Effect of Flow-Induced Shear Stress in Nanomaterial Uptake by Cells: Focus on Targeted Anti-Cancer Therapy

Selective eradication of human non-small cell lung cancer cells using aptamer-decorated nanoparticles harboring a cytotoxic drug cargo

(2019) Shira Engelberg et al.   Cell Death & Disease

Recent advances in functional nanostructures as cancer photothermal therapy

(2018) Essraa Hussein et al.   International Journal of Nanomedicine

Influence of Silica Nanoparticle Density and Flow Conditions on Sedimentation, Cell Uptake, and Cytotoxicity

(2018) Mostafa Yazdimamaghani et al.   MOLECULAR PHARMACEUTICS

Fluid shear stress impacts ovarian cancer cell viability, subcellular organization, and promotes genomic instability

(2018) Alexandra R. Hyler et al.   PLoS One

Nanoparticle elasticity directs tumor uptake

(2018) Peng Guo et al.   Nature Communications

Cancer cell-selective, clathrin-mediated endocytosis of aptamerdecorated nanoparticles

(2018) Shira Engelberg et al.   Oncotarget

In Silico Models for Nanomedicine: Recent Developments

(2018) Pietro Mascheroni et al.   CURRENT MEDICINAL CHEMISTRY

Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles

(2017) Sara Salatin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Gold nanoparticle-gated mesoporous silica as redox-triggered drug delivery for chemo-photothermal synergistic therapy

(2017) Yang Yang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Unique size and shape-dependent uptake behaviors of non-spherical nanoparticles by endothelial cells due to a shearing flow

(2017) Patrick Jurney et al.   JOURNAL OF CONTROLLED RELEASE

Influence of shear stress and size on viability of endothelial cells exposed to gold nanoparticles

(2017) C. Fede et al.   JOURNAL OF NANOPARTICLE RESEARCH

Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip

(2017) Yu Du et al.   LAB ON A CHIP

Fluid shear stress activates YAP1 to promote cancer cell motility

(2017) Hyun Jung Lee et al.   Nature Communications

High Shear Stresses under Exercise Condition Destroy Circulating Tumor Cells in a Microfluidic System

(2017) Sagar Regmi et al.   Scientific Reports

A multi-component parallel-plate flow chamber system for studying the effect of exercise-induced wall shear stress on endothelial cells

(2016) Yan-Xia Wang et al.   Biomedical Engineering Online

GSH-dependent antioxidant defense contributes to the acclimation of colon cancer cells to acidic microenvironment

(2016) Minnan Zhao et al.   CELL CYCLE

Effects of shear stress on the cellular distribution of polystyrene nanoparticles in a biomimetic microfluidic system

(2016) Taehee Kang et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin

(2016) Afu Fu et al.   Oncotarget

Circulatory shear flow alters the viability and proliferation of circulating colon cancer cells

(2016) Rong Fan et al.   Scientific Reports

Elasticity of Nanoparticles Influences Their Blood Circulation, Phagocytosis, Endocytosis, and Targeting

(2015) Aaron C. Anselmo et al.   ACS Nano

Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer

(2015) Long Binh Vong et al.   BIOMATERIALS

Interaction between drug delivery vehicles and cells under the effect of shear stress

(2015) M. Godoy-Gallardo et al.   Biomicrofluidics

Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1

(2015) Jingyan Han et al.   JOURNAL OF CONTROLLED RELEASE

Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo

(2015) Alexandra C. Rinkenauer et al.   JOURNAL OF CONTROLLED RELEASE

Electrostatic interactions favor the binding of positive nanoparticles on cells: A reductive theory

(2015) Valérie Forest et al.   Nano Today

The influence of flow, shear stress and adhesion molecule targeting on gold nanoparticle uptake in human endothelial cells

(2015) Henrik Klingberg et al.   Nanoscale

Engineering and evaluating drug delivery particles in microfluidic devices

(2014) Mattias Björnmalm et al.   JOURNAL OF CONTROLLED RELEASE

Gold nanoparticles explore cells: Cellular uptake and their use as intracellular probes

(2014) Anna Huefner et al.   METHODS

Microfluidic platforms for advanced risk assessments of nanomaterials

(2014) Sanjeev Kumar Mahto et al.   Nanotoxicology

Interstitial fluid flow in cancer: implications for disease progression and treatment

(2014) Jennifer Munson et al.   Cancer Management and Research

Cell response to PEGylated poly(dopamine) coated liposomes considering shear stress

(2013) Boon M. Teo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Roles for GP IIb/IIIa and αvβ3 integrins in MDA-MB-231 cell invasion and shear flow-induced cancer cell mechanotransduction

(2013) Fenglong Zhao et al.   CANCER LETTERS

Shear Stress and Its Effect on the Interaction of Myoblast Cells with Nanosized Drug Delivery Vehicles

(2013) Leticia Hosta-Rigau et al.   MOLECULAR PHARMACEUTICS

Acute and Chronic Shear Stress Differently Regulate Endothelial Internalization of Nanocarriers Targeted to Platelet-Endothelial Cell Adhesion Molecule-1

(2012) Jingyan Han et al.   ACS Nano

Superior Penetration and Retention Behavior of 50 nm Gold Nanoparticles in Tumors

(2012) S. Huo et al.   CANCER RESEARCH

Interstitial Fluid Flow: The Mechanical Environment of Cells and Foundation of Meridians

(2012) Wei Yao et al.   Evidence-based Complementary and Alternative Medicine

Multifactorial determinants that govern nanoparticle uptake by human endothelial cells under flow

(2012) Adriele Prina-Mello et al.   International Journal of Nanomedicine

Shear-stress sensitive lenticular vesicles for targeted drug delivery

(2012) Margaret N. Holme et al.   Nature Nanotechnology

Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels

(2012) N. Korin et al.   SCIENCE

Uptake of hydrogel particles with different stiffness and its influence on HepG2 cell functions

(2012) Weijun Liu et al.   Soft Matter

The Initial Hours of Metastasis: The Importance of Cooperative Host-Tumor Cell Interactions during Hematogenous Dissemination

(2012) M. Labelle et al.   Cancer Discovery

Parallel-plate Flow Chamber and Continuous Flow Circuit to Evaluate Endothelial Progenitor Cells under Laminar Flow Shear Stress

(2012) Whitney O. Lane et al.   Jove-Journal of Visualized Experiments

On-Chip Evaluation of Shear Stress Effect on Cytotoxicity of Mesoporous Silica Nanoparticles

(2011) Donghyuk Kim et al.   ANALYTICAL CHEMISTRY

Gold nanoparticles functionalized with therapeutic and targeted peptides for cancer treatment

(2011) Anil Kumar et al.   BIOMATERIALS

Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy

(2011) Dong Nyoung Heo et al.   BIOMATERIALS

Optimizing particle size for targeting diseased microvasculature: from experiments to artificial neural networks

(2011) Daniela P. Boso et al.   International Journal of Nanomedicine

Biodegradable nanoparticles mimicking platelet binding as a targeted and controlled drug delivery system

(2011) Soujanya Kona et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A new perspective on in vitro assessment method for evaluating quantum dot toxicity by using microfluidics technology

(2010) Sanjeev Kumar Mahto et al.   Biomicrofluidics

Shear-regulated uptake of nanoparticles by endothelial cells and development of endothelial-targeting nanoparticles

(2009) Arthur Lin et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A