Article
Chemistry, Analytical
Yi-Yan Bai, Zhi-Tao Feng, Yan-Ju Yang, Xiao-Yan Yang, Zhi-Ling Zhang
Summary: This study utilized current lifetime as a dynamic parameter to distinguish differently sized nanoparticles successfully. By considering current lifetime instead of current intensity, more accurate evaluation of nanoparticle sizes can be achieved.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Wenhao Ma, Wanyi Xie, Rong Tian, Xiaoqing Zeng, Liyuan Liang, Changjun Hou, Danqun Huo, Deqiang Wang
Summary: Since the outbreak of COVID-19, rapid and effective detection methods have been a focus of research. This study utilized aptamer-functionalized nanopipettes with unique ion current rectification properties to achieve rapid and highly sensitive detection of trace viral protein, reducing the cost of detection. The sensor platform exhibited a wide dynamic working range and a low detection limit, showing great potential as a tool for rapid detection of SARS-CoV-2.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Wei Yi, Xiao Li, XiuXiu He, Feng Yue, Tie Wang
Summary: This review presents the importance of glass nanopipettes in analytical chemistry, including their applications in the analysis of single molecules, single particles, and single cells.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xiaowei Jiang, Yuan Zhou, Yuang Chen, Yuanhua Shao, Jiandong Feng
Summary: A low-voltage nanotweezer for trapping single DNA molecules has been developed by using etching-engineered nanoelectrodes, reducing the minimum trapping voltage and improving trapping stiffness. This advancement is attributed to the increase in spatial heterogeneity and nonuniformity of electric field near the nanoelectrodes caused by etching of quartz.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Kang Wang, Gongming Qian, Yunchuan Li, Ruixia Wang, Jing Guo
Summary: Nanopipette-based nanopore technologies have advanced single molecule/nanoparticle/cell analysis. A multifunctional nanopipette combining a nanopore and a nanoelectrode has been developed for metal ion recognition and detection. This research establishes a platform integrating nanopore sensing and electrochemistry methods for ultra-trace chemical analysis.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Environmental Sciences
Yongyang Su, Guanyi Wei, Wei Wang, Ruiyang Xi, Xi Wang, Jiang Xu, Zhiming Li
Summary: This study evaluates the analytical performance of the commercial Hexin Single particle aerosol mass spectrometer (SPAMS) and extends its application. A universal method for particle size calibration, measurement, and correction is proposed, and isotope measurement is performed. The results show that the achieved accuracy of the isotope ratio for the elements investigated is 5%, and the instrument performance is relatively poor for elements with high ionization potential or bond energy. Additionally, the analysis of suspension particles confirms the effectiveness of the instrument and provides valuable information.
ATMOSPHERIC ENVIRONMENT
(2023)
Review
Chemistry, Analytical
Yi -Tong Xu, Yi -Fan Ruan, Tian-Yang Zhang, Xiao-Mei Shi, Hai-Yan Wang, Wei -Wei Zhao, Hong -Yuan Chen, Jing -Juan Xu
Summary: Single-cell analysis is a challenging yet important task in cell biology, and various techniques have been developed for this purpose. Nanopipette-based ion current rectification electroanalysis has emerged as a promising method in this field. This review discusses the working principle of this method, its key regulation factors, and presents illustrative examples of sensing strategies for single-cell analysis. Future perspectives in this area are also proposed.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Wei Xu, Yige Zhou, Jun Chen, Ye Tian, Li Yang, Shouyi Yin, Guoqiang Zou, Hongshuai Hou, Xiaobo Ji
Summary: The electrochemical collision method focusing on individual particles was applied to study the ions migration process of LiNi0.8Mn0.1Co0.1O2, revealing unique current signals observed with the increase of particle sizes. The trapezoid-like signals and wider-wave signals provide direct and accurate information about the kinetics of ions migration in the particles.
JOURNAL OF POWER SOURCES
(2021)
Article
Chemistry, Multidisciplinary
Cedric David Koolen, Laura Torrent, Ayush Agarwal, Olga Meili-Borovinskaya, Natalia Gasilova, Mo Li, Wen Luo, Andreas Zuttel
Summary: In this study, a high-throughput single-particle inductively coupled plasma mass spectrometry protocol was developed to determine the size, count, and elemental makeup of thousands of nanoparticles with atomistic precision. The proposed protocol has important implications for research and applications in various fields.
Article
Chemistry, Multidisciplinary
Rui Zhang, Xuye Liu, Qiang Zeng, Huanhuan Shen, Lishi Wang
Summary: This study reports a nanopore-based strategy to evaluate and compare the catalytic ability of single MnO2 catalyst particles with different morphologies by monitoring the generated O-2 bubbles from the catalytic decomposition of H2O2.
