Interrogating the immune-modulating roles of radiation therapy for a rational combination with immune-checkpoint inhibitors in treating pancreatic cancer

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Indoleamine Dioxygenase Inhibitors: Clinical Rationale and Current Development

(2019) Mayanne M. T. Zhu et al.   Current Oncology Reports

Radiotherapy is an independent prognostic marker of favorable prognosis in non‐small cell lung cancer patients after treatment with the immune checkpoint inhibitor, nivolumab

(2019) Ou Yamaguchi et al.   Thoracic Cancer

IDO1 inhibition potentiates vaccine-induced immunity against pancreatic adenocarcinoma

(2019) Alex B. Blair et al.   JOURNAL OF CLINICAL INVESTIGATION

Integration of radiation and immunotherapy in breast cancer - Treatment implications

(2018) Jason C. Ye et al.   BREAST

IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma

(2018) Erik Ladomersky et al.   CLINICAL CANCER RESEARCH

Radiation therapy and immunotherapy: what is the optimal timing or sequencing?

(2018) Maureen L Aliru et al.   Immunotherapy

Abscopal Effects With Hypofractionated Schedules Extending Into the Effector Phase of the Tumor-Specific T-Cell Response

(2018) Xuanwei Zhang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The Evolving Role of Radiation in Pancreatic Cancer

(2018) Evan Landau et al.   SURGICAL CLINICS OF NORTH AMERICA

Abstract 4282: Deconvolution of plasma-derived exosomes for tracking and prediction of immunotherapy across multiple tissues

(2018) Alvin Shi et al.   CANCER RESEARCH

Epacadostat (E) plus pembrolizumab (P) versus pembrolizumab alone in patients (pts) with unresectable or metastatic melanoma: Results of the phase 3 ECHO-301/KEYNOTE-252 study.

(2018) Georgina V. Long et al.   JOURNAL OF CLINICAL ONCOLOGY

Epacadostat Plus Pembrolizumab in Patients With Advanced Solid Tumors: Phase I Results From a Multicenter, Open-Label Phase I/II Trial (ECHO-202/KEYNOTE-037)

(2018) Tara C. Mitchell et al.   JOURNAL OF CLINICAL ONCOLOGY

Emerging Role of Immune Checkpoint Blockade in Pancreatic Cancer

(2018) Shravanti Macherla et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Developing combination strategies using PD-1 checkpoint inhibitors to treat cancer

(2018) Emmett V. Schmidt   Seminars in Immunopathology

Stereotactic Radiotherapy Increases Functionally Suppressive Regulatory T Cells in the Tumor Microenvironment

(2017) Yuki Muroyama et al.   Cancer Immunology Research

T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma

(2017) Ingunn M. Stromnes et al.   Cancer Immunology Research

Checkpoint Antibodies but not T Cell-Recruiting Diabodies Effectively Synergize with TIL-Inducing  -Irradiation

(2016) M. Hettich et al.   CANCER RESEARCH

Blocking Indolamine-2,3-Dioxygenase Rebound Immune Suppression Boosts Antitumor Effects of Radio-Immunotherapy in Murine Models and Spontaneous Canine Malignancies

(2016) A. M. Monjazeb et al.   CLINICAL CANCER RESEARCH

Use of a positional therapy device significantly improves nocturnal gastroesophageal reflux symptoms

(2016) S. Allampati et al.   DISEASES OF THE ESOPHAGUS

PD‐L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy

(2016) Abul Azad et al.   EMBO Molecular Medicine

Effect of Chemoradiotherapy vs Chemotherapy on Survival in Patients With Locally Advanced Pancreatic Cancer Controlled After 4 Months of Gemcitabine With or Without Erlotinib

(2016) Pascal Hammel et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cancer of the pancreas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2015) M. Ducreux et al.   ANNALS OF ONCOLOGY

Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6Clow F4/80+ Extratumoral Macrophages

(2015) Gregory L. Beatty et al.   GASTROENTEROLOGY

Reverse-Contrast Imaging and Targeted Radiation Therapy of Advanced Pancreatic Cancer Models

(2015) Daniel L.J. Thorek et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

PD-1/PD-L1 Blockade Together With Vaccine Therapy Facilitates Effector T-Cell Infiltration Into Pancreatic Tumors

(2015) Kevin C. Soares et al.   JOURNAL OF IMMUNOTHERAPY

A phase II study of cisplatin plus S-1 with concurrent thoracic radiotherapy for locally advanced non-small-cell lung cancer: The Okayama Lung Cancer Study Group Trial 0501

(2015) Naoyuki Nogami et al.   LUNG CANCER

Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer

(2015) Kelly Foley et al.   Science Signaling

Small molecule drugs with immunomodulatory effects in cancer

(2015) Adrian G Murphy et al.   Human Vaccines & Immunotherapeutics

Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer

(2015) Kelly Foley et al.   Science Signaling

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

(2014) Liufu Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation

(2014) E. R. Lutz et al.   Cancer Immunology Research

Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death

(2014) Encouse B Golden et al.   OncoImmunology

Stereotactic Body Radiation Therapy for Locally Advanced and Borderline Resectable Pancreatic Cancer Is Effective and Well Tolerated

(2013) Michael D. Chuong et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Radiation-Induced Equilibrium Is a Balance between Tumor Cell Proliferation and T Cell-Mediated Killing

(2013) H. Liang et al.   JOURNAL OF IMMUNOLOGY

2564 resected periampullary adenocarcinomas at a single institution: trends over three decades

(2013) Jin He et al.   HPB

Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma

(2012) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adjuvant Gemcitabine Alone Versus Gemcitabine-Based Chemoradiotherapy After Curative Resection for Pancreatic Cancer: A Randomized EORTC-40013-22012/FFCD-9203/GERCOR Phase II Study

(2010) Jean-Luc Van Laethem et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

(2010) Julie R. Brahmer et al.   JOURNAL OF CLINICAL ONCOLOGY

Systemic effects of local radiotherapy

(2009) Silvia C Formenti et al.   LANCET ONCOLOGY

Analysis of Fluorouracil-Based Adjuvant Chemotherapy and Radiation After Pancreaticoduodenectomy for Ductal Adenocarcinoma of the Pancreas: Results of a Large, Prospectively Collected Database at the Johns Hopkins Hospital

(2008) Joseph M. Herman et al.   JOURNAL OF CLINICAL ONCOLOGY

Expression of Indoleamine 2,3-Dioxygenase in Metastatic Pancreatic Ductal Adenocarcinoma Recruits Regulatory T Cells to Avoid Immune Detection

(2008) Agnes Witkiewicz et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS