Article
Peripheral Vascular Disease
Orna Reges, Hongyan Ning, John T. Wilkins, Colin O. Wu, Xin Tian, Michael J. Domanski, Donald M. Lloyd-Jones, Norrina B. Allen
Summary: This study assessed the association between 10-year cumulative systolic blood pressure in middle age and long-term risk of cardiovascular disease, coronary heart disease, stroke, heart failure, and all-cause mortality. Lower 10-year cumulative systolic blood pressure was found to be associated with longer survival and a later onset of cardiovascular disease, highlighting its importance as a risk factor for CVD beyond current systolic blood pressure levels.
Article
Peripheral Vascular Disease
Yi-Bang Cheng, Lutgarde Thijs, Lucas S. Aparicio, Qi-Fang Huang, Fang-Fei Wei, Yu-Ling Yu, Jessica Barochiner, Chang-Sheng Sheng, Wen-Yi Yang, Teemu J. Niiranen, Jose Boggia, Zhen-Yu Zhang, Katarzyna Stolarz-Skrzypek, Natasza Gilis-Malinowska, Valerie Tikhonoff, Wiktoria Wojciechowska, Edoardo Casiglia, Krzysztof Narkiewicz, Jan Filipovsky, Kalina Kawecka-Jaszcz, Ji-Guang Wang, Yan Li, Jan A. Staessen
Summary: This study investigated the relationship between cardiovascular risk and central and brachial systolic pressure and proposed thresholds to differentiate hypertension from normal blood pressure. Regardless of brachial blood pressure status, central hypertension was associated with increased cardiovascular and cerebrovascular risk, highlighting the importance of controlling central hypertension.
Review
Environmental Sciences
Gyeyoon Yim, Yuting Wang, Caitlin G. Howe, Megan E. Romano
Summary: This scoping review summarizes the literature on the cardiotoxicity of exposure to metal mixtures and identifies the trends and focus areas in the research. The majority of the studies were conducted in the United States and China, with an increase in publications in recent years. The commonly investigated metals included cadmium, lead, arsenic, and cobalt, with a focus on their impact on blood pressure, preeclampsia, dyslipidemia, and cardiovascular disease outcomes.
Article
Clinical Neurology
Yohwan Lim, Bo Chang Kim, Sung Soo Yoon, Hye Jun Kim, Sang Jun Lee, Myeong Hoon Lee, Ju Hee Kim, Sun Jae Park, Seogsong Jeong, Hyun Wook Han
Summary: This study investigates the association between changes in blood pressure (systolic and diastolic) and incident depression. Analysis of 224,192 participants reveals that individuals who experienced a decrease in systolic blood pressure from above 140 mmHg to 120-129 mmHg, as well as a decrease in diastolic blood pressure from above 90 mmHg to 60-79 mmHg, have a higher risk of developing depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Ruizhi Zheng, Yu Xu, Mian Li, Jieli Lu, Shujing Wu, Jingya Niu, Zhiyun Zhao, Li Chen, Yanan Huo, Min Xu, Tiange Wang, Shuangyuan Wang, Hong Lin, Guijun Qin, Li Yan, Qin Wan, Lulu Chen, Lixin Shi, Ruying Hu, Xulei Tang, Qing Su, Xuefeng Yu, Yingfen Qin, Gang Chen, Zhengnan Gao, Guixia Wang, Feixia Shen, Zuojie Luo, Yuhong Chen, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Qiang Li, Yiming Mu, Jiajun Zhao, Weiqing Wang, Guang Ning, Yufang Bi
Summary: There is a significant and linear association between systolic and diastolic blood pressure levels currently considered normal and the incidence of cardiovascular diseases among Chinese adults without major cardiovascular risk factors. No clear thresholds were found.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2022)
Article
Cardiac & Cardiovascular Systems
Shuo Sun, Xiao-cong Liu, Guo-dong He, Kenneth Lo, Ying-qing Feng, Yu-qing Huang
Summary: The study revealed a nonlinear association between normal range SBP levels and all-cause mortality and cardiovascular mortality in older adults without hypertension.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Shishir Rao, Yikuan Li, Milad Nazarzadeh, Dexter Canoy, Mohammad Mamouei, Abdelaali Hassaine, Gholamreza Salimi-Khorshidi, Kazem Rahimi
Summary: A study using deep learning modeling found a monotonic relationship between systolic blood pressure and risk of cardiovascular events in patients with diabetes, without evidence of a J-shaped relationship.
Article
Biochemistry & Molecular Biology
Tomislav Bulum, Martina Tomic, Romano Vrabec, Neva Brkljacic, Spomenka Ljubic
Summary: This study investigated the risk factors for diabetic retinopathy (DR) in patients with type 2 diabetes (T2DM) with and without diabetic nephropathy (DN). The main predictors of DR in patients with T2DM were found to be diabetes duration, glycemic control (HbA1c), and systolic and diastolic blood pressure. The influence of blood pressure on DR development remained significant even after adjusting for diabetes duration and HbA1c.
Article
Cardiac & Cardiovascular Systems
Nathan K. Itoga, Daniel S. Taw, Maria E. Montez-Rath, Tara I. Chang
Summary: The study found that there are differences in the risk pattern of systolic blood pressure (SBP) and diastolic blood pressure (DBP) depending on clinical outcomes, with different SBP and DBP ranges associated with the lowest risk for different cardiovascular events. This suggests that individualization of blood pressure targets may be necessary based on the specific cardiovascular event for which a patient is most at risk.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Peripheral Vascular Disease
Yacong Bo, Tsung Yu, Cui Guo, Ly-yun Chang, Junjie Huang, Martin C. S. Wong, Tony Tam, Xiang Qian Lao
Summary: This study found that young adults with stage 1 or stage 2 isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and systolic and diastolic hypertension (SDH) have an increased risk of cardiovascular death compared to those with normal blood pressure. Regardless of blood pressure stage, SDH was associated with a higher cardiovascular mortality risk than IDH and ISH.
JOURNAL OF HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Anna C. O'Kelly, Erin D. Michos, Chrisandra L. Shufelt, Jane V. Vermunt, Margo B. Minissian, Odayme Quesada, Graeme N. Smith, Janet W. Rich-Edwards, Vesna D. Garovic, Samar R. El Khoudary, Michael C. Honigberg
Summary: In addition to conventional risk factors, women also face sex-specific risk factors for cardiovascular disease. Key stages of a woman's reproductive history, such as early and late menarche, polycystic ovary syndrome, infertility, adverse pregnancy outcomes, and absence of breastfeeding, are associated with increased future cardiovascular disease risk. The menopause transition period also represents an accelerated cardiovascular disease risk, with timing, mechanism, and symptoms of menopause playing a role. Differences in conventional risk factors explain some, but not all, of the observed associations between reproductive history and cardiovascular disease; further research is needed to understand hormonal effects and unique sex-specific mechanisms. A history of reproductive risk factors provides an opportunity for comprehensive screening, refinement of risk assessment, and implementation of prevention strategies to optimize women's long-term cardiometabolic health.
CIRCULATION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Yazan Assaf, Ahmad Barout, Ahmad Alhamid, Ahmad Al-Mouakeh, Maria Irene Barillas-Lara, Sonia Fortin-Gamero, Amanda R. Bonikowske, Carl J. Pepine, Thomas G. Allison
Summary: The study aimed to update norms for peak systolic blood pressure on the graded exercise test and examine its prognostic value in patients without baseline cardiovascular disease. The conclusion indicates that low exercise peak SBP is an independent predictor of higher total and cardiovascular mortality.
Article
Peripheral Vascular Disease
Juan A. Divison-Garrote, Julio A. Carbayo-Herencia, Marta Simarro-Rueda, Francisca Molina-Escribano, Carlos Escobar-Cervantes, Luis M. Artigao-Rodenas, Vicente Gil-Guillen, Jose R. Banegas
Summary: This study found that in primary prevention with low cardiovascular risk, untreated systolic blood pressure (SBP) of 130 to 139 mm Hg still had long-term prognostic value and may benefit from stricter SBP targets. High cardiovascular risk patients had a slightly higher risk and a 4-fold greater risk compared to low-risk individuals. The results highlight the importance of risk stratification and support risk-based decision-making.
Review
Nutrition & Dietetics
Shuaishuai Zhou, Teng Xu, Xu Zhang, Junjie Luo, Peng An, Yongting Luo
Summary: The supplementation of casein hydrolysate can effectively reduce blood pressure without affecting blood lipids or glycemic status.
Article
Endocrinology & Metabolism
Husam Ghanim, Manav Batra, Kelly Green, Jeanne Hejna, Sanaa Abuaysheh, Antione Makdissi, Ajay Chaudhuri, Paresh Dandona
Summary: This study demonstrates that treatment with dapagliflozin can significantly reduce systolic blood pressure in patients with type 2 diabetes, suppress the expression of angiotensin II and angiotensinogen, and increase levels of vasodilators.
DIABETES OBESITY & METABOLISM
(2021)
Review
Cardiac & Cardiovascular Systems
Bibinaz Eghtedari, Sion K. K. Roy, Matthew J. J. Budoff
Summary: Chronic inflammation plays a key role in the progression of atherosclerotic disease, and targeting inflammation has been shown to halt the development of coronary artery disease. Specific anti-inflammatory therapies, such as colchicine, canakinumab, VIA-2291, and methotrexate, have demonstrated efficacy in inhibiting atherosclerosis and cardiovascular disease progression. This review highlights the potential benefits of these anti-inflammatories, particularly for high-risk individuals already on optimal medical therapy.
CARDIOLOGY IN REVIEW
(2023)
Review
Cardiac & Cardiovascular Systems
Mahmoud Al Rifai, Alka M. Kanaya, Namratha R. Kandula, Jaideep Patel, Mouaz H. Al-Mallah, Matthew Budoff, Miguel Cainzos-Achirica, Michael H. Criqui, Salim S. Virani
Summary: Individuals of South Asian ancestry have a higher risk of atherosclerotic cardiovascular disease. Coronary artery calcium volume and density can identify unique plaque characteristics in this population, providing important prognostic information. Cardiovascular risk factors are associated with CAC density and volume.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Muhammad A. Latif, Christopher R. Bailey, Mina Motaghi, Moustafa Abou Areda, Panagis Galiatsatos, Sally E. Mitchell, Clifford R. Weiss
Summary: This study compared the effectiveness of coils, AVPs, and MVPs in treating PAVMs. The results showed that MVPs had the lowest risk of persistence, followed by AVPs and coils.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Article
Rheumatology
George A. Karpouzas, Bianca Papotti, Sarah R. Ormseth, Marcella Palumbo, Elizabeth Hernandez, Cinzia Marchi, Francesca Zimetti, Matthew J. Budoff, Nicoletta Ronda
Summary: This study explores the factors in the serum of patients with rheumatoid arthritis (RA) and their mechanisms of interaction with and influence on the cholesterol loading capacity (CLC) of macrophages. The results show that oxidized LDL can directly influence CLC in dual-seropositive RA patients. Two additional and independent pathways, through anti-oxLDL IgG and PCSK9, may mediate the effects of oxPL-apoB100 on CLC, depending on CRP and seropositivity status.
Article
Cardiac & Cardiovascular Systems
Michael Miller, Deepak L. Bhatt, Ph Gabriel Steg, Eliot A. Brinton, Terry A. Jacobson, Lixia Jiao, Jean-Claude Tardif, Christie M. Ballantyne, Matthew Budoff, R. Preston Mason
Summary: The study found that the use of IPE can reduce the risk of cardiovascular disease in smokers to the level observed in non-smokers.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Gastroenterology & Hepatology
Jacqueline B. B. Henson, Matthew J. J. Budoff, Andrew J. J. Muir
Summary: This study evaluated the performance of the Pooled Cohort Equations (PCE) in non-alcoholic fatty liver disease (NAFLD) patients and found that the PCE performed poorly in cardiovascular risk assessment in NAFLD, particularly in women and individuals with moderate-to-severe steatosis. Therefore, primary prevention may need to be considered at a lower risk threshold in these patients.
LIVER INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Venkat S. Manubolu, Song Mao, April Kinninger, Suraj Dahal, Khadije Ahmad, Ruby Havistin, Yanlin Gao, Chris Dailing, J. Jeffrey Carr, Sion K. Roy, Matthew J. Budoff
Summary: This study examined the relationship between thoracic spine bone mineral density (BMD) and severity of coronary artery calcium (CAC) score. The results showed a significant inverse relationship between BMD and CAC in both genders. Further research is needed to explore the underlying pathophysiological mechanisms.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Letter
Cardiac & Cardiovascular Systems
Charles Ginsberg, Andrew N. Hoofnagle, Ronit Katz, Jonathan H. Cheng, Simon Hsu, Matthew J. Budoff, Deborah M. Kado, Bryan Kestenbaum, David S. Siscovick, Erin D. Michos, Joachim H. Ix, Ian H. de Boer
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Letter
Cardiac & Cardiovascular Systems
Yejin Mok, Yasuyuki Honda, Frances M. Wang, Candace M. Howard, Aaron R. Folsom, Josef Coresh, Matthew Budoff, Michael J. Blaha, Kunihiro Matsushita
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Bibinaz Eghtedari, April Kinninger, Sion K. Roy, Matthew J. Budoff
Summary: Annualized coronary artery calcium progression of greater than 20 units per year significantly predicts all-cause mortality, highlighting the importance of close monitoring and aggressive treatment within this range.
CORONARY ARTERY DISEASE
(2023)
Review
Peripheral Vascular Disease
Daniel Lorenzatti, Pamela Pina, Ibolya Csecs, Aldo L. Schenone, Carlos A. Gongora, Mario J. Garcia, Michael J. Blaha, Matthew J. Budoff, Michelle C. Williams, Damini Dey, Daniel S. Berman, Salim S. Virani, Leandro Slipczuk
Summary: Coronary computed tomography angiography (CCTA) has significantly improved the imaging of adverse coronary plaque features. Recent findings have shown that quantitative and qualitative assessment of coronary plaque by CCTA can enhance the prediction of future major adverse cardiovascular events. It can also aid in the identification of high-risk non-obstructive coronary plaque, differentiate myocardial infarction types, and track disease progression and response to medical therapy.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Meng Wang, Xinmin S. Li, Zeneng Wang, Marcia C. de Oliveira Otto, Rozenn N. Lemaitre, Amanda Fretts, Nona Sotoodehnia, Matthew Budoff, Ina Nemet, Joseph A. DiDonato, Wai Hong Wilson Tang, Bruce M. Psaty, David S. Siscovick, Stanley L. Hazen, Dariush Mozaffarian
Summary: This study aimed to investigate the associations of plasma TMAO levels and its changes over time with all-cause and cause-specific mortality. The study included 6,785 adults and found that higher plasma TMAO levels were associated with increased risks of all-cause mortality, cardiovascular disease mortality, and death due to kidney failure.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Keishi Ichikawa, Shriraj Susarla, Matthew J. Budoff
Summary: Although the overall incidence of atherosclerotic cardiovascular disease (ASCVD) is declining in the United States, the incidence of ASCVD events in young adults is increasing. The use of coronary artery calcium (CAC) scores can improve ASCVD risk assessment, but is not recommended for universal screening in young adults.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Vishal K. K. Narang, Matthew Budoff
Article
Cardiac & Cardiovascular Systems
Rozenn N. N. Lemaitre, Paul N. N. Jensen, Zeneng Wang, Amanda M. M. Fretts, Colleen M. M. Sitlani, Ina Nemet, Nona Sotoodehnia, Marcia C. C. de Oliveira Otto, Weifei Zhu, Matt Budoff, W. T. Longstreth, Bruce M. M. Psaty, David S. S. Siscovick, Stanley L. L. Hazen, Dariush Mozaffarian
Summary: This study examined the association between circulating trimethylamine-N-oxide (TMAO) and incident ischemic stroke in a diverse population. The results showed a positive linear association between TMAO levels and the risk of ischemic stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)