Article
Chemistry, Multidisciplinary
Vasilii S. Kolmogorov, Alexander S. Erofeev, Emily Woodcock, Yuri M. Efremov, Aleksei P. Iakovlev, Nikita A. Savin, Anna V. Alova, Svetlana V. Lavrushkina, Igor I. Kireev, Alexandra O. Prelovskaya, Elena V. Sviderskaya, Denis Scaini, Natalia L. Klyachko, Peter S. Timashev, Yasufumi Takahashi, Sergey V. Salikhov, Yuri N. Parkhomenko, Alexander G. Majouga, Christopher R. W. Edwards, Pavel Novak, Yuri E. Korchev, Petr V. Gorelkin
Summary: A high-resolution estimation method for mechanical properties and the possibility of qualitative and quantitative analysis of living cells have been demonstrated in this study. Forces applied using a nanopipette are much smaller than those using atomic force microscopy, with no detectable effect on live cells.
Article
Optics
Saowaros Dawprateep, Joewono Widjaja
Summary: This study proposes a method for measuring the size of rod-shaped particles from inline holograms using Wigner-Ville distribution (WVD) coefficients. The method eliminates the need for iterative and time-consuming particle depth searches, providing a faster response and higher sizing accuracy compared to conventional numerical reconstructions. The proposed method is experimentally validated using microtube objects of varying diameters.
OPTICS AND LASERS IN ENGINEERING
(2021)
Article
Chemistry, Analytical
Bing Li, Aleks Ponjavic, Wei-Hsin Chen, Lee Hopkins, Craig Hughes, Yu Ye, Clare Bryant, David Klenerman
Summary: The study combines light-sheet microscopy with local delivery to accurately deliver single proteins to specific locations within cells and achieve high-speed 3D detection. This method enables control over the position and quantity of protein delivery, providing a new approach for biological research.
ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Mechanical
Haoxiang He, Baoshun Wang, Weiming Yan
Summary: The new type of particle damper, multiple unidirectional single-particle damper (MUSPD), has better damping effect and is more suitable for mid- and low-rise structures. The controlled structure's energy is transferred through the collision between particles and the controlled structure, making MUSPD an effective acceleration-related damper.
JOURNAL OF ENGINEERING MECHANICS
(2021)
Article
Chemistry, Multidisciplinary
Benjamin T. T. Manard, Veronica C. C. Bradley, C. Derrick Quarles, Lyndsey Hendriks, Daniel R. R. Dunlap, Cole R. R. Hexel, Patrick Sullivan, Hunter B. B. Andrews
Summary: This study developed an innovative autosampler to mix and transport the blanks, standards, and samples into a high-efficiency single particle introduction system for the analysis of gold nanoparticles (Au NPs) and silver shelled gold core nanospheres (Au/Ag NPs). The optimized transport efficiency into the inductively coupled plasma-time of flight-mass spectrometry (ICP-TOF-MS) was more than 80%, allowing for high-throughput sample analysis. The methodology displayed good long-term reproducibility, with a relative standard deviation (%RSD) of 3.54% for in-run variation and 9.52% for day-to-day variation.
Article
Engineering, Chemical
Yanna Lin, Yulong Xu, Yanzhi Xing, Nazhen Liu, Xuwei Chen
Summary: This study develops a smart gating membrane using membrane separation technique for the selective separation and extraction of thrombin from complex matrices. The membrane exhibits temperature-controlled size-screening effect and excellent thrombin capturing specificity, resulting in high separation efficiency and preserved biological activity of thrombin.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jingqi Sun, Limin Jia, Xuwei Chen
Summary: In this study, a glutathione-functionalized GO-POSS composite (GPG) was prepared and showed selective adsorption towards glutathione. The GPG-based solid-phase adsorption process successfully extracted high-purity glutathione/GST.
Article
Chemistry, Analytical
Yanzhi Xing, Mei Yang, Xuwei Chen
Summary: Doping with heteroatoms allows the effective modulation of physicochemical and photochemical properties of carbon dots. In this study, ultrastable P and N co-doped carbon dots (PNCDs) were prepared for the highly selective detection of Fe3+ and tracking of lysosomes in living cells. The PNCDs exhibited a high quantum yield of 22.0%, and their strong coordination interaction with Fe3+ made them efficient probes for selective Fe3+ detection with a detection limit of 0.39 mu M. Moreover, PNCDs showed high lysosomal location specificity in different cell lines and enabled real-time tracking of lysosome morphology in HeLa cells.
Article
Nanoscience & Nanotechnology
Jingqi Sun, Jianhua Wang, Xuwei Chen
Summary: In this study, the binding behaviors of MUTYH adenine DNA glycosylase (MutY) to dsDNA containing different base mismatches were investigated. The type and distribution of base mismatch in the dsDNA greatly influenced the DNA-protein interaction. The [4Fe4S] cluster of MutY protein specifically identified a G-A mismatch in the dsDNA chain and showed strong binding to the protein through multiple H-bonds at the HhH motif.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Huan Wei, Lijuan Li, Yifei Xue, Ping Yu, Lanqun Mao
Summary: Potentiometry based on the galvanic cell mechanism, known as galvanic redox potentiometry (GRP), is a new tool for in vivo neurochemical sensing with high neuronal compatibility and good sensing property. In this study, the stability of the open circuit voltage (E(OC)) in GRP sensing is enhanced by adjusting the redox couple in the indicating electrode. Potassium hexachloroiridate-(IV) (K2IrCl6) shows better chemical stability and produces more stable E(OC) compared to other redox species. Integration with electrophysiology allows for stable neurochemical sensing in vivo.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yuming Zhou, Tianyi Xiong, Jiahao Lu, Ping Yu, Yanan Jiang, Fan Xia, Lanqun Mao
Summary: In this study, a self-assembled two-dimensional metal-organic framework (MOF) membrane was found to be an excellent nanofluidic platform for smart regulation of ion transport. The MOF membrane showed high ion gating ratio and stability in light-controlled ion gating, making it suitable for remote light-switching systems. This research may lead to promising applications of MOF membranes in ion sieving, biosensing, and energy conversion.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemical Research Methods
Xi Wu, Quanxing Mao, Yangguang Hao, Junna Yang, Xiaonan Zhang, Zixin Chi, Guangyan Liu, Mengmeng Wang, Qing Chen, Xuwei Chen
Summary: In this study, a high efficient and selective pretreatment method for Cytochrome C (Cyt-C) in complex protein samples was developed using a polyniobate-modified MOF material. The material exhibited selective adsorption of Cyt-C due to the synergistic effect of electrostatic and hydrogen bond interactions. The adsorption and separation efficiency of Cyt-C was validated through SDS-PAGE and LC-MS/MS analysis.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Physical
Yanzhi Xing, Yulong Xu, Yanna Lin, E. Shuang, Han Leng, Jianhua Wang, Xuwei Chen
Summary: This study presents a new type of fluorescent carbon dots (P, N-CDs) for the direct mapping of alkaline phosphatase (ALP) in cells. P, N-CDs can be exclusively cleaved by ALP, resulting in specific fluorescence enhancement for sensitive sensing of ALP activity. Additionally, P, N-CDs can respond to polarity variations in cells, and exhibit excellent photobleaching resistance and biocompatibility.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jiaxuan Yang, Ning Chu, Xuwei Chen
Summary: A novel porous polyoxometalate-based composite was synthesized by solidifying water-soluble polytungstate on a polymeric ionic liquid through cation exchange reaction. The composite exhibited excellent proteinase K adsorption properties due to the strong covalent coordination and hydrogen-bonding interaction. The adsorption behavior of proteinase K followed the Langmuir isothermal model, and the adsorption capacity reached as high as 1428 mg g(-1). The composite was successfully used for the selective isolation of highly active proteinase K from crude enzyme fluid.
Article
Chemistry, Analytical
Qi Kang, Yulong Xu, Xuwei Chen
Summary: In this study, a new two-dimensional TpBpy COF was synthesized and characterized. It exhibited excellent visible light-induced oxidase-like activity and was applied for uric acid detection, showing promising potential for practical application in biological samples.
Article
Chemistry, Multidisciplinary
Fei Wu, Ping Yu, Lanqun Mao
Summary: In vivo electrochemistry is a powerful tool for studying the chemical consequences in neural networks of the brain. Over the past 50 years, this field has undergone a technology revolution and witnessed innovations in electrochemical concepts, principles, methods, and devices. Electrochemical approaches now have a wide range of applications, from measuring neurochemical concentrations to modulating and mimicking brain signals.
Article
Multidisciplinary Sciences
Tianyi Xiong, Changwei Li, Xiulan He, Boyang Xie, Jianwei Zong, Yanan Jiang, Wenjie Ma, Fei Wu, Junjie Fei, Ping Yu, Lanqun Mao
Summary: In this study, the neuromorphic functions of ion channel-based neural systems were successfully accomplished using a polyelectrolyte-confined fluidic memristor (PFM). PFM emulated various electric pulse patterns with low energy consumption and allowed for chemical-regulated electric pulses. The PFM also enabled chemical-electric signal transduction with a single device. Its similarity to ion channels and ease of interfacing with biological systems make PFM a versatile tool for building advanced neuromorphic devices.
Article
Nanoscience & Nanotechnology
Yali Li, Ping Yu, Wenjie Ma, Lanqun Mao
Summary: This research discovers that the use of a mixed electronic-ionic conductive metal-organic framework can significantly lower the driving voltage of electrochemical actuators and provide excellent actuation performance.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Jianwei Zong, Wenjie Wu, Lanqun Mao, Ping Yu
Summary: Identifying the active sites of electrocatalysts is crucial for catalyst design, but remains challenging. This study demonstrates a simple and efficient method using stochastic collision electrochemistry to identify the active sites of electrocatalysts, overcoming the limitations of traditional methods caused by the large geometric area and limited exposure of active sites. This work enriches the methodology for identifying active sites.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Jianwei Zong, Wenjie Wu, Lanqun Mao, Ping Yu
Summary: Using stochastic collision electrochemistry as a method, the active sites of electrocatalysts can be identified more effectively. Experimental results demonstrate that different active sites play dominant roles in different reactions.
CHEMICAL COMMUNICATIONS
(2023)