Article
Immunology
Ikram Omar Osman, Clea Melenotte, Philippe Brouqui, Matthieu Million, Jean-Christophe Lagier, Philippe Parola, Andreas Stein, Bernard La Scola, Line Meddeb, Jean-Louis Mege, Didier Raoult, Christian A. Devaux
Summary: SARS-CoV-2 infection can lead to variations in ACE2 expression and Ang II plasma concentration, potentially affecting blood pressure regulation and COVID-19 outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Agnieszka Dettlaff-Pokora, Julian Swierczynski
Summary: SARS-CoV-2 impairs the renin-angiotensin-aldosterone system by binding the ACE2 enzyme, leading to an increase in angiotensin 2 and a decrease in angiotensin (1-7), potentially worsening damage to the lungs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Simon B. Gressens, Georges Leftheriotis, Jean-Claude Dussaule, Martin Flamant, Bernard I. Levy, Emmanuelle Vidal-Petiot
Summary: This review explores the risks of using RAAS blockers for patients with cardiovascular comorbidities during the COVID-19 pandemic, investigates the impact of RAAS blockers on viral cell entry, and discusses how to maintain the balance between ACE2 and ACE and the effect of RAAS blockers on the course and prognosis of COVID-19 treatment.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Immunology
Keiji Kuba, Tomokazu Yamaguchi, Josef M. Penninger
Summary: Seventeen years after the SARS epidemic, the emergence of the novel coronavirus SARS-CoV-2 has led to an unprecedented pandemic. ACE2 plays a crucial role in cell entry of SARS-CoV-2 and its high affinity to ACE2 results in increased infectivity and transmissibility. In addition to serving as the receptor for SARS-CoV-2, ACE2 also plays an important role in various aspects of COVID-19 pathogenesis and potential post-COVID-19 syndromes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Michal Herman-Edelstein, Tali Guetta, Amir Barnea, Maayan Waldman, Naomi Ben-Dor, Yaron Barak, Ran Kornowski, Michael Arad, Edith Hochhauser, Dan Aravot
Summary: This study found that ACE2 expression is increased in diabetic hearts and positively correlated with glycosylated hemoglobin, body mass index, and activation of the renin angiotensin system, indicating that patients with uncontrolled diabetes or obesity with RAS activation have higher ACE2 expression and are at higher risk for severe infection. Additionally, there was no correlation between plasma free ACE2 and cardiac tissue ACE2 expression. Transmembrane serine protease 2, metalloprotease ADAM10, and ADAM17, which facilitate viral-ACE2 complex entry and degradation, were increased in diabetic hearts.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Filippo Scialo, Maria Vitale, Aurora Daniele, Ersilia Nigro, Fabio Perrotta, Monica Gelzo, Carlo Iadevaia, Francesco Saverio Cerqua, Adriano Costigliola, Valentino Allocca, Felice Amato, Lucio Pastore, Giuseppe Castaldo, Andrea Bianco
Summary: The COVID-19 pandemic has had a significant impact on socio-economic life, especially posing higher risks for individuals with underlying health conditions. Despite year-long efforts in academic research, there is still much to learn about SARS-CoV-2 and its potential future impacts on human health.
Article
Cardiac & Cardiovascular Systems
Fabio Angeli, Paolo Verdecchia, Antonella Balestrino, Claudio Bruschi, Piero Ceriana, Luca Chiovato, Laura Adelaide Dalla Vecchia, Francesco Fanfulla, Maria Teresa La Rovere, Francesca Perego, Simonetta Scalvini, Antonio Spanevello, Egidio Traversi, Dina Visca, Michele Vitacca, Tiziana Bachetti
Summary: This prospective study indicates that exposure to renin-angiotensin system modifiers, particularly angiotensin receptor blockers (ARBs), significantly reduces the risk of in-hospital mortality in patients with COVID-19.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Biology
Tuemay Capraz, Nikolaus F. Kienzl, Elisabeth Laurent, Jan W. Perthold, Esther Foederl-Hoebenreich, Clemens Gruenwald-Gruber, Daniel Maresch, Vanessa Monteil, Janine Niederhofer, Gerald Wirnsberger, Ali Mirazimi, Kurt Zatloukal, Lukas Mach, Josef M. Penninger, Chris Oostenbrink, Johannes Stadlmann
Summary: The interaction between the Spike protein of SARS-CoV-2 and ACE2 on host cells is crucial for viral entry, with glycosylation playing a critical role. Engineering ACE2 glycosylation can enhance virus neutralization without affecting protein stability or activity. Removing all N-glycans from recombinant soluble human ACE2 can create a superior decoy receptor for effective COVID-19 treatment.
Review
Medicine, General & Internal
Fabio Angeli, Antonio Spanevello, Gianpaolo Reboldi, Dina Visca, Paolo Verdecchia
Summary: SARS-CoV-2 vaccines can elicit immune responses but concerns about cardiovascular adverse reactions have been raised. Vaccines can increase Spike protein synthesis and immune responses, with genetic and immunological factors possibly impacting reactions.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Murtala Bello Abubakar, Dawoud Usman, Gaber El-Saber Batiha, Natalia Cruz-Martins, Ibrahim Malami, Kasimu Ghandi Ibrahim, Bilyaminu Abubakar, Muhammad Bashir Bello, Aliyu Muhammad, Siew Hua Gan, Aliyu Ibrahim Dabai, M. Alblihed, Arabinda Ghosh, Reem H. Badr, Devarajan Thangadurai, Mustapha Umar Imam
Summary: COVID-19 is a potentially fatal multisystemic infection caused by SARS-CoV-2, with a lack of cost-effective, safe, and readily available therapeutic options. Traditional herbs used in African and Asian regions may contribute to a lesser burden of the pandemic. Ethnomedicinal plants containing bioactive compounds could potentially mitigate COVID-19 by modulating ACE2 activity.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biology
Luana Heimfarth, Mario Adriano dos Santos, Jose Augusto Barreto-Filho, Andre Sales Barreto, Fabricio Nunes Macedo, Adriano Antunes de Souza Araujo, Paulo Martins-Filho, Marcus Tullius Scotti, Luciana Scotti, Lucindo Jose Quintans-Junior
Summary: The COVID-19 pandemic has caused chaos in healthcare systems and there is currently no specific treatment available. Drugs with inverse agonist effects to the angiotensin-1 receptor may be promising tools in managing COVID-19 cases. Further research is needed to determine the effectiveness of angiotensin receptor blockers in treating COVID-19.
Article
Virology
Sandeep Singh, Christine Widrich, Martijn Nap, Emile Schokker, Aeilko H. Zwinderman, Sara-Joan Pinto-Sietsma
Summary: A global analysis was conducted to explore the association between antihypertensive medications and SARS-CoV-2 severity. The results suggest that ARBs and CCBs may have a protective effect against death from SARS-CoV-2 infection, while ACEis may be associated with a higher mortality rate.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Pharmacology & Pharmacy
Alexis Q. Dean, William P. Bozza, Julianne D. Twomey, Shen Luo, Ancy Nalli, Baolin Zhang
Summary: ACE2 plays a dual role in COVID-19, depending on the stage of infection and coexisting diseases in patients.
DRUG DISCOVERY TODAY
(2021)
Review
Medicine, General & Internal
Fabio Angeli, Gianpaolo Reboldi, Monica Trapasso, Martina Zappa, Antonio Spanevello, Paolo Verdecchia
Summary: The dysregulation of the renin-angiotensin system (RAS) plays a significant role in the pathogenesis of COVID-19, primarily due to the imbalance between angiotensin II and angiotensin(1-7) caused by the interaction between SARS-CoV-2 and ACE(2) receptors. Understanding the mechanisms of Ang II cleavage and accumulation provides insights into the risk of severe COVID-19 and potential adverse reactions to vaccination.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Gianluigi Savarese, Lina Benson, Johan Sundstrom, Lars H. Lund
Summary: In a nationwide cohort study in Sweden, the use of RAASi was not associated with an increased risk of hospitalization for or death from COVID-19.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Letter
Rheumatology
Martin Sebastian Winkler, Peter Korsten, Claudia Binder, Bjoern Tampe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Environmental Sciences
Paula Yumi Takeda, Jackeline Tatiane Gotardo, Simone Damasceno Gomes
Summary: This study evaluated the performance of anaerobic co-digestion of landfill leachate and crude glycerol, and found that the association of these substrates led to high organic matter removal efficiency and specific biogas production. Optimization through Central Composite Rotational Design and the modified Gompertz model improved the digestion conditions and significantly increased specific biogas production.
ENVIRONMENTAL TECHNOLOGY
(2022)
Article
Environmental Sciences
Luana Negris, Helisson N. Santos, Rochele S. Picoloto, Felipe E. A. Alves, Erico M. M. Flores, Maria F. P. Santos, Maristela A. Vicente
Summary: This study proposes the use of an ultrasound-assisted adsorption system to improve the removal of iron from groundwater. With optimized conditions, the method achieved nearly 100% iron removal efficiency for FeSO(4) solution, which was significantly higher than the efficiency without ultrasound.
ENVIRONMENTAL TECHNOLOGY
(2022)
Article
Oncology
Yi Liao, Senmao Li, Hao Chen, Chunyu Chen, Jintuan Huang, Feng Lin, Jianping Wang, Zuli Yang
Summary: A risk prediction system combining FIT and risk factors was developed to improve the sensitivity of colonoscopy screening. The system effectively stratified participants into high risk and low risk groups, with better predictive ability for colorectal neoplasia compared to using FIT alone.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Luca Giraldi, Jovana Stojanovic, Dario Arzani, Roberto Persiani, Jinfu Hu, Kenneth C. Johnson, Zuo-Feng Zhang, Monica Ferraroni, Domenico Palli, Guo-Pei Yu, Carlo La Vecchia, Claudio Pelucchi, Nuno Lunet, Ana Ferro, Reza Malekzadeh, Joshua Muscat, David Zaridze, Dmitry Maximovich, Nuria Aragones, Vicente Martin, Jesus Vioque, Eva M. Navarrete-Munoz, Mohammadreza Pakseresht, Eva Negri, Matteo Rota, Farhad Pourfarzi, Lina Mu, Robert C. Kurtz, Areti Lagiou, Pagona Lagiou, Roberta Pastorino, Stefania Boccia
Summary: This study aimed to examine the association between height and risk of gastric cancer. Through a large pooled analysis of case-control studies, the study found no significant association between adult height and gastric cancer.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Maria A. Karalexi, Marina Servitzoglou, Vassilios Papadakis, Denis Kachanov, Maja Cesen Mazic, Margaret Baka, Maria Moschovi, Maria Kourti, Sofia Polychronopoulou, Eftichia Stiakaki, Emmanuel Hatzipantelis, Helen Dana, Kalliopi Stefanaki, Astero Malama, Marios S. Themistocleous, Katerina Strantzia, Tatyana Shamanskaya, Panagiota Bouka, Paraskevi Panagopoulou, Maria Kantzanou, Evangelia Ntzani, Nick Dessypris, Eleni Th. Petridou
Summary: The prognosis of children with neuroblastoma varies depending on the stage and biology of the tumor, and early-stage neuroblastoma has a better prognosis. Treatment with anti-GD2 antibody can improve the prognosis of high-risk patients.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Emergency Medicine
Asami Okada, Yohei Okada, Hiromichi Narumiya, Wataru Ishii, Tetsuhisa Kitamura, Ryoji Iiduka
Summary: This study found an association between hypothermia and hyperthermia at hospital arrival and increased in-hospital mortality in adult trauma patients.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Shubhangi Kandwal, Darren Fayne
Summary: The COVID-19 pandemic has had a negative impact on global human life, causing economic crises and health emergencies. In this study, computational drug design technologies were used to repurpose existing drugs as inhibitors of SARS-CoV-2 viral proteins. The results may help accelerate drug development against COVID-19 and have significant implications.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Public, Environmental & Occupational Health
Li-Chien Chien, Christian K. Bey, Kristi L. Koenig
Summary: The authors discuss how Taiwan achieved control of COVID-19 without economic shutdown by implementing established public health principles and non-pharmaceutical interventions. Taiwan's success in creating quasi population immunity and preventing local transmission serves as a model for optimal public health management of COVID-19 and future emerging infectious diseases.
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2022)
Review
Clinical Neurology
Christoph Eckhard Heyde, Ulrich Josef Albert Spiegl, Anna Voelker, Nicolas von der Hoeh, Jeanette Henkelmann
Summary: The prevalence of nonspecific pyogenic spondylodiskitis has increased, causing high morbidity and mortality. The diagnosis is often delayed due to nonspecific clinical manifestations at the early stage. CT can assess the bony condition, while MRI is still the gold standard for diagnosis.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Article
Pharmacology & Pharmacy
David L. Bankes, Hubert Jin, Reginald Williams, Michael S. Awadalla, Joshua Johnson, Jacques Turgeon, Alan Stein
Summary: A medication safety review (MSR) is a pharmacist-driven intervention that aims to mitigate adverse drug event risk. Implementation of pharmacists' recommendations in MSRs was associated with improved health care resource utilization and mortality for beneficiaries enrolled in the enhanced medication therapy management (EMTM) model.
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
(2023)
Editorial Material
Pharmacology & Pharmacy
Pamela Dow, Veronique Michaud, Jacques Turgeon
Summary: A nonoptimized medication therapy (NOMT) event refers to medication-related hazards or incidents that are a leading cause of death, serious injury, and illness. These events are often associated with multidrug interactions in patients with polypharmacy. Advanced clinical decision support systems and interventions can help prevent NOMT events by separating the administration times of certain drugs. Medication reconciliation and considering individual variability in drug response can reduce adverse effects, while patient pharmacogenomic information combined with phenoconversion probability is valuable for patients with polypharmacy. Population-level measures such as adding virtual drugs to drug regimens and using medication risk scores can predict the risk of NOMT events.
CLINICAL THERAPEUTICS
(2023)
Review
Health Care Sciences & Services
Teresa T. T. Ho, Melissa Noble, Bao Anh Tran, Katlynd Sunjic, Sheeba Varghese Gupta, Jacques Turgeon, Rustin D. D. Crutchley
Summary: Diazepam is commonly used to manage severe alcohol withdrawal syndrome, but some patients experience refractory withdrawal syndromes or adverse reactions. The genetic variants in the CYP2C19 gene have an impact on the pharmacokinetics of diazepam and treatment outcomes for alcohol withdrawal syndrome.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Medicine, General & Internal
Joshua Russell, Meghan J. Arwood, Nicole M. Del Toro-Pagan, Nishita S. Amin, Michele D. Cambridge, Jacques Turgeon, Veronique Michaud
Summary: Pharmacotherapy for major depressive disorder often involves trial-and-error and clinician preference, which can lead to prolonged treatment and adverse drug events. Pharmacogenomics can assist in prescribing appropriate antidepressants and reduce the occurrence of drug interactions. This case report highlights the importance of multi-drug interaction assessment and preemptive pharmacogenomic testing to inform prescribing decisions and prevent adverse effects.
MEDICINA-LITHUANIA
(2023)
Article
Ergonomics
Elpidio Maria Garzillo, Maria Grazia Lourdes Monaco, Antonio Spacone, Enrica Inglese, Monica Lamberti, Domenico Pompei
Summary: This study evaluates the response capacity of some Italian companies to the emergency regarding the health and safety of workers. The study found that Italian companies have shown a good response to the regulatory restrictions resulting from the SARS-CoV-2 emergency, especially large enterprises and the banking sector.
INTERNATIONAL JOURNAL OF OCCUPATIONAL SAFETY AND ERGONOMICS
(2022)