Article
Oncology
Ting-Huan Huang, Giun-Yi Hung, Te-Fu Weng, Fu-Mien Wang, Chih-Ying Lee, Dong-Tsamn Lin, Bow-Wen Chen, Kai-Hsin Lin, Kang-Hsi Wu, Hsi-Che Liu, Jiann-Shiuh Chen, Shiann-Tarng Jou, Jen-Yin Hou, Yung-Li Yang, Shih-Hsiang Chen, Hsiu-Hao Chang, Shyh-Shin Chiou, Pei-Chin Lin, Rong-Long Chen, Chih-Cheng Hsiao, Hsiu-Ju Yen, Chao-Ping Yang, Te-Kau Chang, Meng-Yao Lu, Chao-Neng Cheng, Jiunn-Ming Sheen, Yu-Mei Liao, Min-Yu Su, Ting-Chi Yeh
Summary: This study retrospectively analyzed the prognostic factors and treatment outcomes of primary malignant mediastinal germ cell tumors (GCTs) in Taiwanese children. The results showed that surgical treatment was associated with better outcomes, while advanced disease stage and choriocarcinoma histology subtype were associated with poorer outcomes. Additionally, there was no difference in treatment outcomes between cisplatin-based and carboplatin-based chemotherapy.
Article
Biotechnology & Applied Microbiology
Chen Yang, Siqi Wu, Zezhong Mou, Quan Zhou, Xiyu Dai, Yuxi Ou, Xinan Chen, Yiling Chen, Chenyang Xu, Yun Hu, Limin Zhang, Lujia Zou, Shengming Jin, Jimeng Hu, Shanhua Mao, Haowen Jiang
Summary: This study identified differentially expressed circRNAs in bladder cancer tissue and exosomes, and investigated their roles in cancer cell behavior and immune function. The findings revealed the regulatory function of exosome-derived circTRPS1 in BCa cells and provided potential therapeutic targets for BCa.
Article
Immunology
Rebekka Mispelbaum, Sandra Tessa Hattenhauer, Peter Brossart, Annkristin Heine
Summary: This study demonstrates that administration of red blood cell transfusion during immunotherapy, but not before, negatively affects response rates. The findings suggest a need for restrictive transfusion management in patients undergoing immunotherapy to optimize response rates.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Teng Tu, Ye Yuan, Xiaoxue Liu, Xin Liang, Xiaofan Yang, Yue Yang
Summary: This article elucidates the role and regulatory mechanisms of the SLFN5 gene in tumors, as well as its potential as a new biomarker for tumor diagnosis and prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Engineering, Environmental
Yitong Wang, Jinjie Cui, Jiajie Chen, Jianyu Wan, Yakun Liang, Ming Qi, Xudong Wang, Lei Zhang, Kaili Lin
Summary: The bone microenvironment poses a challenge to the treatment of bone tumors. This study presents a novel nanosystem that targets bone tumor cells and effectively inhibits tumor growth and osteolysis. The nanosystem is constructed by covalently attaching a bone tumor cell-targeting peptide to a core-shell structure, allowing for specific targeting and enhanced contrast.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Immunology
Qingbo Li, Patrick Kwabena Oduro, Rui Guo, Ruiqiao Li, Ling Leng, Xianbin Kong, Qilong Wang, Long Yang
Summary: Oncolytic virus therapy is a rapidly advancing approach for treating malignant tumors, with high specificity and safety. The treatment of malignant tumors in the digestive system still requires improvement, and oncolytic viruses may provide therapeutic solutions for this issue.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Oncology
Colin Thorbinson, John-Paul Kilday
Summary: Brain tumors are the leading cause of childhood cancer deaths in developed countries, representing the most common solid tumor in this age group, accounting for approximately one-quarter of all pediatric cancers. Developments in neuro-imaging, neurosurgical techniques, adjuvant therapy, and supportive care have improved survival rates for certain tumors, allowing a focus on optimizing cure while minimizing long-term adverse effects. Recent advancements in the molecular characterization of common pediatric brain tumors have identified unique clinical and biological patient subgroups, but achieving a paradigm shift in translational therapy and subsequent survival for many tumors remains challenging, with recurrence presenting a significant clinical challenge. This review provides insight into key molecular developments and global cooperative trial results for the most common malignant pediatric brain tumors, highlighting potential future directions for management, including novel therapeutic options and unresolved critical challenges.
Review
Physics, Multidisciplinary
Gwenael Page, Philippe Garteiser, Bernard E. Van Beers
Summary: The biomechanical properties of cancer play a crucial role in tumorigenesis, invasiveness, and treatment resistance. Magnetic resonance elastography is a non-invasive imaging method that can assess the mechanical properties of tumors. It has been found that evaluating visco-elastic properties using MRE can help characterize malignant tumors and evaluate treatment response.
FRONTIERS IN PHYSICS
(2022)
Review
Oncology
Aggelos T. Margetis
Summary: Dysregulated metabolism is a fundamental characteristic of carcinogenesis, leading to aggressive features and additional hallmarks. This review provides a comprehensive overview of well-established metabolic changes in tumors and discusses potential therapeutic targets, bridging the gap between basic research and clinical application in oncology. The tumor microenvironment plays a significant role, as extracellular metabolites, pH alterations, and stromal cells interact with malignant cells, influencing tumor-promoting responses, disabling anti-tumor immunity, and promoting treatment resistance.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Corey Neff, Mackenzie Price, Gino Cioffi, Carol Kruchko, Kristin A. Waite, Jill S. Barnholtz-Sloan, Quinn T. Ostrom
Summary: This study estimates the prevalence of malignant and non-malignant brain tumors in comparison to other cancers. The results show that brain tumors contribute significantly to the cancer burden in the United States, especially among those younger than age 65 years. Understanding complete prevalence is crucial for monitoring cancer burden, informing clinical research, and guiding public policy.
Article
Oncology
Zixuan Song, Yizi Wang, Yangzi Zhou, Dandan Zhang
Summary: This study constructed a nomogram using multiple clinical indicators to predict the prognosis of malignant ovarian germ cell tumors (MOGCTs), which was more accurate than FIGO staging alone. The nomogram may assist clinicians in identifying high-risk patients and implementing personalized treatment regimens.
Review
Oncology
Anna Borgenvik, Matko Cancer, Sonja Hutter, Fredrik J. Swartling
Summary: MYC genes are frequently misregulated in malignant brain tumors, with MYCN playing a crucial role in pediatric brain tumors. Targeting MYCN for treatment remains challenging due to its nature as a transcription factor. Efforts to treat MYCN-driven brain tumors through direct or indirect measures could potentially improve patient outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Shuting Cao, Yu-Wen Hung, Yi-Chang Wang, Yiyin Chung, Yue Qi, Ching Ouyang, Xiancai Zhong, Weidong Hu, Alaysia Coblentz, Ellie Maghami, Zuoming Sun, H. Helen Lin, David K. Ann
Summary: Attenuated host autophagy plays a role in inducing tumor rejection through reinforced adaptive immunity, while dietary glutamine supplementation promotes antitumor immunity by exposing differences in plasticity between cancer cells, CD8(+) T cells, and Tregs.
Review
Immunology
Juhee Lim, In Kang, Jeongwoo La, Keun Bon Ku, Byeong Hoon Kang, Yumin Kim, Won Hyung Park, Heung Kyu Lee
Summary: This review focuses on the role of Type I interferons in regulating antitumor immune responses, particularly in malignant gliomas. Type I interferons can promote immune clearance of tumor cells and transform the cold tumor microenvironment into an immune-activating hot environment by modulating the immune response and altering the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Shinji Tsukamoto, Alberto Righi, Andreas F. Mavrogenis, Manabu Akahane, Kanya Honoki, Yasuhito Tanaka, Davide Maria Donati, Costantino Errani
Summary: In cases of giant cell tumor of bone (GCTB), an intermediate malignant bone tumor, approximately 4% experience malignant transformation. Local recurrence is an independent prognostic factor for unfavorable malignant transformation, with late local recurrence of GCTB being associated with a higher risk of malignant transformation.
Article
Chemistry, Multidisciplinary
Han Jiang, Yuedong Guo, Chenyang Wei, Ping Hu, Jianlin Shi
Summary: A novel tumor immunotherapy modality based on nanocatalytic innate immunity activation by inducing oxidative damage in tumor cells' mtDNA is proposed. This approach reactivates macrophages' immune response against cancer cells, leading to the inhibition of primary and distant tumor growth during treatment.
ADVANCED MATERIALS
(2021)
Article
Multidisciplinary Sciences
Bowen Yang, Heliang Yao, Han Tian, Zhiguo Yu, Yuedong Guo, Yuemei Wang, Jiacai Yang, Chang Chen, Jianlin Shi
Summary: Iron gall chelate (GA-Fe) can promote chemical corrosion through oxygen reduction reactions and reactive oxygen species generation, inspiring a composite cancer nanomedicine using gallate loaded into a Fe-engineered mesoporous silica nanocarrier. This nanocomposite degrades in acidic tumors to release Fe3+ and gallate, forming GA-Fe nanocomplex in situ for direct oxidative damage to tumors, providing insights for future anticancer research.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Bowen Yang, Yuedong Guo, Yuemei Wang, Jiacai Yang, Heliang Yao, Jianlin Shi
Summary: The strategy of utilizing the intratumoral redox reactions of dopamine to produce cytotoxic species shows promising prospects for cancer chemotherapy design.
Article
Chemistry, Multidisciplinary
Yuedong Guo, Yingying Xu, Qunqun Bao, Chao Shen, Dalong Ni, Ping Hu, Jianlin Shi
Summary: This study focuses on using endogenous copper ions as a source of Fenton-like agents in cancer treatment, to disrupt the intrinsic protection pathway of cancer cells and induce apoptosis through catalytic oxidative damage reactions. The nanocatalyst shows excellent biosafety and enhanced therapeutic efficacy by simultaneously targeting cancer cell self-protection mechanisms and inducing oxidative damage.
