Article
Oncology
Khalil Saleh, Matthieu Carton, Veronique Dieras, Pierre-Etienne Heudel, Etienne Brain, Veronique D'Hondt, Audrey Mailliez, Anne Patsouris, Marie-Ange Mouret-Reynier, Anthony Goncalves, Jean Marc Ferrero, Thierry Petit, George Emile, Lionel Uwer, Marc Debled, Florence Dalenc, Christelle Jouannaud, Sylvain Ladoire, Marianne Leheurteur, Paul Cottu, Lucie Veron, Alexia Savignoni, Coralie Courtinard, Mathieu Robain, Suzette Delaloge, Elise Deluche
Summary: The study found that being overweight or obese does not lead to poorer outcomes in women with metastatic breast cancer, while being underweight may be an independent adverse prognostic factor.
Article
Oncology
Konstantinos K. Tsilidis, Margarita Cariolou, Nerea Becerra-Tomas, Katia Balducci, Rita Vieira, Leila Abar, Dagfinn Aune, Georgios Markozannes, Neesha Nanu, Darren C. Greenwood, Edward L. Giovannucci, Marc J. Gunter, Alan A. Jackson, Ellen Kampman, Vivien Lund, Kate Allen, Nigel T. Brockton, Helen Croker, Daphne Katsikioti, Deirdre McGinley-Gieser, Panagiota Mitrou, Martin Wiseman, Amanda J. Cross, Elio Riboli, Steven K. Clinton, Anne McTiernan, Teresa Norat, Doris S. M. Chan
Summary: Based on systematic reviews and meta-analyses, this study found a strong association between postdiagnosis body fatness and higher all-cause mortality, breast cancer-specific mortality, and second primary breast cancer. Limited evidence suggests a relationship between body fatness and breast cancer recurrence and nonbreast cancer-related mortality. Limited-suggestive evidence indicates a lower risk of all-cause mortality and breast cancer-specific mortality with recreational physical activity. Data on dietary factors is limited. The study emphasizes the importance of lifestyle recommendations to avoid obesity and engage in physical activity for breast cancer patients.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Matteo Di Maso, Livia S. A. Augustin, Federica Toffolutti, Carmen Stocco, Luigino Dal Maso, David J. A. Jenkins, Neil E. Fleshner, Diego Serraino, Jerry Polesel
Summary: The study found that adherence to the Mediterranean diet and physical activity before diagnosis can have a beneficial impact on overall survival in prostate cancer patients, mainly driven by a reduction in non-prostate cancer mortality, which accounts for about 80% of deaths in men with prostate cancer.
Article
Health Care Sciences & Services
Ahmed Hassoon, Yasmin Baig, Daniel Q. Naiman, David D. Celentano, Dina Lansey, Vered Stearns, Josef Coresh, Jennifer Schrack, Seth S. Martin, Hsin-Chieh Yeh, Hadas Zeilberger, Lawrence J. Appel
Summary: The study found that AI coaching interventions, especially voice-assisted coaching through smart speakers, have the potential to increase physical activity in sedentary cancer survivors in a scalable and personalized manner. Further research is needed to replicate these findings in a larger population of cancer survivors and to explore the effects of these interventions in the general population.
NPJ DIGITAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Renee L. Kokts-Porietis, Seham Elmrayed, Darren R. Brenner, Christine M. Friedenreich
Summary: Excess body fat, especially higher body mass index (BMI), is associated with increased all-cause mortality and recurrence among endometrial cancer survivors, particularly in Type I cases. Obesity at endometrial cancer diagnosis is linked to elevated cancer recurrence and all-cause mortality in survivors, but not to endometrial cancer-specific mortality.
Article
Oncology
Karel C. Smit, Jeroen W. G. Derksen, Geerard L. O. Beets, Eric J. Th. Belt, Maaike Berbee, Peter Paul L. O. Coene, Hester van Cruijsen, Marjan A. Davidis, Jan Willem T. Dekker, Joyce M. van Dodewaard-de Jong, Annebeth W. Haringhuizen, Helgi H. Helgason, Mathijs P. Hendriks, Ronald Hoekstra, Ignace H. J. T. de Hingh, Jan N. M. IJzermans, Johan J. B. Janssen, Joop L. M. Konsten, Maartje Los, Leonie J. M. Mekenkamp, Peter Nieboer, Koen C. M. J. Peeters, Natascha A. J. B. Peters, Hans J. F. M. Pruijt, Patricia Quarles van Ufford-Mannesse, Ron C. Rietbroek, Anandi H. W. Schiphorst, Arjan Schouten van der Velden, Ruud W. M. Schrauwen, Mark P. S. Sie, Dirkje W. Sommeijer, Dirk J. A. Sonneveld, Hein B. A. C. Stockmann, Marleen Tent, Frederiek Terheggen, Manuel L. R. Tjin-A-Ton, Liselot Valkenburg-van Iersel, Ankie M. T. van der Velden, Wouter J. Vles, Theo van Voorthuizen, Johannes A. Wegdam, Johannes H. W. de Wilt, Miriam Koopman, Anne M. May
Summary: Physical activity is associated with longer survival among non-metastasized colorectal cancer patients. This study aimed to investigate whether physical activity is also beneficial for survival among patients with metastatic colorectal cancer (mCRC). The study found that higher levels of physical activity at the time of mCRC diagnosis were associated with longer overall survival. Adherence to physical activity guidelines for cancer survivors was also related to prolonged survival. Future research is needed to examine whether improving exercise levels after the diagnosis of metastasis is beneficial and determine the most effective exercise interventions for improving survival time in mCRC patients.
Article
Geriatrics & Gerontology
Cameron Oswalt, Yingzhou Liu, Herbert Pang, Jennifer Le-Rademacher, Xiaofei Wang, Jeffrey Crawford
Summary: Weight loss is associated with shorter survival in lung cancer patients, while obesity is associated with longer survival. Integrating body mass index and weight loss percentage may provide a powerful prognostic tool for assessing therapeutic interventions in advanced lung cancer.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Nutrition & Dietetics
Jananee Muralidharan, Isabel Moreno-Indias, Monica Bullo, Jesus Vioque Lopez, Dolores Corella, Olga Castaner, Josep Vidal, Alessandro Atzeni, Jose Carlos Fernandez-Garcia, Laura Torres-Collado, Rebeca Fernandez-Carrion, Monsterrat Fito, Romina Olbeyra, Ana Maria Gomez-Perez, Serena Galie, Maria Rosa Bernal-Lopez, Miguel Angel Martinez-Gonzalez, Jordi Salas-Salvado, Francisco Jose Tinahones
Summary: The study investigated the impact of an intensive lifestyle weight loss intervention on gut microbiota, with results showing that an energy-restricted Mediterranean diet and physical activity can lead to weight loss, improvements in metabolic syndrome-related markers, and modulation of gut microbiota.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Esther Molina-Montes, Esther Ubago-Guisado, Dafina Petrova, Pilar Amiano, Maria-Dolores Chirlaque, Antonio Agudo, Maria-Jose Sanchez
Summary: This study reviewed the contribution of the EPIC study to the understanding of the impact of diet, alcohol, body-mass index (BMI), and physical activity on cancer mortality. It identified several dietary factors, physical activity, and healthy lifestyle recommendations that can reduce the risk of cancer mortality, while poor diet quality and obesity were found to increase this risk. The EPIC study provides valuable information on diet and lifestyle factors for cancer mortality prevention.
Article
Oncology
Gabriella N. Heuchan, Phillippa J. Lally, Rebecca J. Beeken, Abigail Fisher, Rana E. Conway
Summary: This study aimed to explore factors associated with perceived need for weight change among cancer survivors. The results showed that a significant proportion of overweight and obese survivors did not perceive a need to lose weight, which was associated with factors such as age, gender, race, marital status, cancer spread, education level, comorbidities, and chemotherapy. Support for weight management is needed for cancer survivors.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Endocrinology & Metabolism
Marsha Dowda, Ruth P. Saunders, Rod K. Dishman, Russell R. Pate
Summary: Background/Objectives: Childhood obesity rates have been increasing, and understanding the behavioral factors that influence adiposity in children transitioning to adolescence is important for future public health interventions. This study aimed to investigate how initial weight status modifies the associations between physical activity, sedentary behavior, and diet quality with changes in adiposity over time.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Review
Public, Environmental & Occupational Health
Tiantian Jia, Yufeng Liu, Yuanyuan Fan, Lintao Wang, Enshe Jiang
Summary: Breast cancer is the most diagnosed cancer in women globally, and lifestyle interventions such as a healthy diet and physical activity have been shown to reduce the risk and improve outcomes. However, their implementation in at-risk and survivor populations is still limited.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Zi Lin Lim, Geok Hoon Lim, Peh Joo Ho, Alexis Jiaying Khng, Yen Shing Yeoh, Amanda Tse Woon Ong, Benita Kiat Tee Tan, Ern Yu Tan, Su-Ming Tan, Veronique Kiak-Mien Tan, Jingmei Li, Mikael Hartman
Summary: This study investigated the association between pre-diagnostic physical activity and the aggressiveness of breast cancer. The results showed that higher levels of pre-diagnostic physical activity were associated with less aggressive breast tumors, further highlighting the importance of physical activity in improving patient prognosis.
Article
Nutrition & Dietetics
Gustavo D. Pimentel, Claude Pichard, Alessandro Laviano, Renata C. Fernandes
Summary: High protein diet is not associated with improved muscle function as measured by handgrip strength, but it is linked to higher overall survival in older adult outpatients with advanced gastrointestinal cancer.
CLINICAL NUTRITION
(2021)
Review
Endocrinology & Metabolism
Rhiannon Berry, Aikaterini Kassavou, Stephen Sutton
Summary: Digital self-monitoring of diet and physical activity is effective at supporting weight loss in adults with obesity or overweight, with tailored interventions showing significantly more effectiveness than nontailored interventions. Future studies should further explore the effectiveness of interventions to support weight loss.
Article
Geriatrics & Gerontology
Giovanni Grandi, Anna Myriam Perrone, Antonino Perrone, Vincenzo Dario Mandato, Giuseppe Comerci, Margaret Sammarini, Carla Merisio, Andrea Amadori, Marco Stefanetti, Ruby Martinello, Fabio Facchinetti, Pierandrea De Iaco
Summary: The study conducted in northern Italy found that 3.5% of subjects undergoing RRSO were diagnosed with ovarian invasive cancer, all of whom were BRCA1 or combined BRCA carriers. Among the 222 procedures, 15 included hysterectomies, but no primary uterine endometrioid or serous cancer was found.
Article
Genetics & Heredity
Angela Toss, Elena Tenedini, Claudia Piombino, Marta Venturelli, Isabella Marchi, Elisa Gasparini, Elena Barbieri, Elisabetta Razzaboni, Federica Domati, Federica Caggia, Giovanni Grandi, Francesca Combi, Giovanni Tazzioli, Massimo Dominici, Enrico Tagliafico, Laura Cortesi
Summary: Individuals with mutations in breast cancer susceptibility genes ATM and CHEK2 exhibit distinct clinical characteristics in the development of breast cancer, including higher rates of bilateral tumors, different histological subtypes, and the presence of in situ carcinomas. Understanding these biological and clinical features can enhance diagnosis, prognosis, and targeted therapeutic approaches for these individuals.
Article
Medicine, General & Internal
Angela Toss, Claudia Piombino, Elena Tenedini, Alessandra Bologna, Elisa Gasparini, Vittoria Tarantino, Maria Elisabetta Filieri, Luca Cottafavi, Filippo Giovanardi, Stefano Madrigali, Monica Civallero, Luigi Marcheselli, Isabella Marchi, Federica Domati, Marta Venturelli, Elena Barbieri, Giovanni Grandi, Enrico Tagliafico, Laura Cortesi
Summary: This study compared the prognostic and predictive roles of somatic BRCA (sBRCA) mutations versus germline BRCA (gBRCA) mutations in epithelial ovarian cancer patients, finding no significant advantage of sBRCA mutations over gBRCA mutations. The introduction of CNV analysis increased the detection rate of sBRCA mutations, but sBRCA mutation patients did not show any outcome advantage compared to wild-type patients.
Review
Biochemistry & Molecular Biology
Claudia Piombino, Ilenia Mastrolia, Claudia Omarini, Olivia Candini, Massimo Dominici, Federico Piacentini, Angela Toss
Summary: Liquid biopsies, as an alternative to molecular re-characterization, have been widely studied for monitoring tumor evolution and applied in early cancer diagnosis, tumor burden monitoring, tumor heterogeneity, molecular resistance, and minimal residual disease detection. Among extracellular vesicles, exosomes are considered one of the most promising predictors of early cancer diagnosis and treatment response due to their ability to reflect the biological fingerprints of parental cells and their crucial role in cell communication.
Editorial Material
Health Care Sciences & Services
Laura Cortesi, Claudia Piombino, Angela Toss
Summary: This article explores the role of germline mutations in HRR-related genes other than BRCA1/2 in predicting responses to treatment and prognosis in breast and pancreatic cancer. Mutations in PALB2 and ATM genes have shown potential as predictive factors for treatment response and prognosis, suggesting their inclusion in routine sequencing for biological characterization of these cancers.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Oncology
Chrystel Isca, Federico Piacentini, Ilenia Mastrolia, Valentina Masciale, Federica Caggia, Angela Toss, Claudia Piombino, Luca Moscetti, Monica Barbolini, Michela Maur, Massimo Dominici, Claudia Omarini
Summary: miRNAs play important roles in breast cancer, especially in HER2-positive breast cancer. They are being studied as potential biomarkers for prognosis and diagnosis. Despite the significant improvement in survival outcomes with anti-HER2 targeted therapies, drug resistance remains a challenge.
Review
Biochemistry & Molecular Biology
Fabio Canino, Federico Piacentini, Claudia Omarini, Angela Toss, Monica Barbolini, Patrizia Vici, Massimo Dominici, Luca Moscetti
Summary: This systematic review analyzed the potential correlations between intrinsic subtype, treatment efficacy, and patient outcome in HR+/HER2- mBC. It found that non-luminal subtypes were more common in endocrine-resistant patients and metastatic sites, had less benefit from endocrine therapy, and worse prognosis. HER2-enriched subtypes behaved similarly to HER2+ tumors and showed benefit from anti-HER2 agents, while basal-like subtypes were more sensitive to chemotherapy. Currently, intrinsic subtype does not play a decisive role in treatment choice but has potential prognostic and predictive value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Claudia Piombino, Laura Cortesi
Summary: The role of the PARP1 enzyme in recognizing and signaling DNA damage is important. PARP inhibitors are primarily used to treat breast, ovarian, pancreatic, and prostate cancers with BRCA1 or BRCA2 pathogenic variants, but their widespread use has raised the issue of therapy resistance. This review summarizes key molecular findings that could explain the development of primary or secondary resistance to PARP inhibitors.
Article
Health Care Sciences & Services
Chrystel Isca, Amelia Spinella, Angela Toss, Marco de Pinto, Guido Ficarra, Luca Fabbiani, Anna Iannone, Luca Magnani, Federica Lumetti, Pierluca Macripo, Caterina Vacchi, Elisa Gasparini, Simonetta Piana, Laura Cortesi, Antonino Maiorana, Carlo Salvarani, Massimo Dominici, Dilia Giuggioli
Summary: Several authors have reported an increased risk of cancer in SSc patients, with potential shared molecular pathways and mechanisms with breast cancer (BC). A study suggested a good prognosis for BC in SSc patients due to autoimmune factors. Analysis revealed higher TILs and PD-L1 expression in BC patients, indicating less aggressive behavior and potential for de-escalation strategy in cancer therapies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Genetics & Heredity
Luciana Mastrodomenico, Claudia Piombino, Beatrice Ricco, Elena Barbieri, Marta Venturelli, Federico Piacentini, Massimo Dominici, Laura Cortesi, Angela Toss
Summary: Hereditary cancer syndromes are inherited disorders caused by germline pathogenic variants that increase the risk of developing certain types of cancer. The personalized treatment of hereditary tumors that target germline pathogenic variants has shown promising results in clinical trials.
Review
Oncology
Claudia Piombino, Elena Tonni, Marco Oltrecolli, Marta Pirola, Stefania Pipitone, Cinzia Baldessari, Massimo Dominici, Roberto Sabbatini, Maria Giuseppa Vitale
Summary: This review summarizes the current evidence and ongoing clinical trials of immune checkpoint inhibitors (ICIs) in urothelial cancer (UC), discussing their role in different stages of the disease and potential benefits in combination with standard therapies. The use of ICIs as first-line treatment in platinum-unfit patients is still uncertain, but a new effective option may emerge from the ongoing EV-302 trial. The optimal duration of maintenance immunotherapy and the definitive patient subset for second-line treatment with ICIs are still under investigation. A promising association of ICIs with antibody-drug conjugates (ADCs) is also highlighted.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
