho, Ana Sayuri Yamagata, Ruy Gastaldoni Jaeger, Patrick Meybohm, Malgorzata Burek, Vanessa Morais Freitas
Summary: This study investigated the trends in breast cancer management related to extracellular vesicle research through bibliometric analysis, revealing a focus on biomarkers, drug delivery, chemotherapy, autophagy, and microRNA. Future research is expected to delve into the roles of extracellular vesicles in autophagy and microRNA, as well as explore their application in liquid biopsy for biomarkers and drug delivery in the development of therapeutic strategies for specific cancers.
Review
Biotechnology & Applied Microbiology
Tingli Luo, Yue Kang, Yushi Liu, Jingyue Li, Jianyi Li
Summary: Extracellular vesicles (EVs) have attracted extensive scientific attention for their potential diagnostic value in carrying biomolecules and participating in intercellular information exchange. Brain metastasis is a major cause of mortality in breast cancer patients, and small EVs have been found to play a crucial role in various pathological processes of breast cancer brain metastasis (BCBM). Understanding the mechanisms of small EVs can provide new insights for the precise treatment of BCBM.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jelle Penders, Anika Nagelkerke, Eoghan M. Cunnane, Simon Pedersen, Isaac J. Pence, R. Charles Coombes, Molly M. Stevens
Summary: The study focuses on extracellular vesicles (EVs) and introduces a high-throughput label-free EV analysis method for cancer diagnosis and monitoring, eliminating interpreter bias. By developing a dedicated device and using dimensional reduction analysis (DRA), a convenient and comprehensive approach for comparing multiple EV spectra is demonstrated. The study shows the high sensitivity and specificity of the dedicated SPARTA system in differentiating cancer and noncancer EVs, and its consistent predictive ability across multiple EV isolations.
Article
Immunology
Seyedeh Alia Moosavian, Maryam Hashemi, Leila Etemad, Sara Daneshmand, Zahra Salmasi
Summary: Exosomes play a crucial role in early diagnosis and various functions related to angiogenesis, immune modulation, migration, metastasis, chemotherapy resistance, and tumor progression in melanoma. Natural exosomes have the potential to be utilized as nanocarriers and cancer vaccines for more efficient cancer treatment in the era of novel bioengineering and immunotherapy approaches.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Oana Baldasici, Valentina Pileczki, Daniel Cruceriu, Laura Ioana Gavrilas, Oana Tudoran, Loredana Balacescu, Laurian Vlase, Ovidiu Balacescu
Summary: Metastasis is the leading cause of breast cancer-related mortality, and efforts are being made to identify blood-based biomarkers that can distinguish highly metastatic cancer patients. Exosomal miRNAs hold promise as prognostic biomarkers for metastatic breast cancer and have shown potential in both research and clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Rares Drula, Barbara Pardini, Xiao Fu, Mireia Cruz De los Santos, Ancuta Jurj, Lan Pang, Sherien M. El-Daly, Linda Fabris, Erik Knutsen, Mihnea P. Dragomir, Recep Bayraktar, Yongfeng Li, Meng Chen, Filippo Del Vecchio, Lea Berland, Jessica Dae, Daniel Fan, Masayoshi Shimizu, Anh M. Tran, Mercedes Barzi, Carlotta Pioppini, Angelica M. Gutierrez, Cristina Ivan, Salyna Meas, Carolyn S. Hall, Suresh K. Alahari, Ioana Berindan-Neagoe, Muller Fabbri, Anthony Lucci, Banu Arun, Simone Anfossi, George A. Calin
Summary: The causes and consequences of abnormal biogenesis of extracellular vesicles (EVs) in breast cancers (BCs), especially estrogen receptor-positive (ER+) BCs, have been investigated. It was found that physiological doses of estrogen can promote EV secretion from ER+ BC cells by inhibiting miR-149-5p, which affects the regulatory activity of SP1 on the EV biogenesis factor nSMase2. In addition, the downregulation of miR-149-5p promotes the expression of hnRNPA1, responsible for loading let-7's miRNAs into EVs. This estrogen-driven mechanism leads to the elimination of tumor suppressor miRNAs in EVs, affecting tumor-associated macrophages in the microenvironment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Shizhen Shen, Zhangjin Shen, Conghui Wang, Xiaodong Wu, Lingfang Wang, Lele Ye, Songfa Zhang, Xiaodong Cheng
Summary: In this study, a method for extracting extracellular vesicles (EVs) from epithelial ovarian cancer (EOC) tissues was optimized to investigate the effect of cryopreservation on the phenotypes, contents, and biological functions of the extracted EVs. The results showed that cryopreservation affected the yield and distribution of EVs, but not their morphology or particle mass ratio. The storage of tissues at -80°C increased both small and large EV yields, while the storage of lysates at -80°C decreased large EV yield and increased small EV yield. The cryopreserved EOC tissue retained a high percentage of proteins and miRNAs, and the extracted EVs could promote angiogenesis and invasive migration ability in human endothelial cells. This suggests that cryopreserved EOC tissue has clinical value for studying tissue-derived EVs, especially those related to EV proteins.
Review
Biochemistry & Molecular Biology
Shaojuan Huang, Ming Dong, Qiang Chen
Summary: Breast cancer metastasis, which is the leading cause of death in breast cancer patients, is a complex process involving multiple physiological changes. Recent studies have shown that exosomes, membrane-bound extracellular vesicles, play a crucial role in cancer metastasis. In this review, the role of breast cancer-derived exosomes in metastasis organotropism is summarized, and the potential clinical applications of targeting exosomes for breast cancer diagnosis and therapy are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Theresa Akoto, Sharanjot Saini
Summary: Prostate cancer is a life-threatening disease among men globally, with metastasis being the major cause of mortality. Cell-to-cell communication plays a crucial role in the progression and metastasis of prostate cancer, with exosomes/extracellular vesicles demonstrating significant involvement in signaling pathways related to metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Biomaterials
Kailong Zhang, Huanru Fu, Chao Xing, Yi Luo, Fangfang Cheng, Qiang Fu, Yujie Huang, Longxin Qiu
Summary: The study focused on inducing TNBC cell apoptosis to secrete ABAs for therapeutic drug delivery, which showed promising results in inhibiting TNBC growth and metastasis. ABAs possess desirable characteristics for targeted drug delivery therapy, particularly for efficient TNBC treatment. The results suggest the potential of ABAs in enhancing targeted drug delivery strategies.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Oncology
Weiqiang Tang, Min Xia, Yajie Liao, Yuan Fang, Gebo Wen, Jing Zhong
Summary: Exosomes are lipid bilayer extracellular vesicles that play critical roles in cancer initiation and progression, including TNBC. Tumor-derived exosomes have been found to be involved in various key processes of cancer, such as invasion, metastasis, angiogenesis, epithelial-mesenchymal transition, and drug resistance. Their dysregulation has been linked to the clinicopathological characteristics and prognosis of TNBC patients, making them a potential target for diagnosis and treatment.
Article
Biochemistry & Molecular Biology
Suzann Duan, Senny Nordmeier, Aidan E. Byrnes, Iain L. O. Buxton
Summary: The study found that nucleoside diphosphate kinase A and B (NDPK) secreted by breast cancer cells can promote endothelial cell migration and disrupt monolayer integrity, facilitating the formation of a pre-metastatic lung niche and metastatic outgrowth. Experimental results showed that treatment with an NDPK inhibitor or a P2Y1 purinoreceptor antagonist can attenuate pulmonary vascular leakage and enhance experimental lung metastasis in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Fabrizio Ceraudo, Giovanna Caparello, Angelo Galluccio, Ennio Avolio, Giuseppina Augimeri, Daniela De Rose, Adele Vivacqua, Catia Morelli, Ines Barone, Stefania Catalano, Cinzia Giordano, Diego Sisci, Daniela Bonofiglio
Summary: The study evaluated the impact of Mediterranean food choices on lipid and glycemic metabolic profile in adolescents. The results indicated that adopting a Mediterranean diet could significantly reduce glucose and lipid profile in healthy adolescents.
Review
Nutrition & Dietetics
Elisa Mattavelli, Elena Olmastroni, Daniela Bonofiglio, Alberico L. Catapano, Andrea Baragetti, Paolo Magni
Summary: The Mediterranean diet is a comprehensive lifestyle that promotes health and reduces the prevalence of chronic diseases. Its implementation is influenced by sociocultural and geographical factors, as well as personal food preferences and nutrition habits.
Editorial Material
Nutrition & Dietetics
Daniela Bonofiglio
Article
Food Science & Technology
Serena Carpentieri, Giuseppina Augimeri, Jessica Ceramella, Adele Vivacqua, Maria Stefania Sinicropi, Gianpiero Pataro, Daniela Bonofiglio, Giovanna Ferrari
Summary: The study utilized pulsed electric field pretreatment to enhance the extractability of valuable compounds from artichoke by-products, demonstrating the antioxidant and anti-inflammatory properties of the extracts. Biological effects on THP-1 macrophages were investigated.
Article
Biochemistry & Molecular Biology
Luca Gelsomino, Ines Barone, Amanda Caruso, Francesca Giordano, Matteo Brindisi, Giovanna Morello, Felice Maria Accattatis, Salvatore Panza, Anna Rita Cappello, Daniela Bonofiglio, Sebastiano Ando, Stefania Catalano, Cinzia Giordano
Summary: Tumor extracellular vesicles (EVs) play a crucial role in cell-to-cell communication in breast cancer by transporting nucleic acids, proteins, and metabolites. Leptin induces the release of EVs from breast cancer cells, and these vesicles have a specific proteomic signature related to mitochondrial processes and activity. Lep-EVs increase ATP levels and modulate the oxidative metabolism of breast cancer cells. Furthermore, Lep-EVs sustain the polarization of macrophages in the tumor microenvironment (TME) towards a tumor-promoting phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Michele Pellegrino, Elena Ricci, Rosangela Ceraldi, Alessandra Nigro, Daniela Bonofiglio, Marilena Lanzino, Catia Morelli
Summary: This review highlights the anti-tumor activity of several antiepileptic drugs in breast, prostate, and other cancers. It focuses on their ability to block ion channels and inhibit histone deacetylases, which are well-established tumor markers and molecular targets. The repurposing of already approved drugs as adjuvants in cancer treatment is advantageous due to reduced toxicity and faster clinical approval. The review also discusses the attempt to administer antiepileptic drugs through drug delivery systems to improve their effectiveness and reduce toxicity.
Article
Oncology
Giuseppina Augimeri, Marco Fiorillo, Catia Morelli, Salvatore Panza, Cinzia Giordano, Ines Barone, Stefania Catalano, Diego Sisci, Sebastiano Ando, Daniela Bonofiglio
Summary: Triple-negative breast cancer (TNBC), lacking effective targeted therapies, can be attenuated by DHEA through reducing cell migration, invasion, and metabolic activity. In addition, DHEA suppresses macrophage recruitment by reducing CCL5 secretion from TNBC cells, providing a potential treatment option against TNBC.
Review
Biochemistry & Molecular Biology
Giuseppina Augimeri, Daniela Bonofiglio
Summary: Unhealthy dietary habits increase the risk of cancer, and adopting a healthy eating pattern, such as the Mediterranean diet high in omega-3 polyunsaturated fatty acids (N-3 PUFAs), is recommended to prevent various types of cancers, including breast cancer. The consumption of N-3 PUFAs, particularly EPA and DHA, reduces the risk and progression of breast cancer, and also helps counteract side effects of chemotherapy. DHA, in particular, has shown significant antitumoral effects in breast cancer cells and its derivative DHEA has potential therapeutic benefits.
Article
Chemistry, Multidisciplinary
Giovanna Caparello, Angelo Galluccio, Fabrizio Ceraudo, Claudio Pecorella, Fabio Buzzanca, Francesco Cuccomarino, Daniela Bonofiglio, Ennio Avolio
Summary: An optimal body composition in volleyball players can be achieved by monitoring training plans and nutritional habits, and the Mediterranean Diet (MD) is a good choice to meet the nutritional needs of athletes. This study used bioelectrical impedance vector analysis (BIVA) to monitor body composition changes in volleyball players following MD recommendations. The results showed that athletes maintained an optimal MD adherence and experienced significant changes in BIVA parameters, indicating improved body cell mass and skeletal muscle mass. These findings support the use of BIVA as a tool to monitor athlete's body adaptations and highlight the importance of the MD in sports settings.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Cinzia Giordano, Felice Maria Accattatis, Luca Gelsomino, Piercarlo Del Console, Balazs Gyorffy, Mario Giuliano, Bianca Maria Veneziani, Grazia Arpino, Carmine De Angelis, Pietro De Placido, Erica Pietroluongo, Francesco Zinno, Daniela Bonofiglio, Sebastiano Ando, Ines Barone, Stefania Catalano
Summary: This study identified novel miRNA signatures, miRNA-27a and miRNA-128, in breast cancer by analyzing the expression profiles of EV-derived miRNAs in the blood circulation. These miRNAs showed diagnostic accuracy in distinguishing breast cancer patients from non-cancer controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Giuseppina Augimeri, Marco Fiorillo, Giovanna Caparello, Fabrizio Ceraudo, Ennio Avolio, Catia Morelli, Ines Barone, Stefania Catalano, Sebastiano Ando, Cinzia Giordano, Diego Sisci, Adele Vivacqua, Daniela Bonofiglio
Summary: This study found that the COVID-19 lockdown had a negative impact on the metabolic and inflammatory profile of adolescents, despite no significant differences in anthropometric measurements and adherence to the Mediterranean diet. Post-lockdown adolescents had higher levels of fasting glucose, triglycerides, total cholesterol, LDL, tumor necrosis factor (TNF)-alpha, interleukin-1 beta, and ferritin, along with lower levels of high-density lipoprotein (HDL). The study also identified several serum markers as predictors for metabolic and inflammatory profiling after the lockdown period.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Simona De Angelis, Emanuela Medda, Daniela Rotondi, Maria Masocco, Valentina Minardi, Benedetta Contoli, Valentina Possenti, Angela Sorbo, Marilena D'Amato, Anna Chiara Turco, Alberto Augusto Pastorelli, Paolo Stacchini, Roberto Da Cas, Marcello Bagnasco, Daniela Bonofiglio, Maurizio Gasperi, Domenico Meringolo, Caterina Mian, Mariacarla Moleti, Francesco Vermiglio, Efisio Puxeddu, Augusto Taccaliti, Massimo Tonacchera, Salvatore Ulisse, Antonio Dimida, Teresa Rago, Elena Nazzari, Mara Schiavo, Irene Bossert, Giacomo Sturniolo, Carlo Corbetta, Cristina Cereda, Laura Cappelletti, Marta Camilot, Francesca Teofoli, Renzo Ciatti, Elisabetta Tarsi, Nicola Perrotti, Onorina Marasco, Giovanna Scozzafava, Francesca Righetti, Sebastiano Ando, Stefania Catalano, Mariarosaria Cristofaro, Giovanni Sorrenti, Simona Censi, Silvia Morelli, Enke Baldini, Giuseppe Plutino, Roberto Copparoni, Elena Alonzo, Claudia Giacomozzi, Marco Silano, Antonella Olivieri
Summary: This study evaluated the efficiency and adverse effects of the iodine prophylaxis program in Italy. The results showed that Italy has achieved iodine sufficiency through the program, but there are still concerns about iodine nutritional status during pregnancy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
