Role of Lopinavir/Ritonavir in the Treatment of Covid-19: A Review of Current Evidence, Guideline Recommendations, and Perspectives

Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore

(2020) Barnaby Edward Young et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Systematic Review of Lopinavir Therapy for SARS Coronavirus and MERS Coronavirus–A Possible Reference for Coronavirus Disease‐19 Treatment Option

(2020) Tian‐Tian Yao et al.   JOURNAL OF MEDICAL VIROLOGY

Why Are Lopinavir and Ritonavir Effective against the Newly Emerged Coronavirus 2019? Atomistic Insights into the Inhibitory Mechanisms

(2020) Bodee Nutho et al.   BIOCHEMISTRY

Discontinuation of antiviral drugs may be the reason for recovered COVID-19 patients testing positive again

(2020) Fanqi Wu et al.   BRITISH JOURNAL OF HOSPITAL MEDICINE

Treatment of patients with nonsevere and severe coronavirus disease 2019: an evidence-based guideline

(2020) Zhikang Ye et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Risk Factors of Severe Disease and Efficacy of Treatment in Patients Infected with COVID-19: A Systematic Review, Meta-Analysis and Meta-Regression Analysis

(2020) John J Y Zhang et al.   CLINICAL INFECTIOUS DISEASES

Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19

(2020) Adarsh Bhimraj et al.   CLINICAL INFECTIOUS DISEASES

Balancing evidence and frontline experience in the early phases of the COVID-19 pandemic: current position of the Italian Society of Anti-infective Therapy (SITA) and the Italian Society of Pulmonology (SIP)

(2020) M. Bassetti et al.   CLINICAL MICROBIOLOGY AND INFECTION

Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19)

(2020) Waleed Alhazzani et al.   CRITICAL CARE MEDICINE

SARS CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and Other Drugs for the Treatment of the New Coronavirus

(2020) Michele Costanzo et al.   CURRENT MEDICINAL CHEMISTRY

Lopinavir/ritonavir in COVID-19 patients: maybe yes, but at what dose?

(2020) Sara Baldelli et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Fast Identification of Possible Drug Treatment of Coronavirus Disease-19 (COVID-19) through Computational Drug Repurposing Study

(2020) Junmei Wang   Journal of Chemical Information and Modeling

Arbidol monotherapy is superior to lopinavir/ritonavir in treating COVID-19

(2020) Zhen Zhu et al.   JOURNAL OF INFECTION

Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study

(2020) Lisi Deng et al.   JOURNAL OF INFECTION

Lopinavir/ritonavir did not shorten the duration of SARS CoV-2 shedding in patients with mild pneumonia in Taiwan

(2020) Chien-Yu Cheng et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

(2020) Ivan Fan-Ngai Hung et al.   LANCET

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Race to find COVID-19 treatments accelerates

(2020) Kai Kupferschmidt et al.   SCIENCE

Drug treatment options for the 2019-new coronavirus (2019-nCoV)

(2020) Hongzhou Lu   BioScience Trends

Systematic review of the efficacy and safety of antiretroviral drugs against SARS, MERS or COVID‐19: initial assessment

(2020) Nathan Ford et al.   Journal of the International AIDS Society

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

(2020) Ka-Tim Choy et al.   ANTIVIRAL RESEARCH

Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy

(2020) Simone Piva et al.   JOURNAL OF CRITICAL CARE

Efficacy and safety of current therapeutic options for COVID-19 - lessons to be learnt from SARS and MERS epidemic: A systematic review and meta-analysis

(2020) Han Zhong et al.   PHARMACOLOGICAL RESEARCH

Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial

(2018) Yaseen M. Arabi et al.   Trials

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

(2015) Jasper Fuk-Woo Chan et al.   JOURNAL OF INFECTIOUS DISEASES

Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture

(2014) Adriaan H. de Wilde et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY