Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy

Pyk2 Signaling through Graf1 and RhoA GTPase is Required for Amyloid-β Oligomer Triggered Synapse Loss

(2019) Suho Lee et al.   JOURNAL OF NEUROSCIENCE

A systematic review of closed head injury models of mild traumatic brain injury in mice and rats

(2019) Colleen N Bodnar et al.   JOURNAL OF NEUROTRAUMA

Modelling human pathology of traumatic brain injury in animal models

(2019) M. Risling et al.   JOURNAL OF INTERNAL MEDICINE

Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model

(2019) Gehua Wen et al.   Frontiers in Psychiatry

Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease

(2019) Christopher H. van Dyck et al.   JAMA Neurology

Chronic Traumatic Encephalopathy: A Brief Overview

(2019) Arman Fesharaki-Zadeh   Frontiers in Neurology

A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity

(2019) Travis Rush et al.   NEUROBIOLOGY OF DISEASE

Chronic post-traumatic stress disorder-related traits in a rat model of low-level blast exposure

(2018) Georgina Perez-Garcia et al.   BEHAVIOURAL BRAIN RESEARCH

Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

(2018) Claudia B. Späni et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Minocycline plus N-Acetylcysteine Reduce Behavioral Deficits and Improve Histology with a Clinically Useful Time Window

(2018) Michael A. Sangobowale et al.   JOURNAL OF NEUROTRAUMA

Male and Female Mice Exhibit Divergent Responses of the Cortical Vasculature to Traumatic Brain Injury

(2018) Amandine Jullienne et al.   JOURNAL OF NEUROTRAUMA

Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model

(2018) Levi M. Smith et al.   NEUROPHARMACOLOGY

Gait and Conditioned Fear Impairments in a Mouse Model of Comorbid TBI and PTSD

(2018) Peyton Teutsch et al.   BEHAVIOURAL NEUROLOGY

Blast-induced "PTSD": Evidence from an animal model

(2018) Georgina Perez-Garcia et al.   NEUROPHARMACOLOGY

Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β Induced Synaptic Dysfunction and Loss

(2018) Santiago V. Salazar et al.   JOURNAL OF NEUROSCIENCE

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

(2018) Borislav Dejanovic et al.   NEURON

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

(2018) Alexandra Litvinchuk et al.   NEURON

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

(2017) Daniel J. Apicco et al.   NATURE NEUROSCIENCE

Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice

(2017) Zoe A. Klein et al.   NEURON

Sex differences in the effect of chronic mild stress on mouse prefrontal cortical BDNF levels: A role of major ovarian hormones

(2017) Bhanu Chandra Karisetty et al.   NEUROSCIENCE

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

(2017) Sarah L. DeVos et al.   Science Translational Medicine

Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer’s Mouse Phenotypes

(2017) Laura T. Haas et al.   Cell Reports

Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men

(2016) Joseph O. Ojo et al.   EXPERIMENTAL NEUROLOGY

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

(2016) Jing L. Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mild Traumatic Brain Injury with Social Defeat Stress Alters Anxiety, Contextual Fear Extinction, and Limbic Monoamines in Adult Rats

(2016) Daniel R. Davies et al.   Frontiers in Behavioral Neuroscience

Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease

(2016) Dawn H. W. Lau et al.   Acta Neuropathologica Communications

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

(2015) Adam C. Kaufman et al.   ANNALS OF NEUROLOGY

Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer’s disease

(2015) Laura T. Haas et al.   BRAIN

Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury

(2015) Y. Zou et al.   JOURNAL OF NEUROSCIENCE

A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer’s disease

(2015) Haakon B Nygaard et al.   Alzheimers Research & Therapy

Overcoming Drug Development Bottlenecks With Repurposing: Old drugs learn new tricks

(2014) Stephen M Strittmatter   NATURE MEDICINE

Fyn kinase inhibition as a novel therapy for Alzheimer’s disease

(2014) Haakon B Nygaard et al.   Alzheimers Research & Therapy

Neurobehavioral, neuropathological and biochemical profiles in a novel mouse model of co-morbid post-traumatic stress disorder and mild traumatic brain injury

(2014) Joseph O. Ojo et al.   Frontiers in Behavioral Neuroscience

Controlled Cortical Impact Model for Traumatic Brain Injury

(2014) Jennifer Romine et al.   Jove-Journal of Visualized Experiments

Prion Protein-mediated Toxicity of Amyloid-β Oligomers Requires Lipid Rafts and the Transmembrane LRP1

(2013) Jo V. Rushworth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Animal models of traumatic brain injury

(2013) Ye Xiong et al.   NATURE REVIEWS NEUROSCIENCE

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

Reversible Behavioral Deficits in Rats during a Cycle of Demyelination-Remyelination of the Fimbria

(2013) Natalia M. Grin'kina et al.   PLoS One

Amyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease

(2013) Ji Won Um et al.   Prion

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

The Complex PrPc-Fyn Couples Human Oligomeric A  with Pathological Tau Changes in Alzheimer's Disease

(2012) M. Larson et al.   JOURNAL OF NEUROSCIENCE

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model

(2012) L. E. Goldstein et al.   Science Translational Medicine

Mechanisms of Protein Seeding in Neurodegenerative Diseases

(2012) Lary C. Walker et al.   JAMA Neurology

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy

(2010) K. Bhaskar et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY