Glutamic-Pyruvic Transaminase 1 Facilitates Alternative Fuels for Hepatocellular Carcinoma Growth—A Small Molecule Inhibitor, Berberine

Berberine decelerates glucose metabolism via suppression of mTOR‑dependent HIF‑1α protein synthesis in colon cancer cells

(2018) Liyuan Mao et al.   ONCOLOGY REPORTS

An update on Chinese herbal medicines as adjuvant treatment of anticancer therapeutics

(2018) Zhixue Wang et al.   BioScience Trends

Cancer Treatment by Using Traditional Chinese Medicine: Probing Active Compounds in Anti-multidrug Resistance During Drug Therapy

(2018) Jian-Shu Lou et al.   CURRENT MEDICINAL CHEMISTRY

Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling

(2017) Yuan Cao et al.   Theranostics

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells

(2016) Jonathan L. Coloff et al.   Cell Metabolism

Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients

(2016) Ming-Da Wang et al.   HEPATOLOGY

Friendly neighbours feed tumour cells

(2016) Jurre J. Kamphorst et al.   NATURE

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Stromal–cancer cell crosstalk supports tumour metabolism

(2016) Iain Dickson   Nature Reviews Gastroenterology & Hepatology

IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization

(2016) Jing Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features

(2016) Qing Ouyang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

(2016) Yujun Hao et al.   Nature Communications

Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells

(2016) Bradley Smith et al.   Cell Reports

Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies

(2015) Angela Pirillo et al.   ATHEROSCLEROSIS

Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma

(2015) Chi Man Tsang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate

(2015) P. Korangath et al.   CLINICAL CANCER RESEARCH

Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level

(2015) Kun Qian et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Glutaminolysis as a target for cancer therapy

(2015) L Jin et al.   ONCOGENE

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

(2015) M van Geldermalsen et al.   ONCOGENE

In silico analysis and molecular docking studies of potential angiotensin-converting enzyme inhibitor using quercetin glycosides

(2015) SyedAun Muhammad et al.   Pharmacognosy Magazine

Berberine-induced tumor suppressor p53 up-regulation gets involved in the regulatory network of MIR-23a in hepatocellular carcinoma

(2014) Ning Wang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Suppression of Vascular Endothelial Growth Factor via Inactivation of Eukaryotic Elongation Factor 2 by Alkaloids in Coptidis rhizome in Hepatocellular Carcinoma

(2013) Hor Yue Tan et al.   INTEGRATIVE CANCER THERAPIES

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo

(2011) Joon-Ho Sheen et al.   CANCER CELL

F-Actin Reorganization and Inactivation of Rho Signaling Pathway Involved in the Inhibitory Effect of Coptidis Rhizoma on Hepatoma Cell Migration

(2010) Ning Wang et al.   INTEGRATIVE CANCER THERAPIES

Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: The cellular mechanism

(2010) Ning Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of the mitochondrial and catalytically active alanine aminotransferase in human tissues and plasma

(2009) Glinghammar   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Alanine aminotransferase isoenzymes: Molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity

(2008) Rong-Ze Yang et al.   HEPATOLOGY