Article
Biochemistry & Molecular Biology
Jingjing Cui, Jian Wang, Yeke Lv, Dong Xu
Summary: The study found that the expression of lncRNA NEAT1 was up-regulated in the serum of infantile pneumonia patients, while miR-146b was down-regulated. Knocking down lncRNA NEAT1 promoted cell growth and reduced apoptosis, while over-expressing miR-146b enhanced cell viability. This study demonstrated that lncRNA NEAT1 regulates infantile pneumonia by sponging miR-146b.
MOLECULAR BIOTECHNOLOGY
(2021)
Article
Cell & Tissue Engineering
Rongxiang Wu, Zhan Su, Le Zhao, Ruifeng Pei, Yiren Ding, Deqiang Li, Shuo Zhu, Lu Xu, Wei Zhao, Wuyuan Zhou
Summary: This study elucidated a possible mechanism by which EV-encapsulated NEAT1 from ADSCs might mediate gemcitabine resistance in pancreatic cancer (PCa) by regulating the miR-491-5p/Snail/SOCS3 axis. The findings suggested that NEAT1 competitively bound to miR-491-5p, leading to upregulation of Snail and downregulation of SOCS3, thereby promoting PCa cell proliferation, migration, and gemcitabine resistance. This study provides new insights into the potential strategy for gemcitabine resistance in PCa.
STEM CELLS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Yabin Li, Xirui Wang, Zhihuang Zhao, Jinxing Shang, Gang Li, Ruijian Zhang
Summary: NEAT1 plays an oncogenic role in glioma progression by promoting cell proliferation and interacting with miR-98-5p and BZW1. Inhibition of NEAT1 through the miR-98-5p/BZW1 pathway suppresses glioma cell proliferation in vivo. Targeting NEAT1/miR-98-5p/BZW1 may provide a novel therapeutic approach for glioma patients.
BIOSCIENCE REPORTS
(2021)
Article
Oncology
Duanyang Zhai, Tianfu Li, Runyi Ye, Jiong Bi, Xiaying Kuang, Yawei Shi, Nan Shao, Ying Lin
Summary: This study identified that the lncRNA LGALS8-AS1 is highly expressed in breast cancer and promotes the metastasis of breast cancer cells. LGALS8-AS1 upregulates SOX12 by sponging miR-125b-5p, thus activating the PI3K/AKT signaling pathway to facilitate breast cancer metastasis. The reciprocal regulatory loop of LGALS8-AS1/miR-125b-5p/SOX12 may serve as a potential therapeutic target for breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Yangwei Xu, Yanyan Li, Yue Qiu, Fei Sun, Guifang Zhu, Jingbo Sun, Guixing Cai, Wanmei Lin, Yun Fu, Hongmei Wu, Shanshan Jiang, Zhihui Wen, Feiyan Feng, Junjie Luo, Yuqin Yang, Qingling Zhang
Summary: NEAT1 is upregulated in most GC samples and is associated with poor prognosis. It promotes GC angiogenesis by competitively sponging miR-17-5p to activate the TGF beta/Smad pathway and upregulate proangiogenic factors like VEGF.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yongzhi Li, Benkang Shi, Fengming Dong, Xingwang Zhu, Bing Liu, Yili Liu
Summary: The study demonstrates that high expression of KCNQ1OT1 in bladder cancer promotes tumor progression by regulating the miR-218-5p/HS3ST3B1 signaling pathway.
CANCER GENE THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Li Dong, Yumin Zheng, Xiaoguang Luo
Summary: This study focused on exploring the role of NEAT1 in Parkinson's disease (PD) and its effects on PD and related molecular mechanisms. The results showed that NEAT1 was involved in the development of PD, regulating cellular proliferation, apoptosis, and autophagy. Interfering with NEAT1 had potential therapeutic effects on PD by increasing the level of miR-107-5p.
Article
Biochemistry & Molecular Biology
Xiang Wei, Shan Xu, Liang Chen
Summary: Sevoflurane exacerbates neurotoxicity by inhibiting cell viability and promoting cell apoptosis, neuroinflammation, and ROS production. Neat1 is up-regulated in sevoflurane-treated cells, and its knockdown can improve sevoflurane-induced neurotoxicity. Through a ceRNA mechanism, it was found that Neat1 interacts with miR-298-5p to up-regulate Srpk1, ultimately contributing to sevoflurane-stimulated neurotoxicity.
NEUROCHEMICAL RESEARCH
(2021)
Review
Biotechnology & Applied Microbiology
Feifei Wei, Zhiying Yan, Xianming Zhang, Yaoyao Wang, MiaoJing Wang, Yingwei Zhu, Kequn Xu
Summary: This study aimed to investigate the inhibitory effect of LNCNA-NEA1 on pancreatic cancer development and progression via spongiosa miR-146b-5p/TRAF6. The expression level of NEAT1 in cancerous and adjacent non-cancerous tissues was detected using real-time fluorescence quantitative polymerase chain reaction (RTFQ-PCR). Cell counting kit-8 (CCK-8) and transwell assays were conducted to determine the effect of LNCNA-NEA1 on the proliferation and migration of pancreatic cancer cells (Panc-1). The results showed that knockdown of nea 1 could inhibit the proliferation, migration and invasion of pancreatic cancer cells by upregulating the level of miR-146b-5p/TRAF6, suggesting that the expression of lnc RNA-nea 1 could be used as an indicator for preoperative diagnosis and postoperative prognosis of pancreatic cancer patients.
BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS
(2023)
Article
Medicine, Research & Experimental
Yuqin Ding, Yuting Huang, Fanrong Zhang, Lijie Gong, Chenlu Liang, Kaijing Ding, Xiangming He, Xiaowen Ding, Yiding Chen
Summary: Our study investigated the role of lncRNA TDRKH-AS1 in breast cancer (BC). We found that TDRKH-AS1 was upregulated in BC tissues and cell lines, and its high expression was associated with advanced stages and poor outcomes in BC patients. Knockdown of TDRKH-AS1 inhibited BC cell proliferation and invasion. Mechanistically, TDRKH-AS1 acted as a sponge for miR-134-5p, thereby promoting the expression of cAMP response element-binding protein 1 (CREB1), a downstream target of miR-134-5p. In vivo experiments confirmed the tumor-promoting role of TDRKH-AS1 in BC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Pathology
Jinxiang Zhu, Hao Dai, Xiang Li, Longwei Guo, Xin Sun, Zhiwei Zheng, Chongwen Xu
Summary: The study found that the role of TRG-AS1 in breast cancer bone metastasis is still unclear. Patients with high expression of TRG-AS1 had longer disease-free survival in breast cancer. TRG-AS1 was shown to be downregulated in breast cancer tissues and even lower in bone metastatic tumor tissues. Experimental results demonstrated that TRG-AS1 upregulated WISP2 expression by competitively binding with miR-877-5p, thereby inhibiting bone metastasis of breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biotechnology & Applied Microbiology
Yan Wang, Changkun Lin, Yang Liu
Summary: It was found that OIP5-AS1 is highly expressed in colorectal cancer tissues and associated with poor prognosis. Silencing OIP5-AS1 inhibited malignant behaviors and growth of CC cells. miR-34b-5p inhibits proliferation and invasion of CC cells by targeting OIP5-AS1 and the PI3K/Akt pathway.
CANCER GENE THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Zhiping Chen, Tianyu Zhong, Tao Li, Jinghua Zhong, Yang Tang, Zhanyu Liu, Baodian Ling, Lanfeng Wang
Summary: The study revealed that SNHG15 exerts oncogenic properties in gastric cancer by targeting miR-506-5p, potentially offering a novel target for GC treatment.
BIOSCIENCE REPORTS
(2021)
Article
Cell Biology
Yang Yang, Jianhua Xue, Lili Qin, Jiaxuan Zhang, Jiajia Liu, Junbo Yu
Summary: NEAT1 inhibits the progression of sepsis induced by LPS in RAW264.7 cells by modulating the miR-31-5p/POU2F1 axis, suggesting NEAT1 as a potential therapeutic target for sepsis.
Article
Oncology
Jingjing Ran, Yan Li, Lei Liu, Yihan Zhu, Yinyun Ni, Hong Huang, Zhiqiang Liu, Zhiyong Miao, Li Zhang
Summary: This study revealed that apelin may enhance the proliferation and invasion ability of lung cancer cells by inhibiting miR-15a-5p encapsulated in exosomes.