Article
Chemistry, Multidisciplinary
Jiacai Yang, Heliang Yao, Yuedong Guo, Bowen Yang, Jianlin Shi
Summary: In this study, a co-catalytic concept was introduced to enhance the efficacy of Fenton reactions in tumor catalytic therapy by dispersing single-atom iron species on two-dimensional molybdenum disulfide nanosheets. The iron species act as active sites for triggering the Fenton reactions, while the sulfur vacancies on the nanosheets promote hydroxyl radical production. Moreover, the nanosheets also serve as a co-catalyst to accelerate the conversion of iron ions and promote the overall catalytic process. The study demonstrates the feasibility of applying this co-catalytic concept to improve anticancer efficacy both in vitro and in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Bowen Yang, Heliang Yao, Jiacai Yang, Chang Chen, Yuedong Guo, Hao Fu, Jianlin Shi
Summary: The study demonstrates the design of therapeutic nanomedicine with antioxidant activity by mimicking the coordination geometry of active metal sites of natural enzymes. This nanomedicine can be used for treating immune-mediated diseases like rheumatoid arthritis, while also promoting cellular antioxidative efficacy and biomineralization by bone cells.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
Yingying Xu, Zhiguo Yu, Hao Fu, Yuedong Guo, Ping Hu, Jianlin Shi
Summary: The new strategy of dual inhibition on glucose and glutamine metabolisms by silencing mutated gene Kras and glutaminase 1 (GLS1) via nanomaterial-based siKras and siGLS1 delivery can enhance pancreatic cancer treatment efficacy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Han Jiang, Hao Fu, Yuedong Guo, Ping Hu, Jianlin Shi
Summary: This study proposes a novel immunogenic cell death (ICD) modality based on mitochondrial heat stress by magnetic hyperthermia treatment (MHT), which effectively evokes tumor-associated macrophages (TAMs) against cancer cells. A nanomedicine named MRT is synthesized for mitochondria-targeted heat stress-induced oxidative damage of tumor cells, leading to the release of damage-associated molecular patterns (DAMPs) and the activation of TAMs-mediated immune response against cancer cells.
Article
Multidisciplinary Sciences
Han Jiang, Yuedong Guo, Zhiguo Yu, Ping Hu, Jianlin Shi
Summary: A nanocatalytic tumor-immunotherapeutic modality based on bacteria-specific oxidative damage under magnetic hyperthermia (MH) reverses immunosuppression of tumor microenvironment and achieves excellent therapeutic efficacy in an orthotopic colorectal cancer model.
NATIONAL SCIENCE REVIEW
(2022)
Article
Chemistry, Multidisciplinary
Qishuai Feng, Wenming Fang, Yuedong Guo, Ping Hu, Jianlin Shi
Summary: Cancer stem cells (CSCs) play a critical role in the initiation and progression of early lung cancer. By modulating the communication between tumor-associated macrophages (TAMs) and CSCs, we developed a nebulized therapeutic strategy that triggers CSC ferroptosis, leading to the suppression of early lung cancer.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Hao Fu, Yuedong Guo, Wenming Fang, Jiaxing Wang, Ping Hu, Jianlin Shi
Summary: This study proposes a novel therapeutic modality for rheumatoid arthritis (RA) by using an LDH-CeO2 nanocatalytic platform, which enhances the antioxidation activity and anti-inflammatory modulation. The platform also promotes osteogenesis, leading to satisfactory RA mitigation.
Article
Multidisciplinary Sciences
Yuedong Guo, Qunqun Bao, Ping Hu, Jianlin Shi
Summary: The authors report the design of a pH-responsive nanomedicine for the co-delivery of a T-type calcium channel inhibitor and a small molecule targeting CD47, promoting anti-tumor immune responses in orthotopic lung cancer preclinical models.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Yingying Xu, Yuedong Guo, Lei Chen, Dalong Ni, Ping Hu, Jianlin Shi
Summary: The study proposes a novel therapeutic strategy of tumor suffocation by concurrently suppressing glycolysis and mitochondrial oxidative phosphorylation through the co-deliveries of EDTA and rotenone into a glutathione-overexpressed tumor microenvironment. EDTA blocks glycolytic pathway by chelating magnesium ion to inhibit glycolytic enzymes, while rotenone inhibits mitochondrial OXPHOS. This work provides a new approach to treating tumors by inhibiting glucose metabolism, especially by de-functioning glycolytic enzymes.
Article
Chemistry, Multidisciplinary
Yuemei Wang, Wei Feng, Meiqi Chang, Jiacai Yang, Yuedong Guo, Li Ding, Luodan Yu, Hui Huang, Yu Chen, Jianlin Shi
Summary: 2D monoelemental nanomaterials (Xenes), particularly bismuthene, have shown great potential for versatile biomedical applications due to their unique optical performance, high biocompatibility, stability, and relatively low cost. A novel strategy to intercalate and delaminate bulk bismuth for generating few-layered 2D bismuthene has been proposed, enabling applications in photonic cancer nanomedicine settings such as photothermal hyperthermia and photodynamic therapy. The research also explores the use of bismuthene for dual photonic therapy under the guidance of multimodal imaging techniques.
ADVANCED FUNCTIONAL MATERIALS
(2021)
