Genetic Analysis of the Coronavirus SARS-CoV-2 Host Protease TMPRSS2 in Different Populations

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A novel coronavirus outbreak of global health concern

(2020) Chen Wang et al.   LANCET

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations

(2020) Yanan Cao et al.   Cell Discovery

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Camostat mesilate therapy for COVID-19

(2020) Yoshiharu Uno   Internal and Emergency Medicine

First comprehensive computational analysis of functional consequences of TMPRSS2 SNPs in susceptibility to SARS-CoV-2 among different populations

(2020) Alireza Paniri et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome

(2020) Christian A. Devaux et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Ethnicity and COVID-19: an urgent public health research priority

(2020) Manish Pareek et al.   LANCET

TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?

(2020) Konrad H. Stopsack et al.   Cancer Discovery

The Expression and Polymorphism of Entry Machinery for COVID-19 in Human: Juxtaposing Population Groups, Gender, and Different Tissues

(2020) Behrooz Darbani   International Journal of Environmental Research and Public Health

ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy

(2020) Rosanna Asselta et al.   Aging-US

ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population

(2020) Elisa Benetti et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

(2020) David Ellinghaus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface

(2020) Joseph Collin et al.   Ocular Surface

TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection

(2019) Naoko Iwata-Yoshikawa et al.   JOURNAL OF VIROLOGY

Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry

(2018) Kazuya Shirato et al.   VIROLOGY

Host genetics of severe influenza: from mouse Mx1 to human IRF7

(2016) Michael J Ciancanelli et al.   CURRENT OPINION IN IMMUNOLOGY

Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry

(2016) Kazuya Shirato et al.   JOURNAL OF VIROLOGY

Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases

(2016) Liang He et al.   Frontiers in Genetics

Protease inhibitors targeting coronavirus and filovirus entry

(2015) Yanchen Zhou et al.   ANTIVIRAL RESEARCH

Identification ofTMPRSS2as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza

(2015) Zhongshan Cheng et al.   JOURNAL OF INFECTIOUS DISEASES

The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies

(2013) S. Gierer et al.   JOURNAL OF VIROLOGY

Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Severe Acute Respiratory Syndrome Coronavirus Entry

(2012) M. Kawase et al.   JOURNAL OF VIROLOGY

Influenza and SARS-Coronavirus Activating Proteases TMPRSS2 and HAT Are Expressed at Multiple Sites in Human Respiratory and Gastrointestinal Tracts

(2012) Stephanie Bertram et al.   PLoS One

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY