Article
Rheumatology
Hong Ki Min, Se Hee Kim, Kyung-Ann Lee, Joon-Hyung Jo, Young So, Hyun Woo Chung, Sang-Heon Lee, Hae-Rim Kim
Summary: This study compared the findings of salivary gland ultrasonography (SGUS) and salivary gland scintigraphy (SGS) in patients with primary SS. The study found that patients with a higher SGUS score had lower salivary gland function, and there was a significant correlation between SGUS score and SGS results. These findings suggest a possible predictive role of SGUS in diagnosing salivary gland dysfunction.
Article
Multidisciplinary Sciences
Youngjae Park, Minae Oh, Youn Soo Lee, Wan-Uk Kim
Summary: This study aimed to investigate the diagnostic performance of salivary ultrasonography (SGUS) and shear wave elastography (SWE) in evaluating secondary Sjogren's syndrome (sSS) in rheumatoid arthritis (RA) patients. The results showed that SGUS had good diagnostic performance in differentiating sSS from RA patients with simple sicca symptoms, similar to primary SS (pSS). Additionally, SWE reflected the histopathologic chronicity of minor salivary gland biopsy well in both pSS and sSS.
SCIENTIFIC REPORTS
(2023)
Article
Rheumatology
Esther Mossel, Martha S. van Ginkel, Erlin A. Haacke, Suzanne Arends, Silvia C. Liefers, Konstantina Delli, Jolien F. van Nimwegen, Alja J. Stel, Fred K. L. Spijkervet, Arjan Vissink, Bert van der Vegt, Frans G. M. Kroese, Hendrika Bootsma
Summary: The study aimed to understand the relative value of different approaches in assessing salivary gland involvement in pSS. The results showed that histopathology, salivary flow, and ultrasonography assess different constructs of salivary gland involvement and have low correlations. Therefore, these three modalities are complementary and cannot directly replace each other in the diagnosis of pSS.
Article
Pediatrics
Kristin Drew, Rene Kronlage, Seunghee Cha, Akaluck Thatayatikom, Thomas Schrepfer
Summary: Childhood Sjogren's Disease (cSjD) differs from Sjogren's Disease (SjD) in adults and is often underdiagnosed. A multimodal treatment plan involving sialendoscopy and medical management can effectively manage cSjD and achieve good treatment outcomes.
PEDIATRIC RHEUMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Raphael Andre, Minerva Becker, Tommaso Lombardi, Samanta Buchholzer, Francis Marchal, Jorg D. Seebach
Summary: This study retrospectively and observationally investigated the reliability and effectiveness of detecting glandular anomalies in patients with Sjogren's syndrome (SS) through MRSIAL examination. The results showed that MRSIAL accurately depicts the characteristic radiological signs of the parotid, sublingual, and submandibular salivary glands, which is crucial for the diagnosis of SS.
Article
Rheumatology
Ji-Won Kim, Roh Jin, Jae Ho Han, Jeong-Hyun Kang, Ju-Yang Jung, Chang-Hee Suh, Young-Sil An, Hyoun-Ah Kim
Summary: This study evaluated the association between salivary gland scintigraphy and clinical parameters in patients with primary Sjogren's syndrome (pSS). The results suggest that salivary gland scintigraphy may be an acceptable alternative method, especially when a non-invasive test is required.
CLINICAL RHEUMATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nao Wakasugi-Sato, Tatsurou Tanaka, Masafumi Oda, Shinobu Matsumoto-Takeda, Manabu Habu, Shun Nishimura, Osamu Takahashi, Ikuko Nishida, Hiroki Tsurushima, Taishi Otani, Jumpei Tanaka, Susumu Nishina, Daigo Yoshiga, Masaaki Sasaguri, Yasuhiro Morimoto
Summary: This study used MR sialography to investigate the distribution and drainage patterns of sublingual gland ducts in patients with ranula. The results suggest that the distribution of the sublingual gland ducts may be related to the formation of ranula.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Medicine, General & Internal
Weijia Li, Dipan Uppal, Yu Chiang Wang, Xiaobo Xu, Damianos G. Kokkinidis, Mark I. Travin, James M. Tauras
Summary: Cardiac amyloidosis is a challenging disease to diagnose due to its heterogeneous manifestations. While endomyocardial biopsy is considered the gold standard for diagnosis, radionuclide cardiac imaging has become more commonly used for diagnosing ATTR amyloidosis. Further research in imaging protocols is needed to improve quantification of disease burden and prognosis prediction.
Review
Oncology
Boon Fei Tan, Wei Chang Colin Tan, Fu Qiang Wang, Matt Lechner, Volker Hans Schartinger, Daniel Shao Weng Tan, Kelvin Siu Hoong Loke, Wen Long Nei
Summary: This systematic review explores the potential role of PSMA PET imaging and therapy as a theranostic tool for adenoid cystic carcinoma (ACC) and other salivary gland cancers (SGCs). Despite a limited number of studies, PSMA PET shows promising prospects in detecting lesions in ACC and SGC that are not detected on standard imaging. Further research is needed to guide its real-world use.
Article
Medicine, General & Internal
K. Hakki Karagozoglu, Anissa Mahraoui, Joseph C. J. Bot, Seunghee Cha, Jean-Pierre T. F. Ho, Marco N. Helder, Henk S. Brand, Imke H. Bartelink, Arjan Vissink, Gary A. Weisman, Derk Hendrik Jan Jager
Summary: Through sialendoscopy, CEUSS was tested for its safety and feasibility in SS patients. The results showed that CEUSS is a safe and feasible treatment that has the potential to increase salivary secretion and reduce xerostomia in SS patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Alen Zabotti, Sara Zandonella Callegher, Michele Lorenzon, Enrico Pegolo, Cathryn A. Scott, Alessandro Tel, Ivan Giovannini, Massimo Robiony, Carla Di Loreto, Chiara Zuiani, Salvatore De Vita
Summary: This study evaluated the diagnostic accuracy and safety of US-guided core needle biopsy (CNB) of major salivary glands compared with open surgical biopsy in patients with primary Sjögren's syndrome (pSS). The results showed that US-guided CNB is a novel, clinically relevant, and safe approach for managing pSS patients with persistent enlargement of the parotid or submandibular glands.
Article
Radiology, Nuclear Medicine & Medical Imaging
Omneya Gamaleldin, Emad Magdy, Hesham Zoheir, Gihan Shehata, Nermeen Elsebaie
Summary: This study evaluated the role of MRI and MR sialography in salivary gland calculi and compared the findings with sialendoscopy. The results showed excellent agreement between the two methods in detecting and counting calculi, as well as accurately measuring their size and location. MRI was also found to accurately map the ducts, which is beneficial for sialendoscopists.
POLISH JOURNAL OF RADIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Y. Zhao, D. Zheng, L. Zhang, X. Xie, D. Liu, G. Yu
Summary: The aim of this study was to evaluate the gland function of patients who had undergone endoscopy-assisted removal of impacted hilo-parenchymal stones in the Wharton's duct. The study found that postoperative ultrasonography revealed regular gland size in 58.8% of affected glands, normal parenchyma density in 51.0%, and ductal ectasia in 80.4%. Sialograms showed different types of ectasia and contrast retention. The study concluded that endoscopy-assisted surgery and extended follow-up can preserve the gland with good function in patients with hilo-parenchymal submandibular gland stones.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2023)
Article
Medicine, Research & Experimental
Philippe Galli, Antoine Ceva, Jean-Marc Foletti, Nicolas Iline, Roch Giorgi, Cyrille Chossegros, Nicolas Graillon
Summary: The study evaluated the recurrence rate of salivary gland lithiasis after minimally invasive surgery, finding a low recurrence rate occurring typically between 3 to 46 months postoperatively. Recurrences most frequently involved the submandibular gland and patients initially treated by transoral approach were more likely to experience recurrence.
Article
Otorhinolaryngology
Urs Borner, Lukas Anschuetz, Marco Caversaccio, Moritz von Werdt, Eugene Panosetti, Jerome Keghian, Marc Remacle
Summary: Multiple affected salivary gland diseases are rare and pose diagnostic challenges. Interventional sialendoscopy is an effective and safe therapeutic option for this specific patient cohort.
ENT-EAR NOSE & THROAT JOURNAL
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Alfred O. Ankrah, Ismaheel O. Lawal, Rudi A. J. O. Dierckx, Mike M. Sathekge, Andor W. J. M. Glaudemans
Summary: The population at risk for invasive fungal disease has increased due to medical therapy advances and diseases compromising the immune system. Non-invasive and indirect evidence, such as serology and imaging, has been used for early diagnosis of fungal infection. Imaging serves as a non-invasive biomarker for early diagnosis and monitoring of infection during treatment.
SEMINARS IN NUCLEAR MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Nick D. van Rijsewijk, Frank F. A. IJpma, Marjan Wouthuyzen-Bakker, Andor W. J. M. Glaudemans
Summary: F-18-FDG PET/CT has good diagnostic accuracy and value in the diagnosis of fever of unknown origin, providing reliable results in various patient groups. Compared to 67Ga-citrate and WBC scintigraphy, F-18-FDG PET/CT has been more extensively researched and is preferred due to its advantages and shorter procedural duration.
SEMINARS IN NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
N. D. van Rijsewijk, B. van Leer, O. V. Ivashchenko, E. H. Scholvinck, F. van den Heuvel, J. H. van Snick, R. H. J. A. Slart, W. Noordzij, A. W. J. M. Glaudemans
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Mieke C. Zwager, Rico Bense, Stijn Waaijer, Si-Qi Qiu, Hetty Timmer-Bosscha, Elisabeth G. E. de Vries, Carolien P. Schroder, Bert van der Vegt
Summary: The purpose of this study was to optimize the assessment of tumour-associated macrophage subsets in different breast cancer subtypes and relate them to clinicopathological characteristics and clinical outcomes. The results showed that CD68+, CD163+, and CSF-1R+ macrophages correlated with tumour grade in Luminal-B breast cancer. However, total or subset TAM numbers did not correlate with disease outcome in any breast cancer subtype.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Infectious Diseases
Marjan Wouthuyzen-Bakker, Marleen van Oosten, Wouter Bierman, Rik Winter, Andor Glaudemans, Riemer Slart, Marlous Toren-Wielema, Ignace Tielliu, Clark J. Zeebregts, Niek H. J. Prakken, Jean Paul de Vries, Ben R. Saleem
Summary: Vascular graft or endograft infection (VGEI) is a serious complication of vascular surgery, which has high morbidity and mortality rates. To diagnose and treat VGEI effectively, a multidisciplinary team of vascular surgeons, infectious disease specialists, medical microbiologists, radiologists, nuclear medicine specialists, and hospital pharmacists is required. A structured diagnostic, antibiotic, and surgical treatment algorithm can help guide clinical decision-making and improve the clinical outcome of patients with VGEI.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Derk ten Hove, Ali R. Wahadat, Riemer H. J. A. Slart, Marjan Wouthuyzen-Bakker, Gianclaudio Mecozzi, Kevin Damman, Hester Witteveen, Kadir Caliskan, Olivier C. Manintveld, Bhanu Sinha, Ricardo P. J. Budde, Andor W. J. M. Glaudemans
Summary: This study evaluated the diagnostic capability of [F-18]FDG PET/CT for device-related infections (DRIs) in heart failure patients and investigated the factors affecting its accuracy. The results showed that [F-18]FDG PET/CT reliably predicts the presence of DRI in LVAD recipients, and semi-quantitative analysis can increase the specificity of [F-18]FDG PET/CT for the analysis of central device component infection.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Kornelis S. M. van der Geest, Berend G. C. Slijkhuis, Alessandro Tomelleri, Olivier Gheysens, William F. Jiemy, Costanza Piccolo, Pieter Nienhuis, Maria Sandovici, Elisabeth Brouwer, Andor W. J. M. Glaudemans, Douwe J. Mulder, Riemer H. J. A. Slart
Summary: FDG-PET/CT is a valuable diagnostic tool for identifying inflammation in large and medium-sized blood vessels in patients with systemic vasculitides. It can complement other vascular imaging techniques such as ultrasound, CTA, and MRA. In addition, FDG-PET/CT plays an important role in monitoring the treatment of vasculitis patients. The introduction of new immune-cell targeted radiotracers may enable direct visualization of inflammatory cell infiltrates in the vasculature of vasculitis patients.
CARDIOLOGY CLINICS
(2023)
Article
Oncology
E. C. de Heer, C. E. Zois, E. Bridges, B. van der Vegt, H. Sheldon, W. A. Veldman, M. C. Zwager, T. van der Sluis, S. Haider, T. Morita, O. Baba, C. P. Schroder, S. de Jong, A. L. Harris, M. Jalving
Summary: The study found that the gene GYS1 is related to tumor growth and therapy resistance in breast cancer, especially in triple-negative breast cancer. Inhibiting GYS1 weakens the proliferation ability of breast cancer cells and makes them more sensitive to inhibition of mitochondrial proteostasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, General & Internal
Navin Suthahar, Dongyu Wang, Joseph Pierre Aboumsallem, Canxia Shi, Sanne de Wit, Elizabeth E. Liu, Emily S. Lau, Stephan J. L. Bakker, Ron. T. Gansevoort, Bert van der Vegt, Manol Jovani, Bernard E. Kreger, Greta Lee Splansky, Emelia J. Benjamin, Ramachandran S. Vasan, Martin G. Larson, Daniel Levy, Jennifer E. Ho, Rudolf A. de Boer
Summary: This study evaluated the value of serial CRP measurements in predicting the risk of CVD, cancer, and mortality. The results showed that both baseline CRP levels and subsequent increases in CRP were associated with future CVD, cancer, and mortality.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Rheumatology
Martha S. van Ginkel, Suzanne Arends, Bert van der Vegt, Marcel Nijland, Fred K. L. Spijkervet, Arjan Vissink, Frans G. M. Kroese, Andor W. J. M. Glaudemans, Hendrika Bootsma
Summary: This study aimed to assess the usefulness of [F-18]-fluorodeoxyglucose (FDG)-PET/CT in discriminating primary Sjögren's syndrome (pSS) patients with and without lymphomas, as well as evaluating systemic disease activity in pSS. The results showed that FDG-PET/CT can assist in identifying pSS-associated lymphomas and detecting systemic manifestations in pSS patients.
Article
Medicine, General & Internal
Andor W. J. M. Glaudemans, Olivier Gheysens
Summary: Nuclear medicine imaging techniques have gained widespread acceptance in diagnosing and monitoring infectious and inflammatory diseases. PET imaging has been incorporated into diagnostic flowcharts in recent clinical guidelines. This perspective paper discusses current guidelines, limitations, and future research goals for achieving the differentiation between infection, inflammation, and malignancy in nuclear medicine.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Sarah Pringle, Floris J. Bikker, Wouter Vogel, Bernadette S. de Bakker, Ingrid Hofland, Bert van der Vegt, Hendrika Bootsma, Frans Kroese, Arjan Vissink, Matthijs Valstar
Summary: Based on histological and immunohistochemical analyses, the tubarial glands resemble salivary glands in terms of tissue and cellular expression, specifically resembling the palatal and labial glands.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Mostafa Roya, Samaneh Mostafapour, Philipp Mohr, Laura Providencia, Zekai Li, Johannes H. van Snick, Adrienne H. Brouwers, Walter Noordzij, Antoon T. M. Willemsen, Rudi A. J. O. Dierckx, Adriaan A. Lammertsma, Andor W. J. M. Glaudemans, Charalampos Tsoumpas, Riemer H. J. A. Slart, Joyce van Sluis
Summary: Recently, a new type of PET scanner with long axial field-of-view (LAFOV) has been introduced in clinical practice. Compared to conventional PET scanners, LAFOV scanners have a larger coverage and higher sensitivity, providing new opportunities for clinical applications, such as reducing scan time, decreasing the amount of radiotracer used, and using dynamic or parametric imaging. Emerging technologies like artificial intelligence and imaging with multiple radiotracers can further enhance the clinical application of LAFOV PET.
Article
Biochemistry & Molecular Biology
Chiara Lauri, Giuseppe Campagna, Andor W. J. M. Glaudemans, Riemer H. J. A. Slart, Bram van Leer, Janesh Pillay, Marzia Colandrea, Chiara Maria Grana, Antonio Stigliano, Alberto Signore
Summary: This study aimed to evaluate the metabolic activity of the thyroid and adrenal glands in COVID-19 patients using F-18-FDG PET/CT. The results showed persistent low adrenal uptake in COVID-19 patients, suggesting chronic hypofunction. However, the thyroid uptake in COVID-19 patients was comparable to normal subjects at disease onset, but some patients showed increased metabolism after recovery, potentially indicating the onset of inflammatory thyroiditis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Bram van Leer, Johannes H. van Snick, Mark Londema, Maarten W. N. Nijsten, Oemer Kasalak, Riemer H. J. A. Slart, Andor W. J. M. Glaudemans, Janesh Pillay
Summary: We report the findings of four critically ill patients with persistent inflammation during late phase of COVID-19 who underwent [F-18]FDG-PET/CT imaging. PET/CT findings showed that bilateral lung anomalies could explain the increased CRP and leukocytes in all patients. Based on PET/CT results, secondary infection/inflammatory focus was suspected in two patients (pancreatitis and gastritis). Lymphadenopathy was present in patients with detectable SARS-CoV-2 viral load. Muscle uptake around the hips or shoulders was observed in all patients, possibly due to the process of heterotopic ossification.
CLINICAL AND TRANSLATIONAL IMAGING
(2023)
